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21. 发明授权

US07214384B2 Lipid-conjugated polyamide compounds 失效
标题翻译：脂质共轭聚酰胺化合物
公开(公告)号：US07214384B2
公开(公告)日：2007-05-08
申请号：US10445642
申请日：2003-05-27
申请人： Ronald N. Zuckermann , Chin-Yi Huang , John E. Murphy , Tetsuo Uno
发明人： Ronald N. Zuckermann , Chin-Yi Huang , John E. Murphy , Tetsuo Uno
IPC分类号： A61K9/127 , C08K5/20 , C12N15/00 , C07C231/00
CPC分类号： C12N15/87 , A61K47/645
摘要： In accordance with the present invention, there are provided lipid-conjugated polyamide compounds and related compositions and methods thereof. Lipid-conjugated polyamide compounds of the present invention are particularly useful as vehicles for delivering biologically active agents to a target site. In particular, the invention compounds are effective at facilitating the delivery of polynucleotides to cells. The present invention also provides a method for producing stable formulations of polynucleotides complexed with a delivery vehicle.
摘要翻译：根据本发明，提供了脂质共轭聚酰胺化合物及其相关组合物和方法。本发明的脂质偶联的聚酰胺化合物特别可用作将生物活性剂递送到靶位点的载体。特别地，本发明化合物有利于促进将多核苷酸递送至细胞。本发明还提供了用于制备与递送载体复合的多核苷酸的稳定制剂的方法。

22. 发明授权

US06251433B1 Polycationic polymers 失效
标题翻译：聚阳离子聚合物
公开(公告)号：US06251433B1
公开(公告)日：2001-06-26
申请号：US08910647
申请日：1997-08-13
申请人： Ronald N. Zuckermann , Nathalie Dubois-Stringfellow , Varavani Dwarki , Michael A. Innis , John E. Murphy , Fred E. Cohen , Tetsuo Uno
发明人： Ronald N. Zuckermann , Nathalie Dubois-Stringfellow , Varavani Dwarki , Michael A. Innis , John E. Murphy , Fred E. Cohen , Tetsuo Uno
IPC分类号： A61F914
CPC分类号： A61K38/2264 , A61K38/1816 , A61K47/645 , A61K48/00 , A61K48/0008 , A61K48/0041 , C07K7/08 , C07K14/001 , C12N15/87 , C12N2810/858
摘要： This invention relates compositions and methods for increasing the uptake of polynucleotides into cells. Specifically, the invention relates to vectors, targeting ligands, and polycationic agents. The polycationic agents are capable of (1) increasing the frequency of uptake of polynucleotides into a cell, (2) condensing polynucleotides; and (3) inhibiting serum and/or nuclease degradation of polynucleotides.
摘要翻译：本发明涉及用于增加多核苷酸进入细胞的摄取的组合物和方法。具体地，本发明涉及载体，靶向配体和聚阳离子剂。聚阳离子剂能够（1）增加多核苷酸进入细胞的频率，（2）缩合多核苷酸; 和（3）抑制多核苷酸的血清和/或核酸酶降解。

23. 发明授权

US06197332B1 Lipid-conjugated polyamide compounds and related compositions and methods thereof 有权
标题翻译：脂质共轭聚酰胺化合物及其相关组合物和方法
公开(公告)号：US06197332B1
公开(公告)日：2001-03-06
申请号：US09132808
申请日：1998-08-12
申请人： Ronald N. Zuckermann , Chin-Yi Huang , John E. Murphy , Tetsuo Uno
发明人： Ronald N. Zuckermann , Chin-Yi Huang , John E. Murphy , Tetsuo Uno
IPC分类号： A61K9127
CPC分类号： C12N15/87 , A61K47/645
摘要： In accordance with the present invention, there are provided lipid-conjugated polyamide compounds and related compositions and methods thereof. Lipid-conjugated polyamide compounds of the present invention are particularly useful as vehicles for delivering biologically active agents to a target site. In particular, the invention compounds are effective at facilitating the delivery of polynucleotides to cells. The present invention also provides a method for producing stable formulations of polynucleotides complexed with a delivery vehicle.
摘要翻译：根据本发明，提供了脂质共轭聚酰胺化合物及其相关组合物和方法。本发明的脂质偶联的聚酰胺化合物特别可用作将生物活性剂递送到靶位点的载体。特别地，本发明化合物有利于促进将多核苷酸递送至细胞。本发明还提供了用于制备与递送载体复合的多核苷酸的稳定制剂的方法。

