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21. 发明授权

US07826185B2 Structure and circuit technique for uniform triggering of multifinger semiconductor devices with tunable trigger voltage 有权
标题翻译：用于均匀触发具有可调谐触发电压的多光子半导体器件的结构和电路技术
公开(公告)号：US07826185B2
公开(公告)日：2010-11-02
申请号：US11692481
申请日：2007-03-28
申请人： Michel J. Abou-Khalil , Robert Gauthier, Jr. , Hongmei Li , Junjun Li , Souvick Mitra , Christopher S. Putnam
发明人： Michel J. Abou-Khalil , Robert Gauthier, Jr. , Hongmei Li , Junjun Li , Souvick Mitra , Christopher S. Putnam
IPC分类号： H02H9/00 , H01C7/12 , H02H1/00 , H02H1/04 , H02H3/22 , H02H9/06
CPC分类号： H01L27/0277 , H01L27/0262 , H01L2924/0002 , H01L2924/00
摘要： An external current injection source is provided to individual fingers of a multi-finger semiconductor device to provide the same trigger voltage across the multiple fingers. For example, the external injection current is supplied to the body of a MOSFET or the gate of a thyristor. The magnitude of the supplied current from each external current injection source is adjusted so that each finger has the same trigger voltage. The external current supply circuit may comprise diodes or an RC triggered MOSFET. The components of the external current supply circuit may be tuned to achieve a desired predetermined trigger voltage across all fingers of the multi-finger semiconductor device.
摘要翻译：外部电流注入源被提供给多指半导体器件的各个指状物，以跨多个指状物提供相同的触发电压。例如，外部注入电流被提供给MOSFET的主体或晶闸管的栅极。调整来自每个外部电流注入源的供给电流的大小，使得每个手指具有相同的触发电压。外部电流供应电路可以包括二极管或RC触发MOSFET。可以调谐外部电流供应电路的组件以实现多指半导体器件的所有指状物上期望的预定触发电压。

22. 发明申请

US20090224772A1 SYSTEM AND METHOD FOR DE-EMBEDDING A DEVICE UNDER TEST EMPLOYING A PARAMETRIZED NETLIST 失效
标题翻译：在使用参数化列表的测试中去除嵌入式设备的系统和方法
公开(公告)号：US20090224772A1
公开(公告)日：2009-09-10
申请号：US12043169
申请日：2008-03-06
申请人： Basanth Jagannathan , Zhenrong Jin , Hongmei Li
发明人： Basanth Jagannathan , Zhenrong Jin , Hongmei Li
IPC分类号： G01R35/00
CPC分类号： G01R27/32 , G01R35/00
摘要： S-parameter data is measured on an embedded device test structure, an open dummy, and a short dummy. A 4-port network of the pad set parasitics of the embedded device test structure is modeled by a parameterized netlist containing a lumped element network having at least one parameterized lumped element. The S-parameter data across a range of measurement frequencies is fitted with the parametrized netlist employing the at least one parameterized lumped element as at least one fitting parameter for the S-parameter data. Thus, the fitting method is a multi-frequency fitting for the at least one parameterized lumped element. A 4-port Y-parameter (admittance parameter) is obtained from the fitted parameterized netlist. The Y-parameter of the device under test is obtained from the measured admittance of the embedded device test structure and the calculated 4-port Y parameter.
摘要翻译： S参数数据是在嵌入式设备测试结构上测量的，一个开放虚拟的和一个短虚拟的。嵌入式设备测试结构的焊盘组寄生效应的4端口网络由包含具有至少一个参数化集总元件的集总元件网络的参数化网表建模。将测量频率范围内的S参数数据与采用至少一个参数化集总元件的参数化网表拟合为S参数数据的至少一个拟合参数。因此，拟合方法是用于至少一个参数化的集总元件的多频率拟合。从拟合的参数化网表获得4端口Y参数（导纳参数）。被测器件的Y参数是从嵌入式器件测试结构的测量导纳和计算的4端口Y参数获得的。

