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21. 发明授权

US5245886A Rotary temperature mechanism 失效
标题翻译：旋转温度机制
公开(公告)号：US5245886A
公开(公告)日：1993-09-21
申请号：US930253
申请日：1992-08-14
申请人： Robin L. Truesdell , John W. Willis , Clifton B. Ward , Timothy A. Gasaway
发明人： Robin L. Truesdell , John W. Willis , Clifton B. Ward , Timothy A. Gasaway
IPC分类号： B60H1/00 , F16C1/18 , F16H25/18
CPC分类号： F16C1/18 , B60H1/0065 , F16H25/186 , Y10T74/18312 , Y10T74/18832 , Y10T74/1896 , Y10T74/20402 , Y10T74/2042 , Y10T74/20636 , Y10T74/2084 , Y10T74/2101 , Y10T74/2107
摘要： A rotary temperature mechanism for controlling the temperature door of a HVAC system of a vehicle includes a rotatable cam connected by a shaft to a rotary temperature control knob. The cam includes a helical rib thereon coacting with a carrier restricted to linear, sliding motion by the housing in response to rotation of the cam. The housing provides a linear track for guiding the carrier. Detent members are provided between the cam and housing to impart discrete stepping feel on rotation of the knob. The detent members include ball bearings on the cam rolling along a corrugated track of the housing. A cable is connected to the carrier and controls the temperature door by linear motion imparted thereon.
摘要翻译：用于控制车辆HVAC系统的温度门的旋转温度机构包括通过轴连接到旋转温度控制旋钮的可旋转凸轮。凸轮包括与载体相互作用的螺旋肋，其受壳体响应于凸轮的旋转而被限制为线性滑动运动。壳体提供用于引导载体的线性轨道。在凸轮和壳体之间设置有止动构件，以在旋钮旋转时赋予离散的踏步感。棘爪构件包括沿着壳体的波纹轨道滚动的凸轮上的球轴承。电缆连接到载体并通过在其上施加的线性运动来控制温度门。

22. 发明授权

US08672207B2 Transwall visualization arrangements and methods for surgical circular staplers 有权
标题翻译：用于外科圆形缝合器的跨墙可视化装置和方法
公开(公告)号：US08672207B2
公开(公告)日：2014-03-18
申请号：US12846956
申请日：2010-07-30
申请人： Frederick E. Shelton, IV , John W. Willis
发明人： Frederick E. Shelton, IV , John W. Willis
IPC分类号： A61B17/125
CPC分类号： A61B17/1155 , A61B17/0218 , A61B17/1114 , A61B17/115 , A61B17/320016 , A61B17/3421 , A61B17/3431 , A61B2017/00057 , A61B2017/00115 , A61B2017/00128 , A61B2017/00349 , A61B2017/00473 , A61B2017/00867 , A61B2017/00876 , A61B2017/0225 , A61B2017/07214 , A61B2017/07257 , A61B2017/07285 , A61B2017/1132 , A61B2017/22034 , A61B2017/2943 , A61B2017/320052 , A61B2090/0427 , A61B2090/061 , A61B2090/0801 , A61B2090/08021 , A61B2090/0807 , A61B2090/0816 , A61B2090/309 , A61B2090/3912 , A61B2090/3945 , A61B2090/3966
摘要： A surgical instrument is disclosed. Various embodiments include an elongated shaft that defines a central axis and has a distal end portion that is configured to operably support a circular staple cartridge therein. At least one detection member may be operably supported within the elongated shaft. Each detection member may have a distal portion that is radially deployable away from the central axis upon application of a deployment motion thereto. The distal end portions may have a bumper or light mounted thereto.
摘要翻译：公开了一种外科器械。各种实施例包括限定中心轴线的细长轴并且具有构造成在其中可操作地支撑圆形钉仓的远端部分。至少一个检测构件可以可操作地支撑在细长轴内。每个检测构件可以具有远端部分，该远端部分在向其施加展开运动时可远离中心轴线展开。前端部可以具有安装在其上的保险杠或灯。

