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21. 发明授权

US06423790B1 Biodegradable poly(propylene fumarate) networks cross linked with poly(propylene fumarate)-diacrylate macromers 失效
标题翻译：与聚（丙烯酸富马酸酯） - 二丙烯酸酯大分子单体交联的可生物降解的聚（丙烯富马酸）网络
公开(公告)号：US06423790B1
公开(公告)日：2002-07-23
申请号：US09549485
申请日：2000-04-14
申请人： Shulin He , Michael J. Yaszemski , Antonios G. Mikos
发明人： Shulin He , Michael J. Yaszemski , Antonios G. Mikos
IPC分类号： C08L6706
CPC分类号： C08L67/06 , A61L27/18 , A61L27/50 , A61L27/58 , C08G63/676 , C08G63/918 , C08G81/025 , C08L67/07 , Y10S530/812 , Y10S530/815 , C08L67/00 , C08L71/02
摘要： A network consisting essentially of poly(propylene fumarate) cross linked with diacrylate and a method for making same.
摘要翻译：基本上由二丙烯酸酯交联的聚（丙烯富马酸酯）组成的网络及其制备方法。

22. 发明授权

US06384105B1 Poly(Propylene Fumarate) cross linked with Poly(Ethylene Glycol) 失效
公开(公告)号：US06384105B1
公开(公告)日：2002-05-07
申请号：US09550372
申请日：2000-04-14
申请人： Shulin He , Michael J. Yaszemski , Antonios G. Mikos
发明人： Shulin He , Michael J. Yaszemski , Antonios G. Mikos
IPC分类号： C08F828
CPC分类号： C08L67/06 , A61L27/18 , A61L27/50 , A61L27/58 , C08G63/676 , C08G63/918 , C08G81/025 , C08L67/07 , Y10S530/812 , Y10S530/815 , C08L67/00 , C08L71/02
摘要： New injectable, in situ crosslinkable biodegradable polymer composites comprise poly(propylene fumarate) (PPF), poly(ethylene glycol)-dimethacrylate (PEG-DMA), an, optionally, &bgr;-tricalcium phosphate (&bgr;-TCP). A method for controlling the crosslinking characteristics of the composites, including the maximum crosslinking temperature and the gel point, as well as the properties of the cross linked composites such as the compressive strength and modulus and the water holding capacity, is disclosed.

23. 发明授权

US06355755B1 Synthesis of poly(propylene fumarate) by acylation of propylene glycol in the presence of a proton scavenger 有权
标题翻译：在质子清除剂存在下，通过丙二醇酰化合成聚（丙烯酸富马酸酯）
公开(公告)号：US06355755B1
公开(公告)日：2002-03-12
申请号：US09678816
申请日：2000-10-04
申请人： Susan J. Peter , Laura J. Suggs , Paul S. Engel , Antonios G. Mikos
发明人： Susan J. Peter , Laura J. Suggs , Paul S. Engel , Antonios G. Mikos
IPC分类号： C08F11800
CPC分类号： C08G63/56 , A61L24/0084 , A61L24/046 , A61L27/18 , C08G63/52 , C08L67/06 , A61L27/58 , A61L27/56 , A61L27/54 , A61L24/0042 , A61L24/0036 , A61L24/0015
摘要： High molecular weight linear poly(propylene fumarate) having a relatively low polydispersity index by utilizing a relatively pure intermediate and a method for making same. Fumaryl chloride and propylene glycol are reacted in the presence of potassium carbonate. The potassium carbonate present in the reaction solution prevents the acid by-product from catalyzing reactions at the fumarate double bond. The bis(propyl fumarate) produced according to this technique can be transesterified using conventional processing steps to yield P(PF). The P(PF) produced from bis(propyl fumarate) produced according to the present method has a higher molecular weight and is purer than P(PF) produced using previously known techniques.
摘要翻译：通过利用相对纯的中间体具有相对低的多分散性指数的高分子量线性聚（富马酸丙烯酯）及其制备方法。芳基氯和丙二醇在碳酸钾存在下反应。存在于反应溶液中的碳酸钾防止酸副产物催化富马酸酯双键上的反应。根据该技术生产的双（丙基富马酸酯）可以使用常规的加工步骤进行酯交换，得到P（PF）。由本方法生产的双（丙基富马酸盐）产生的P（PF）具有较高的分子量，并且比使用先前已知技术产生的P（PF）更纯。

