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21. 发明授权

US08060211B2 Method of reducing retinal stress caused by an implantable retinal electrode array 有权
标题翻译：减少由植入式视网膜电极阵列引起的视网膜应力的方法
公开(公告)号：US08060211B2
公开(公告)日：2011-11-15
申请号：US11728144
申请日：2007-03-23
申请人： Robert J. Greenberg , Alfred E. Mann , James S. Little , Karl-Heinz Ihrig , Brian V. Mech , Neil H. Talbot , DaoMin Zhou
发明人： Robert J. Greenberg , Alfred E. Mann , James S. Little , Karl-Heinz Ihrig , Brian V. Mech , Neil H. Talbot , DaoMin Zhou
IPC分类号： A61N1/375
CPC分类号： A61N1/0543
摘要： This invention is methods of reducing stress in the retina that are caused by the implanted electrode array body having an oval shape that is curved to conform to the curvature of the retina and having a mounting aperture in the body for attaching the electrode array to the retina with a tack where a strain relief internal tab is place around a strain relief slot.
摘要翻译：本发明是一种降低由植入的电极阵列体引起的视网膜应力的方法，所述植入电极阵列体具有弯曲以符合视网膜的曲率的椭圆形，并且在体内具有用于将电极阵列附着到视网膜上的安装孔其中应力消除内部突片位于应变消除槽周围。

22. 发明授权

US07920915B2 Implantable stimulator 有权
标题翻译：植入式刺激器
公开(公告)号：US07920915B2
公开(公告)日：2011-04-05
申请号：US11280620
申请日：2005-11-16
申请人： Alfred E. Mann , Tom Xiaohai He
发明人： Alfred E. Mann , Tom Xiaohai He
IPC分类号： A61N1/00
CPC分类号： A61N1/375 , A61N1/3605 , A61N1/37205 , A61N1/3756
摘要： An implantable stimulator includes a tube assembly that is configured to house a number of components that are configured to apply at least one stimulus to at least one stimulation site within a patient. The tube assembly has a shape that allows the stimulator to be implanted within said patient in a pre-determined orientation. Exemplary methods of stimulating a stimulation site within a patient include applying an electrical stimulation current to a stimulation site via one or more electrodes extending along one or more sides of a stimulator. The stimulator has a shape allowing the stimulator to be implanted within the patient in a pre-determined orientation.
摘要翻译：可植入刺激器包括管组件，其被配置为容纳多个部件，所述部件被配置为将至少一个刺激应用于患者内的至少一个刺激部位。管组件具有允许刺激器以预定方向植入所述患者体内的形状。刺激患者内的刺激部位的示例性方法包括通过沿刺激器的一侧或多侧延伸的一个或多个电极将电刺激电流施加到刺激部位。刺激器具有允许刺激器以预定方向植入患者体内的形状。

23. 发明授权

US07815602B2 External infusion device with remote programming, bolus estimator and/or vibration alarm capabilities 有权
标题翻译：具有远程编程的外部输液装置，推注器和/或振动报警功能
公开(公告)号：US07815602B2
公开(公告)日：2010-10-19
申请号：US10445477
申请日：2003-05-27
申请人： Alfred E. Mann , James D. Causey, III , Alan Haubach , Luis J. Malave , John Livingston , Cliff Hague , Chad Srisathapat , Jay Yonemoto , Deborah Ruppert , Dennis P. Bishop , Adrian Gut , Bob Murtfeldt
发明人： Alfred E. Mann , James D. Causey, III , Alan Haubach , Luis J. Malave , John Livingston , Cliff Hague , Chad Srisathapat , Jay Yonemoto , Deborah Ruppert , Dennis P. Bishop , Adrian Gut , Bob Murtfeldt
IPC分类号： A61M37/00
CPC分类号： A61M5/1723 , A61M5/14244 , A61M5/172 , A61M5/36 , A61M2005/1402 , A61M2005/1403 , A61M2205/18 , A61M2205/3561 , A61M2205/3592 , A61M2205/505 , A61M2205/52 , A61M2205/581 , A61M2205/582 , A61M2205/583 , A61M2209/01 , A61M2230/201 , G06F19/00 , G06F19/3468 , Y02A90/22 , Y02A90/26 , Y10S128/903
摘要： An infusion system for infusing a liquid into a body includes an external infusion device and a remote commander. The external infusion device includes a housing, a receiver, a processor and an indication device. The receiver is coupled to the housing and for receiving remotely generated commands. The processor is coupled to the housing and the receiver to receive remotely generated commands and to control the external infusion device in accordance with the commands. The indication device indicates when a command has been received and indicates when the command is being utilized to control the external infusion device so that the external infusion device is capable of being concealed from view when being remotely commanded. The remote commander includes a commander housing, a keypad for transmitting commands, and a transmitter for transmitting commands to the receiver of the external infusion device.
摘要翻译：用于将液体注入身体的输注系统包括外部输注装置和远程指挥器。外部输注装置包括壳体，接收器，处理器和指示装置。接收器耦合到壳体并用于接收远程产生的命令。处理器耦合到壳体和接收器以接收远程产生的命令并根据命令控制外部输注装置。指示装置指示何时已经接收到命令，并且指示何时正在利用命令来控制外部输注装置，使得外部输注装置能够在远程命令时被隐藏。遥控器包括指挥器壳体，用于发送命令的键盘和用于向外部输注装置的接收器发送命令的发射器。

