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21. 发明申请

US20060135535A1 Phosphodiesterase 4 inhibitors 失效
标题翻译：磷酸二酯酶4抑制剂
公开(公告)号：US20060135535A1
公开(公告)日：2006-06-22
申请号：US11253812
申请日：2005-10-20
申请人： Allen Hopper , Robert Dunn , Erik Kuester , Richard Conticello , Ruiping Liu , Ashok Tehim
发明人： Allen Hopper , Robert Dunn , Erik Kuester , Richard Conticello , Ruiping Liu , Ashok Tehim
IPC分类号： A61K31/497 , A61K31/433 , A61K31/4245
CPC分类号： C07D207/26 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D407/14 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
摘要： Selective PDE4 inhibition is achieved by novel compounds, e.g., 4-(substituted-phenyl)-2-pyrrolidinone compounds. The compounds of the present invention are of formula I: wherein R1, R2, and R3 are as defined herein. The disclosure also relates to methods of preparing such compounds, compositions containing such compounds, and methods of use thereof.
摘要翻译：选择性PDE4的抑制是通过新的化合物，例如4-（取代的 - 苯基）-2-吡咯烷酮化合物实现的。本发明的化合物具有式I：其中R 1，R 2和R 3如本文所定义。本公开还涉及制备这种化合物的方法，含有这些化合物的组合物及其使用方法。

22. 发明申请

US20050026913A1 Phosphodiesterase 4 inhibitors 失效
标题翻译：磷酸二酯酶4抑制剂
公开(公告)号：US20050026913A1
公开(公告)日：2005-02-03
申请号：US10825610
申请日：2004-04-16
申请人： Ashok Tehim , Allen Hopper , Ruiping Liu , Erik Kuester , Robert Dunn , Thomas Renau
发明人： Ashok Tehim , Allen Hopper , Ruiping Liu , Erik Kuester , Robert Dunn , Thomas Renau
IPC分类号： A61P25/16 , A61P25/18 , A61P25/28 , C07D207/26 , C07D405/12 , C07D417/14 , C07D417/02 , C07D413/02 , C07
CPC分类号： C07D207/26 , C07D405/12 , C07D417/14
摘要： Selective PDE4 inhibition is achieved by 4-(substituted-phenyl)-2-pyrrolidinone compounds. The compounds exhibit improved PDE4 inhibition as compared to compounds like rolipram and show selectivity with regard to inhibition of other classes of PDEs. The compounds of the present invention are of formula I: wherein R1, R2, and R3 are as defined herein.
摘要翻译：选择性PDE4抑制由4-（取代的 - 苯基）-2-吡咯烷酮化合物实现。与化合物如咯利普兰相比，化合物表现出改善的PDE4抑制，并且显示关于抑制其它类别的PDE的选择性。本发明的化合物具有式I：其中R 1，R 2和R 3如本文所定义。

23. 发明申请

US20080269260A1 PHOSPHODIESTERASE 4 INHIBITORS 审中-公开
公开(公告)号：US20080269260A1
公开(公告)日：2008-10-30
申请号：US12031135
申请日：2008-02-14
申请人： Allen T. Hopper , Ruiping Liu
发明人： Allen T. Hopper , Ruiping Liu
IPC分类号： A61K31/52 , A61P25/18
CPC分类号： C07D473/00 , C07D473/34 , C07D473/40
摘要： PDE4 inhibition is achieved by novel compounds of the Formula I: wherein R1 and R2 are as defined herein.

24. 发明授权

US09460450B2 Method and apparatus for providing application list 有权
公开(公告)号：US09460450B2
公开(公告)日：2016-10-04
申请号：US13640262
申请日：2010-08-17
申请人： Ruiping Liu , Yan Luo , Xin Huang , Juan Huang , Xiaofei Zuo , Xianming Cui , Xiongwei Li
发明人： Ruiping Liu , Yan Luo , Xin Huang , Juan Huang , Xiaofei Zuo , Xianming Cui , Xiongwei Li
IPC分类号： G06Q30/00 , G06Q30/02 , G06F9/445
CPC分类号： G06Q30/0246 , G06F8/61
摘要： The present disclosure provides a method for providing an application list. The method includes: a mobile terminal records and processes information on a user's usage of third party applications to obtain history data about the third party applications, matches the history data about the third party applications with application information in a database of an application store, forms a third party application selection list from the matched result, and pushes the content of the third party application selection list to a display interface of the application store on the mobile terminal. An apparatus for providing an application list is also provided. The method and the apparatus can push different third party application selection lists to different users, display the third party applications in which users may be interested to indirectly realize user's customization, enable a user to rapidly choose and purchase the third party applications the user like, improve the purchasing and using ratio of various applications in the application store, and ensure Average Revenue Per User (ARPU) of an operator.