24. 发明授权

US08052239B2 Driving apparatus of inkjet head 有权
标题翻译：喷墨头驱动装置
公开(公告)号：US08052239B2
公开(公告)日：2011-11-08
申请号：US11901193
申请日：2007-09-14
申请人： Hiroaki Arakawa , Tetsuo Uno , Masakazu Mori
发明人： Hiroaki Arakawa , Tetsuo Uno , Masakazu Mori
IPC分类号： B41J29/38
CPC分类号： B41J2/04581 , B41J2/04521 , B41J2/04541 , B41J2/04573 , B41J2/0458
摘要： An inkjet head driving apparatus, wherein serial data indicating emission or non emission of nozzles respectively for a plurality of heads, is latched and memorized, and the nozzles are driven respectively based on the data memorized, the inkjet head driving apparatus having: an emission timing signal outputting device disposed in common for a plurality of heads so as to output a plurality of emission timing signals in one emission cycle; a setting device disposed respectively for the plurality of the heads so as to select the sequential emission timing signals at which emission starts synchronously, among the emission timing signals outputted from the emission timing signal outputting device in one emission cycle.
摘要翻译：一种喷墨头驱动装置，其中分别指示用于多个头的喷嘴的发射或不发射的串行数据被锁存和存储，并且基于所记录的数据分别驱动喷嘴，该喷墨头驱动装置具有：发射定时信号输出装置，用于多个头共用，以便在一个发射周期中输出多个发射定时信号; 在一个发射周期中，从发射定时信号输出装置输出的发射定时信号中，分别设置用于多个磁头的设定装置，以选择同步发射的顺序发射定时信号。

25. 发明申请

US20110190259A1 COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS 有权
标题翻译：作为蛋白激酶抑制剂的化合物和组合物
公开(公告)号：US20110190259A1
公开(公告)日：2011-08-04
申请号：US13048636
申请日：2011-03-15
申请人： Pierre-Yves Michellys , Wei Pei , Thomas H. Marsilje , Bei Chen , Tetsuo Uno , Yunho Jin , Tao Jiang
发明人： Pierre-Yves Michellys , Wei Pei , Thomas H. Marsilje , Bei Chen , Tetsuo Uno , Yunho Jin , Tao Jiang
IPC分类号： A61K31/506 , C07D401/14 , C12N9/99 , C07D239/24 , C07D413/14 , A61K31/5377 , C07D403/02 , A61P25/00 , A61P37/06
CPC分类号： A61K31/506 , A61K31/5377 , A61K45/06 , C07D213/74 , C07D239/48 , C07D239/95 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D413/12 , C07D417/12 , C07D451/02 , C07D453/02 , C07D471/04 , C07D473/16 , C07D487/04 , C07D487/08
摘要： The invention provides novel pyrimidine and pyridine derivatives and pharmaceutical compositions thereof, and methods for using such compounds. For example, the pyrimidine and pyridine derivatives of the invention may be used to treat, ameliorate or prevent a condition which responds to inhibition of anaplastic lymphoma kinase (ALK) activity, focal adhesion kinase (FAK), zeta-chain-associated protein kinase 70 (ZAP-70), insulin-like growth factor (IGF-1R), or a combination thereof.
摘要翻译：本发明提供新颖的嘧啶和吡啶衍生物及其药物组合物，以及使用这些化合物的方法。例如，本发明的嘧啶和吡啶衍生物可用于治疗，改善或预防响应于间变性淋巴瘤激酶（ALK）活性，粘着斑激酶（FAK），ζ-链相关蛋白激酶70 （ZAP-70），胰岛素样生长因子（IGF-1R）或其组合。