23. 发明申请

US20060040936A1 Substituted N-arylsulfonylheterocyclic amines as gamma-secretase inhibitors 失效
标题翻译：取代的N-芳基磺酰基杂环胺作为γ-分泌酶抑制剂
公开(公告)号：US20060040936A1
公开(公告)日：2006-02-23
申请号：US11168797
申请日：2005-06-28
申请人： Hubert Josien , John Clader , Thomas Bara , Ruo Xu , Hongmei Li , Dmitri Pissarnitski , Zhiqiang Zhao
发明人： Hubert Josien , John Clader , Thomas Bara , Ruo Xu , Hongmei Li , Dmitri Pissarnitski , Zhiqiang Zhao
IPC分类号： A61K31/5377 , A61K31/498 , A61K31/496 , A61K31/46 , C07D43/02 , C07D413/02 , C07D487/04
CPC分类号： C07D265/30 , C07D413/12 , C07D451/02 , C07D487/08
摘要： This invention discloses novel gamma secretase inhibitors of the formula: wherein: L is —O—, —N(R6)—, —S—, —S(O)—, or —S(O2)—; R1 is selected from the group consisting of aryl and heteroaryl; R2 is selected from the group consisting of alkyl, —C(O)—Y, —X—C(O)—Y, -alkylene-X—C(O)—Y, -alkylene-C(O)—Y, -alkylene-cycloalkylene-X—C(O)—Y, -alkylene-cycloalkylene-C(O)—Y, -cycloalkylene-alkylene-X—C(O)—Y, -cycloalkylene-alkylene-C(O)—Y, -cycloalkylene-X—C(O)—Y, -cycloalkylene-C(O)—Y, -alkylene-cycloalkylene-alkylene-X—C(O)—Y, -alkylene-cycloalkylene-alkylene-C(O)—Y, aryl, and heteroaryl; R3 is selected from the group consisting of aryl, heteroaryl, alkyl, cycloalkyl, arylalkyl, arylcycloalkyl, heteroarylalkyl, heteroarylcycloalkyl, arylheterocycloalkyl, and alkoxyalkyl; each R4 and R5 is independently selected from the group consisting of H and alkyl; and Y is selected from the group consisting of —NR8R9, —N(R6)—(CH2)b—NR8R9, aryl, heteroaryl, alkyl, cycloalkyl, arylalkyl, arylcycloalkyl, heteroarylalkyl, heteroarylcycloalkyl, and arylheterocycloalkyl; or Y is selected from the group consisting of: One or more compounds of formula I, or formulations comprising such compounds, may be useful, e.g. in treating Alzheimer's Disease.
摘要翻译：本发明公开了下式的新型γ分泌酶抑制剂：其中：L是-O-，-N（R 6） - ， - S - ， - S（O） - 或-S（O - ; R 1选自芳基和杂芳基; R 2选自烷基，-C（O）-Y，-XC（O）-Y， - 亚烷基-XC（O）-Y， - 亚烷基-C（O ）-Y-亚烷基 - 亚环烷基-OC（O）-Y-亚烷基 - 亚环烷基-C（O）-Y-亚烷基 - 亚烷基-OC（O）-Y-亚烷基 - 亚烷基-C（O） Y（ - ）亚环烷基-C（O）-Y-亚烷基-C（O）-Y-亚烷基 - 亚环烷基亚烷基-XC（O）-Y-亚烷基 - 亚环烷基 - 亚烷基-C（O）-Y，芳基和杂芳基; R 3选自芳基，杂芳基，烷基，环烷基，芳基烷基，芳基环烷基，杂芳基烷基，杂芳基环烷基，芳基杂环烷基和烷氧基烷基; 每个R 4和R 5独立地选自H和烷基; 并且Y选自-NR 8 R 9，-N（R 6） - （CH 2）芳基，杂芳基，烷基，环烷基，芳基烷基，芳基环烷基，杂芳基烷基，杂芳基环烷基和芳基杂环烷基 ; 或Y选自：一种或多种式I化合物或包含该化合物的制剂可用于，例如，治疗阿尔茨海默病。