25. 发明申请

US20100181258A1 THE FERRIC AND MANGANESE BINARY OXIDE BASED ADSORBENT, AND THE METHODS FOR THE PREPARATION AND APPLICAITON OF THE ADSORBENT 有权
标题翻译：基于二氧化锰和二氧化锰的吸附剂，以及吸附剂的制备和应用方法
公开(公告)号：US20100181258A1
公开(公告)日：2010-07-22
申请号：US12668971
申请日：2007-07-13
申请人： Jiuhui Qu , Huijuan Liu , Pengju Lei , Gaosheng Zhang , Ruiping Liu , Fangfang Chang
发明人： Jiuhui Qu , Huijuan Liu , Pengju Lei , Gaosheng Zhang , Ruiping Liu , Fangfang Chang
IPC分类号： C02F1/42 , B01J20/06 , B01F5/04
CPC分类号： C02F1/281 , B01J20/0222 , B01J20/0229 , B01J20/06 , B01J20/14 , B01J20/3204 , B01J20/3236 , B01J2220/42 , C02F2101/103 , Y10S502/526
摘要： The present invention relates to a ferric and manganese binary oxide (FMBO) based adsorbent, its preparation and application method. The FMBO based adsorbent comprises a ferric and manganese binary oxide (FMBO) and a carrier. The mass ratio of FMBO to the carrier is between 0.2:100 and 15:100. The FMBO based adsorbent effectively removes the arsenic in groundwater, particularly the arsenite. The present invention also provides the equipment for preparation and application of the adsorbent.
摘要翻译：本发明涉及一种基于三元和锰二元氧化物（FMBO）的吸附剂，其制备和应用方法。基于FMBO的吸附剂包括铁和锰二元氧化物（FMBO）和载体。 FMBO与载体的质量比在0.2:100到15:100之间。基于FMBO的吸附剂有效地去除了地下水中的砷，特别是亚砷酸盐。本发明还提供了用于制备和应用吸附剂的设备。

26. 发明申请

US20090054434A1 ISOQUINOLONE DERIVATIVES AS PHOSPHODIESTERASE 10 INHIBITORS 审中-公开
标题翻译： ISOQUINOLONE衍生物作为磷酸二酯酶10抑制剂
公开(公告)号：US20090054434A1
公开(公告)日：2009-02-26
申请号：US12197177
申请日：2008-08-22
申请人： Essa Hu , Roxanne Kunz , Ning Chen , Ruiping Liu
发明人： Essa Hu , Roxanne Kunz , Ning Chen , Ruiping Liu
IPC分类号： A61K31/4725 , C07D413/14 , C07D401/04 , C07D401/14 , A61K31/496 , C07D417/02 , A61P3/00 , A61K31/5377
CPC分类号： C07D401/04 , C07D401/14 , C07D403/04
摘要： The present invention is directed to certain isoquinolin-1(2H)-one compounds, useful as PDE10 inhibitors, having the formula: where R1, R2, R3, R4 and R5 are as defined herein, pharmaceutical compositions containing such compounds and processes for preparing such compounds. The invention is also directed to methods of treating diseases mediated by PDE10, such as obesity, non-insulin dependent diabetes, schizophrenia, bipolar disorder, obsessive-compulsive disorder, and the like.
摘要翻译：本发明涉及可用作PDE10抑制剂的某些异喹啉-1（2H） - 酮化合物，其具有下式：其中R1，R2，R3，R4和R5如本文所定义，含有这些化合物的药物组合物和制备方法这样的化合物。本发明还涉及治疗PDE10介导的疾病的方法，例如肥胖症，非胰岛素依赖性糖尿病，精神分裂症，双相障碍，强迫症等。

