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21. 发明授权

US06822650B1 Formatting object for modifying the visual attributes of visual objects to reflect data values 有权
标题翻译：格式化对象以修改视觉对象的视觉属性以反映数据值
公开(公告)号：US06822650B1
公开(公告)日：2004-11-23
申请号：US09596604
申请日：2000-06-19
申请人： Randall Davis , Jeff Couckuyt , Paul Davies
发明人： Randall Davis , Jeff Couckuyt , Paul Davies
IPC分类号： G06F15167
CPC分类号： G06F15/16
摘要： A formatting object according to the present invention conveys information to the reader of a document (such as a table or chart) by associating visual attributes (such as color, fill type, border width, line width, line style, font size, marker size and marker type) to characters or markers within the document. The formatting object may be used to emphasize data within a table or a chart by modifying the structural visual attributes of characters or markers within the table or chart according to pre-defined criteria. Similarly, the formatting object may be used to increase information density within a table or chart, and to elegantly represent the relationships between four or more interrelated variables in a two-dimensional chart. The formatting object accomplishes this by defining at least one format map that comprises one or more mapping segments. Each mapping segment includes a beginning boundary value, an ending boundary value, at least one beginning visual attribute corresponding to the beginning boundary value, and at least one ending visual attribute corresponding to the ending boundary value. The formatting object uses the information within the format maps, in combination with interpolation techniques, to determine one or more visual attributes that correspond to data points falling within the various mapping segments. The formatting object then expresses the data values by applying the appropriate visual attribute to a visual object displayed on a computer screen.
摘要翻译：根据本发明的格式化对象通过将视觉属性（诸如颜色，填充类型，边界宽度，线宽，线型，字体大小，标记尺寸等）相关联来向读者传达信息给读者（例如表或图表）和标记类型）到文档中的字符或标记。格式化对象可以用于通过根据预定义的标准修改表或图表中的字符或标记的结构视觉属性来强调表或图表中的数据。类似地，格式化对象可以用于增加表或图表中的信息密度，并且优雅地表示二维图中四个或更多个相关变量之间的关系。格式化对象通过定义至少一个包含一个或多个映射段的格式映射来实现。每个映射段包括开始边界值，结束边界值，对应于开始边界值的至少一个开始视觉属性，以及对应于结束边界值的至少一个结束视觉属性。格式化对象使用格式图中的信息结合插值技术来确定对应于落在各种映射段内的数据点的一个或多个视觉属性。然后，格式化对象通过将适当的视觉属性应用于显示在计算机屏幕上的可视对象来表达数据值。

22. 发明申请

US20210295969A1 MEASURING REPRESENTATIONAL MOTIONS IN A MEDICAL CONTEXT 有权
公开(公告)号：US20210295969A1
公开(公告)日：2021-09-23
申请号：US17164992
申请日：2021-02-02
申请人： Randall Davis , Dana L. Penney
发明人： Randall Davis , Dana L. Penney
IPC分类号： G16H15/00 , A61B5/16 , G06Q10/10 , G06Q50/00 , A61B5/00 , G16H40/63 , G16H50/00
摘要： A method includes receiving data representing graphomotor motion during a succession of executions of graphomotor diagnostic tasks performed in a medical context by a subject, processing the received data using a computer, including determining a first set of quantitative features from a first execution of a task by the subject, and determining a second set of quantitative features from a second execution of a task by the subject, determining one or more metrics based on a comparison to the successive executions, including using at least the first set of quantitative features and the second set of quantitative features to determine said metrics, and providing a diagnostic report associated with neurocognitive mechanisms underlying the subject's execution of the tasks based on the determined metrics.

23. 发明授权

US10943683B2 Measuring representational motions in a medical context 有权
公开(公告)号：US10943683B2
公开(公告)日：2021-03-09
申请号：US15867458
申请日：2018-01-10
申请人： Randall Davis , Dana Penney
发明人： Randall Davis , Dana Penney
IPC分类号： G16H15/00 , A61B5/16 , G16H50/00 , G16H50/20 , G06Q10/10 , G06Q50/00 , A61B5/00 , G16H40/63
摘要： A method includes receiving data representing graphomotor motion during a succession of executions of graphomotor diagnostic tasks performed in a medical context by a subject, processing the received data using a computer, including determining a first set of quantitative features from a first execution of a task by the subject, and determining a second set of quantitative features from a second execution of a task by the subject, determining one or more metrics based on a comparison to the successive executions, including using at least the first set of quantitative features and the second set of quantitative features to determine said metrics, and providing a diagnostic report associated with neurocognitive mechanisms underlying the subject's execution of the tasks based on the determined metrics.