23. 发明申请

US20120029547A1 SURGICAL CIRCULAR STAPLER WITH TISSUE RETENTION ARRANGEMENTS 有权
标题翻译：具有组织保持安慰的手术通气瓶
公开(公告)号：US20120029547A1
公开(公告)日：2012-02-02
申请号：US12846978
申请日：2010-07-30
申请人： Frederick E. Shelton, IV , John W. Willis
发明人： Frederick E. Shelton, IV , John W. Willis
IPC分类号： A61B17/115 , A61B17/32
CPC分类号： A61B17/1155 , A61B17/0218 , A61B17/1114 , A61B17/115 , A61B17/320016 , A61B17/3421 , A61B17/3431 , A61B2017/00057 , A61B2017/00115 , A61B2017/00128 , A61B2017/00349 , A61B2017/00473 , A61B2017/00867 , A61B2017/00876 , A61B2017/0225 , A61B2017/07214 , A61B2017/07257 , A61B2017/07285 , A61B2017/1132 , A61B2017/22034 , A61B2017/2943 , A61B2017/320052 , A61B2090/0427 , A61B2090/061 , A61B2090/0801 , A61B2090/08021 , A61B2090/0807 , A61B2090/0816 , A61B2090/309 , A61B2090/3912 , A61B2090/3945 , A61B2090/3966
摘要： Surgical instruments and procedures for performing a circular anastomosis of a tubular organ. The surgical instruments may include selectively deployable tissue acquisition members configured to puncture through a portion of the tubular organ and position the portion of the organ adjacent to a fastener face of a staple cartridge supported in the instrument. At least one cutting member may be radially deployed and rotated to sever the positioned portion of organ from a distal portion of the organ. An anvil may be employed to draw another portion of the organ adjacent to the portion of organ positioned adjacent to the fastener face of the staple cartridge. The staples may then be deployed through the adjacent portions of organ and an annular knife may be advanced through the adjacent organ portions to complete the anastomosis.
摘要翻译：用于执行管状器官的圆形吻合的手术器械和程序。手术器械可以包括可选择性展开的组织采集部件，其构造成穿刺管状器官的一部分并且将器官的部分定位成邻近装置中支撑的钉仓的紧固件面。至少一个切割构件可以径向展开和旋转，以从器官的远端部分切断器官的定位部分。可以使用砧座来吸引器官的邻近于与钉仓的紧固件面相邻定位的器官部分的另一部分。缝钉然后可以通过器官的相邻部分展开，并且环形刀可以推进穿过相邻的器官部分以完成吻合。

24. 发明申请

US20120029544A1 CIRCULAR STAPLING INSTRUMENTS WITH SECONDARY CUTTING ARRANGEMENTS AND METHODS OF USING SAME 有权
标题翻译：具有二次切割装置的圆形包装仪器及其使用方法
公开(公告)号：US20120029544A1
公开(公告)日：2012-02-02
申请号：US12846968
申请日：2010-07-30
申请人： Frederick E. Shelton, IV , John W. Willis
发明人： Frederick E. Shelton, IV , John W. Willis
IPC分类号： A61B17/115 , A61B17/32
CPC分类号： A61B17/1155 , A61B17/0218 , A61B17/1114 , A61B17/115 , A61B17/320016 , A61B17/3421 , A61B17/3431 , A61B2017/00057 , A61B2017/00115 , A61B2017/00128 , A61B2017/00349 , A61B2017/00473 , A61B2017/00867 , A61B2017/00876 , A61B2017/0225 , A61B2017/07214 , A61B2017/07257 , A61B2017/07285 , A61B2017/1132 , A61B2017/22034 , A61B2017/2943 , A61B2017/320052 , A61B2090/0427 , A61B2090/061 , A61B2090/0801 , A61B2090/08021 , A61B2090/0807 , A61B2090/0816 , A61B2090/309 , A61B2090/3912 , A61B2090/3945 , A61B2090/3966
摘要： Surgical instruments are disclosed. Various non-limiting embodiments may include an elongated shaft that has a distal end portion that is configured to operably support a circular staple cartridge therein. A tissue acquisition shaft may be rotatably supported within said elongated shaft and have a distal portion that protrudes distally beyond the distal end portion of the elongated shaft. At least one tissue acquisition member may be pivotally attached to the distal end portion of the tissue acquisition shaft such that the tissue acquisition members are selectively pivotable from a retracted position to deployed positions upon application of a deployment motion thereto. A rotatable cutting member may be operably supported adjacent to the tissue acquisition member and being selectively rotatable about the central axis upon application of a cutting actuation motion thereto.
摘要翻译：公开了手术器械。各种非限制性实施例可以包括细长轴，其具有构造成在其中可操作地支撑圆形钉仓的远端部分。组织采集轴可以可旋转地支撑在所述细长轴内，并具有远端部分，其远端突出超过细长轴的远端部分。至少一个组织采集构件可以枢转地附接到组织采集轴的远端部分，使得组织采集构件在对其施加展开运动时可选择性地从缩回位置枢转到展开位置。可旋转切割构件可以可靠地支撑在组织采集构件附近，并且在施加切割致动运动时可围绕中心轴线选择性地旋转。