27. 发明申请

US20070265270A1 Cinnoline derivatives as phosphodiesterase 10 inhibitors 审中-公开
标题翻译：噌啉衍生物作为磷酸二酯酶10抑制剂
公开(公告)号：US20070265270A1
公开(公告)日：2007-11-15
申请号：US11708868
申请日：2007-02-20
申请人： Stephen Hitchcock , Ruiping Liu , Mark Arrington , Allen Hopper , Richard Conticello , Truc Nguyen , M. Danca , Carla Gauss
发明人： Stephen Hitchcock , Ruiping Liu , Mark Arrington , Allen Hopper , Richard Conticello , Truc Nguyen , M. Danca , Carla Gauss
IPC分类号： A61K31/502 , A61K31/5375 , A61P25/00 , A61P25/18 , A61P3/00 , C07D237/28 , C07D295/00
CPC分类号： C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/04 , C07D405/14 , C07D409/14 , C07D413/04 , C07D413/14
摘要： The present invention is directed to certain cinnoline compounds that are PDE10 inhibitors, pharmaceutical compositions containing such compounds and process for preparing such compounds. The invention is also directed to methods of treating diseases treatable by modulation of PDE10 enzyme, such as obesity, non-insulin dependent diabetes, schizophrenia, bipolar disorder, obsessive-compulsive disorder, and the like.
摘要翻译：本发明涉及某些作为PDE10抑制剂的噌啉化合物，含有这些化合物的药物组合物及其制备方法。本发明还涉及治疗通过调节PDE10酶可治疗的疾病的方法，例如肥胖症，非胰岛素依赖型糖尿病，精神分裂症，双相情感障碍，强迫症等。

28. 发明申请

US20070265256A1 Phosphodiesterase 10 inhibitors 审中-公开
标题翻译：磷酸二酯酶10抑制剂
公开(公告)号：US20070265256A1
公开(公告)日：2007-11-15
申请号：US11708866
申请日：2007-02-20
申请人： Mark Arrington , Ruiping Liu , Allen Hopper , Richard Conticello , Truc Nguyen , Carla Gauss , Roland Burli , Stephen Hitchcock , Essa Hu , Roxanne Kunz , Thomas Nixey , Shannon Rumfelt , Nign Chen
发明人： Mark Arrington , Ruiping Liu , Allen Hopper , Richard Conticello , Truc Nguyen , Carla Gauss , Roland Burli , Stephen Hitchcock , Essa Hu , Roxanne Kunz , Thomas Nixey , Shannon Rumfelt , Nign Chen
IPC分类号： A61K31/535 , A61K31/50 , A61P25/18 , C07D237/26 , C07D413/00
CPC分类号： C07D237/28 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/10 , C07D405/10 , C07D405/14 , C07D409/10 , C07D409/14 , C07D413/04 , C07D413/10 , C07D413/14 , C07D417/04 , C07D417/10 , C07D417/14 , C07D471/04 , C07D487/04 , C07D513/04
摘要： The present invention is directed to certain cinnoline compounds that are PDE10 inhibitors, pharmaceutical compositions containing such compounds and process for preparing such compounds. This invention is also directed to methods of treating diseases treatable by inhibition of PDE10 enzyme, such as obesity, non-insulin dependent diabetes, schizophrenia, bipolar disorder, obsessive-compulsive disorder, and the like.
摘要翻译：本发明涉及某些作为PDE10抑制剂的噌啉化合物，含有这些化合物的药物组合物及其制备方法。本发明还涉及通过抑制PDE10酶如肥胖症，非胰岛素依赖型糖尿病，精神分裂症，双相情感障碍，强迫症等治疗疾病的方法。