24. 发明申请

US20190076078A1 SYSTEMS AND METHODS FOR TREMOR DETECTION AND QUANTIFICATION 审中-公开
公开(公告)号：US20190076078A1
公开(公告)日：2019-03-14
申请号：US16124689
申请日：2018-09-07
申请人： Randall Davis , Catherine Medlock , Bruce Musicus , Alan V. Oppenheim , Dana L. Penney , William A. Souillard-Mandar
发明人： Randall Davis , Catherine Medlock , Bruce Musicus , Alan V. Oppenheim , Dana L. Penney , William A. Souillard-Mandar
IPC分类号： A61B5/00 , G06F3/0488 , G06F3/0354 , A61B5/11 , G16H50/20
摘要： Systems and methods are disclosed for detecting tremors in a subject. One method comprises receiving data from a digital device, the data comprising a plurality of digital device positions and a plurality of timestamps, each timestamp in the plurality of timestamps being associated with a digital device position in the plurality of digital device positions. The method further comprises determining a plurality of frequencies of hand movements of the subject based on the plurality of digital device positions and plurality of timestamps. The method further comprises determining a subportion of the data corresponding to frequencies of hand movements above a low tremor threshold, and determining a magnitude of tremors of the subject's hand based, at least in part, on the subportion of the data.

25. 发明申请

US20120141032A1 SKETCH RECOGNITION SYSTEM 有权
标题翻译：草图识别系统
公开(公告)号：US20120141032A1
公开(公告)日：2012-06-07
申请号：US13310182
申请日：2011-12-02
申请人： Tom Yu Ouyang , Randall Davis
发明人： Tom Yu Ouyang , Randall Davis
IPC分类号： G06K9/46
CPC分类号： G06K9/00416 , G06K9/00422 , G06K9/00476
摘要： Handwriting interpretation tools, such as optical character recognition (OCR), have improved over the years such that OCR is a common tool in business for interpreting typed text and sometimes handwritten text. OCR does not apply well to non-text-only diagrams, such as chemical structure diagrams. A method according to an embodiment of the present invention of interpreting a human-drawn sketch includes determining a local metric indicating whether a candidate symbol belongs to a certain classification based on a set of features. The set of features includes, as a feature, scores generated from feature images of the candidate symbol. Also included is determining a joint metric of multiple candidate symbols based on their respective classifications and interpreting the sketch as a function of the local and joint metrics. Sketches can be chemical composition, biological composition, electrical schematic, mechanical, or any other science- or engineering-based diagrams for which human-drawn symbols have well-known counterparts.
摘要翻译：手写解读工具（如光学字符识别（OCR））多年来有所改善，因此OCR是用于解释类型文本和有时手写文本的通用工具。 OCR不适用于非纯文本图，如化学结构图。根据本发明的实施例的解释人画草图的方法包括基于一组特征来确定指示候选符号是否属于某个分类的本地度量。作为特征的一组特征包括从候选符号的特征图像生成的分数。还包括基于它们各自的分类来确定多个候选符号的联合度量，并且将草图解释为局部和联合度量的函数。草图可以是化学成分，生物组成，电气原理图，机械或任何其他人类绘制符号具有知名对象的基于科学或工程的图表。

