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21. 发明授权

US08206685B2 Cupredoxin derived transport agents and methods of use thereof 有权
标题翻译：铜氧还蛋白衍生的运输剂及其使用方法
公开(公告)号：US08206685B2
公开(公告)日：2012-06-26
申请号：US12754197
申请日：2010-04-05
申请人： Ananda Chakrabarty , Tapas Das Gupta , Tohru Yamada , Arsenio Fialho
发明人： Ananda Chakrabarty , Tapas Das Gupta , Tohru Yamada , Arsenio Fialho
IPC分类号： A61K49/00 , A61K39/02 , C07H21/04
CPC分类号： C07K14/28 , A61K35/13 , A61K38/00 , A61K38/08 , A61K38/10 , A61K38/164 , A61K45/06 , A61K49/00 , A61K49/04 , A61K49/14 , A61K49/221 , C07K14/195 , C07K14/21 , C07K14/22 , C07K14/235 , C07K2319/02
摘要： The present invention discloses methods and materials for delivering a cargo compound into a cancer cell. Delivery of the cargo compound is accomplished by the use of protein transduction domains derived from cupredoxins. The invention further discloses methods for treating cancer and diagnosing cancer.
摘要翻译：本发明公开了将货物化合物输送到癌细胞中的方法和材料。货物化合物的交付是通过使用来自铜氧还蛋白的蛋白质转导结构域完成的。本发明还公开了治疗癌症和诊断癌症的方法。

22. 发明申请

US20080312413A1 COMPOSITIONS AND METHODS FOR TREATING CONDITIONS RELATED TO EPHRIN SIGNALING WITH CUPREDOXINS 有权
标题翻译：用于治疗与丙泊酚的EPHRIN信号相关的条件的组合物和方法
公开(公告)号：US20080312413A1
公开(公告)日：2008-12-18
申请号：US12130705
申请日：2008-05-30
申请人： Ananda Chakrabarty , Tapas Das Gupta , Tohru Yamada , Anita Chaudhari , Arsento Fialho , Yonghua Zhu
发明人： Ananda Chakrabarty , Tapas Das Gupta , Tohru Yamada , Anita Chaudhari , Arsento Fialho , Yonghua Zhu
IPC分类号： C07K14/195
CPC分类号： C07K14/21 , A61K38/164 , A61K38/168 , C07K14/195 , C07K14/705
摘要： The present invention relates to compositions and methods of use of cupredoxins, and variants, derivatives and structural equivalents of cupredoxins that interfere with the ephrin signaling system in mammalian cells. Specifically, the invention relates to compositions and methods that use cupredoxins, such as azurin, rusticyanin and plastocyanin, and variants, derivatives and structural equivalents thereof to treat cancer in mammals.
摘要翻译：本发明涉及使用铜氧还蛋白的组合物和方法，以及干扰哺乳动物细胞中ephrin信号系统的铜氧还蛋白的变体，衍生物和结构等同物。具体而言，本发明涉及使用铜氧还蛋白的组合物和方法，例如azurin，铁水球蛋白和质体蛋白，以及其在哺乳动物中治疗癌症的变体，衍生物和结构等价物。

23. 发明申请

US20060292136A1 Cytotoxic factors for modulating cell death 有权
公开(公告)号：US20060292136A1
公开(公告)日：2006-12-28
申请号：US11508173
申请日：2006-08-23
申请人： Ananda Chakrabarty , Tapas Das Gupta , Vasu Punj , Olga Zaborina , Yoshinori Hiraoka , Tohru Yamada
发明人： Ananda Chakrabarty , Tapas Das Gupta , Vasu Punj , Olga Zaborina , Yoshinori Hiraoka , Tohru Yamada
IPC分类号： A61K38/44 , C12N9/02
CPC分类号： C07K14/80 , A61K38/164 , A61K38/168 , A61K38/415 , C07K14/195
摘要： Cytotoxic factors having use in modulating cell death, and their use in methods of treating necrosis or apoptosis-related conditions are disclosed. The invention also relates to methods for identifying active agents useful in treating conditions related to cell death or uncontrolled growth. The present inventors have found that different microorganisms produce different cytotoxic factor(s) having anticancer activity. The substantially pure cytotoxic factors can be used in a method of treating an infectious disease or a cancer.

