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21. 发明申请

US20050176105A1 Kunitz domain polypeptide Zkun10 失效
标题翻译： Kunitz结构域多肽Zkun10
公开(公告)号：US20050176105A1
公开(公告)日：2005-08-11
申请号：US11082148
申请日：2005-03-16
申请人： Paul Sheppard , Brian Fox
发明人： Paul Sheppard , Brian Fox
IPC分类号： A61K38/00 , C07K14/81 , C07H21/04 , C07K14/755 , C12N9/64 , C12P21/04
CPC分类号： C07K14/8114 , A61K38/00
摘要： Proteinase inhibitors comprising a Kunitz domain are disclosed. The Kunitz domain comprises a motif of amino acid residues as shown in SEQ ID NO:4, and the sequence of the Kunitz domain is shown in residues 57 through 107 of SEQ ID NO:2. The polypeptide also includes an N-terminal collagen domain in which a von Willebrand domain resides, and is shown in SEQ ID NO: 5. Also disclosed are methods for making the proteinase inhibitors, and expression vectors and cultured cells that are useful within the methods. The proteinase inhibitors may be used as components of cell culture media, in protein purification, and as inhibitors of protease degradation of plasma proteins.
摘要翻译：公开了包含Kunitz结构域的蛋白酶抑制剂。 Kunitz结构域包含如SEQ ID NO：4所示的氨基酸残基的基序，Kunitz结构域的序列显示于SEQ ID NO：2的残基57至107中。多肽还包括其中von Willebrand结构域所在的N-末端胶原结构域，并且显示于SEQ ID NO：5中。还公开了制备蛋白酶抑制剂的方法，以及在该方法中有用的表达载体和培养细胞。蛋白酶抑制剂可以用作细胞培养基的组分，蛋白质纯化，以及作为血浆蛋白质蛋白酶降解的抑制剂。

22. 发明申请

US20050032700A1 Adipocyte complement related protein zacrp12 审中-公开
标题翻译：脂肪细胞补体相关蛋白zacrp12
公开(公告)号：US20050032700A1
公开(公告)日：2005-02-10
申请号：US10912899
申请日：2004-08-06
申请人： Brian Fox , Andrew Feldhaus
发明人： Brian Fox , Andrew Feldhaus
IPC分类号： A61K38/00 , C07K14/47 , A61K38/18 , C07K14/475
CPC分类号： C07K14/47 , A61K38/00
摘要： Novel zacrp12 polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed. Also disclosed are antibodies to the zacrp12 protein or fragments thereof.
摘要翻译：公开了新的zacrp12多肽，编码多肽的多核苷酸，以及相关的组合物和方法。还公开了对zacrp12蛋白或其片段的抗体。

23. 发明申请

US20050003475A1 Soluble interleukin-20 receptor 有权
标题翻译：可溶性白介素20受体
公开(公告)号：US20050003475A1
公开(公告)日：2005-01-06
申请号：US09745792
申请日：2000-12-22
申请人： Donald Foster , Wenfeng Xu , Karen Madden , James Kelly , Cindy Sprecher , Cameron Brandt , Mark Rixon , Scott Presnell , Brian Fox
发明人： Donald Foster , Wenfeng Xu , Karen Madden , James Kelly , Cindy Sprecher , Cameron Brandt , Mark Rixon , Scott Presnell , Brian Fox
IPC分类号： A61K38/00 , C07K14/715 , A61K38/17 , C07H21/04
CPC分类号： C07K16/2866 , A61K38/00 , C07K14/7155 , C07K2319/00
摘要： A soluble receptor to IL-20 having two polypeptide subunits, IL-20RA (formerly called ZcytoR7) and IL-20RB (formerly called DIRS1). The two subunits are preferably linked together. In one embodiment one subunit is fused to the constant region of the light chain of an immunoglobulin, and the other subunit is fused to the constant region of the heavy chain of the immunoglobulin. The light chain and the heavy chain are connected via a disulfide bond.
摘要翻译：具有两个多肽亚单位IL-20RA（以前称为ZcytoR7）和IL-20RB（以前称为DIRS1）的IL-20的可溶性受体。两个亚基优选连接在一起。在一个实施方案中，一个亚基与免疫球蛋白的轻链的恒定区融合，另一个亚基与免疫球蛋白的重链的恒定区融合。轻链和重链通过二硫键连接。

