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21. 发明申请

US20090156526A1 COMPOSITIONS AND METHODS FOR MODULATION OF LMNA EXPRESSION 有权
标题翻译： LMNA表达调控的组成和方法
公开(公告)号：US20090156526A1
公开(公告)日：2009-06-18
申请号：US12090847
申请日：2006-10-17
申请人： C. Frank Bennett , Kenneth W. Dobie , Susan M. Freier , Stanley T. Crooke
发明人： C. Frank Bennett , Kenneth W. Dobie , Susan M. Freier , Stanley T. Crooke
IPC分类号： A61K31/711 , C12Q1/68 , C12N5/00 , C07H21/04
CPC分类号： C12N15/113 , C12N15/111 , C12N2310/11 , C12N2320/33
摘要： Disclosed herein are compounds, compositions and methods for modulating the expression of LMNA in a cell, tissue or animal. Also provided are methods of target validation. Also provided are uses of disclosed compounds and compositions in the manufacture of a medicament for treatment of diseases and disorders. Further provided are methods of identifying cis splicing regulatory elements of a selected mRNA using the disclosed compounds.
摘要翻译：本文公开了用于调节细胞，组织或动物中LMNA表达的化合物，组合物和方法。还提供了目标验证的方法。还提供了所公开的化合物和组合物在制备用于治疗疾病和病症的药物中的用途。还提供了使用所公开的化合物鉴定所选mRNA的顺式剪接调节元件的方法。

22. 发明授权

US08921331B2 Methods for slowing familial ALS disease progression 有权
标题翻译：减慢家族性ALS疾病进展的方法
公开(公告)号：US08921331B2
公开(公告)日：2014-12-30
申请号：US13406256
申请日：2012-02-27
申请人： C. Frank Bennett , Susan M. Freier , Kenneth W. Dobie
发明人： C. Frank Bennett , Susan M. Freier , Kenneth W. Dobie
IPC分类号： A61K48/00 , C12N15/113 , A61K38/00
CPC分类号： C12N15/1137 , A61K38/00 , C12N2310/11 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12Y115/01001 , Y02P20/582 , C12N2310/3525
摘要： Methods for slowing disease progression in an individual suffering from familial ALS are provided. Also provided are methods of increasing the survival time of an individual suffering from familial ALS. These methods employ antisense oligonucleotides targeted to SOD1, for use in inhibiting the expression of SOD1 in the central nervous system of an individual suffering from familial ALS.
摘要翻译：提供了减轻患有家族性ALS的个体疾病进展的方法。还提供了增加患有家族性ALS的个体的存活时间的方法。这些方法使用靶向SOD1的反义寡核苷酸，用于抑制患有家族性ALS的个体的中枢神经系统中SOD1的表达。

23. 发明授权

US08791088B2 Compositions and methods for modulation of LMNA expression 有权
标题翻译： LMNA表达调控的组成和方法
公开(公告)号：US08791088B2
公开(公告)日：2014-07-29
申请号：US13566922
申请日：2012-08-03
申请人： C. Frank Bennett , Kenneth W. Dobie , Susan M. Freier , Stanley T. Crooke
发明人： C. Frank Bennett , Kenneth W. Dobie , Susan M. Freier , Stanley T. Crooke
IPC分类号： C12N15/11
CPC分类号： C12N15/113 , C12N15/111 , C12N2310/11 , C12N2320/33
摘要： Disclosed herein are compounds, compositions and methods for modulating the expression of LMNA in a cell, tissue or animal. Also provided are methods of target validation. Also provided are uses of disclosed compounds and compositions in the manufacture of a medicament for treatment of diseases and disorders. Further provided are methods of identifying cis splicing regulatory elements of a selected mRNA using the disclosed compounds.
摘要翻译：本文公开了用于调节细胞，组织或动物中LMNA表达的化合物，组合物和方法。还提供了目标验证的方法。还提供了所公开的化合物和组合物在制备用于治疗疾病和病症的药物中的用途。还提供了使用所公开的化合物鉴定所选mRNA的顺式剪接调节元件的方法。