24. 发明授权

US10086037B2 Compositions and methods to prevent cancer with cupredoxins 有权
公开(公告)号：US10086037B2
公开(公告)日：2018-10-02
申请号：US13561225
申请日：2012-07-30
申请人： Tapas Das Gupta , Ananda Chakrabarty , Craig Beattie , Tohru Yamada
发明人： Tapas Das Gupta , Ananda Chakrabarty , Craig Beattie , Tohru Yamada
IPC分类号： A61K38/00 , A61K38/16 , A61K49/00 , A61K49/04 , A61K49/08 , A61K49/14 , C07K14/21 , C07K14/415 , A61M5/00 , C07K14/00 , C07K14/22 , C07K14/225 , C07K14/235 , C07K14/28 , C07K14/32 , C12Q1/02 , C12Q1/04 , A61K47/54 , A61K47/64 , B82Y5/00
摘要： The present invention discloses methods and materials for delivering a cargo compound into a cancer cell. Delivery of the cargo compound is accomplished by the use of protein transduction domains derived from cupredoxins. The cargo compound may be a nucleic acid and specifically a DNA, RNA or anti-sense. The invention further discloses methods for treating cancer and diagnosing cancer.

25. 发明授权

US08232244B2 Compositions and methods to prevent cancer with cupredoxins 有权
标题翻译：用氧化还原铁预防癌症的组合物和方法
公开(公告)号：US08232244B2
公开(公告)日：2012-07-31
申请号：US12028683
申请日：2008-02-08
申请人： Tapas Das Gupta , Ananda Chakrabarty , Craig Beattie , Tohru Yamada
发明人： Tapas Das Gupta , Ananda Chakrabarty , Craig Beattie , Tohru Yamada
IPC分类号： C07K14/00
CPC分类号： A61K38/164 , A61K38/00 , A61K47/549 , A61K47/64 , A61K49/0002 , A61K49/04 , A61K49/085 , A61K49/14 , A61M5/00 , B82Y5/00 , C07K14/00 , C07K14/21 , C07K14/22 , C07K14/225 , C07K14/235 , C07K14/28 , C07K14/32 , C07K14/415 , C12Q1/025 , C12Q1/04
摘要： The present invention discloses methods and materials for delivering a cargo compound into a cancer cell. Delivery of the cargo compound is accomplished by the use of protein transduction domains derived from cupredoxins. The cargo compound may be a nucleic acid and specifically a DNA, RNA or anti-sense. The invention further discloses methods for treating cancer and diagnosing cancer.
摘要翻译：本发明公开了将货物化合物输送到癌细胞中的方法和材料。货物化合物的交付是通过使用来自铜氧还蛋白的蛋白质转导结构域完成的。货物化合物可以是核酸，特别是DNA，RNA或反义词。本发明还公开了治疗癌症和诊断癌症的方法。

26. 发明申请

US20130084247A1 COMPOSITIONS AND METHODS TO PREVENT CANCER WITH CUPREDOXINS 审中-公开
标题翻译：用于预防癌症的组合物和方法
公开(公告)号：US20130084247A1
公开(公告)日：2013-04-04
申请号：US13561225
申请日：2012-07-30
申请人： Tapas Das Gupta , Ananda Chakrabarty , Craig Beattie , Tohru Yamada
发明人： Tapas Das Gupta , Ananda Chakrabarty , Craig Beattie , Tohru Yamada
IPC分类号： A61K38/16 , C07K14/32 , C07K14/235 , C07K14/225 , C07K14/22 , C07K14/21 , C07K14/28 , A61K49/00 , A61K49/04 , A61K49/14 , A61K49/22 , C12Q1/02 , C12Q1/04 , A61M5/00 , C07K14/00
CPC分类号： A61K38/164 , A61K38/00 , A61K47/549 , A61K47/64 , A61K49/0002 , A61K49/04 , A61K49/085 , A61K49/14 , A61M5/00 , B82Y5/00 , C07K14/00 , C07K14/21 , C07K14/22 , C07K14/225 , C07K14/235 , C07K14/28 , C07K14/32 , C07K14/415 , C12Q1/025 , C12Q1/04
摘要： The present invention discloses methods and materials for delivering a cargo compound into a cancer cell. Delivery of the cargo compound is accomplished by the use of protein transduction domains derived from cupredoxins. The cargo compound may be a nucleic acid and specifically a DNA, RNA or anti-sense. The invention further discloses methods for treating cancer and diagnosing cancer.
摘要翻译：本发明公开了将货物化合物输送到癌细胞中的方法和材料。货物化合物的交付是通过使用来自铜氧还蛋白的蛋白质转导结构域完成的。货物化合物可以是核酸，特别是DNA，RNA或反义词。本发明还公开了治疗癌症和诊断癌症的方法。

