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21. 发明申请

US20100274219A1 ACQUIRING NERVE ACTIVITY FROM CAROTID BODY AND/OR SINUS 有权
标题翻译：从CAROTID身体和/或SINUS获得神经活动
公开(公告)号：US20100274219A1
公开(公告)日：2010-10-28
申请号：US12833170
申请日：2010-07-09
申请人： Brian Jeffrey Wenzel , Taraneh Ghaffari Farazi
发明人： Brian Jeffrey Wenzel , Taraneh Ghaffari Farazi
IPC分类号： A61N1/365 , A61M37/00
CPC分类号： A61N1/36114 , A61B5/04001 , A61B5/4047 , A61B5/7264 , A61N1/36117 , A61N1/36514 , A61N1/36557 , A61N1/36564
摘要： An exemplary includes acquiring an electroneurogram of the right carotid sinus nerve or the left carotid sinus nerve, analyzing the electroneurogram for at least one of chemosensory information and barosensory information and calling for one or more therapeutic actions based at least in part on the analyzing. Therapeutic actions may aim to treat conditions such as sleep apnea, an increase in metabolic demand, hypoglycemia, hypertension, renal failure, and corgestive heart failure. Other exemplary methods, devices, systems, etc., are also disclosed.
摘要翻译：示例性的包括获取右颈动脉窦神经或左颈动脉窦神经的电子图，分析至少一个化学感觉信息和感知信息的电子图，并至少部分地基于分析来呼叫一个或多个治疗动作。治疗作用可能旨在治疗诸如睡眠呼吸暂停，代谢需求增加，低血糖症，高血压，肾衰竭和充血性心力衰竭等病症。还公开了其它示例性方法，装置，系统等。

22. 发明申请

US20100057158A1 Neurostimulation Based On Glycemic Condition 审中-公开
标题翻译：基于血糖条件的神经刺激
公开(公告)号：US20100057158A1
公开(公告)日：2010-03-04
申请号：US12198791
申请日：2008-08-26
申请人： Rodolfo Rodriguez , Brian Jeffrey Wenzel , Fujian Qu , Rupinder Bharmi , Karin Jarverud , Taraneh Ghaffari Farazi
发明人： Rodolfo Rodriguez , Brian Jeffrey Wenzel , Fujian Qu , Rupinder Bharmi , Karin Jarverud , Taraneh Ghaffari Farazi
IPC分类号： A61N1/365 , A61N1/36
CPC分类号： A61N1/36114 , A61N1/365
摘要： A glycemic condition is indicated based on variance of a feature derived from cardiac electrogram data. Neurostimulation is then used to counteract a cardiac-related autonomic response to the glycemic condition. For example, stimulation of parasympathetic innervation may be used to counteract an autonomic sympathetic response that is associated with hypoglycemia or hyperglycemia. In addition, stimulation of sympathetic innervation may be used to counteract an autonomic parasympathetic response that is associated with hypoglycemia or hyperglycemia.
摘要翻译：根据心脏电图数据得出的特征的方差来指示血糖状况。然后使用神经刺激来抵消对血糖状况的心脏相关的自主反应。例如，可以使用副交感神经支配的刺激来抵消与低血糖或高血糖相关的自主交感神经反应。此外，交感神经支配的刺激可用于抵消与低血糖或高血糖相关的自主神经副交感神经反应。