24. 发明授权

US06306821B1 Functionalized poly(propylene fumarate) and poly(propylene fumarate-co-ethylene glycol) 有权
标题翻译：官能化聚（富马酸丙烯酯）和聚（丙烯富马酸酯 - 共 - 乙二醇）
公开(公告)号：US06306821B1
公开(公告)日：2001-10-23
申请号：US09549483
申请日：2000-04-14
申请人： Antonios G. Mikos , Seongbong Jo
发明人： Antonios G. Mikos , Seongbong Jo
IPC分类号： A23L128
CPC分类号： C08L67/06 , A61L27/18 , A61L27/50 , A61L27/58 , C08G63/676 , C08G63/918 , C08G81/025 , C08L67/07 , Y10S530/812 , Y10S530/815 , C08L67/00 , C08L71/02
摘要： Poly(ethylene glycol) (PEG), a highly biocompatible hydrophilic polyether, is tethered to poly(propylene fumarate) (PPF), a biodegradable polyester. To avoid change in molecular weight distribution of PPF, end hydroxyl groups of PPF are reacted with bis-carboxymethyl PEG after being treated with thionyl chloride. New end carboxyl groups of the PEG-tethered PPF are further reacted with N-hydroxysuccinimide (NHS) in the presence of dicyclohexylcarbodiimide (DCC) to couple bioactive molecules. Glutamine and glycine-arginine-glycine-aspartic acid (GRGD) are attached to the PEG-tethered PPF in 50 mM phosphate buffer of pH of 7.4. The method is valuable for the preparation of a triblock copolymer with PEG end blocks and the coupling of biologically active molecules.
摘要翻译：聚（乙二醇）（PEG），一种高度生物相容的亲水性聚醚，连接于聚（丙烯富马酸酯）（PPF），一种可生物降解的聚酯。为了避免PPF的分子量分布发生变化，用亚硫酰氯处理后，PPF的末端羟基与双 - 羧甲基PEG反应。在二环己基碳二亚胺（DCC）存在下，PEG-束缚PPF的新端羧基进一步与N-羟基琥珀酰亚胺（NHS）反应以偶联生物活性分子。谷氨酰胺和甘氨酸 - 精氨酸 - 甘氨酸 - 天冬氨酸（GRGD）在pH 7.4的50mM磷酸盐缓冲液中连接到PEG-束缚的PPF上。该方法对于制备具有PEG端嵌段和生物活性分子偶联的三嵌段共聚物是有价值的。

25. 发明授权

US09688023B2 Continuous digital light processing additive manufacturing of implants 有权
公开(公告)号：US09688023B2
公开(公告)日：2017-06-27
申请号：US13817612
申请日：2011-08-22
申请人： H. David Dean , Jonathan E. Wallace , Antonios G. Mikos , Martha Wang , Ali Siblani , Kyobum Kim , John P. Fisher
发明人： H. David Dean , Jonathan E. Wallace , Antonios G. Mikos , Martha Wang , Ali Siblani , Kyobum Kim , John P. Fisher
IPC分类号： B29C67/00 , A61L27/50 , A61L27/56 , G02B26/08 , A61L27/60
CPC分类号： B29C67/0066 , A61L27/50 , A61L27/56 , A61L27/60 , B29C64/135 , B33Y30/00 , B33Y50/00 , B33Y80/00 , G02B26/0833
摘要： A process for additive manufacturing of a resorbable implant to be implanted into a patient includes providing a biocompatible resin including a liquid light-polymerizable material that is resorbable after polymerization and an initiator. The process further includes actuating an additive manufacturing apparatus to expose an amount of the biocompatible resin to light to at least partially cure the exposed amount of biocompatible resin to form a layer of the resorbable implant and actuating the additive manufacturing apparatus to expose at least some additional amount of biocompatible resin to light to at least partially cure the exposed additional amount of biocompatible resin to form an additional layer of the resorbable implant and to at least partially overcure previously cured layers to cause at least some interlayer binding between the previously cured layers and the additional layer.

