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21. 发明申请

US20130316125A1 CORE LAYER COMPRISING ZIGZAG-SHAPED WOOD ELEMENTS AND MULTILAYER COMPOSITE COMPRISING THE CORE LAYER 审中-公开
标题翻译：包含ZIGZAG型木材元件的核心层和包含核心层的多层复合材料
公开(公告)号：US20130316125A1
公开(公告)日：2013-11-28
申请号：US13886444
申请日：2013-05-03
申请人： Achim Moeller , Thomas Eckstein , Johannes Graesser
发明人： Achim Moeller , Thomas Eckstein , Johannes Graesser
IPC分类号： E04C2/32
CPC分类号： E04C2/322 , E04C2/12 , E04C2/3405 , E04C2002/345 , E04C2002/3472 , Y10T156/10 , Y10T428/24066 , Y10T428/24719
摘要： A core layer, a multilayer composite, and methods of making and using the same are provided. The core layer includes wooden zigzag-shaped elements and is suitable for producing a multilayer composite, or for use in a multilayer composite. The multilayer composite includes at least one cover layer and a core layer, and the cover layer is arranged such that it at least partially covers the core layer and is fixedly connected to the core layer.
摘要翻译：提供核心层，多层复合材料及其制造和使用方法。芯层包括木状锯齿形元件，适用于生产多层复合材料，或用于多层复合材料。多层复合材料包括至少一个覆盖层和芯层，并且覆盖层被布置成使得其至少部分地覆盖芯层并且固定地连接到芯层。

22. 发明申请

US20100209346A1 AMYLOID BETA(1-42) OLIGOMERS, DERIVATIVES THEREOF AND ANTIBODIES THERETO, METHODS OF PREPARATION THEREOF AND USE THEREOF 审中-公开
标题翻译： AMYLOID BETA（1-42）低聚物，其衍生物及其抗体，其制备方法及其用途
公开(公告)号：US20100209346A1
公开(公告)日：2010-08-19
申请号：US12559255
申请日：2009-09-14
申请人： Heinz Hillen , Andreas Striebinger , Carsten Krantz , Achim Moeller , Reinhold Mueller
发明人： Heinz Hillen , Andreas Striebinger , Carsten Krantz , Achim Moeller , Reinhold Mueller
IPC分类号： A61K49/00 , C07K14/435 , G01N33/68 , G01N33/53 , C12P21/00 , C07K16/00 , C07K14/00 , A61K38/16 , A61K39/00 , A61P25/28
CPC分类号： C07K14/4711 , A61K38/1709 , A61K39/0007 , A61K2039/57 , C07K16/005 , C07K16/18 , C07K2317/76 , C07K2317/92 , C07K2319/30 , G01N33/6896 , G01N2333/4709
摘要： The invention relates to neuromodulatory oligomers of the amyloid β(1-42) protein, a particular production method, by means of which the oligomer can be obtained in a reproducible manner at high yield, the use of the oligomers and diagnostic and therapeutic agents, for the generation of oligomer-specific antibodies and for the discovery of substances which can interact with the oligomers and in the formation thereof.
摘要翻译：本发明涉及淀粉样蛋白（1-42）蛋白的神经调节性低聚物，一种特定的制备方法，通过该方法可以以高产率以可重复的方式获得寡聚体，使用寡聚物和诊断和治疗剂，用于产生寡聚体特异性抗体以及用于发现可与低聚物相互作用并在其形成中的物质。