24. 外观设计

USD401117S Cooler 失效
公开(公告)号：USD401117S
公开(公告)日：1998-11-17
申请号：US73665
申请日：1997-07-22
申请人： Christine C. Anderson , Terence J. Anderson , Brian Fox , Mark Hoben
设计人： Christine C. Anderson , Terence J. Anderson , Brian Fox , Mark Hoben

25. 发明授权

US08072234B2 Micro-granular delay testing of configurable ICs 有权
标题翻译：可配置IC的微粒延迟测试
公开(公告)号：US08072234B2
公开(公告)日：2011-12-06
申请号：US12785484
申请日：2010-05-23
申请人： Brian Fox
发明人： Brian Fox
IPC分类号： H03K19/00
CPC分类号： G01R31/3177 , G01R31/3016 , G01R31/31725 , G01R31/318516 , G01R31/318519 , H03K19/17764
摘要： A method for testing a set of circuitry in an integrated circuit (IC) is described. The IC includes multiple configurable circuits for configurably performing multiple operations. The method configures the IC to operate in a user mode with a set of test paths that satisfies a set of evaluation criteria. Each test path includes a controllable storage element for controllably storing a signal that the storage element receives. The method operates the IC in user mode. The method reads the values stored in the storage elements to determine whether the set of circuitry is operating within specified performance limits.
摘要翻译：描述了用于测试集成电路（IC）中的一组电路的方法。 IC包括用于可配置地执行多个操作的多个可配置电路。该方法将IC配置为以一组满足一组评估标准的测试路径在用户模式下运行。每个测试路径包括用于可控地存储存储元件接收的信号的可控存储元件。该方法在用户模式下操作IC。该方法读取存储在存储元件中的值，以确定该组电路是否在指定的性能限制内运行。

26. 发明申请

US20070298037A1 ZTNFR14, A Tumor Necrosis Factor Receptor 审中-公开
标题翻译： ZTNFR14，肿瘤坏死因子受体
公开(公告)号：US20070298037A1
公开(公告)日：2007-12-27
申请号：US11556854
申请日：2006-11-06
申请人： Brian Fox , James Holloway , Paul Sheppard , Stacey Dillon
发明人： Brian Fox , James Holloway , Paul Sheppard , Stacey Dillon
IPC分类号： A61K39/395 , A61K38/17 , A61P1/00 , A61P17/06 , A61P25/00
CPC分类号： C07K14/7151 , A61K38/1793 , A61K2039/505 , C07K16/2878 , C07K2317/71 , C07K2319/30 , C07K2319/32 , C07K2319/40
摘要： Novel tumor necrosis factor receptor (TNFR) polypeptides, polynucleotides encoding the polypeptides, antibodies and related compositions and methods are disclosed. The polypeptides may be used for detecting ligand, as well as agonists and antagonists. The polypeptides, polynucleotides and antibodies may also be used in methods that modulate tumor growth, metastasis, and immunity such as separating resting from stimulated immune cells.
摘要翻译：公开了新型肿瘤坏死因子受体（TNFR）多肽，编码多肽的多核苷酸，抗体及相关组合物和方法。多肽可用于检测配体，以及激动剂和拮抗剂。多肽，多核苷酸和抗体也可以用于调节肿瘤生长，转移和免疫的方法，例如从刺激的免疫细胞分离休息。

27. 发明申请

US20070264684A1 CYTOKINE PROTEIN FAMILY 有权
公开(公告)号：US20070264684A1
公开(公告)日：2007-11-15
申请号：US11539061
申请日：2006-10-05
申请人： Paul Sheppard , Brian Fox , Kevin Klucher , David Taft , Wayne Kindsvogel
发明人： Paul Sheppard , Brian Fox , Kevin Klucher , David Taft , Wayne Kindsvogel
IPC分类号： C12P21/06 , C07H21/04
CPC分类号： C07K14/715 , A61K38/20 , A61K38/21 , C07K14/56 , C07K16/24 , C07K16/2866 , C07K2317/76 , C12Q2600/158 , Y02A50/473
摘要： The present invention relates to polynucleotide and polypeptide molecules for zcyto20, zcyto21, zcyto22, zycto24, and zcyto25 proteins which are most closely related to interferon-α at the amino acid sequence level. The receptor for this protein family is a class II cytokine receptor. The present invention includes methods of reducing viral infections and increasing monocyte counts. The present invention also includes antibodies to the zcyto20 polypeptides, and methods of producing the polynucleotides and polypeptides.