26. 发明申请

US20100075420A1 Novel Gene Delivery Vectors for Human Mesenchymal Stem Cells 审中-公开
标题翻译：用于人间充质干细胞的新型基因递送载体
公开(公告)号：US20100075420A1
公开(公告)日：2010-03-25
申请号：US12563181
申请日：2009-09-21
申请人： Anita Saraf , Michael C. Hacker , Antonios G. Mikos
发明人： Anita Saraf , Michael C. Hacker , Antonios G. Mikos
IPC分类号： C12N15/00 , C08L5/00 , C12N15/63 , C12N5/00
CPC分类号： C12N15/87 , A61K47/59 , A61K47/61 , A61K2039/55505 , C08B37/0072 , C08L5/08
摘要： Novel gene delivery vector compositions that interact with human mesenchymal stem cells are provided, as well as methods of synthesizing and using such compositions. Such compositions may comprise a plurality of hyaluronic acid hexamers covalently attached to a branched polyethylenimine. Such methods of synthesis may comprise providing a plurality of hyaluronic acid hexamers and a branched polyethylenimine, and allowing a hexamer of hyaluronic acid to covalently attach to a branched polyethylenimine to form a conjugate. Such methods of use may comprise providing a conjugate comprising a plurality of hyaluronic acid hexamers covalently attached to a branched polyethylenimine, and administering the conjugate to a cell.
摘要翻译：提供了与人间充质干细胞相互作用的新型基因递送载体组合物，以及合成和使用这些组合物的方法。这样的组合物可以包含共价连接到支化聚乙烯亚胺的多个透明质酸六聚体。这种合成方法可以包括提供多个透明质酸六聚体和支链聚乙烯亚胺，并且使透明质酸的六聚体共价连接到支化聚乙烯亚胺以形成缀合物。这种使用方法可以包括提供共轭物，其包含共价连接到支化聚乙烯亚胺的多个透明质酸六聚体，并将该缀合物施用于细胞。

27. 发明授权

US07629388B2 Synthesis and characterization of biodegradable cationic poly(propylene fumarate-co-ethylene glycol) copolymer hydrogels modified with agmatine for enhanced cell adhesion 有权
标题翻译：用丁胺改性的可生物降解阳离子聚（丙烯富马酸酯 - 共 - 乙二醇）共聚物水凝胶的合成和表征，增强细胞粘附
公开(公告)号：US07629388B2
公开(公告)日：2009-12-08
申请号：US10300202
申请日：2002-11-20
申请人： Antonios G. Mikos , Kazuhiro Tanahashi
发明人： Antonios G. Mikos , Kazuhiro Tanahashi
IPC分类号： A67K47/00 , A01N25/00
CPC分类号： A61K47/60
摘要： A cross-linkable monomer comprises a fumaric acid functional group having a first end and a second end, a first spacer group affixed to said first end and comprising at least repeating unit, a first terminal group affixed to said first spacer group, a second spacer group affixed to said second end and comprising at least one ethylene glycol repeating unit, and a second terminal group affixed to said second spacer group. A hydrogel formed by cross-linking the present monomer and a method for making the monomer. A method for forming a hydrogel, comprises the steps of a) synthesizing a copolymer of poly(propylene fumarate) (PPF) and poly(ethylene glycol (PEG) so as to produce P(PF-co-EG), b) synthesizing a PEG-tethered fumarate (PEGF), c) coupling agmatine sulfate to the PEGF to produce PEGF modified with agmatine (Agm-PEGF), and d) cross-linking the P(PF-co-EG) from step a) with Agm-PEGF from step c).
摘要翻译：可交联单体包括具有第一末端和第二末端的富马酸官能团，第一间隔基团固定在所述第一末端并且包含至少重复单元，固定到所述第一间隔基团的第一末端基团，第二间隔基团固定在所述第二端并且包含至少一个乙二醇重复单元的基团和固定到所述第二间隔基团上的第二末端基团。通过交联本发明单体形成的水凝胶和制备该单体的方法。一种形成水凝胶的方法，包括以下步骤：a）合成聚（丙烯酸富马酸酯）（PPF）和聚（乙二醇（PEG））以产生P（PF-co-EG）的共聚物，b） PEG连接的富马酸酯（PEGF），c）将硫酸胍加到PEGF上以产生用胍丁胺（Agm-PEGF）修饰的PEGF，和d）将来自步骤a）的P（PF-co-EG）与Agm- 来自步骤c）的PEGF。