27. 发明申请

US20120302509A1 COMPOSITIONS AND METHODS TO PREVENT CANCER WITH CUPREDOXINS 审中-公开
标题翻译：用于预防癌症的组合物和方法
公开(公告)号：US20120302509A1
公开(公告)日：2012-11-29
申请号：US13555376
申请日：2012-07-23
申请人： Tapas Das Gupta , Ananda Chakrabarty
发明人： Tapas Das Gupta , Ananda Chakrabarty
IPC分类号： A61K38/16 , C12N15/63 , A61P35/00 , C07K7/08 , C07K14/22 , C07K14/21 , C07K14/235 , C07K14/28 , C07K14/225 , C12Q1/02 , C07K7/06
CPC分类号： A61K38/16 , A61K38/00 , A61K38/164 , A61K38/168 , A61K45/06 , C07K14/195 , C07K14/21 , C07K14/22 , C07K14/225 , C07K14/235 , C07K14/28 , C07K14/35 , C07K14/415 , G01N33/5011 , G01N33/5017 , G01N33/569 , G01N2510/00
摘要： The present invention relates to compositions comprising peptides that may be variants, derivatives and structural equivalents of cupredoxins that inhibit the development of premalignant lesions in mammalian cells, tissues and animals. Specifically, these compositions may comprise azurin from Pseudomonas aeruginosa, and/or the 50-77 residue region of azurin (p28). The present invention further relates to compositions that may comprise cupredoxin(s), and/or variants, derivatives or structural equivalents of cupredoxins, that retain the ability to inhibit the development of premalignant lesions in mammalian cells, tissues or animals. These compositions may be peptides or pharmaceutical compositions, among others. The compositions of the invention may be used to prevent the development of premalignant lesions in mammalian cells, tissues and animals, and thus prevent cancer.
摘要翻译：本发明涉及包含肽的组合物，其可以是抑制哺乳动物细胞，组织和动物中恶化前病变发展的铜氧还蛋白的变体，衍生物和结构等同物。具体地，这些组合物可以包含来自绿脓假单胞菌的吖啶素和/或吖啶的50-77残基区域（p28）。本发明还涉及可包含铜氧还蛋白的组合物和/或氧还蛋白的变体，衍生物或结构等同物，其保留抑制哺乳动物细胞，组织或动物中恶化前病变发展的能力。这些组合物可以是肽或药物组合物等。本发明的组合物可用于预防哺乳动物细胞，组织和动物中癌前病变的发展，从而预防癌症。

28. 发明授权

US08227402B2 Compositions and methods to prevent cancer with cupredoxins 有权
标题翻译：用氧化还原铁预防癌症的组合物和方法
公开(公告)号：US08227402B2
公开(公告)日：2012-07-24
申请号：US12617841
申请日：2009-11-13
申请人： Tapas Das Gupta , Ananda Chakrabarty
发明人： Tapas Das Gupta , Ananda Chakrabarty
IPC分类号： C07K14/00
CPC分类号： A61K38/16 , A61K38/00 , A61K38/164 , A61K38/168 , A61K45/06 , C07K14/195 , C07K14/21 , C07K14/22 , C07K14/225 , C07K14/235 , C07K14/28 , C07K14/35 , C07K14/415 , G01N33/5011 , G01N33/5017 , G01N33/569 , G01N2510/00
摘要： The present invention relates to compositions comprising peptides that may be variants, derivatives and structural equivalents of cupredoxins that inhibit the development of premalignant lesions in mammalian cells, tissues and animals. Specifically, these compositions may comprise azurin from Pseudomonas aeruginosa, and/or the 50-77 residue region of azurin (p28). The present invention further relates to compositions that may comprise cupredoxin(s), and/or variants, derivatives or structural equivalents of cupredoxins, that retain the ability to inhibit the development of premalignant lesions in mammalian cells, tissues or animals. These compositions may be peptides or pharmaceutical compositions, among others. The compositions of the invention may be used to prevent the development of premalignant lesions in mammalian cells, tissues and animals, and thus prevent cancer.
摘要翻译：本发明涉及包含肽的组合物，其可以是抑制哺乳动物细胞，组织和动物中恶化前病变发展的铜氧还蛋白的变体，衍生物和结构等同物。具体地，这些组合物可以包含来自绿脓假单胞菌的吖啶素和/或吖啶的50-77残基区域（p28）。本发明还涉及可包含铜氧还蛋白的组合物和/或氧还蛋白的变体，衍生物或结构等同物，其保留抑制哺乳动物细胞，组织或动物中恶化前病变发展的能力。这些组合物可以是肽或药物组合物等。本发明的组合物可用于预防哺乳动物细胞，组织和动物中癌前病变的发展，从而预防癌症。

