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21. 发明授权

US6133246A Antisense oligonucleotide compositions and methods for the modulation of JNK proteins 有权
公开(公告)号：US6133246A
公开(公告)日：2000-10-17
申请号：US287796
申请日：1999-04-07
申请人： Robert McKay , Nicholas Dean , Brett P. Monia , Pamela S. Nero , William A. Gaarde
发明人： Robert McKay , Nicholas Dean , Brett P. Monia , Pamela S. Nero , William A. Gaarde
IPC分类号： A61K38/00 , C07H21/00 , C12N15/113 , C12Q1/68 , A01K48/00 , C07H21/04 , C12N15/11 , C12N15/85
CPC分类号： C12N15/1137 , C07H21/00 , C12Q1/6886 , A61K38/00 , C12N2310/315 , C12N2310/321 , C12N2310/334 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/3515 , C12Q2600/158
摘要： Compositions and methods for the treatment and diagnosis of diseases or disorders amenable to treatment through modulation of expression of a gene encoding a Jun N-terminal kinase (JNK protein) are provided. Oligonucleotide are herein provided which are specifically hybridizable with nucleic acids encoding JNK1, JNK2 and JNK3, as well as other JNK proteins and specific isoforms thereof. Methods of treating animals suffering from diseases or disorders amenable to therapeutic intervention by modulating the expression of one or more JNK proteins with such oligonucleotide are also provided. Methods for the treatment and diagnosis of diseases or disorders associated with aberrant expression of one or more JNK proteins are also provided. Methods for inducing apoptosis and for treating diseases or conditions associated with a reduction in apoptosis are also provided.

22. 外观设计

USD698863S1 Carpenter's pencil 有权
标题翻译：木匠的铅笔
公开(公告)号：USD698863S1
公开(公告)日：2014-02-04
申请号：US29420204
申请日：2012-05-07
申请人： Jason Ryan , Nicholas Dean
设计人： Jason Ryan , Nicholas Dean

23. 发明申请

US20060234239A1 Modulation of insulin like growth factor i receptor expression 有权
标题翻译：调节胰岛素样生长因子i受体表达
公开(公告)号：US20060234239A1
公开(公告)日：2006-10-19
申请号：US10545354
申请日：2004-02-11
申请人： Christopher Wraight , George Werther , Nicholas Dean , Michael Dobie
发明人： Christopher Wraight , George Werther , Nicholas Dean , Michael Dobie
IPC分类号： A61K48/00 , C12Q1/68 , C07H21/02
CPC分类号： C07H21/04 , A61K38/00 , C07H21/00 , C07H21/02 , C12N15/1138 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/346 , C12Q1/6883 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , C12Q2600/16 , Y10T436/143333 , C12N2310/3525
摘要： The present invention provides compositions and methods for modulating the expression of growth factor gene. In particular, this invention relates to compounds, particularly oligonucleotide compounds, which, in preferred embodiments, hybridize with nucleic acid molecules encoding the Insulin Like Growth Factor I receptor (IGF-I receptor or IGF-IR) and in particular human IGF-IR. Such compounds are exemplified herein to modulate proliferation which is relevant to the treatment of proliferative and inflammatory skin disorders and cancer. It will be understood, however, that the compounds can be used for any other condition in which the IGF-IR is involved including inflammatory conditions.
摘要翻译：本发明提供调节生长因子基因表达的组合物和方法。特别地，本发明涉及化合物，特别是寡核苷酸化合物，其在优选的实施方案中与编码胰岛素样生长因子I受体（IGF-1受体或IGF-1R），特别是人IGF-1R的核酸分子杂交。这些化合物在本文中示例以调节与治疗增殖性和炎症性皮肤病症和癌症有关的增殖。然而，应当理解，所述化合物可用于涉及IGF-1R的任何其它病症，包括炎性病症。

