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21. 发明授权

US07575930B2 Method for analyzing oligosaccharides from blood plasma 有权
标题翻译：从血浆中分析寡糖的方法
公开(公告)号：US07575930B2
公开(公告)日：2009-08-18
申请号：US11777431
申请日：2007-07-13
申请人： Pierre Mourier , Christian Viskov
发明人： Pierre Mourier , Christian Viskov
IPC分类号： G01N33/00
CPC分类号： G01N33/50 , G01N2030/027 , G01N2030/8813 , G01N2030/8822 , G01N2030/8836 , G01N2400/00 , Y10T436/142222 , Y10T436/143333
摘要： The present invention relates to a method for analyzing oligosaccharides constituting the heparins of low molecular weight and the heparins of very low molecular weight from blood plasma.
摘要翻译：本发明涉及一种分析低分子量肝素的低聚糖和血浆中非常低分子量的肝素的方法。

22. 发明申请

US20090023171A1 Method for determining specific groups constituting heparins or low molecular weight heparins 有权
标题翻译：确定构成肝素或低分子量肝素的特定组的方法
公开(公告)号：US20090023171A1
公开(公告)日：2009-01-22
申请号：US12007695
申请日：2008-01-14
申请人： Christian Viskov , Pierre Mourier
发明人： Christian Viskov , Pierre Mourier
IPC分类号： C12Q1/34 , G01N30/02 , C12Q1/00
CPC分类号： B01D15/366 , B01D15/363 , B01J2220/54 , C08B37/0078 , G01N2030/8813 , Y10T436/143333
摘要： The invention provides methods for analysing heparins, low-molecular-weight heparins, ultralow-molecular-weight heparins, and oligosaccharides by high performance liquid chromatography a stationary phase dynamically coated with a quaternary ammonium salt. The methods of the invention may be used to analyse samples without pre-treatment or to analyse samples that have been partially or exhaustively depolymerised and, optionally, reduced. Specific saccharides can be detected.
摘要翻译：本发明提供了通过高效液相色谱分析动态涂覆有季铵盐的固定相来分析肝素，低分子量肝素，超低分子量肝素和寡糖的方法。本发明的方法可用于分析样品而无需预处理或分析已部分或全面解聚并任选还原的样品。可以检测特异性糖。

23. 发明申请

US20080318328A1 Process for oxidizing unfractionated heparins and detecting presence or absence of glycoserine in heparin and heparin products 审中-公开
$Process for oxidizing unfractionated heparins and detecting presence or absence of glycoserine in heparin and heparin products$
标题翻译：氧化未分级肝素的方法，检测肝素和肝素产品中糖苷的存在或不存在
公开(公告)号：US20080318328A1
公开(公告)日：2008-12-25
申请号：US11878793
申请日：2007-07-26
申请人： Christian Viskov , Pierre Mourier
发明人： Christian Viskov , Pierre Mourier
IPC分类号： C08B37/10 , G01N30/00
CPC分类号： C08B37/0078 , Y10T436/143333
摘要： The invention provides a process for preparing heparin products with a reduced content of glycoserine. A method for detecting glycoserine in preparations of heparin is also provided.
摘要翻译：本发明提供了制备具有降低的糖苷含量的肝素产物的方法。还提供了一种在肝素制剂中检测糖苷的方法。

24. 发明申请

US20050186679A1 Method for determining specific groups constituting heparins or low molecular weight heparins 审中-公开
标题翻译：确定构成肝素或低分子量肝素的特定组的方法
公开(公告)号：US20050186679A1
公开(公告)日：2005-08-25
申请号：US10808410
申请日：2004-03-25
申请人： Christian Viskov , Pierre Mourier
发明人： Christian Viskov , Pierre Mourier
IPC分类号： B01D15/32 , B01D15/36 , C08B37/00 , G01N30/88 , G01N33/00 , A61K31/727
CPC分类号： B01D15/366 , B01D15/363 , B01J2220/54 , C08B37/0078 , G01N2030/8813 , Y10T436/143333
摘要： The invention provides methods for analysing heparins, low-molecular-weight heparins, ultralow-molecular-weight heparins, and oligosaccharides by high performance liquid chromatography a stationary phase dynamically coated with a quaternary ammonium salt. The methods of the invention may be used to analyse samples without pre-treatment or to analyse samples that have been partially or exhaustively depolymerised and, optionally, reduced. Specific saccharides can be detected.
摘要翻译：本发明提供了通过高效液相色谱分析动态涂覆有季铵盐的固定相来分析肝素，低分子量肝素，超低分子量肝素和寡糖的方法。本发明的方法可用于分析样品而无需预处理或分析已部分或全面解聚并任选还原的样品。可以检测特异性糖。