26. 发明申请

US20050240006A1 Members of the fc receptor homolog gene family (fcrh1-3, 6), related reagents, and uses thereof 有权
标题翻译： fc受体同源基因家族（fcrh1-3,6）的成员，相关试剂及其用途
公开(公告)号：US20050240006A1
公开(公告)日：2005-10-27
申请号：US10508374
申请日：2003-03-25
申请人： Randall Davis , Max Cooper
发明人： Randall Davis , Max Cooper
IPC分类号： G01N33/53 , A61K31/7088 , A61K38/00 , A61K39/395 , A61K48/00 , A61P35/00 , A61P35/02 , A61P37/02 , C07K2/00 , C07K14/735 , C07K16/28 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12P21/02 , C12P21/08 , C12Q1/68 , G01N33/566 , G01N33/574
CPC分类号： C07K16/283 , A61K38/00 , A61K48/00 , A61K2039/505 , C07K14/70535
摘要： The invention relates to members of the Fc receptor homolog (FcRH) subfamily, as well as fragments and variants thereof. Each FcRH is a Type I transmembrane receptor, preferably, comprises an extracellular region, a transmembrane region, and a cytoplasmic region. The cytoplasmic region preferably comprises one or more immunoreceptor tyrosine-based inhibitory or activation motifs (“ITIMs” or “ITAMs). The invention provides polypeptides, nucleic acids, vectors, expression systems, and antibodies and antibody fragments related to the FcRHs as well as uses thereof. Such uses include uses in the diagnosis and treatment of a malignancy of hematopoietic cell lineage or an inflammatory or autoimmune disease in a subject and in the modulation of a humoral immune response in a subject.
摘要翻译：本发明涉及Fc受体同源物（FcRH）亚族的成员，以及其片段和变体。每个FcRH是I型跨膜受体，优选包含胞外区，跨膜区和胞质区。细胞质区域优选包含一种或多种基于免疫受体酪氨酸的抑制或活化基序（“ITIM”或“ITAM”）。本发明提供多肽，核酸，载体，表达系统以及与FcRH相关的抗体和抗体片段，以及这些用途包括用于诊断和治疗受试者造血细胞谱系恶性肿瘤或炎性或自身免疫性疾病以及受试者体液免疫应答调节中的用途。

27. 发明申请

US20190184666A1 APPARATUS FOR RECOVERING SOLVENT FROM BIOMASS 审中-公开
公开(公告)号：US20190184666A1
公开(公告)日：2019-06-20
申请号：US15846092
申请日：2017-12-18
申请人： Jacqueline McGrane , Randall Davis , Saman Razani
发明人： Jacqueline McGrane , Randall Davis , Saman Razani
IPC分类号： B30B9/06 , A61K36/00 , B01D11/02 , F26B5/14
CPC分类号： B30B9/06 , A61K36/00 , A61K2236/33 , A61K2236/50 , B01D11/0219 , F26B5/14
摘要： Apparatuses for recovering solvent from biomass are disclosed herein. In one example, the apparatus can include a mechanical press configured to exert pressure on wetted plant material to force liquid solvent from the plant matter so the solvent can be collected for reuse. The apparatus can also be configured to flow pressurized gas through the wetted plant matter, thereby forcing liquid solvent from the plant material so the solvent can be collected for reuse.

28. 发明申请

US20080089887A1 Members of the FC Receptor Homolog Gene Family (FcRH1-3,6) Related Reagents and Uses Thereof 有权
标题翻译： FC受体同源基因家族成员（FcRH1-3,6）相关试剂及其用途
公开(公告)号：US20080089887A1
公开(公告)日：2008-04-17
申请号：US11835226
申请日：2007-08-07
申请人： Randall Davis , Max Cooper
发明人： Randall Davis , Max Cooper
IPC分类号： A61K39/395 , A61P35/00 , C07K16/00 , G01N33/53
CPC分类号： C07K16/283 , A61K38/00 , A61K48/00 , A61K2039/505 , C07K14/70535
摘要： The invention relates to members of the Fc receptor homolog (FcRH) subfamily, as well as fragments and variants thereof. Each FcRH is a Type I transmembrane receptor, preferably, comprises an extracellular region, a transmembrane region, and a cytoplasmic region. The cytoplasmic region preferably comprises one or more immunoreceptor tyrosine-based inhibitory or activation motifs (“ITIMs” or “ITAMs). The invention provides polypeptides, nucleic acids, vectors, expression systems, and antibodies and antibody fragments related to the FcRHs as well as uses thereof. Such uses include uses in the diagnosis and treatment of a malignancy of hematopoietic cell lineage or an inflammatory or autoimmune disease in a subject and in the modulation of a humoral immune response in a subject.
摘要翻译：本发明涉及Fc受体同源物（FcRH）亚族的成员，以及其片段和变体。每个FcRH是I型跨膜受体，优选包含胞外区，跨膜区和胞质区。细胞质区域优选包含一种或多种基于免疫受体酪氨酸的抑制或活化基序（“ITIM”或“ITAM”）。本发明提供多肽，核酸，载体，表达系统以及与FcRH相关的抗体和抗体片段，以及这些用途包括用于诊断和治疗受试者造血细胞谱系恶性肿瘤或炎性或自身免疫性疾病以及受试者体液免疫应答调节中的用途。