24. 发明授权

US08759337B2 Gamma secretase modulators 有权
标题翻译：伽玛分泌酶调节剂
公开(公告)号：US08759337B2
公开(公告)日：2014-06-24
申请号：US13140987
申请日：2009-12-18
申请人： Theodros Asberom , Xianhai Huang , Zhaoning Zhu , John W. Clader , Dmitri A. Pissarnitski , Hubert B. Josien , Hongmei Li
发明人： Theodros Asberom , Xianhai Huang , Zhaoning Zhu , John W. Clader , Dmitri A. Pissarnitski , Hubert B. Josien , Hongmei Li
IPC分类号： A61K31/553 , C07D498/04
CPC分类号： C07D498/04
摘要： This invention provides novel compounds that are modulators of gamma secretase. The compounds have the formula (Chemical formula should be inserted here as it appears on abstract in paper form). Also disclosed are methods of modulating gamma secretase activity and methods of treating Alzheimer's Disease using the compounds of formula (I).
摘要翻译：本发明提供了作为γ分泌酶调节剂的新型化合物。这些化合物具有式（化学式应该插在这里，如纸上所示）。还公开了使用式（I）化合物调节γ-分泌酶活性和治疗阿尔茨海默病的方法的方法。

25. 发明申请

US20130324562A1 FUSED BICYCLIC HETEROCYCLES USEFUL AS DIPEPTIDYL PEPTIDASE-IV INHIBITORS 有权
标题翻译：作为DIPEPTIDYL PEPTIDASE-IV抑制剂的FUSED BICYCLIC HETEROCYCLES有用
公开(公告)号：US20130324562A1
公开(公告)日：2013-12-05
申请号：US14000641
申请日：2012-03-01
申请人： Chad E. Bennett , Duane A. Burnett , Hongmei Li , Yonggang Chen , Troy McCracken , Monica Vicarel
发明人： Chad E. Bennett , Duane A. Burnett , Hongmei Li , Yonggang Chen , Troy McCracken , Monica Vicarel
IPC分类号： C07D487/04 , A61K45/06 , A61K31/522 , A61K31/519 , C07D473/28
CPC分类号： C07D487/04 , A61K31/155 , A61K31/427 , A61K31/519 , A61K31/522 , A61K31/64 , A61K45/06 , C07D473/18 , C07D473/28 , A61K2300/00
摘要： The present invention is directed to novel bicyclic heterocycles of structural formula (I) which are inhibitors of the dipeptidyl peptidase-IV enzyme and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly Type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.
摘要翻译：本发明涉及结构式（I）的新型双环杂环，其是二肽基肽酶-IV酶的抑制剂，其可用于治疗或预防涉及二肽基肽酶-IV酶的疾病，例如糖尿病特别是2型糖尿病。本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及二肽基肽酶-IV酶的疾病中的用途。

26. 发明申请

US20130246031A1 Constructing Geologic Models From Geologic Concepts 审中-公开
标题翻译：从地质概念构建地质模型
公开(公告)号：US20130246031A1
公开(公告)日：2013-09-19
申请号：US13884592
申请日：2011-08-29
申请人： XiaoHui Wu , Christine Iannello Bachtel , Roger B. Bloch , Larisa Branets , Xiuli Gai , Subhash Kalla , Hongmei Li , Rossen R. Parashkevov , Gregory D. Robertson
发明人： XiaoHui Wu , Christine Iannello Bachtel , Roger B. Bloch , Larisa Branets , Xiuli Gai , Subhash Kalla , Hongmei Li , Rossen R. Parashkevov , Gregory D. Robertson
IPC分类号： G06F17/50
CPC分类号： G06F17/5009 , G01V99/00 , G06T17/05
摘要： Method for constructing a geologic model of a subsurface region. A concept region and a geologic concept is selected (300). A design region is created corresponding to the concept region (310). A conceptual model is generated compatible to data in the design legion (320). The conceptual model is mapped from the design legion concept region (330). The conceptual interfaces and region properties may be adjusted to match data in the concept region (340).
摘要翻译：构建地下地质地质模型的方法。选择概念区域和地质概念（300）。创建对应于概念区域（310）的设计区域。生成与设计军团（320）中的数据兼容的概念模型。概念模型从设计军团概念区域（330）映射。可以调整概念界面和区域属性以匹配概念区域中的数据（340）。