24. 发明申请

US20060172962A1 Modification of MYD88 splicing using modified oligonucleotides 有权
标题翻译：使用修饰的寡核苷酸修饰MYD88剪接
公开(公告)号：US20060172962A1
公开(公告)日：2006-08-03
申请号：US11339785
申请日：2006-01-24
申请人： Timothy Vickers , Nicholas Dean
发明人： Timothy Vickers , Nicholas Dean
IPC分类号： A61K48/00
CPC分类号： C12N15/113 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2310/3231 , C12N2310/341 , C12N2310/345 , C12N2310/3521
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of MyD88. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding MyD88. Methods of using these compounds for modulation of MyD88 expression and for treatment of diseases associated with expression of MyD88 are provided.
摘要翻译：提供反义化合物，组合物和方法用于调节MyD88的表达。组合物包含靶向编码MyD88的核酸的反义化合物，特别是反义寡核苷酸。提供了使用这些化合物调节MyD88表达和治疗MyD88表达相关疾病的方法。

25. 发明申请

US20060154882A1 Methods for blocking adipocyte differentiation and triglyceride accumulation with g-alpha-i3 inhibitors 审中-公开
标题翻译：用g-α-i3抑制剂阻断脂肪细胞分化和甘油三酯积累的方法
公开(公告)号：US20060154882A1
公开(公告)日：2006-07-13
申请号：US10515546
申请日：2003-06-10
申请人： Eric Marcusson , Nicholas Dean
发明人： Eric Marcusson , Nicholas Dean
IPC分类号： A61K48/00
CPC分类号： C12N15/113 , A61K38/00
摘要： Methods for blocking adipocyte differentiation and triglyceride accumulation with inhibitors of G-alpha-i3 are provided. G-alpha-i3 inhibitors of the present invention include small molecules, antibodies, peptides (including dominant negative peptides) and antisense compounds, including ribozymes, inhibitory RNA molecules including siRNA molecules and antisense oligonucleotides.
摘要翻译：提供了用G-α-i3抑制剂阻断脂肪细胞分化和甘油三酯积聚的方法。本发明的G-α-i3抑制剂包括小分子，抗体，肽（包括显性阴性肽）和反义化合物，包括核酶，包括siRNA分子和反义寡核苷酸的抑制性RNA分子。

26. 发明授权

US5959096A Antisense oligonucleotides against human protein kinase C 失效
标题翻译：针对人类蛋白激酶C的反义寡核苷酸
公开(公告)号：US5959096A
公开(公告)日：1999-09-28
申请号：US481066
申请日：1995-06-07
申请人： C. Frank Bennett , Nicholas Dean
发明人： C. Frank Bennett , Nicholas Dean
IPC分类号： A61K38/00 , A61K48/00 , C07H21/00 , C07K14/705 , C12N9/12 , C12N15/113 , C12Q1/68 , C07H21/04
CPC分类号： A61K48/00 , C07H21/00 , C07K14/70564 , C12N15/1137 , C12N9/12 , C12Q1/6876 , C12Q1/6883 , C12Y207/11013 , A61K38/00 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2310/341 , C12N2310/346 , C12N2310/3521 , C12N2310/3527 , C12N2310/3533 , C12Q2600/158
摘要： Compositions and methods are provided for the treatment and diagnosis of diseases associated with protein kinase C. Oligonucleotides are provided which are targeted to nucleic acids encoding PKC. Oligonucleotides specifically hybridizable with a translation initiation site, 5'-untranslated region or 3'-untranslated region are provided. Oligonucleotides specifically hybridizable with a particular PKC isozyme or set of isozymes are also provided. In preferred embodiments, the oligonucleotides contain one or more chemical modifications. Methods of modulating PKC expression and of treating animals suffering from disease amenable to therapeutic intervention by modulating protein kinase C expression using oligonucleotides targeted to PKC are disclosed.
摘要翻译：提供组合物和方法用于治疗和诊断与蛋白激酶C相关的疾病。提供靶向编码PKC的核酸的寡核苷酸。提供了与翻译起始位点，5'-非翻译区或3'非翻译区特异性杂交的寡核苷酸。还提供了与特定PKC同功酶或同功酶组特异性杂交的寡核苷酸。在优选的实施方案中，寡核苷酸含有一种或多种化学修饰。公开了通过使用靶向PKC的寡核苷酸调节蛋白激酶C表达来调节PKC表达和治疗患有适于治疗性干预的疾病的方法。