29. 发明申请

US20070132762A1 Formatting Object for Modifying the Visual Attributes of Visual Objects to Reflect Data Values 有权
标题翻译：格式化对象以修改可视对象的可视属性以反映数据值
公开(公告)号：US20070132762A1
公开(公告)日：2007-06-14
申请号：US11674540
申请日：2007-02-13
申请人： Randall Davis , Jeff Couckuyt , Paul Davies
发明人： Randall Davis , Jeff Couckuyt , Paul Davies
IPC分类号： G06T11/20
CPC分类号： G06F15/16
摘要： A formatting object according to the present invention conveys information to the reader of a document (such as a table or chart) by associating visual attributes (such as color, fill type, border width, line width, line style, font size, marker size and marker type) to characters or markers within the document. The formatting object may be used to emphasize data within a table or a chart by modifying the structural visual attributes of characters or markers within the table or chart according to pre-defined criteria. Similarly, the formatting object may be used to increase information density within a table or chart, and to elegantly represent the relationships between four or more interrelated variables in a two-dimensional chart. The formatting object accomplishes this by defining at least one format map that comprises one or more mapping segments. Each mapping segment includes a beginning boundary value, an ending boundary value, at least one beginning visual attribute corresponding to the beginning boundary value, and at least one ending visual attribute corresponding to the ending boundary value. The formatting object uses the information within the format maps, in combination with interpolation techniques, to determine one or more visual attributes that correspond to data points falling within the various mapping segments. The formatting object then expresses the data values by applying the appropriate visual attribute to a visual object displayed on a computer screen.
摘要翻译：根据本发明的格式化对象通过将视觉属性（诸如颜色，填充类型，边界宽度，线宽，线型，字体大小，标记尺寸等）相关联来向读者传达信息给读者（例如表或图表）和标记类型）到文档中的字符或标记。格式化对象可以用于通过根据预定义的标准修改表或图表中的字符或标记的结构视觉属性来强调表或图表中的数据。类似地，格式化对象可以用于增加表或图表中的信息密度，并且优雅地表示二维图中四个或更多个相关变量之间的关系。格式化对象通过定义至少一个包含一个或多个映射段的格式映射来实现。每个映射段包括开始边界值，结束边界值，对应于开始边界值的至少一个开始视觉属性，以及对应于结束边界值的至少一个结束视觉属性。格式化对象使用格式图中的信息结合插值技术来确定对应于落在各种映射段内的数据点的一个或多个视觉属性。然后，格式化对象通过将适当的视觉属性应用于显示在计算机屏幕上的可视对象来表达数据值。

30. 发明申请

US20050224094A1 Apparatus and methods for isolating bioreactive materials on a microarray substrate surface 审中-公开
标题翻译：用于在微阵列基底表面上分离生物反应性材料的装置和方法
公开(公告)号：US20050224094A1
公开(公告)日：2005-10-13
申请号：US10814810
申请日：2004-03-31
申请人： Randall Davis
发明人： Randall Davis
IPC分类号： B08B7/02 , B08B13/00
CPC分类号： B08B7/02
摘要： Apparatus and methods of isolating functionalizing reagents and unreacted bioreactive material in an array of microscopic sense site wells in a substrate surface and to scrub clean the sense site substrate surface. The disclosed apparatus and methods improve systems for detecting biochemical reactions to any of a variety of microarray probe materials by a variety of techniques including, but not limited to, electrical, fluorescent, calorimetric, or enzymatic detection.
摘要翻译：将功能化试剂和未反应的生物活性物质分离在基底表面中的微观意义位点孔阵列中的装置和方法，以及擦洗感测位置底物表面。所公开的装置和方法通过各种技术改进了用于检测对任何多种微阵列探针材料的生化反应的系统，包括但不限于电，荧光，量热或酶检测。

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