27. 发明申请

US20110294756A1 GAMMA SECRETASE MODULATORS 有权
标题翻译： GAMMA秘密调节器
公开(公告)号：US20110294756A1
公开(公告)日：2011-12-01
申请号：US13128493
申请日：2009-11-12
申请人： Zhaoning Zhu , William J. , Xianhai Huang , Jun Qin , XIaoxiang Liu , Hongmei Li , Wei Zhou , Anandan Palani , Xiaohong Zhu , Monica L. Vicarel , Mihirbaran Mandal , Zhong-Yue Sun , Chad E. Bennett , Troy Michael McCracken , Gioconda V. Gallo
发明人： Zhaoning Zhu , William J. , Xianhai Huang , Jun Qin , XIaoxiang Liu , Hongmei Li , Wei Zhou , Anandan Palani , Xiaohong Zhu , Monica L. Vicarel , Mihirbaran Mandal , Zhong-Yue Sun , Chad E. Bennett , Troy Michael McCracken , Gioconda V. Gallo
IPC分类号： A61K31/695 , C07D413/10 , C07D471/04 , A61P25/28 , A61K31/519 , C07D498/20 , C07F7/18 , C07D498/04 , A61K31/5395
CPC分类号： C07D471/04 , C07D498/04
摘要： In its many embodiments, the present invention provides a novel class of heterocyclic compounds of Group A or Group, as defined herein, as modulators of gamma secretase, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the central nervous system using such compounds or pharmaceutical compositions.
摘要翻译：在其许多实施方案中，本发明提供了一类新颖的本文所定义的组A或组的杂环化合物作为γ-分泌酶的调节剂，制备此类化合物的方法，含有一种或多种此类化合物的药物组合物，制备药物的方法包含一种或多种这样的化合物的制剂，以及使用这些化合物或药物组合物治疗，预防，抑制或改善与中枢神经系统相关的一种或多种疾病的方法。

28. 发明授权

US08067621B2 Benzenesulfonyl-chromane, thiochromane, tetrahydronaphthalene and related gamma secretase inhibitors 有权
标题翻译：苯磺酰基 - 苯并二氢吡喃，二氢苯并噻喃，四氢萘和相关的γ分泌酶抑制剂
公开(公告)号：US08067621B2
公开(公告)日：2011-11-29
申请号：US11654821
申请日：2007-01-18
申请人： Theodros Asberom , Thomas A. Bara , Chad E. Bennett , Duane A. Burnett , Mary Ann Caplen , John W. Clader , David J. Cole , Martin S. Domalski , Hubert B. Josien , Chad E. Knutson , Hongmei Li , Mark D. McBriar , Dmitri A. Pissarnitski , Li Qiang , Murali Rajagopalan , Thavalakulamgara K. Sasikumar , Jing Su , Haiqun Tang , Wen-Lian Wu , Ruo Xu , Zhiqiang Zhao
发明人： Theodros Asberom , Thomas A. Bara , Chad E. Bennett , Duane A. Burnett , Mary Ann Caplen , John W. Clader , David J. Cole , Martin S. Domalski , Hubert B. Josien , Chad E. Knutson , Hongmei Li , Mark D. McBriar , Dmitri A. Pissarnitski , Li Qiang , Murali Rajagopalan , Thavalakulamgara K. Sasikumar , Jing Su , Haiqun Tang , Wen-Lian Wu , Ruo Xu , Zhiqiang Zhao
IPC分类号： C07D493/00 , A61K31/35
CPC分类号： C07D311/22 , C07C317/14 , C07C317/20 , C07C317/44 , C07C2602/08 , C07C2602/10 , C07C2602/12 , C07D311/80 , C07D311/92 , C07D311/94 , C07D313/08 , C07D335/06 , C07D405/12 , C07D409/12 , C07D491/04 , C07D493/04
摘要： This invention discloses novel gamma secretase inhibitors of the formula: R2 and R3, or R2 and R4, or R3 and R4, together with the atoms to which they are bound, can form a fused cycloalkyl or fused heterocycloalkyl ring. The cycloalkyl ring or the heterocycloalkyl ring can be optionally substituted with one or more substitutents. One or more compounds of formula (I), or formulations comprising such compounds, may be useful, e.g. in treating Alzheimer's Disease.
摘要翻译：本发明公开了具有下式的新型γ分泌酶抑制剂：R2和R3，或R2和R4，或R3和R4与它们所连接的原子一起可以形成稠合的环烷基或稠合的杂环烷基环。环烷基环或杂环烷基环可任选被一个或多个取代基取代。一种或多种式（I）化合物或包含这些化合物的制剂可以是有用的，例如，治疗阿尔茨海默病。