28. 发明授权

US06884778B2 Biocompatible macromers 有权
标题翻译：生物相容的大分子单体
公开(公告)号：US06884778B2
公开(公告)日：2005-04-26
申请号：US09845570
申请日：2001-04-30
申请人： Seongbong Jo , Antonios G. Mikos
发明人： Seongbong Jo , Antonios G. Mikos
IPC分类号： A61K47/48 , A61L27/18 , C08G63/676 , C08G63/91 , C08G65/329 , C08G65/332 , C08G81/02 , A61K38/16 , A61K9/70
CPC分类号： C08G65/3322 , A61K47/60 , A61L27/18 , C08G63/676 , C08G63/918 , C08G65/329 , C08G81/025 , C08L67/00
摘要： A new oligomer based on alternating fumaric acid and poly(ethylene glycol) (PEG) units is provided. The oligo(PEG fumarate) (OPF) may be functionalized by modification with a biocompatible organic group. Further, the OPF may be cross-linked using radical polymerization in the presence of either a chemical or photo initiator. A cross-linked OPF gel has a swelling behavior that is tunable dependent on the molecular weight of PEG. A cross-linkable PEG macromer, as exemplified by oligo(PEG fumarate), has unsaturated double bonds, for example in the fumaryl groups, along its macromolecular chain that allows for the preparation of hydrogels with tailored structure and properties.
摘要翻译：提供了基于交替富马酸和聚（乙二醇）（PEG）单元的新的低聚物。寡聚（富马酸戊二醇酯）（OPF）可通过用生物相容性有机基团进行改性来官能化。此外，OPF可以在化学或光引发剂的存在下使用自由基聚合进行交联。交联的OPF凝胶具有取决于PEG的分子量的可调谐的溶胀行为。可交联的PEG大分子单体如寡聚（富马酸PEG）所示，具有不饱和双键，例如在富马酰基中沿其大分子链，其允许用定制的结构和性质制备水凝胶。

29. 发明授权

US6124373A Bone replacement compound comprising poly(polypropylene fumarate) 有权
标题翻译：包含聚（聚丙烯富马酸酯）的骨替代化合物
公开(公告)号：US6124373A
公开(公告)日：2000-09-26
申请号：US289361
申请日：1999-04-09
申请人： Susan J. Peter , Michael J. Yaszemski , Antonios G. Mikos
发明人： Susan J. Peter , Michael J. Yaszemski , Antonios G. Mikos
IPC分类号： A61L27/00 , A61L24/00 , A61L24/04 , A61L27/18 , C08G63/52 , C08G63/56 , C08G63/78 , C08K3/32 , C08L67/06
CPC分类号： C08G63/56 , A61L24/0084 , A61L24/046 , A61L27/18 , C08G63/52
摘要： A method for controlling the gel point of a bone cement containing poly(polypropylene fumarate), a cross-linking monomer, an initiator, an inorganic filler, and a radical initiator. The gel point is controlled by varying the molecular weight of the poly(polypropylene fumarate) while maintaining the weight average molecular weight (M.sub.w) of the poly(polypropylene fumarate) above 2000 and the polydispersity index of the poly(polypropylene fumarate) below 2. In a preferred embodiment, the molecular weight of the poly(polypropylene fumarate) greater than 4000, and more preferably greater than 5000.
摘要翻译：一种控制含有聚（聚丙烯富马酸盐），交联单体，引发剂，无机填料和自由基引发剂的骨水泥凝胶点的方法。凝胶点通过改变聚（聚丙烯富马酸酯）的分子量来控制，同时保持聚（聚丙烯富马酸酯）的重均分子量（Mw）大于2000，聚（聚丙烯·富马酸酯）的多分散指数低于2。在优选的实施方案中，聚（聚丙烯富马酸盐）的分子量大于4000，更优选大于5000。

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