24. 发明申请

US20100217241A1 FLUID CARTRIDGES AND PARTIALLY IMPLANTABLE MEDICAL DEVICES FOR USE WITH SAME 有权
标题翻译：流体盒和部分可植入的医疗装置与其一起使用
公开(公告)号：US20100217241A1
公开(公告)日：2010-08-26
申请号：US12390432
申请日：2009-02-21
申请人： Alfred E. Mann , Tom Xiaohai He
发明人： Alfred E. Mann , Tom Xiaohai He
IPC分类号： A61M5/142
CPC分类号： A61M5/14244 , A61M5/14276 , A61M5/16854 , A61M39/0247 , A61M39/04 , A61M2205/12 , A61M2205/50 , A61M2205/6054 , A61M2205/8206
摘要： Partially implantable medical devices and methods associated with partially implantable medical devices.
摘要翻译：部分可植入的医疗设备和与部分可植入医疗设备相关的方法。

25. 发明授权

US07338522B2 Implantable retinal electrode array configuration for minimal retinal damage and method of reducing retinal stress 有权
标题翻译：植入式视网膜电极阵列配置，用于最小的视网膜损伤和减少视网膜应力的方法
公开(公告)号：US07338522B2
公开(公告)日：2008-03-04
申请号：US09783236
申请日：2001-02-13
申请人： Robert J. Greenberg , Alfred E. Mann , James S. Little , Karl-Heinz Ihrig , Brian V. Mech , Neil H. Talbot , DaoMin Zhou
发明人： Robert J. Greenberg , Alfred E. Mann , James S. Little , Karl-Heinz Ihrig , Brian V. Mech , Neil H. Talbot , DaoMin Zhou
IPC分类号： A61F2/16
CPC分类号： A61N1/0543
摘要： This invention is a retinal electrode array assembly and methods of using the same that facilitate surgical implant procedures by providing the operating surgeon with visual references and grasping means and with innovations that reduce actual and potential damage to the retina and the surrounding tissue.
摘要翻译：本发明是一种视网膜电极阵列组件及其使用方法，其通过向操作外科医生提供视觉参考和抓握装置以及减少对视网膜和周围组织的实际和潜在损伤的创新来促进手术植入程序。

26. 发明授权

US07025743B2 External infusion device with remote programming, bolus estimator and/or vibration alarm capabilities 有权
公开(公告)号：US07025743B2
公开(公告)日：2006-04-11
申请号：US10401152
申请日：2003-03-27
申请人： Alfred E. Mann , James D. Causey, III , Alan Haubach , Luis J. Malave , John Livingston , Cliff Hague , Chad Srisathapat , Jay Yonemoto , Deborah Ruppert , Dennis P. Bishop , Adrian Gut , Bob Murtfeldt
发明人： Alfred E. Mann , James D. Causey, III , Alan Haubach , Luis J. Malave , John Livingston , Cliff Hague , Chad Srisathapat , Jay Yonemoto , Deborah Ruppert , Dennis P. Bishop , Adrian Gut , Bob Murtfeldt
IPC分类号： A61M31/00 , H04B7/00 , G05B19/00
CPC分类号： A61M5/1723 , A61M5/14244 , A61M5/172 , A61M5/36 , A61M2005/1402 , A61M2005/1403 , A61M2205/18 , A61M2205/3561 , A61M2205/3592 , A61M2205/505 , A61M2205/52 , A61M2205/581 , A61M2205/582 , A61M2205/583 , A61M2209/01 , A61M2230/201 , G06F19/00 , G06F19/3468 , Y02A90/22 , Y02A90/26 , Y10S128/903
摘要： An infusion system for infusing a liquid into a body includes an external infusion device and a remote commander. The external infusion device includes a housing, a receiver, a processor and an indication device. The receiver is coupled to the housing and for receiving remotely generated commands. The processor is coupled to the housing and the receiver to receive remotely generated commands and to control the external infusion device in accordance with the commands. The indication device indicates when a command has been received and indicates when the command is being utilized to control the external infusion device so that the external infusion device is capable of being concealed from view when being remotely commanded. The remote commander includes a commander housing, a keypad for transmitting commands, and a transmitter for transmitting commands to the receiver of the external infusion device.