24. 发明授权

US08669102B2 Modulation of prion expression 有权
标题翻译：调节朊病毒表达
公开(公告)号：US08669102B2
公开(公告)日：2014-03-11
申请号：US13059058
申请日：2009-08-14
申请人： C. Frank Bennett , Gene Hung , Susan M. Freier , Kenneth W. Dobie
发明人： C. Frank Bennett , Gene Hung , Susan M. Freier , Kenneth W. Dobie
IPC分类号： C12N15/85 , C07H21/04 , C07H21/02
CPC分类号： A61K31/7125
摘要： Disclosed herein are compounds and methods for decreasing PrP and preventing, ameliorating, or treating a prion disease or conformational neurodegenerative disorder, in an individual in need thereof. Examples of disease conditions that can be ameliorated with the administration of antisense compounds targeted to PrP include Creutzfeldt-Jakob disease (CJD); variant Creutzfeldt-Jakob Disease (vCJD); Gerstmann-Straussler-Scheinker syndrome; fatal familial insomnia; kuru; Bovine Spongiform Encephalopathy (BSE), e.g. “mad cow disease”; Chronic Wasting Disease (CWD); scrapie; transmissible mink encephalopathy; feline spongiform encephalopathy; ungulate spongiform encephalopathy; Alzheimer's disease; Parkinson's disease; Huntington's disease; and Amyotrophic Lateral Sclerosis (ALS).
摘要翻译：本文公开了在有需要的个体中减少PrP并预防，改善或治疗朊病毒疾病或构象神经变性疾病的化合物和方法。通过施用针对PrP的反义化合物可以改善的疾病状况的实例包括克雅氏病（CJD）; 变异克雅氏病（vCJD）; Gerstmann-Straussler-Scheinker综合征; 致命性家族性失眠; 库鲁牛海绵状脑病（BSE），例如。 “疯牛病”; 慢性疾病（CWD）; scrap子传染性貂脑病猫海绵状脑病; 有蹄型海绵状脑病阿尔茨海默氏病; 帕金森病亨廷顿氏病和肌萎缩性侧索硬化（ALS）。

25. 发明申请

US20130035370A1 COMPOSITIONS AND METHODS FOR MODULATION OF LMNA EXPRESSION 有权
公开(公告)号：US20130035370A1
公开(公告)日：2013-02-07
申请号：US13566922
申请日：2012-08-03
申请人： C. Frank Bennett , Kenneth W. Dobie , Susan M. Freier , Stanley T. Crooke
发明人： C. Frank Bennett , Kenneth W. Dobie , Susan M. Freier , Stanley T. Crooke
IPC分类号： A61K31/712 , C12N5/071
CPC分类号： C12N15/113 , C12N15/111 , C12N2310/11 , C12N2320/33
摘要： Disclosed herein are compounds, compositions and methods for modulating the expression of LMNA in a cell, tissue or animal. Also provided are methods of target validation. Also provided are uses of disclosed compounds and compositions in the manufacture of a medicament for treatment of diseases and disorders. Further provided are methods of identifying cis splicing regulatory elements of a selected mRNA using the disclosed compounds.

26. 发明授权

US08258109B2 Compositions and methods for modulation of LMNA expression 有权
标题翻译： LMNA表达调控的组成和方法
公开(公告)号：US08258109B2
公开(公告)日：2012-09-04
申请号：US12090847
申请日：2006-10-17
申请人： C. Frank Bennett , Kenneth W. Dobie , Susan M. Freier , Stanley T. Crooke
发明人： C. Frank Bennett , Kenneth W. Dobie , Susan M. Freier , Stanley T. Crooke
IPC分类号： C12N15/11
CPC分类号： C12N15/113 , C12N15/111 , C12N2310/11 , C12N2320/33
摘要： Disclosed herein are compounds, compositions and methods for modulating the expression of LMNA in a cell, tissue or animal. Also provided are methods of target validation. Also provided are uses of disclosed compounds and compositions in the manufacture of a medicament for treatment of diseases and disorders. Further provided are methods of identifying cis splicing regulatory elements of a selected mRNA using the disclosed compounds.
摘要翻译：本文公开了用于调节细胞，组织或动物中LMNA表达的化合物，组合物和方法。还提供了目标验证的方法。还提供了所公开的化合物和组合物在制备用于治疗疾病和病症的药物中的用途。还提供了使用所公开的化合物鉴定所选mRNA的顺式剪接调节元件的方法。

27. 发明授权

US07399853B2 Modulation of glucagon receptor expression 有权
标题翻译：调节胰高血糖素受体表达
公开(公告)号：US07399853B2
公开(公告)日：2008-07-15
申请号：US10832777
申请日：2004-04-27
申请人： Susan M. Freier , Kenneth W. Dobie , Sanjay Bhanot , Robert McKay
发明人： Susan M. Freier , Kenneth W. Dobie , Sanjay Bhanot , Robert McKay
IPC分类号： C07H21/04 , C12Q1/68 , C12N15/85
CPC分类号： C12N15/1138 , C07K14/705 , C07K14/723 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/3525
摘要： Compounds, compositions and methods are provided for modulating the expression of glucagon receptor. The compositions comprise oligonucleotides, targeted to nucleic acid encoding glucagon receptor. Methods of using these compounds for modulation of glucagon receptor expression and for diagnosis and treatment of disease associated with expression of glucagon receptor are provided.
摘要翻译：提供化合物，组合物和方法用于调节胰高血糖素受体的表达。组合物包含针对编码胰高血糖素受体的核酸的寡核苷酸。提供了使用这些化合物调节胰高血糖素受体表达和用于诊断和治疗与胰高血糖素受体表达相关的疾病的方法。