29. 发明申请

US20110236400A1 TETRAHYDROPYRANOCHROMENE GAMMA SECRETASE INHIBITORS 有权
标题翻译：四氢吡喃葡萄糖消炎酶抑制剂
公开(公告)号：US20110236400A1
公开(公告)日：2011-09-29
申请号：US12665580
申请日：2008-07-01
申请人： Wen-Lian Wu , Thomas A. Bara , Duane A. Burnett , John W. Clader , Martin S. Domalski , Yan Jin , Hubert B. Josien , Hongmei Li , Xian Liang , Dmitri A. Pissarnitski , Thavalakulamgara K. Sasikumar , Jesse K. Wong , Ruo Xu , Zhiqiang Zhao , Paul E. McNamara
发明人： Wen-Lian Wu , Thomas A. Bara , Duane A. Burnett , John W. Clader , Martin S. Domalski , Yan Jin , Hubert B. Josien , Hongmei Li , Xian Liang , Dmitri A. Pissarnitski , Thavalakulamgara K. Sasikumar , Jesse K. Wong , Ruo Xu , Zhiqiang Zhao , Paul E. McNamara
IPC分类号： A61K39/395 , C07D493/04 , C07D311/80 , C07D407/12 , A61K31/35 , A61K31/352 , A61K31/381 , A61P25/28 , A61P29/00 , A61P31/00 , C07C201/12 , C07C67/343
CPC分类号： C07D493/04 , C07D311/78 , C07D407/12
摘要： Disclosed are novel gamma secretase inhibitors of the formula. Also disclosed are methods of inhibiting gamma-secretase, methods of treating neurodegenerative diseases, and methods of treating Alzheimer's Disease. Also disclosed are processes for preparing alkenes in one reaction step using a mixture of an aldehyde (or ketone) and an alkyl substituted with two electron withdrawing groups, and reacting the mixture with: (a) a sulfonyl halide (e.g., a sulfonyl chloride) and a basic tertiary amine, or, (b) a sulfonyl anhydride and a basic amine, or (c) an aryl-C(O)-halide and a basic tertiary amine, or (d) an aryl-C(O)—O—C(O)-aryl and a basic tertiary amine, or (e) an heteroaryl-C(O)-halide and a basic tertiary amine, or (f) a heteroaryl-C(O)—O—C(O)-heteroaryl and a basic tertiary amine.
摘要翻译：公开了下式的新型γ-分泌酶抑制剂。还公开了抑制γ-分泌酶，治疗神经变性疾病的方法和治疗阿尔茨海默氏病的方法。还公开了在一个反应步骤中使用醛（或酮）和被两个吸电子基团取代的烷基的混合物制备烯烃的方法，并使该混合物与：（a）磺酰卤（例如磺酰氯）和（b）磺酰基酐和碱性胺，或（c）芳基-C（O） - 卤化物和碱式叔胺，或（d）芳基-C（O） - （O） - 芳基和碱式叔胺，或（e）杂芳基-C（O） - 卤化物和碱式叔胺，或（f）杂芳基-C（O）-O-C（O ） - 杂芳基和碱性叔胺。