27. 发明授权

US06809653B1 Telemetered characteristic monitor system and method of using the same 有权
标题翻译：遥测特征监测系统及其使用方法
公开(公告)号：US06809653B1
公开(公告)日：2004-10-26
申请号：US09465715
申请日：1999-12-17
申请人： Alfred E. Mann , Richard E. Purvis , John J. Mastrototaro , James D. Causey , James Henke , Peter Hong , John H. Livingston , Clifford W. Hague , Brad T. Hite
发明人： Alfred E. Mann , Richard E. Purvis , John J. Mastrototaro , James D. Causey , James Henke , Peter Hong , John H. Livingston , Clifford W. Hague , Brad T. Hite
IPC分类号： A61M500
CPC分类号： A61B5/1495 , A61B5/0002 , A61B5/14532 , A61B5/14865 , A61B5/6848 , A61B5/6849 , A61B2560/0214 , A61B2560/0223 , A61M2005/1726 , G06F19/00
摘要： A telemetered characteristic monitor system includes a remotely located data receiving device, a sensor for producing signal indicative of a characteristic of a user, and a transmitter device. The transmitter device includes a housing, a sensor connector, a processor, and a transmitter. The transmitter receives the signals from the sensor and wirelessly transmits the processed signals to the remotely located data receiving device. The processor coupled to the sensor processes the signals from the sensor for transmission to the remotely located data receiving device. The data receiving device may be a characteristic monitor, a data receiver that provides data to another device, an RF programmer for a medical device, a medication delivery device (such as an infusion pump), or the like.
摘要翻译：遥测特征监视器系统包括远程定位的数据接收装置，用于产生指示用户特征的信号的传感器和发射机装置。发射器装置包括壳体，传感器连接器，处理器和发射器。发射机接收来自传感器的信号，并将经处理的信号无线发送到位于远程的数据接收装置。耦合到传感器的处理器处理来自传感器的信号以传输到位于远程的数据接收装置。数据接收装置可以是特征监视器，向另一设备提供数据的数据接收器，用于医疗装置的RF编程器，药物输送装置（例如输液泵）等。

28. 发明授权

US06754537B1 Hybrid implantable cochlear stimulator hearing aid system 有权
标题翻译：混合植入式耳蜗刺激助听器系统
公开(公告)号：US06754537B1
公开(公告)日：2004-06-22
申请号：US09979804
申请日：2001-11-13
申请人： William Vanbrooks Harrison , Janusz A. Kuzma , Alfred E. Mann , Thomas J. Balkany
发明人： William Vanbrooks Harrison , Janusz A. Kuzma , Alfred E. Mann , Thomas J. Balkany
IPC分类号： A61N118
CPC分类号： A61N1/36036 , A61N1/0541
摘要： A hybrid cochlear implant hearing aid sytem (10) provides low frequency acoustic energy boost, if needed, and high frequency direct neural stimulation. Tinnitus suppression may also be provided. The neurons responsible for sensing high frequency sounds are located at the basal end of the cochlea. A short basal electrode (52) that extends into the cochlea only at the basal region allows direct stimulation of these neurons by an appropriately-controlled cochlear stimulator (50). The basal electrode array typically has from four to eight electrode contacts (54). The design of the electrode array allows the surgeon to place the array using minimally invasive surgical techniques and requires no cochleostomy. The electrode array is thin, and can typically be inserted directly through the round window membrane to make contact with, or to be positioned in close proximity to, the modiolus wall in the basal region of the cochlea. The hybrid implantable cochlear stimulator and hearing aid system relies primarily on the cochlear stimulator portion of the system for being able to sense high frequency sounds, and relies primarily on normal hearing processes, or other acoustic boosting devices and systems, for being able to sense lower frequency sounds.
摘要翻译：混合耳蜗植入式助听器系统（10）提供低频声能增强，如果需要，以及高频直接神经刺激。也可以提供耳鸣抑制。负责感测高频声音的神经元位于耳蜗的基端。仅在基底区域延伸到耳蜗的短基底电极（52）允许通过适当控制的耳蜗刺激器（50）直接刺激这些神经元。基极电极阵列通常具有四至八个电极触点（54）。电极阵列的设计允许外科医生使用微创手术技术来放置阵列，并且不需要耳蜗造口术。电极阵列是薄的，并且通常可以直接插入通过圆窗膜以与耳蜗的基底区域中的闭孔壁接触或靠近位置。混合植入式耳蜗刺激器和助听器系统主要依赖于系统的人工耳蜗刺激器部分，以便能够感测高频声音，并且主要依赖于正常听力过程或其他声学增强装置和系统，以便能够感测较低频频率声音。