26. 发明授权

US07990563B2 Printing unit and inkjet recording apparatus 有权
标题翻译：印刷单元和喷墨记录装置
公开(公告)号：US07990563B2
公开(公告)日：2011-08-02
申请号：US12210388
申请日：2008-09-15
申请人： Tetsuo Uno
发明人： Tetsuo Uno
IPC分类号： G06K15/22
CPC分类号： H04N1/32358 , G06K15/10 , H04N1/12 , H04N1/193 , H04N1/3247 , H04N2201/0082 , H04N2201/0466 , H04N2201/3287
摘要： A print unit memorizes image data to be output to a page of recording media at a register as jetting data in an order of storing a plurality of image data of one line in page memory, wherein each of the image data of one line is memorized at the register in an order of storing the plurality of image data of one dot, in case when a conveyance direction of recording media is normal; and memorizes the image data to be output to the page of the recording media at the register in the order of storing the plurality of the image data of one line, wherein each of the image data of one line is memorized in a reverse order to the order of storing the plurality of the image data of one dot, in case when the conveyance direction is reverse.
摘要翻译：打印单元将要输出的图像数据存储在寄存器中的记录介质页面上，以按照一行存储页面存储器的多个图像数据的顺序喷射数据，其中一行的每个图像数据被存储在在记录介质的传送方向正常的情况下，以存储一个点的多个图像数据的顺序存储该寄存器; 并以存储一行的多个图像数据的顺序将要输出的要输出的图像数据存储在记录介质的页面上，其中一行的图像数据中的每一个以相反的顺序被存储到在输送方向相反的情况下存储一个点的多个图像数据的顺序。

27. 发明申请

US20110003798A1 COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS 失效
标题翻译：化合物和组合物作为激酶抑制剂
公开(公告)号：US20110003798A1
公开(公告)日：2011-01-06
申请号：US12865339
申请日：2009-01-27
申请人： Barun Okram , Tetsuo Uno , Qiang Ding , Yahua Liu , Yunho Jin , Qihui Jin , Xu Wu , Jianwei Che , S. Frank Yan , Xueshi Hao
发明人： Barun Okram , Tetsuo Uno , Qiang Ding , Yahua Liu , Yunho Jin , Qihui Jin , Xu Wu , Jianwei Che , S. Frank Yan , Xueshi Hao
IPC分类号： A61K31/5415 , C07D471/04 , C07D498/04 , A61K31/4375 , A61K31/5377 , A61K31/506 , A61K31/496 , A61K31/541 , A61K31/497 , A61K31/538 , A61K31/5383 , A61K31/501 , A61P11/06 , A61P11/08 , A61P11/00 , A61P17/00 , A61P17/06 , A61P11/02 , A61P29/00 , A61P25/00 , A61P35/00 , A61P31/18 , A61P37/02
CPC分类号： C07D471/04
摘要： The invention provides a novel class of 2,7-naphthyridin derivatives; pharmaceutical compositions comprising such compounds and methods of using such compounds to treat o prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly Syk, ZAP70, KDR, FMS, FLT*, c-Kit, RET, TrkA, TrkB, TrkC-GR-1R, Alk, c-FMS or combinations thereof.
摘要翻译：本发明提供了一类新的2,7-萘啶衍生物; 包含这些化合物的药物组合物和使用这些化合物治疗的方法o预防与异常或失调的激酶活性相关的疾病或病症，特别是Syk，ZAP70，KDR，FMS，FLT *，c-Kit，RET，TrkA，TrkB，TrkC- GR-1R，Alk，c-FMS或其组合。