27. 发明授权

US5922686A Oligonucleotide modulation of protein kinase C 失效
标题翻译：蛋白激酶C的寡核苷酸调节
公开(公告)号：US5922686A
公开(公告)日：1999-07-13
申请号：US664336
申请日：1996-06-14
申请人： C. Frank Bennett , Nicholas Dean
发明人： C. Frank Bennett , Nicholas Dean
IPC分类号： A61K38/00 , A61K48/00 , C07H21/00 , C07K14/705 , C12N9/12 , C12N15/113 , C12Q1/68 , A61K31/70
CPC分类号： C12N15/1137 , A61K48/00 , C07H21/00 , C07K14/70564 , C12N9/12 , C12Q1/6876 , C12Q1/6883 , C12Y207/11013 , A61K38/00 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2310/341 , C12N2310/346 , C12N2310/3521 , C12N2310/3527 , C12N2310/3533 , C12Q2600/158
摘要： Compositions and methods are provided for the treatment and diagnosis of diseases associated with protein kinase C. Oligonucleotides are provided which are targeted to nucleic acids encoding PKC. Oligonucleotides specifically hybridizable with a translation initiation site, 5'-untranslated region or 3'-untranslated region are provided. Oligonucleotides specifically hybridizable with a particular PKC isozyme or set of isozymes are also provided. In preferred embodiments, the oligonucleotides contain one or more chemical modifications. Methods of modulating PKC expression and of treating animals suffering from disease amenable to therapeutic intervention by modulating protein kinase C expression using oligonucleotides targeted to PKC are disclosed.
摘要翻译：提供组合物和方法用于治疗和诊断与蛋白激酶C相关的疾病。提供靶向编码PKC的核酸的寡核苷酸。提供了与翻译起始位点，5'-非翻译区或3'非翻译区特异性杂交的寡核苷酸。还提供了与特定PKC同功酶或同功酶组特异性杂交的寡核苷酸。在优选的实施方案中，寡核苷酸含有一种或多种化学修饰。公开了通过使用靶向PKC的寡核苷酸调节蛋白激酶C表达来调节PKC表达和治疗患有适于治疗性干预的疾病的方法。

28. 发明授权

US5916807A Antisense oligonucleotides against human protein kinase C 失效
标题翻译：针对人类蛋白激酶C的反义寡核苷酸
公开(公告)号：US5916807A
公开(公告)日：1999-06-29
申请号：US481072
申请日：1995-06-07
申请人： C. Frank Bennett , Nicholas Dean
发明人： C. Frank Bennett , Nicholas Dean
IPC分类号： A61K38/00 , A61K48/00 , C07H21/00 , C07K14/705 , C12N9/12 , C12N15/113 , C12Q1/68 , C07H21/04 , C12N15/85
CPC分类号： A61K48/00 , C07H21/00 , C07K14/70564 , C12N15/1137 , C12N9/12 , C12Q1/6876 , C12Q1/6883 , C12Y207/11013 , A61K38/00 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2310/341 , C12N2310/346 , C12N2310/3521 , C12N2310/3527 , C12N2310/3533 , C12Q2600/158
摘要： Compositions and methods are provided for the treatment and diagnosis of diseases associated with protein kinase C. Oligonucleotides are provided which are targeted to nucleic acids encoding PKC. Oligonucleotides specifically hybridizable with a translation initiation site, 5'-untranslated region or 3'-untranslated region are provided. Oligonucleotides specifically hybridizable with a particular PKC isozyme or set of isozymes are also provided. Methods of treating animals suffering from disease amenable to therapeutic intervention by modulating protein kinase C expression with an oligonucleotide targeted to PKC are disclosed.
摘要翻译：提供组合物和方法用于治疗和诊断与蛋白激酶C相关的疾病。提供靶向编码PKC的核酸的寡核苷酸。提供了与翻译起始位点，5'-非翻译区或3'非翻译区特异性杂交的寡核苷酸。还提供了与特定PKC同功酶或同功酶组特异性杂交的寡核苷酸。公开了通过用靶向PKC的寡核苷酸调节蛋白激酶C表达来治疗患有治疗性干预的疾病的方法。