29. 发明申请

US20090226405A1 COMPOSITIONS AND METHODS TO TREAT CANCER WITH CUPREDOXINS AND CpG RICH DNA 有权
标题翻译：用CUPREDOXINS和CpG Rich DNA治疗癌症的组合物和方法
公开(公告)号：US20090226405A1
公开(公告)日：2009-09-10
申请号：US11950165
申请日：2007-12-04
申请人： Tapas Das Gupta , Ananda Chakrabarty
发明人： Tapas Das Gupta , Ananda Chakrabarty
IPC分类号： A61K35/74 , C07H21/04 , A61K31/7088 , A61K38/16 , C12N1/20
CPC分类号： C07K14/195 , A61K38/00 , C07K14/21
摘要： The present invention relates to compositions comprising CpG rich DNA from Pseudomonas aeruginosa. The compositions optionally comprise a cupredoxin. The present invention includes specific CpG DNAs from Pseudomonas aeruginosa that are useful for treating cancer and other conditions in patients. These compositions are optionally in a pharmaceutically acceptable carrier and also optionally comprise a cupredoxin. The present invention further relates to methods to express proteins near cancer cells. These methods may be used to express therapeutic or diagnostic proteins near cancer cells in a patient suffering from cancer or other conditions, and can also be used for diagnosing cancer in a patient. This method uses the gene for azurin from P. aeruginosa as an expression system for azurin or heterologous proteins in P. aeruginosa or heterologous cells.
摘要翻译：本发明涉及包含来自绿脓假单胞菌的富含CpG的DNA的组合物。组合物任选地包含铜氧还蛋白。本发明包括来自铜绿假单胞菌的特异性CpG DNA，其可用于治疗患者的癌症和其它病症。这些组合物任选地在药学上可接受的载体中，并且还任选地包含铜氧还蛋白。本发明还涉及在癌细胞附近表达蛋白质的方法。这些方法可以用于表达患有癌症或其他病症的患者中的癌细胞附近的治疗或诊断蛋白质，并且还可以用于诊断患者的癌症。该方法使用来自铜绿假单胞菌的azurin基因作为铜绿假单胞菌或异源细胞中的azurin或异源蛋白质的表达系统。

30. 发明授权

US09134298B2 Compositions and methods to prevent cancer with cupredoxins 有权
公开(公告)号：US09134298B2
公开(公告)日：2015-09-15
申请号：US13555376
申请日：2012-07-23
申请人： Tapas Das Gupta , Ananda Chakrabarty
发明人： Tapas Das Gupta , Ananda Chakrabarty
IPC分类号： G01N33/50 , C07K14/195 , C07K14/21 , C07K14/22 , C07K14/225 , C07K14/235 , C07K14/28 , A61K38/16
CPC分类号： A61K38/16 , A61K38/00 , A61K38/164 , A61K38/168 , A61K45/06 , C07K14/195 , C07K14/21 , C07K14/22 , C07K14/225 , C07K14/235 , C07K14/28 , C07K14/35 , C07K14/415 , G01N33/5011 , G01N33/5017 , G01N33/569 , G01N2510/00
摘要： The present invention relates to compositions comprising peptides that may be variants, derivatives and structural equivalents of cupredoxins that inhibit the development of premalignant lesions in mammalian cells, tissues and animals. Specifically, these compositions may comprise azurin from Pseudomonas aeruginosa, and/or the 50-77 residue region of azurin (p28). The present invention further relates to compositions that may comprise cupredoxin(s), and/or variants, derivatives or structural equivalents of cupredoxins, that retain the ability to inhibit the development of premalignant lesions in mammalian cells, tissues or animals. These compositions may be peptides or pharmaceutical compositions, among others. The compositions of the invention may be used to prevent the development of premalignant lesions in mammalian cells, tissues and animals, and thus prevent cancer.

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