28. 发明授权

US08642753B2 Modulation of glucagon receptor expression 有权
标题翻译：调节胰高血糖素受体表达
公开(公告)号：US08642753B2
公开(公告)日：2014-02-04
申请号：US13566642
申请日：2012-08-03
申请人： Susan M. Freier , Kenneth W. Dobie , Robert McKay , Sanjay Bhanot
发明人： Susan M. Freier , Kenneth W. Dobie , Robert McKay , Sanjay Bhanot
IPC分类号： C07H21/04
CPC分类号： C12N15/1138 , C07K14/705 , C07K14/723 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/3525
摘要： Compounds, compositions and methods are provided for modulating the expression of glucagon receptor. The compositions comprise oligonucleotides, targeted to nucleic acid encoding glucagon receptor. Methods of using these compounds for modulation of glucagon receptor expression and for diagnosis and treatment of disease associated with expression of glucagon receptor are provided.
摘要翻译：提供化合物，组合物和方法用于调节胰高血糖素受体的表达。组合物包含针对编码胰高血糖素受体的核酸的寡核苷酸。提供了使用这些化合物调节胰高血糖素受体表达和用于诊断和治疗与胰高血糖素受体表达相关的疾病的方法。

29. 发明授权

US08513400B2 Modulation of HIF1α and HIF2α expression 有权
标题翻译： HIF1alpha和HIF2alpha表达的调控
公开(公告)号：US08513400B2
公开(公告)日：2013-08-20
申请号：US12642534
申请日：2009-12-18
申请人： Donna T. Ward , Kenneth W. Dobie , Eric G. Marcusson , Susan M. Freier
发明人： Donna T. Ward , Kenneth W. Dobie , Eric G. Marcusson , Susan M. Freier
IPC分类号： C07H21/04 , C12N15/113
CPC分类号： C07F9/65586 , A61K38/00 , C07F9/65616 , C12N15/113 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/3525
摘要： Compounds, compositions and methods are provided for modulating the expression of HIF1α and/or HIF2α. The compositions comprise oligonucleotides, targeted to nucleic acid encoding HIF1α and HIF2α. Methods of using these compounds for modulation of HIF1α and/or HIF2α expression and for diagnosis and treatment of disease associated with expression of HIF1α and/or HIF2α are provided.
摘要翻译：提供化合物，组合物和方法用于调节HIF1α和/或HIF2α的表达。组合物包含针对编码HIF1α和HIF2α的核酸的寡核苷酸。提供了使用这些化合物调节HIF1α和/或HIF2α表达以及用于诊断和治疗与HIF1α和/或HIF2α的表达相关的疾病的方法。

30. 发明申请

US20110190370A1 MODULATION OF HIF1(ALPHA) AND HIF2(ALPHA) EXPRESSION 有权
标题翻译： HIF1（ALPHA）和HIF2（ALPHA）表达的调控
公开(公告)号：US20110190370A1
公开(公告)日：2011-08-04
申请号：US12642534
申请日：2009-12-18
申请人： Donna T. Ward , Kenneth W. Dobie , Eric G. Marcusson , Susan M. Freier
发明人： Donna T. Ward , Kenneth W. Dobie , Eric G. Marcusson , Susan M. Freier
IPC分类号： A61K31/7088 , C07H21/04 , A61P35/00 , C12N5/00
CPC分类号： C07F9/65586 , A61K38/00 , C07F9/65616 , C12N15/113 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/3525
摘要： Compounds, compositions and methods are provided for modulating the expression of HIF1α and/or HIF2α. The compositions comprise oligonucleotides, targeted to nucleic acid encoding HIF1α and HIF2α. Methods of using these compounds for modulation of HIF1α and/or HIF2α expression and for diagnosis and treatment of disease associated with expression of HIF1α and/or HIF2α are provided.
摘要翻译：提供化合物，组合物和方法用于调节HIF1α和/或HIF2α的表达。组合物包含针对编码HIF1α和HIF2α的核酸的寡核苷酸。提供了使用这些化合物调节HIF1α和/或HIF2α表达以及用于诊断和治疗与HIF1α和/或HIF2α的表达相关的疾病的方法。

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