28. 发明申请

US20070129538A1 CYTOKINE PROTEIN FAMILY 有权
公开(公告)号：US20070129538A1
公开(公告)日：2007-06-07
申请号：US11539052
申请日：2006-10-05
申请人： Paul Sheppard , Brian Fox , Kevin Klucher , David Taft , Wayne Kindsvogel
发明人： Paul Sheppard , Brian Fox , Kevin Klucher , David Taft , Wayne Kindsvogel
IPC分类号： C07K16/10
CPC分类号： C07K14/715 , A61K38/20 , A61K38/21 , C07K14/56 , C07K16/24 , C07K16/2866 , C07K2317/76 , C12Q2600/158 , Y02A50/473
摘要： The present invention relates to polynucleotide and polypeptide molecules for zcyto20, zcyto21, zcyto22, zycto24, and zcyto25 proteins which are most closely related to interferon-α at the amino acid sequence level. The receptor for this protein family is a class II cytokine receptor. The present invention includes methods of reducing viral infections and increasing monocyte counts. The present invention also includes antibodies to the zcyto20 polypeptides, and methods of producing the polynucleotides and polypeptides.

29. 发明申请

US20070128205A1 CYTOKINE PROTEIN FAMILY 有权
标题翻译：细胞因子蛋白家族
公开(公告)号：US20070128205A1
公开(公告)日：2007-06-07
申请号：US11539078
申请日：2006-10-05
申请人： Paul Sheppard , Brian Fox , Kevin Klucher , David Taft , Wayne Kindsvogel
发明人： Paul Sheppard , Brian Fox , Kevin Klucher , David Taft , Wayne Kindsvogel
IPC分类号： A61K39/42
CPC分类号： C07K14/715 , A61K38/20 , A61K38/21 , C07K14/56 , C07K16/24 , C07K16/2866 , C07K2317/76 , C12Q2600/158 , Y02A50/473
摘要： The present invention relates to polynucleotide and polypeptide molecules for zcyto20, zcyto21, zcyto22, zycto24, and zcyto25 proteins which are most closely related to interferon-α at the amino acid sequence level. The receptor for this protein family is a class TI cytokine receptor. The present invention includes methods of reducing viral infections and increasing monocyte counts. The present invention also includes antibodies to the zcyto20 polypeptides, and methods of producing the polynucleotides and polypeptides.
摘要翻译：本发明涉及与氨基酸序列水平上与干扰素-α最密切相关的zcyto20，zcyto21，zcyto22，zycto24和zcyto25蛋白的多核苷酸和多肽分子。该蛋白家族的受体是TI类细胞因子受体。本发明包括减少病毒感染和增加单核细胞计数的方法。本发明还包括针对zcyto20多肽的抗体，以及产生多核苷酸和多肽的方法。

30. 发明申请

US20070043209A1 INTERFERON-LIKE PROTEIN ZCYTO21 审中-公开
标题翻译：类似蛋白质的ZCYTO21
公开(公告)号：US20070043209A1
公开(公告)日：2007-02-22
申请号：US11548108
申请日：2006-10-10
申请人： Paul Sheppard , Scott Presnell , Brian Fox , Teresa Gilbert , Betty Haldeman , Francis Grant
发明人： Paul Sheppard , Scott Presnell , Brian Fox , Teresa Gilbert , Betty Haldeman , Francis Grant
IPC分类号： C07K16/24
CPC分类号： C07K14/47 , C07K14/52 , C07K2319/00
摘要： The present invention relates to polynucleotide and polypeptide molecules for Zcyto21, an interferon-like protein, which is most closely related to interferon-α at the amino acid sequence level. The present invention also includes antibodies to the Zcyto21 polypeptides, and methods of using the polynucleotides and polypeptides.
摘要翻译：本发明涉及用于Zcyto21的多核苷酸和多肽分子，干扰素样蛋白与氨基酸序列水平上的干扰素-α最相关。本发明还包括对Zcyto21多肽的抗体，以及使用多核苷酸和多肽的方法。

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