25. 发明授权

US08801734B2 Circular stapling instruments with secondary cutting arrangements and methods of using same 有权
标题翻译：具有二次切割装置的圆形缝合器具及其使用方法
公开(公告)号：US08801734B2
公开(公告)日：2014-08-12
申请号：US12846968
申请日：2010-07-30
申请人： Frederick E. Shelton, IV , John W. Willis
发明人： Frederick E. Shelton, IV , John W. Willis
IPC分类号： A61B17/04
CPC分类号： A61B17/1155 , A61B17/0218 , A61B17/1114 , A61B17/115 , A61B17/320016 , A61B17/3421 , A61B17/3431 , A61B2017/00057 , A61B2017/00115 , A61B2017/00128 , A61B2017/00349 , A61B2017/00473 , A61B2017/00867 , A61B2017/00876 , A61B2017/0225 , A61B2017/07214 , A61B2017/07257 , A61B2017/07285 , A61B2017/1132 , A61B2017/22034 , A61B2017/2943 , A61B2017/320052 , A61B2090/0427 , A61B2090/061 , A61B2090/0801 , A61B2090/08021 , A61B2090/0807 , A61B2090/0816 , A61B2090/309 , A61B2090/3912 , A61B2090/3945 , A61B2090/3966
摘要： Surgical instruments are disclosed. Various non-limiting embodiments may include an elongated shaft that has a distal end portion that is configured to operably support a circular staple cartridge therein. A tissue acquisition shaft may be rotatably supported within said elongated shaft and have a distal portion that protrudes distally beyond the distal end portion of the elongated shaft. At least one tissue acquisition member may be pivotally attached to the distal end portion of the tissue acquisition shaft such that the tissue acquisition members are selectively pivotable from a retracted position to deployed positions upon application of a deployment motion thereto. A rotatable cutting member may be operably supported adjacent to the tissue acquisition member and being selectively rotatable about the central axis upon application of a cutting actuation motion thereto.
摘要翻译：公开了手术器械。各种非限制性实施例可以包括细长轴，其具有构造成在其中可操作地支撑圆形钉仓的远端部分。组织采集轴可以可旋转地支撑在所述细长轴内，并具有远端部分，其远端突出超过细长轴的远端部分。至少一个组织采集构件可以枢转地附接到组织采集轴的远端部分，使得组织采集构件在对其施加展开运动时可选择性地从缩回位置枢转到展开位置。可旋转切割构件可以可靠地支撑在组织采集构件附近，并且在施加切割致动运动时可围绕中心轴线选择性地旋转。

26. 发明申请

US20120024935A1 TISSUE ACQUISITION ARRANGEMENTS AND METHODS FOR SURGICAL STAPLING DEVICES 有权
标题翻译：组织收集装置和手术装置的方法
公开(公告)号：US20120024935A1
公开(公告)日：2012-02-02
申请号：US12846964
申请日：2010-07-30
申请人： Frederick E. Shelton, IV , John W. Willis
发明人： Frederick E. Shelton, IV , John W. Willis
IPC分类号： A61B17/068 , A61B17/115
CPC分类号： A61B17/1114 , A61B17/068 , A61B17/1155 , A61B2017/00115 , A61B2017/00734 , A61B2017/00867 , A61B2017/07264 , A61B2017/07285 , A61B2017/1125 , A61B2017/1142 , G07F17/3239 , G07F17/3255
摘要： A surgical instrument that includes an elongated shaft that defines defining a central axis. The elongated shaft may have a distal end portion that is configured to operably support a circular staple cartridge therein. A tissue acquisition shaft may be axially movable within the elongated shaft such that a distal end portion of the tissue acquisition shaft may be distally advanced beyond the distal end portion of the elongated shaft. At least one tissue acquisition member may be pivotally attached to the distal end portion of the tissue acquisition shaft such that at least one tissue acquisition member is selectively pivotable about a corresponding acquisition axis that is substantially parallel to the central axis from a retracted position to deployed positions upon application of a deployment motion thereto. Various embodiments include an annular cutting member that is supported by the distal end of the elongated shaft for selective axial travel relative thereto.
摘要翻译：一种外科器械，其包括限定中心轴线的细长轴。细长轴可以具有构造成在其中可操作地支撑圆形钉仓的远端部分。组织采集轴可以在细长轴内轴向移动，使得组织采集轴的远端部分可以向远侧前进超过细长轴的远端部分。至少一个组织采集构件可以枢转地附接到组织采集轴的远端部分，使得至少一个组织采集构件可选择性地围绕对应的采集轴线枢转，该对应采集轴线基本上平行于中心轴线从缩回位置到部署应用部署动作时的位置。各种实施例包括由细长轴的远端支撑的环形切割构件，用于相对于其选择性地轴向移动。