29. 发明授权

US06520936B1 Method and apparatus for infusing liquids using a chemical reaction in an implanted infusion device 失效
标题翻译：用于在植入的输注装置中使用化学反应注入液体的方法和装置
公开(公告)号：US06520936B1
公开(公告)日：2003-02-18
申请号：US09590482
申请日：2000-06-08
申请人： Alfred E. Mann
发明人： Alfred E. Mann
IPC分类号： A61M3700
CPC分类号： A61M5/14276 , A61M5/14593 , A61M2005/14204 , A61M2005/14513 , A61M2205/8243 , A61M2209/045
摘要： Embodiments of implantable infusion pumps are provided that use a process of converting a first substance to a second gaseous substance (e.g. by electrolysis) to provide a motivating force to expel a desired fluid (e.g. drug or medication) from the pump into the body of a patient. An expandable sack may be provided around a gas producing electrolytic cell, such that as the gas expands it displaces a portion of the volume originally allocated to the desired fluid, and thereby forces the fluid from the pump. Pumps may be provided with a double septum to allow refilling of the desired fluid while simultaneously allowing removal of the generated gas from the system while using a single needle. Recharging of pump batteries may occur by direct electrical conduction through one or more needles and/or by r.f. energy transfer. Programming of the pump may occur by way of conductive paths provided by one or more needles or by means of r.f. transfer. A pressure regulator may be provided in vicinity to an outlet port of the pump so as to enable more reliable operation of the pump when subjected to changes in ambient pressure. A one-way valve may also be provided to reduce risk of back flow into the pump.
摘要翻译：提供了可植入输液泵的实施方案，其使用将第一物质转化为第二气态物质（例如通过电解）的方法，以提供驱动力以将期望的流体（例如药物或药物）从泵排入体内患者。可以在产生气体的电解池周围设置可膨胀袋，使得当气体膨胀时，其移动初始分配给期望流体的体积的一部分，从而迫使来自泵的流体。泵可以设置有双隔膜，以允许重新填充所需的流体，同时在使用单个针的同时允许从系统中除去产生的气体。泵电池的充电可以通过一个或多个针和/或r.f的直接电传导而发生。能量转移。泵的编程可以通过由一个或多个针或通过r.f提供的导电路径进行。转让。可以在泵的出口附近设置压力调节器，以便在受到环境压力变化时使泵更可靠地运行。还可以提供单向阀以减少回流到泵中的风险。

30. 发明授权

US06266568B1 Inflatable cochlear electrode array and method of making same 失效
标题翻译：充气耳蜗电极阵列及其制作方法
公开(公告)号：US06266568B1
公开(公告)日：2001-07-24
申请号：US09300800
申请日：1999-04-27
申请人： Alfred E. Mann , Thomas H. R. Lenarz , Janusz A. Kuzma , William Vanbrooks Harrison
发明人： Alfred E. Mann , Thomas H. R. Lenarz , Janusz A. Kuzma , William Vanbrooks Harrison
IPC分类号： A61N104
CPC分类号： A61N1/0541
摘要： An inflatable cochlear electrode array adapted for insertion into a human cochlear includes a flexible carrier on which a multiplicity of spaced-apart electrode contacts are carried, preferably along one side, e.g., a medial side, of the carrier. The flexible carrier also includes an inflatable compartment or section. In one embodiment, the inflatable section is located at the distal tip of the electrode array on a side of the flexible carrier that is opposite the electrode contacts. In another embodiment, the inflatable compartment or section is located along at least one half of the full length of the flexible carrier, forming a spine. In either embodiment, the electrode is readily inserted into the cochlea to a desired depth while the inflatable compartment or section remains in a deflated state. Thereafter, a desired modiolus-hugging position is achieved by inflating the inflatable compartment or section by injecting therein a suitable biocompatible fluid. A method of making an inflatable cochlear electrode is also disclosed.
摘要翻译：适于插入到人类耳蜗中的充气耳蜗电极阵列包括柔性载体，其上承载有多个间隔开的电极触点，优选地沿载体的一侧，例如内侧。柔性载体还包括可充气的隔室或部分。在一个实施例中，可充气部分位于与电极接触件相对的柔性载体侧上的电极阵列的远端。在另一个实施例中，可充气隔室或部分沿柔性载体的全长的至少一半定位，形成脊柱。在任一实施例中，电极容易地插入耳蜗到期望的深度，同时可充气隔间或部分保持在放气状态。此后，通过在其中注射合适的生物相容性流体来使充气室或部分膨胀来实现所需的夹层位置。还公开了制造充气耳蜗电极的方法。

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