28. 发明申请

US20090181991A1 COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS 审中-公开
标题翻译：作为蛋白激酶抑制剂的化合物和组合物
公开(公告)号：US20090181991A1
公开(公告)日：2009-07-16
申请号：US12090844
申请日：2006-11-03
申请人： Qiong Zhang , Nathanael S. Gray , Yi Liu , Qiang Ding , Tetsuo Uno
发明人： Qiong Zhang , Nathanael S. Gray , Yi Liu , Qiang Ding , Tetsuo Uno
IPC分类号： A61K31/505 , C07D239/42 , C07D213/74 , A61K31/44
CPC分类号： C07D239/48 , C07D213/74 , C07D239/42 , C07D239/47 , C07D239/52
摘要： The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of the Lck, IR, IGF-1R, JNK1α, Flt3, Fes, EFGR (Her-1, erbB-1), cSRC, CDK1/cyclinB, c-RAF, BTK, Bmx, Axl, Aurora-A, Abl, BCR-Abl, TrkB, Tie2, Syk, SGK, SAPK2a, Rsk1 and Met kinases.
摘要翻译：本发明提供了一类新颖的化合物，包含这些化合物的药物组合物和使用这些化合物治疗或预防与异常或失调的激酶活性相关的疾病或病症的方法，特别是涉及Lck，IR，IGF异常活化的疾病或病症 -1R，JNK1alpha，Flt3，Fes，EFGR（Her-1，erbB-1），cSRC，CDK1 / cyclinB，c-RAF，BTK，Bmx，Ax1，Aurora-A，Abl，BCR-Abl，TrkB，Tie2， Syk，SGK，SAPK2a，Rsk1和Met激酶。

29. 发明授权

US07462592B2 Compositions and methods for polynucleotide delivery 失效
标题翻译：用于多核苷酸递送的组合物和方法
公开(公告)号：US07462592B2
公开(公告)日：2008-12-09
申请号：US10278751
申请日：2002-10-22
申请人： Ronald N. Zuckermann , Nathalie Dubois-Stringfellow , Varavani Dwarki , Michael A. Innis , John E. Murphy , Fred E. Cohen , Tetsuo Uno
发明人： Ronald N. Zuckermann , Nathalie Dubois-Stringfellow , Varavani Dwarki , Michael A. Innis , John E. Murphy , Fred E. Cohen , Tetsuo Uno
IPC分类号： A01N37/18 , A61K9/14 , A61K38/00
CPC分类号： A61K38/2264 , A61K38/1816 , A61K47/645 , A61K48/00 , A61K48/0008 , A61K48/0041 , C07K7/08 , C07K14/001 , C12N15/87 , C12N2810/858
摘要： This invention relates compositions and methods for increasing the uptake of polynucleotides into cells. Specifically, the invention relates to vectors, targeting ligands, and polycationic agents. The polycationic agents are capable of (1) increasing the frequency of uptake of polynucleotides into a cell, (2) condensing polynucleotides; and (3) inhibiting serum and/or nuclease degradation of polynucleotides.
摘要翻译：本发明涉及用于增加多核苷酸进入细胞的摄取的组合物和方法。具体地，本发明涉及载体，靶向配体和聚阳离子剂。聚阳离子剂能够（1）增加多核苷酸进入细胞的频率，（2）缩合多核苷酸; 和（3）抑制多核苷酸的血清和/或核酸酶降解。

30. 发明申请

US20080089938A9 Compositions and methods for polynucleotide delivery 失效
公开(公告)号：US20080089938A9
公开(公告)日：2008-04-17
申请号：US10278751
申请日：2002-10-22
申请人： Ronald Zuckermann , Nathalie Dubois-Stringfellow , Varavani Dwarki , Michael Innis , John Murphy , Fred Cohen , Tetsuo Uno
发明人： Ronald Zuckermann , Nathalie Dubois-Stringfellow , Varavani Dwarki , Michael Innis , John Murphy , Fred Cohen , Tetsuo Uno
IPC分类号： A61K48/00 , C07K7/08 , C07K14/00 , A61K9/14
CPC分类号： A61K38/2264 , A61K38/1816 , A61K47/645 , A61K48/00 , A61K48/0008 , A61K48/0041 , C07K7/08 , C07K14/001 , C12N15/87 , C12N2810/858
摘要： This invention relates compositions and methods for increasing the uptake of polynucleotides into cells. Specifically, the invention relates to vectors, targeting ligands, and polycationic agents. The polycationic agents are capable of (1) increasing the frequency of uptake of polynucleotides into a cell, (2) condensing polynucleotides; and (3) inhibiting serum and/or nuclease degradation of polynucleotides.

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