23. 发明授权

US09176150B2 Amyloid beta(1-42) oligomers, derivatives thereof and antibodies thereto, methods of preparation thereof and use thereof 有权
标题翻译：淀粉样蛋白β（1-42）寡聚体，其衍生物和抗体，其制备方法和用途
公开(公告)号：US09176150B2
公开(公告)日：2015-11-03
申请号：US13195533
申请日：2011-08-01
申请人： Heinz Hillen , Andreas Striebinger , Carsten Krantz , Achim Moeller , Reinhold Mueller
发明人： Heinz Hillen , Andreas Striebinger , Carsten Krantz , Achim Moeller , Reinhold Mueller
IPC分类号： C07K16/18 , G01N33/68 , A61K38/17 , C07K14/47 , G01N33/53 , A61K39/395
CPC分类号： C07K14/4711 , A61K38/1709 , A61K39/0007 , A61K2039/57 , C07K16/005 , C07K16/18 , C07K2317/76 , C07K2317/92 , C07K2319/30 , G01N33/6896 , G01N2333/4709
摘要： The invention relates to neuromodulatory oligomers of the amyloid-β(1-42) protein, a particular production method, by means of which the oligomer can be obtained in a reproducible manner at high yield, the use of the oligomers as diagnostic and therapeutics agents, for the generation of oligomer-specific antibodies and for the discovery of substances which can interact with the oligomers and in the formation thereof. Corresponding methods for the production of the antibodies and for discovery of the substances are also disclosed as are the antibodies themselves and the use of the antibodies or substances as diagnostic and therapeutic agents. The invention further relates to derivatives of the oligomers and oligomers based on abbreviated forms of the amyloid-β(1-42) proteins, the production and use thereof.
摘要翻译：本发明涉及淀粉样蛋白（1-42）蛋白的神经调节性低聚物，一种特定的制备方法，通过该方法可以以高产率以可重复的方式获得寡聚体，使用低聚物作为诊断和治疗用于产生寡聚体特异性抗体以及用于发现可与低聚物相互作用并在其形成中的物质。还公开了生产抗体和发现物质的相应方法，抗体本身以及抗体或物质作为诊断和治疗剂的用途也是如此。本发明还涉及基于淀粉样蛋白（1-42）蛋白质的缩写形式的寡聚物和低聚物的衍生物，其生产和用途。

24. 发明申请

US20120034166A1 AMYLOID BETA(1-42) OLIGOMERS, DERIVATIVES THEREOF AND ANTIBODIES THERETO, METHODS OF PREPARATION THEREOF AND USE THEREOF 有权
标题翻译： AMYLOID BETA（1-42）低聚物，其衍生物及其抗体，其制备方法及其用途
公开(公告)号：US20120034166A1
公开(公告)日：2012-02-09
申请号：US13195533
申请日：2011-08-01
申请人： Heinz Hillen , Andreas Striebinger , Carsten Krantz , Achim Moeller , Reinhold Mueller
发明人： Heinz Hillen , Andreas Striebinger , Carsten Krantz , Achim Moeller , Reinhold Mueller
IPC分类号： A61K49/00 , A61K39/00 , C12P21/06 , C12N5/16 , G01N33/566 , C12P21/00 , C40B50/06 , C07K7/08 , C07K14/00 , C07K16/18 , C07K1/00 , C07H21/04 , A61K39/395 , C40B30/00
CPC分类号： C07K14/4711 , A61K38/1709 , A61K39/0007 , A61K2039/57 , C07K16/005 , C07K16/18 , C07K2317/76 , C07K2317/92 , C07K2319/30 , G01N33/6896 , G01N2333/4709
摘要： The invention relates to neuromodulatory oligomers of the amyloid-β(1-42) protein, a particular production method, by means of which the oligomer can be obtained in a reproducible manner at high yield, the use of the oligomers as diagnostic and therapeutics agents, for the generation of oligomer-specific antibodies and for the discovery of substances which can interact with the oligomers and in the formation thereof. Corresponding methods for the production of the antibodies and for discovery of the substances are also disclosed as are the antibodies themselves and the use of the antibodies or substances as diagnostic and therapeutic agents. The invention further relates to derivatives of the oligomers and oligomers based on abbreviated forms of the amyloid-β(1-42) proteins, the production and use thereof.
摘要翻译：本发明涉及淀粉样蛋白（1-42）蛋白的神经调节性低聚物，一种特定的制备方法，通过该方法可以以高产率以可重复的方式获得寡聚体，使用低聚物作为诊断和治疗用于产生寡聚体特异性抗体以及用于发现可与低聚物相互作用并在其形成中的物质。还公开了生产抗体和发现物质的相应方法，抗体本身以及抗体或物质作为诊断和治疗剂的用途也是如此。本发明还涉及基于淀粉样蛋白（1-42）蛋白质的缩写形式的寡聚物和低聚物的衍生物，其生产和用途。