23. 发明申请

US20120065528A1 PRE-EJECTION INTERVAL (PEI) MONITORING DEVICES, SYSTEMS AND METHODS 有权
标题翻译：预引导间隔（PEI）监控设备，系统和方法
公开(公告)号：US20120065528A1
公开(公告)日：2012-03-15
申请号：US12882084
申请日：2010-09-14
申请人： Jong Gill , Brian Jeffrey Wenzel , Allen Keel , Wenbo Hou , Edward Karst , Taraneh G. Farazi
发明人： Jong Gill , Brian Jeffrey Wenzel , Allen Keel , Wenbo Hou , Edward Karst , Taraneh G. Farazi
IPC分类号： A61B5/042
CPC分类号： A61B5/0456 , A61B5/02028 , A61B5/0295 , A61B5/0422 , A61B5/686 , A61B5/7239 , A61N1/3684
摘要： Provided herein are implantable systems, and methods for use therewith, for monitoring a patient's pre-ejection interval (PEI). A signal indicative of cardiac electrical activity and a signal indicative of changes in arterial blood volume are obtained. One or more predetermined features of the signal indicative of cardiac electrical activity and the signal indicative of changes in arterial blood volume are detected. The patient's PEI is determined by determining an interval between the predetermined feature of the signal indicative of cardiac electrical activity and the predetermined feature of the signal indicative of changes in arterial blood volume.
摘要翻译：本文提供了可植入系统及其使用的方法，用于监测患者的预喷射间隔（PEI）。获得指示心脏电活动的信号和指示动脉血容量变化的信号。检测到指示心脏电活动的信号的一个或多个预定特征以及指示动脉血容量变化的信号。通过确定指示心脏电活动的信号的预定特征与指示动脉血容量变化的信号的预定特征之间的间隔来确定患者的PEI。

24. 发明申请

US20120065527A1 Methods and Systems for Monitoring Aterial Stiffness 审中-公开
标题翻译：监测动静刚度的方法和系统
公开(公告)号：US20120065527A1
公开(公告)日：2012-03-15
申请号：US12882099
申请日：2010-09-14
申请人： Jong Gill , Brian Jeffrey Wenzel , Allen Keel , Wenbo Hou , Edward Karst , Taraneh G. Farazi
发明人： Jong Gill , Brian Jeffrey Wenzel , Allen Keel , Wenbo Hou , Edward Karst , Taraneh G. Farazi
IPC分类号： A61B5/0295
CPC分类号： A61B5/02007 , A61B5/0295 , A61B5/686
摘要： Implanted systems and methods for monitoring a patient's arterial stiffness are provided. An implanted sensor is used to produce a signal indicative of changes in arterial blood volume for a plurality of beats of the patient's heart. A pulse duration metric is determined for each of a plurality of pulses of the signal, wherein each pulse of the signal corresponds to a beat of the patient's heart. Arterial stiffness is monitored based on the determined pulse duration metric for the plurality of pulses of the signal. This can include monitoring arterial stiffness based on a dispersion of the pulse duration metric and/or an average of the pulse duration metric.
摘要翻译：提供了用于监测患者动脉硬度的植入系统和方法。植入的传感器用于产生指示患者心脏的多个节拍的动脉血容量变化的信号。为信号的多个脉冲中的每一个确定脉冲持续时间度量，其中信号的每个脉冲对应于患者心脏的搏动。基于确定的信号的多个脉冲的脉冲持续时间度量监测动脉硬度。这可以包括基于脉冲持续时间度量的偏差和/或脉冲持续时间度量的平均值监视动脉硬度。

25. 发明授权

US08165664B1 Systems and methods for increased specificity in diagnostics 有权
标题翻译：在诊断中提高特异性的系统和方法
公开(公告)号：US08165664B1
公开(公告)日：2012-04-24
申请号：US11928233
申请日：2007-10-30
申请人： Taraneh Ghaffari Farazi , Rupinder Bharmi , Brian Jeffrey Wenzel
发明人： Taraneh Ghaffari Farazi , Rupinder Bharmi , Brian Jeffrey Wenzel
IPC分类号： A61B5/0402
CPC分类号： A61B5/0452 , A61B5/4842 , A61B5/686 , A61N1/365
摘要： Specific embodiments provided herein relate to diagnosing, with improved specificity, occurrences of episodes relating to disorders that are known to affect T-wave morphology. One or more propensity metric is obtained, each of which is indicative of a patient's propensity for a specific disorder that is known to affect T-wave morphology. T-wave variability is monitored. Additionally, there is monitoring for a specific change in T-wave morphology that is known to be indicative of episodes relating to a disorder. When the specific change in T-wave morphology is detected, a diagnosis is determined for detecting the specific change in T-wave morphology, taking into account the propensity metric(s) and the T-wave variability.
摘要翻译：本文提供的具体实施方案涉及具有改善的特异性诊断与已知影响T波形态的病症相关的发作的发生。获得一个或多个倾向度量，每个倾向度量指示患者对已知影响T波形态的特定病症的倾向。监测T波变化。另外，监测T波形态的具体变化已知是指示与病症相关的发作。当检测到T波形态的具体变化时，考虑到倾向度量和T波变异性，确定检测T波形态的具体变化的诊断。