27. 发明申请

US20120024934A1 TRANSWALL VISUALIZATION ARRANGEMENTS AND METHODS FOR SURGICAL CIRCULAR STAPLERS 有权
标题翻译：用于外科手术切片的可视化安排和方法
公开(公告)号：US20120024934A1
公开(公告)日：2012-02-02
申请号：US12846956
申请日：2010-07-30
申请人： Frederick E. Shelton, IV , John W. Willis
发明人： Frederick E. Shelton, IV , John W. Willis
IPC分类号： A61B17/068
CPC分类号： A61B17/1155 , A61B17/0218 , A61B17/1114 , A61B17/115 , A61B17/320016 , A61B17/3421 , A61B17/3431 , A61B2017/00057 , A61B2017/00115 , A61B2017/00128 , A61B2017/00349 , A61B2017/00473 , A61B2017/00867 , A61B2017/00876 , A61B2017/0225 , A61B2017/07214 , A61B2017/07257 , A61B2017/07285 , A61B2017/1132 , A61B2017/22034 , A61B2017/2943 , A61B2017/320052 , A61B2090/0427 , A61B2090/061 , A61B2090/0801 , A61B2090/08021 , A61B2090/0807 , A61B2090/0816 , A61B2090/309 , A61B2090/3912 , A61B2090/3945 , A61B2090/3966
摘要： A surgical instrument is disclosed. Various embodiments include an elongated shaft that defines a central axis and has a distal end portion that is configured to operably support a circular staple cartridge therein. At least one detection member may be operably supported within the elongated shaft. Each detection member may have a distal portion that is radially deployable away from the central axis upon application of a deployment motion thereto. The distal end portions may have a bumper or light mounted thereto.
摘要翻译：公开了一种外科器械。各种实施例包括限定中心轴线的细长轴并且具有构造成在其中可操作地支撑圆形钉仓的远端部分。至少一个检测构件可以可操作地支撑在细长轴内。每个检测构件可以具有远端部分，该远端部分在向其施加展开运动时可远离中心轴线展开。前端部可以具有安装在其上的保险杠或灯。

28. 发明授权

US08783543B2 Tissue acquisition arrangements and methods for surgical stapling devices 有权
标题翻译：用于外科缝合装置的组织采集布置和方法
公开(公告)号：US08783543B2
公开(公告)日：2014-07-22
申请号：US12846964
申请日：2010-07-30
申请人： Frederick E. Shelton, IV , John W. Willis
发明人： Frederick E. Shelton, IV , John W. Willis
IPC分类号： A61B17/068
CPC分类号： A61B17/1114 , A61B17/068 , A61B17/1155 , A61B2017/00115 , A61B2017/00734 , A61B2017/00867 , A61B2017/07264 , A61B2017/07285 , A61B2017/1125 , A61B2017/1142 , G07F17/3239 , G07F17/3255
摘要： A surgical instrument that includes an elongated shaft that defines defining a central axis. The elongated shaft may have a distal end portion that is configured to operably support a circular staple cartridge therein. A tissue acquisition shaft may be axially movable within the elongated shaft such that a distal end portion of the tissue acquisition shaft may be distally advanced beyond the distal end portion of the elongated shaft. At least one tissue acquisition member may be pivotally attached to the distal end portion of the tissue acquisition shaft such that at least one tissue acquisition member is selectively pivotable about a corresponding acquisition axis that is substantially parallel to the central axis from a retracted position to deployed positions upon application of a deployment motion thereto. Various embodiments include an annular cutting member that is supported by the distal end of the elongated shaft for selective axial travel relative thereto.
摘要翻译：一种外科器械，其包括限定中心轴线的细长轴。细长轴可以具有构造成在其中可操作地支撑圆形钉仓的远端部分。组织采集轴可以在细长轴内轴向移动，使得组织采集轴的远端部分可以向远侧前进超过细长轴的远端部分。至少一个组织采集构件可以枢转地附接到组织采集轴的远端部分，使得至少一个组织采集构件可选择性地围绕对应的采集轴线枢转，该对应采集轴线基本上平行于中心轴线从缩回位置到部署应用部署动作时的位置。各种实施例包括由细长轴的远端支撑的环形切割构件，用于相对于其选择性地轴向移动。