25. 发明申请

US20080279859A1 NEUTRALIZING MONOCLONAL ANTIBODIES AGAINST THE NOGO-66 RECEPTOR (NgR) AND USES THEREOF 有权
标题翻译：去除NOGO-66受体（NgR）的单克隆抗体及其用途
公开(公告)号：US20080279859A1
公开(公告)日：2008-11-13
申请号：US11943770
申请日：2007-11-21
申请人： Mario Mezler , Achim Moeller , Reinhold Mueller , Bernhard K. Mueller , Tariq Ghayur , Eve H. Barlow , Martin Schmidt , Axel Meyer , Nicole E. Teusch
发明人： Mario Mezler , Achim Moeller , Reinhold Mueller , Bernhard K. Mueller , Tariq Ghayur , Eve H. Barlow , Martin Schmidt , Axel Meyer , Nicole E. Teusch
IPC分类号： A61K39/395 , C07K16/18 , C12N5/06 , C12N15/11 , C12N15/00 , A61P25/00 , C12N5/04 , C12N1/14 , C12P21/04
CPC分类号： C07K16/28 , A61K39/3955 , A61K2039/505 , C07H21/00 , C07K16/2863 , C07K2317/14 , C07K2317/34 , C07K2317/41 , C07K2317/56 , C07K2317/73 , C07K2317/76 , C07K2317/92 , Y02A50/466
摘要： The subject invention relates to isolated proteins, particularly monoclonal antibodies, which bind to the Nogo-66 receptor. Specifically, these antibodies have the ability to inhibit the binding of the natural ligand of the Nogo-66 receptor and neutralize the Nogo-66 receptor. These antibodies or portions thereof of the invention are useful for detecting NgR and for inhibiting NgR activity, for example in a human suffering from a disorder in which NgR or Nogo-66 activity is detrimental.
摘要翻译：本发明涉及结合Nogo-66受体的分离的蛋白质，特别是单克隆抗体。具体地说，这些抗体具有抑制Nogo-66受体的天然配体结合并中和Nogo-66受体的能力。本发明的这些抗体或其部分可用于检测NgR和抑制NgR活性，例如在患有NgR或Nogo-66活性有害的病症的人中。

26. 发明授权

US5157106A N-terminal deletions of lymphotoxin, their preparation and use 失效
标题翻译： LYMPHOTOXIN的N-末端残基，其制备和使用
公开(公告)号：US5157106A
公开(公告)日：1992-10-20
申请号：US61439
申请日：1987-06-15
申请人： Klaus Schollmeier , Achim Moeller , Wolfgang Koerwer , Thomas Doerper , Heinz Hillen , Lothar Daum , Franz Emling , Gerhard Keilhauer
发明人： Klaus Schollmeier , Achim Moeller , Wolfgang Koerwer , Thomas Doerper , Heinz Hillen , Lothar Daum , Franz Emling , Gerhard Keilhauer
IPC分类号： C07K14/52 , A61K38/00 , A61P35/00 , C07K14/00 , C07K14/525 , C12N15/00 , C12N15/09 , C12P21/02 , C12R1/19
CPC分类号： C07K14/525 , A61K38/00 , Y10S530/82 , Y10S930/143 , Y10S930/144
摘要： Polypeptides which differ from lymphotoxin by the absence of amino acids at the N-terminal end of the lymphotoxin are described. The polypeptides can be prepared by gene manipulation and are suitable, alone or in combination with lymphokines, as pharmaceuticals.
摘要翻译：描述了通过在淋巴毒素的N-末端不存在氨基酸而与淋巴毒素不同的多肽。多肽可以通过基因操作制备，并且单独或与淋巴因子组合适合作为药物。