29. 外观设计

USD805585S1 Carpenter's pencil 有权
公开(公告)号：USD805585S1
公开(公告)日：2017-12-19
申请号：US29481278
申请日：2014-02-04
申请人： Jason Ryan , Nicholas Dean
设计人： Jason Ryan , Nicholas Dean

30. 发明申请

US20050272683A1 Antisense oligonucleotides against thymidylate synthase 审中-公开
标题翻译：针对胸苷酸合酶的反义寡核苷酸
公开(公告)号：US20050272683A1
公开(公告)日：2005-12-08
申请号：US11171435
申请日：2005-07-01
申请人： Donald Koropatnick , Mark Vincent , Nicholas Dean
发明人： Donald Koropatnick , Mark Vincent , Nicholas Dean
IPC分类号： C12N15/09 , A61K31/7088 , A61K38/00 , A61K48/00 , A61P35/00 , A61P43/00 , C12N9/10 , C12N15/113 , A61K31/522 , C07H21/02
CPC分类号： C12N15/1137 , A61K38/00 , C12N2310/111
摘要： Antisene oligonucleotides targeted to sequences in thymidylate synthase (TS) mRNA. In particular the invention relates to antisense oligonucleotides targeted to sequences in the 3′ end of TS mRNA, which are both cytostatic on their own when administered to human tumour cell lines, and which also enhance the toxicity of anticancer drugs such as Tomudex. The invention also relates to antisense oligonucleotides targeted to sequences at or near the translation start site at the 5′ end of TS mRNA which induce TS gene transcription and enhance cell growth. The invention further relates to a combination product comprising an antisense oligonucleotide in combination with an anticancer agent such as Tomudex (N-(5[N-3,4-dihydro-2-methyl-4-oxoquinazolin-6-ylmethyl)-N-methylamino]-2-thenoyl)-L-glutamic acid) or the Zeneca development compound ZD 9331 ((S)-2-(2-fluoro-4-[N-(4-hydroxy-2,7-dimethylquinazolin-6-ylmethyl)-N-(prop-2-ynyl)amino] benzamido-4-(1H-1,2,3,4-tetrazol-5-yl) butyric acid), and to the use of such a combination product in the treatment of cancer.
摘要翻译：靶向胸苷酸合酶（TS）mRNA序列的反义寡核苷酸。特别地，本发明涉及靶向TS mRNA的3'端的序列的反义寡核苷酸，当被给予人肿瘤细胞系时它们本身都是细胞抑制的，并且还增强抗肿瘤药物如Tomudex的毒性。本发明还涉及针对诱导TS基因转录并增强细胞生长的TS mRNA的5'末端的翻译起始位点处或附近的序列的反义寡核苷酸。本发明还涉及包含反义寡核苷酸与抗癌剂如Tomudex（N-（5-N，3,4-二氢-2-甲基-4-氧代喹唑啉-6-基甲基）-N- 甲基氨基] -2-噻吩甲酰基）-L-谷氨酸）或Zeneca显影化合物ZD 9331（（S）-2-（2-氟-4- [N-（4-羟基-2,7-二甲基喹唑啉-6-基）吡啶-2-基甲基）-N-（丙-2-炔基）氨基]苯甲酰氨基-4-（1H-1,2,3,4-四唑-5-基）丁酸），以及这种组合产物在治疗癌症。

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