26. 发明申请

US20110196254A1 ACQUIRING NERVE ACTIVITY FROM CAROTID BODY AND/OR SINUS 有权
公开(公告)号：US20110196254A1
公开(公告)日：2011-08-11
申请号：US13088223
申请日：2011-04-15
申请人： Brian Jeffrey Wenzel , Taraneh Ghaffari Farazi
发明人： Brian Jeffrey Wenzel , Taraneh Ghaffari Farazi
IPC分类号： A61N1/365 , A61N1/36 , A61B5/04
CPC分类号： A61B5/04001 , A61B5/4047 , A61B5/4818 , A61B5/4866 , A61B5/7264 , A61N1/36117 , A61N1/365 , A61N1/3702
摘要： An exemplary includes acquiring an electroneurogram of the right carotid sinus nerve or the left carotid sinus nerve, analyzing the electroneurogram for at least one of chemosensory information and barosensory information and calling for one or more therapeutic actions based at least in part on the analyzing. Therapeutic actions may aim to treat conditions such as sleep apnea, an increase in metabolic demand, hypoglycemia, hypertension, renal failure, and congestive heart failure. Other exemplary methods, devices, systems, etc., are also disclosed.

27. 发明授权

US08326428B2 Acquiring nerve activity from carotid body and/or sinus 有权
标题翻译：从颈动脉体和/或窦获得神经活动
公开(公告)号：US08326428B2
公开(公告)日：2012-12-04
申请号：US13088209
申请日：2011-04-15
申请人： Brian Jeffrey Wenzel , Taraneh Ghaffari Farazi
发明人： Brian Jeffrey Wenzel , Taraneh Ghaffari Farazi
IPC分类号： A61N1/08
CPC分类号： A61N1/36114 , A61B5/04001 , A61B5/4047 , A61B5/7264 , A61N1/36117 , A61N1/36514 , A61N1/36557 , A61N1/36564
摘要： An exemplary includes acquiring an electroneurogram of the right carotid sinus nerve or the left carotid sinus nerve, analyzing the electroneurogram for at least one of chemosensory information and barosensory information and calling for one or more therapeutic actions based at least in part on the analyzing. Therapeutic actions may aim to treat conditions such as sleep apnea, an increase in metabolic demand, hypoglycemia, hypertension, renal failure, and congestive heart failure. Other exemplary methods, devices, systems, etc., are also disclosed.
摘要翻译：示例性的包括获取右颈动脉窦神经或左颈动脉窦神经的电子图，分析至少一个化学感觉信息和感知信息的电子图，并至少部分地基于分析来呼叫一个或多个治疗动作。治疗作用可能旨在治疗诸如睡眠呼吸暂停，代谢需求增加，低血糖症，高血压，肾衰竭和充血性心力衰竭等病症。还公开了其它示例性方法，装置，系统等。

28. 发明授权

US07949398B1 Acquiring nerve activity from carotid body and/or sinus 有权
公开(公告)号：US07949398B1
公开(公告)日：2011-05-24
申请号：US11964941
申请日：2007-12-27
申请人： Brian Jeffrey Wenzel , Taraneh Ghaffari Farazi
发明人： Brian Jeffrey Wenzel , Taraneh Ghaffari Farazi
IPC分类号： A61N1/08
CPC分类号： A61B5/04001 , A61B5/4047 , A61B5/4818 , A61B5/4866 , A61B5/7264 , A61N1/36117 , A61N1/365 , A61N1/3702
摘要： An exemplary includes acquiring an electroneurogram of the right carotid sinus nerve or the left carotid sinus nerve, analyzing the electroneurogram for at least one of chemosensory information and barosensory information and calling for one or more therapeutic actions based at least in part on the analyzing. Therapeutic actions may aim to treat conditions such as sleep apnea, an increase in metabolic demand, hypoglycemia, hypertension, renal failure, and congestive heart failure. Other exemplary methods, devices, systems, etc., are also disclosed.