27. 发明申请

US20140363606A1 METHOD AND APPARATUS FOR THE FABRICATION OF AN ENDLESS BAND FROM A FIBER MATERIAL BLOCK, ENDLESS BAND AND FIBER MATERIAL BLOCK 审中-公开
标题翻译：用于从纤维材料块，无缝带和纤维材料块制造无端带的方法和装置
公开(公告)号：US20140363606A1
公开(公告)日：2014-12-11
申请号：US14122104
申请日：2012-05-22
申请人： Achim Moeller , Christian Korn , Andreas Knauff
发明人： Achim Moeller , Christian Korn , Andreas Knauff
IPC分类号： B27D1/10 , B27L5/00
CPC分类号： B27D1/10 , B27L5/00 , Y10T428/192 , Y10T428/249921
摘要： The invention is related to a method and an apparatus (1) for the fabrication of an endless band (300) containing fiber material, in particular wood, comprising at least the following method steps: providing at least one fiber material block, the fiber material block having a face side; cutting off a plate element (31) from the face side of a fiber material block, the plate element (31) having a cutting surface from the fiber material block, a main surface facing the cutting surface, and an edge surface connecting the cutting surface and the main surface; arranging in relation to each other the cutting surface of the plate element (31) and a fiber material block such that the main surface of the plate element (31) follows the face surface of the fiber material block, wherein said face surface forms the main surface of a further plate element; connecting the plate element and the further plate element by a connecting means; cutting off the further plate element from the face side of the fiber material block. The invention is further related to the endless band (300) and the fiber material block, which is the source for the fabrication of the endless band (300).
摘要翻译：本发明涉及用于制造包含纤维材料（特别是木材）的环形带（300）的方法和装置（1），其包括至少以下方法步骤：提供至少一个纤维材料块，所述纤维材料具有面侧的块; 从纤维材料块的表面侧切下板状元件（31），所述板状元件（31）具有从所述纤维材料块的切割面，与所述切割面相对的主面，以及连接所述切割面和主表面; 相对于板元件（31）的切割面和纤维材料块彼此相对配置，使得板元件（31）的主表面与纤维材料块的表面相邻，其中所述表面形成主体另一个板元件的表面; 通过连接装置连接板元件和另一板元件; 从纤维材料块的表面侧切下另外的板状元件。本发明还涉及作为环形带（300）的制造源的环形带（300）和纤维材料块。

28. 发明授权

US07906120B2 Neutralizing monoclonal antibodies against the Nogo-66 receptor (NgR) 有权
标题翻译：针对Nogo-66受体（NgR）的中和单克隆抗体
公开(公告)号：US07906120B2
公开(公告)日：2011-03-15
申请号：US11943770
申请日：2007-11-21
申请人： Mario Mezler , Achim Moeller , Reinhold Mueller , Bernhard K. Mueller , Tariq Ghayur , Eve H. Barlow , Martin Schmidt , Axel Meyer , Nicole E. Teusch
发明人： Mario Mezler , Achim Moeller , Reinhold Mueller , Bernhard K. Mueller , Tariq Ghayur , Eve H. Barlow , Martin Schmidt , Axel Meyer , Nicole E. Teusch
IPC分类号： A61K39/395 , C12P21/08
CPC分类号： C07K16/28 , A61K39/3955 , A61K2039/505 , C07H21/00 , C07K16/2863 , C07K2317/14 , C07K2317/34 , C07K2317/41 , C07K2317/56 , C07K2317/73 , C07K2317/76 , C07K2317/92 , Y02A50/466
摘要： The subject invention relates to isolated proteins, particularly monoclonal antibodies, which bind to the Nogo-66 receptor. Specifically, these antibodies have the ability to inhibit the binding of the natural ligand of the Nogo-66 receptor and neutralize the Nogo-66 receptor. These antibodies or portions thereof of the invention are useful for detecting NgR and for inhibiting NgR activity, for example in a human suffering from a disorder in which NgR or Nogo-66 activity is detrimental.
摘要翻译：本发明涉及结合Nogo-66受体的分离的蛋白质，特别是单克隆抗体。具体地说，这些抗体具有抑制Nogo-66受体的天然配体结合并中和Nogo-66受体的能力。本发明的这些抗体或其部分可用于检测NgR和抑制NgR活性，例如在患有NgR或Nogo-66活性有害的病症的人中。