30. 发明申请

US20100087425A1 Substituted N-Arylsulfonylheterocyclic Amines As Gamma-Secretase Inhibitors 审中-公开
标题翻译：取代的N-芳基磺酰基杂环胺作为γ-分泌酶抑制剂
公开(公告)号：US20100087425A1
公开(公告)日：2010-04-08
申请号：US12633286
申请日：2009-12-08
申请人： Hubert B. Josien , John W. Clader , Thomas A. Bara , Ruo Xu , Hongmei Li , Dmitri A. Pissarnitaki , Zhiqiang Zhao
发明人： Hubert B. Josien , John W. Clader , Thomas A. Bara , Ruo Xu , Hongmei Li , Dmitri A. Pissarnitaki , Zhiqiang Zhao
IPC分类号： A61K31/5377 , C07D413/14 , C07D413/12 , C07D417/12 , C07D417/14 , A61K31/541 , A61P25/00 , A61P25/28
CPC分类号： C07D265/30 , C07D413/12 , C07D451/02 , C07D487/08
摘要： This invention discloses novel gamma secretase inhibitors of the formula: wherein: L is —O—, —N(R6)—, —S—, —S(O)—, or —S(O2)—; R1 is selected from the group consisting of aryl and heteroaryl; R2 is selected from the group consisting of alkyl, —C(O)—Y, —X—C(O)—Y, -alkylene-X—C(O)—Y, -alkylene-C(O)—Y, -alkylene-cycloalkylene-X—C(O)—Y, -alkylene-cycloalkylene-C(O)—Y, -cycloalkylene-alkylene-X—C(O)—Y, -cycloalkylene-alkylene-C(O)—Y, -cycloalkylene-X—C(O)—Y, -cycloalkylene-C(O)—Y, -alkylene-cycloalkylene-alkylene-X—C(O)—Y, -alkylene-cycloalkylene-alkylene-C(O)—Y, aryl, and heteroaryl; R3 is selected from the group consisting of aryl, heteroaryl, alkyl, cycloalkyl, arylalkyl, arylcycloalkyl, heteroarylalkyl, heteroarylcycloalkyl, arylheterocycloalkyl, and alkoxyalkyl; each R4 and R5 is independently selected from the group consisting of H and alkyl; and Y is selected from the group consisting of —NR8R9, —N(R6)—(CH2)b—NR8R9, aryl, heteroaryl, alkyl, cycloalkyl, arylalkyl, arylcycloalkyl, heteroarylalkyl, heteroarylcycloalkyl, and aryl heterocycloalkyl; or Y is selected from the group consisting of: One or more compounds of formula I, or formulations comprising such compounds, may be useful, e.g. in treating Alzheimer's Disease.
摘要翻译：本发明公开了下式的新型γ-分泌酶抑制剂：其中：L是-O - ， - N（R6） - ， - S - ， - S（O） - 或-S（O 2） - ; R 1选自芳基和杂芳基; R 2选自烷基，-C（O）-Y，-X-C（O）-Y， - 亚烷基-X-C（O）-Y， - 亚烷基-C（O）-Y， - 亚烷基 - 亚环烷基-X-C（O）-Y-亚烷基 - 亚环烷基-C（O）-Y-亚烷基 - 亚烷基-X-C（O）-Y-亚烷基 - 亚烷基-C（O）（O）-Y-亚烷基-C（O）-Y-亚烷基 - 亚环烷基 - 亚烷基-X-C（O）-Y-亚烷基 - 亚环烷基 - 亚烷基-C（O ）-Y，芳基和杂芳基; R 3选自芳基，杂芳基，烷基，环烷基，芳基烷基，芳基环烷基，杂芳基烷基，杂芳基环烷基，芳基杂环烷基和烷氧基烷基; 每个R 4和R 5独立地选自H和烷基; 并且Y选自-NR8R9，-N（R6） - （CH2）b-NR8R9，芳基，杂芳基，烷基，环烷基，芳基烷基，芳基环烷基，杂芳基烷基，杂芳基环烷基和芳基杂环烷基; 或Y选自：一种或多种式I化合物或包含该化合物的制剂可用于，例如，治疗阿尔茨海默病。

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