29. 发明授权

US07909764B1 Methods and systems to monitor venous blood oxygen saturation 有权
标题翻译：监测静脉血氧饱和度的方法和系统
公开(公告)号：US07909764B1
公开(公告)日：2011-03-22
申请号：US11948381
申请日：2007-11-30
申请人： Brian Jeffrey Wenzel , Fujian Qu , Taraneh Ghaffari Farazi
发明人： Brian Jeffrey Wenzel , Fujian Qu , Taraneh Ghaffari Farazi
IPC分类号： A61B5/00 , A61B5/04
CPC分类号： A61B5/14542 , A61B5/0452 , A61N1/36557
摘要： Methods and system are provided for monitoring a patients venous blood oxygen saturation (SvO2). At least one signal indicative of electrical activity of a patient's heart is obtained. Such a signal can be, e.g., an IEGM or ECG signal. In specific embodiments, such a signal(s) can be obtained from implanted electrodes, and thus, embodiments of the present invention can be implemented by an implantable system. Additionally, there are measurements of at least one metric of cardiac cycles represented in the at least one signal indicative of electrical activity of the patient's heart, where the metric changes with changes in SvO2. Examples of such metric include T-wave metrics and PR intervals. SvO2, and changes therein, are monitored based on the measured metric(s).
摘要翻译：方法和系统用于监测患者静脉血氧饱和度（SvO2）。获得指示患者心脏的电活动的至少一个信号。这样的信号可以是例如IEGM或ECG信号。在具体实施例中，可以从植入的电极获得这样的信号，因此本发明的实施例可以由可植入系统实现。此外，在指示患者心脏的电活动的至少一个信号中表示的心脏周期的至少一个度量的度量，其中度量随SvO2的变化而变化。这种度量的示例包括T波度量和PR间隔。 SvO2及其中的变化基于测量的度量来监测。

30. 发明授权

US07848816B1 Acquiring nerve activity from carotid body and/or sinus 有权
标题翻译：从颈动脉体和/或窦获得神经活动
公开(公告)号：US07848816B1
公开(公告)日：2010-12-07
申请号：US11964865
申请日：2007-12-27
申请人： Brian Jeffrey Wenzel , Taraneh Ghaffari Farazi
发明人： Brian Jeffrey Wenzel , Taraneh Ghaffari Farazi
IPC分类号： A61N1/08
CPC分类号： A61N1/36114 , A61B5/04001 , A61B5/4047 , A61B5/7264 , A61N1/36117 , A61N1/36514 , A61N1/36557 , A61N1/36564
摘要： An exemplary includes acquiring an electroneurogram of the right carotid sinus nerve or the left carotid sinus nerve, analyzing the electroneurogram for at least one of chemosensory information and barosensory information and calling for one or more therapeutic actions based at least in part on the analyzing. Therapeutic actions may aim to treat conditions such as sleep apnea, an increase in metabolic demand, hypoglycemia, hypertension, renal failure, and congestive heart failure. Other exemplary methods, devices, systems, etc., are also disclosed.
摘要翻译：示例性的包括获取右颈动脉窦神经或左颈动脉窦神经的电子图，分析至少一个化学感觉信息和感知信息的电子图，并至少部分地基于分析来呼叫一个或多个治疗动作。治疗作用可能旨在治疗诸如睡眠呼吸暂停，代谢需求增加，低血糖症，高血压，肾衰竭和充血性心力衰竭等病症。还公开了其它示例性方法，装置，系统等。

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