29. 发明申请

US20070098721A1 Amyloid beta(1-42) oligomers, derivatives thereof and antibodies thereto, methods of preparation thereof and use thereof 有权
标题翻译：淀粉样蛋白β（1-42）寡聚体，其衍生物和抗体，其制备方法和用途
公开(公告)号：US20070098721A1
公开(公告)日：2007-05-03
申请号：US10543841
申请日：2004-02-02
申请人： Heinz Hillen , Andreas Striebinger , Carsten Krantz , Achim Moeller , Reinhold Mueller
发明人： Heinz Hillen , Andreas Striebinger , Carsten Krantz , Achim Moeller , Reinhold Mueller
IPC分类号： A01K67/00 , G01N33/567 , C12P21/06 , C12P21/04 , A61K39/395 , C07K16/18
CPC分类号： C07K14/4711 , A61K38/1709 , A61K39/0007 , A61K2039/57 , C07K16/005 , C07K16/18 , C07K2317/76 , C07K2317/92 , C07K2319/30 , G01N33/6896 , G01N2333/4709
摘要： The invention relates to neuromodulatory oligomers of the amyloid-β(1-42) protein, a particular production method, by means of which the oligomer can be obtained in a reproducible manner at high yield, the use of the oligomers as diagnostic and therapeutics agents, for the generation of oligomer-specific antibodies and for the discovery of substances which can interact with the oligomers and in the formation thereof. Corresponding methods for the production of the antibodies and for discovery of the substances are also disclosed as are the antibodies themselves and the use of the antibodies or substances as diagnostic and therapeutic agents. The invention further relates to derivatives of the oligomers and oligomers based on abbreviated forms of the amyloid-β(1-42) proteins, the production and use thereof.
摘要翻译：本发明涉及淀粉样蛋白-β（1-42）蛋白的神经调节性低聚物，一种特定的制备方法，通过该方法可以以高产率以可重复的方式获得寡聚体，使用低聚物作为诊断和治疗剂，用于产生寡聚体特异性抗体以及用于发现可与低聚物相互作用并在其形成中的物质。还公开了生产抗体和发现物质的相应方法，抗体本身以及抗体或物质作为诊断和治疗剂的用途也是如此。本发明还涉及基于淀粉样蛋白-β（1-42）蛋白的缩写形式的寡聚物和寡聚体的衍生物，其生产和用途。

30. 发明授权

US5180811A Proteins having a TNF action comprising TNF-fibromectin fusion protein 失效
标题翻译：具有包含TNF-FIBROMECTIN融合蛋白的TNF作用的蛋白质
公开(公告)号：US5180811A
公开(公告)日：1993-01-19
申请号：US193661
申请日：1988-05-13
申请人： Thomas Doerper , Achim Moeller , Heinz Hillen , Gerhard Keilhauer , Franz Emling , Lothar Daum
发明人： Thomas Doerper , Achim Moeller , Heinz Hillen , Gerhard Keilhauer , Franz Emling , Lothar Daum
IPC分类号： C12N15/09 , A61K38/00 , A61P35/00 , C07K1/20 , C07K14/00 , C07K14/52 , C07K14/525 , C07K14/78 , C07K19/00 , C12P21/02 , C12R1/19
CPC分类号： C07K14/78 , C07K14/525 , A61K38/00 , C07K2319/00 , C07K2319/33 , C07K2319/75 , Y10S930/144
摘要： Derivatives of a tumor necrosis factor (TNF), which originate from a modification at the amino terminus of the TNF molecule are suitable for controlling diseases.
摘要翻译：起源于TNF分子氨基末端修饰的肿瘤坏死因子（TNF）的衍生物适用于控制疾病。

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