29. 发明授权

US06545033B1 Fused 1-(2,6-dichloro-4-trifluoromethylphenyl)-pyrazoles, the synthesis thereof and the use thereof as pesticides 有权
标题翻译：熔融的1-（2,6-二氯-4-三氟甲基苯基） - 吡唑，其合成及其作为农药的用途
公开(公告)号：US06545033B1
公开(公告)日：2003-04-08
申请号：US09680275
申请日：2000-10-06
申请人： Daljit S. Dhanoa , Sanath Meegalla , Richard M. Soll , Dario Doller , Deyou Sha , Ruiping Liu , Gary Silver , Yu-Kai Lee
发明人： Daljit S. Dhanoa , Sanath Meegalla , Richard M. Soll , Dario Doller , Deyou Sha , Ruiping Liu , Gary Silver , Yu-Kai Lee
IPC分类号： A61K31416
CPC分类号： C07D495/10 , A01N43/56 , A01N43/90 , C07D231/54 , C07D231/56 , C07D491/04 , C07D491/10 , C07D495/04 , C07D513/04
摘要： The present invention is directed to novel pyrazole derivatives and their use as pesticidal agents. The pyrazole derivatives have Formula I: or a salt thereof, where R1 is amino, hydrogen, alkyl, hydroxy, halo, alkoxy, alkylamino, dialkylamino, alkylthio, alkylsulfinyl, alkylsulfonyl, trifluoroalkylsulfinyl, trifluoroalkylsulfonyl, hydroxy, amino, trifluoromethyl, acetylamino, —OSO2R2, —OS(O)R2, —OC(O)R2, —OC(O)NHR2, or —NHC(O)NHR2 where R2 is C1-4 alkyl or optionally substituted aryl; X, Y and Z are each independently (CH)n, (CR3R4)n, S, S(O), or SO2, wherein n is 1-2, R3 and R4 are defined herein; Q is N or C—R6, wherein R6 is fluoro, chloro, bromo, or iodo; R5 is halo, C1-C6 alkyl, C1-C4 alkenyl, C1-C4 alkoxy, C1-C4 alkylamino, C1-C4 dialkylamino, C1-C4 alkylthio, C1-C4 alkylsulfinyl, C1-C4 alkylsulfonyl, C1-C4 trifluoroalkylsulfinyl, C1-C4 trifluoroalkylsulfonyl, hydroxy, amino, or trifluoromethyl; and with the proviso that only one of X, Y and Z can be S, S(O) or SO2.
摘要翻译：本发明涉及新颖的吡唑衍生物及其作为杀虫剂的用途。吡唑衍生物具有式I或其盐，其中R 1是氨基，氢，烷基，羟基，卤素，烷氧基，烷基氨基，二烷基氨基，烷硫基，烷基亚磺酰基，烷基磺酰基，三氟烷基亚磺酰基，三氟烷基磺酰基，羟基，氨基，三氟甲基，乙酰氨基，，-OS（O）R 2，-OC（O）R 2，-OC（O）NHR 2或-NHC（O）NHR 2，其中R 2为C 1-4烷基或任选取代的芳基; X，Y和Z各自独立地为 CH）n，（CR 3 R 4）n，S，S（O）或SO 2，其中n为1-2，R 3和R 4如本文所定义; Q为N或C-R6，其中R6为氟，氯，溴，或碘; R5是卤素，C1-C6烷基，C1-C4链烯基，C1-C4烷氧基，C1-C4烷基氨基，C1-C4二烷基氨基，C1-C4烷硫基，C1-C4烷基亚磺酰基，C1-C4烷基磺酰基，C1-C4 三氟烷基亚磺酰基，C 1 -C 4三氟烷基磺酰基，羟基，氨基或三氟甲基; 并且条件是X，Y和Z中只有一个可以是S，S（O）或SO 2。

30. 发明申请

US20130030954A1 Method and apparatus for providing application list 有权
标题翻译：提供应用程序列表的方法和装置
公开(公告)号：US20130030954A1
公开(公告)日：2013-01-31
申请号：US13640262
申请日：2010-08-17
申请人： Ruiping Liu , Yan Luo , Xin Huang , Juan Huang , Xiaofei Zuo , Xianming Cui , Xiongwei Li
发明人： Ruiping Liu , Yan Luo , Xin Huang , Juan Huang , Xiaofei Zuo , Xianming Cui , Xiongwei Li
IPC分类号： G06Q30/00
CPC分类号： G06Q30/0246 , G06F8/61
摘要： The present disclosure provides a method for providing an application list. The method includes: a mobile terminal records and processes information on a user's usage of third party applications to obtain history data about the third party applications, matches the history data about the third party applications with application information in a database of an application store, forms a third party application selection list from the matched result, and pushes the content of the third party application selection list to a display interface of the application store on the mobile terminal. An apparatus for providing an application list is also provided. The method and the apparatus can push different third party application selection lists to different users, display the third party applications in which users may be interested to indirectly realize user's customization, enable a user to rapidly choose and purchase the third party applications the user like, improve the purchasing and using ratio of various applications in the application store, and ensure Average Revenue Per User (ARPU) of an operator.
摘要翻译：本公开提供了一种用于提供应用列表的方法。该方法包括：移动终端记录和处理关于用户对第三方应用的使用的信息以获得关于第三方应用的历史数据，将关于第三方应用的历史数据与应用商店的数据库中的应用信息相匹配，形式来自匹配结果的第三方应用选择列表，并将第三方应用选择列表的内容推送到移动终端上的应用商店的显示界面。还提供了一种用于提供应用列表的设备。该方法和装置可以将不同的第三方应用选择列表推送到不同的用户，显示用户可能感兴趣的第三方应用来间接地实现用户的定制，使用户能够快速地选择和购买用户喜欢的第三方应用，提高应用商店各种应用的采购和使用比例，确保运营商的平均每用户收入（ARPU）。

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