29. 发明授权

US5590567A Snap retainer and retainer system 失效
标题翻译：卡扣和保持架系统
公开(公告)号：US5590567A
公开(公告)日：1997-01-07
申请号：US403611
申请日：1995-03-14
申请人： Robert A. Marrs , Kurt J. Hudoba , John W. Willis
发明人： Robert A. Marrs , Kurt J. Hudoba , John W. Willis
IPC分类号： F16C1/22 , F16C1/26 , F16L3/13 , F16C1/14
CPC分类号： F16L3/13 , F16C1/105 , F16C1/226 , F16C1/262 , F16C2226/74 , Y10T74/2045 , Y10T74/20462
摘要： The end of a cable or other elongated object is held in a plastic retainer molded of one piece. The retainer has a base with a pocket for holding the object, upstanding supports alongside the pocket and a retaining element mounted between adjacent supports at each side of the pocket. The retaining element defines a snap element and resilient hinges, either flexible webs or torsion arms, which couple each end of the snap element to a support for rotation of the snap element about an axis. The axes are above the pocket and the snap element extends down to hold the object in the pocket. Optional over-center action provides a locking function. Release tabs on the retaining element extending above the axis permits release of the cable by pinching the tabs together. Grooves or ridges on the cable end engage the retainer for axial retention and permit axial adjustment as well. A receiving opening in the retainer is shaped to guide cable end insertion.
摘要翻译：电缆或其他细长物体的端部被保持在由一片成型的塑料保持器中。保持器具有底座，其具有用于保持物体的口袋，沿着口袋的直立支撑件以及安装在口袋每侧的相邻支架之间的保持元件。保持元件限定卡扣元件和弹性铰链，柔性腹板或扭转臂，其将卡扣元件的每个端部联接到支撑件，以使卡扣元件围绕轴线旋转。轴位于口袋上方，卡扣元件向下延伸以将物体保持在口袋中。可选的超中心动作提供锁定功能。在轴上延伸的保持元件上的释放卡舌允许通过将突片夹在一起而释放电缆。电缆端部上的槽或脊与保持器接合，用于轴向保持，并允许轴向调节。保持器中的接收开口成形为引导电缆端插入。

30. 发明授权

US5378806A Fusion protein produced by retrovirus-mediated secretion 失效
标题翻译：由逆转录病毒介导的分泌产生的融合蛋白
公开(公告)号：US5378806A
公开(公告)日：1995-01-03
申请号：US881585
申请日：1992-05-12
申请人： John W. Willis
发明人： John W. Willis
IPC分类号： C07K14/15 , C12N15/62 , C12N15/867 , C07K13/00
CPC分类号： C12N15/86 , C07K14/005 , C12N15/62 , C07K2319/00 , C07K2319/033 , C07K2319/40 , C07K2319/735 , C12N2740/13022 , C12N2740/13043
摘要： The present invention is directed to replicable expression vectors for producing fusion proteins which are secreted in membraneous particles budded from the cell membrane. In particular these vectors express a hybrid gene product composed of a modified retrovirus gag gene fused to a heterologous gene, or any part thereof, wherein the gag gene modification is sufficient to enable a cell to produce the hybrid gene product in a membraneous particle by budding from the cell membrane into the culture medium or extracellular space, a process known as retrovirus-mediated secretion. The minimum gag sequences needed to obtain particle formation are described. The invention also provides hosts containing the expression vectors, and the fusion proteins produced by the vectors. Further the invention provides the membraneous particles produced by retrovirus-mediated secretion and uses of these particles for protein purification and in therapeutics.
摘要翻译：本发明涉及用于产生分泌于从细胞膜发芽的膜状颗粒中的融合蛋白的可复制的表达载体。特别地，这些载体表达由与异源基因或其任何部分融合的修饰的逆转录病毒gag基因组成的杂合基因产物，其中所述gag基因修饰足以使细胞能够通过出芽在膜状颗粒中产生杂交基因产物从细胞膜进入培养基或细胞外空间，称为逆转录病毒介导的分泌过程。描述了获得颗粒形成所需的最小gag序列。本发明还提供含有表达载体的宿主和载体产生的融合蛋白。此外，本发明提供了由逆转录病毒介导的分泌产生的膜状颗粒和这些颗粒用于蛋白质纯化和治疗的用途。

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