25. 发明申请

US20050119477A1 Method for determining specific groups constituting heparins or low molecular weight heparins 审中-公开
标题翻译：确定构成肝素或低分子量肝素的特定组的方法
公开(公告)号：US20050119477A1
公开(公告)日：2005-06-02
申请号：US10665872
申请日：2003-09-18
申请人： Pierre Mourier , Christian Viskov
发明人： Pierre Mourier , Christian Viskov
IPC分类号： C07H1/00 , C12Q1/34 , C12Q1/527 , G01N33/86
CPC分类号： C07H1/00 , C12Q1/34 , C12Q1/527 , G01N33/86
摘要： The subject of the invention is a method for analysing heparins or low-molecular-weight heparins, characterized in that the sample to be assayed is depolymerized by the action of heparinases and then, where appropriate, the depolymerizate obtained is reduced and then an analysis is carried out by high performance liquid chromatography.
摘要翻译：本发明的主题是分析肝素或低分子量肝素的方法，其特征在于，待测定的样品通过肝素酶的作用解聚，然后在适当的情况下减少所得的解聚物，然后进行分析通过高效液相色谱进行。

26. 发明授权

US09346894B2 Polysaccharides comprising two antithrombin III-binding sites, preparation thereof and use thereof as antithrombotic medicaments 有权
标题翻译：包含两个抗凝血酶III结合位点的多糖，其制备及其作为抗血栓药物的用途
公开(公告)号：US09346894B2
公开(公告)日：2016-05-24
申请号：US14111300
申请日：2012-04-11
申请人： Pierre Mourier , Christian Viskov
发明人： Pierre Mourier , Christian Viskov
IPC分类号： C08B37/00 , A61K31/727 , G01N30/86 , B01D15/34 , B01D15/36 , B01D15/38 , A61K45/06 , B01D15/18
CPC分类号： A61K31/727 , A61K45/06 , B01D15/1878 , B01D15/34 , B01D15/363 , B01D15/3823 , C08B37/0075 , Y10T436/143333
摘要： The invention relates to sulphated polysaccharides which have the general structure of the constituent polysaccharides of heparin and which have a molecular weight of less than 8000 Daltons, comprising two antithrombin III-binding hexasaccharide sequences corresponding to formula (I) in which: R1 represents an OH group when the hexasaccharide of formula (I) is located at the reducing end of the polysaccharide, or else R1 represents a bond with another saccharide unit of said polysaccharide; R2 represents a hydrogen atom when the hexasaccharide of formula (I) is located at the non-reducing end of the polysaccharide, in which case the bond between carbon atoms 4 and 5 of the first saccharide unit of said hexasaccharide is a double bond, or else R2 represents a bond with another saccharide unit of said polysaccharide, in which case the bond between carbon atoms 4 and 5 of the first saccharide unit is a single bond. Preparation thereof, use thereof as antithrombotic medicaments, and also use thereof in a method for analyzing a sample of a heparin derivative.
摘要翻译：本发明涉及具有肝素成分多糖的分子量小于8000道尔顿的硫酸化多糖，其包含对应于式（I）的两种抗凝血酶III结合六糖序列，其中：R1表示OH 当式（I）的六糖位于多糖的还原端时，或者R1表示与所述多糖的另一个糖单元的键; 当式（I）的六糖位于多糖的非还原端时，R2表示氢原子，在这种情况下，所述六糖的第一糖单元的碳原子4和5之间的键是双键，或否则R2表示与所述多糖的另一个糖单元的键，在这种情况下，第一糖单元的碳原子4和5之间的键是单键。其制备方法，作为抗血栓药物的用途，以及其在分析肝素衍生物样品的方法中的应用。

27. 发明授权

US08546354B2 Acylated decasaccharides and their use as antithrombotic agents 有权
标题翻译：酰化十二糖及其作为抗血栓形成剂的用途
公开(公告)号：US08546354B2
公开(公告)日：2013-10-01
申请号：US13288585
申请日：2011-11-03
申请人： Pierre Mourier , Christian Viskov
发明人： Pierre Mourier , Christian Viskov
IPC分类号： A61K31/727 , A61P7/02 , C08B37/10
CPC分类号： C08B37/0078
摘要： The instant invention relates to decasaccharides of formula (I): wherein Ac represents an acetyl group and R represents a group of formula —OH or —OSO3−, in their acid form or in the form of any one of their pharmaceutically acceptable salts, and to their process of preparation. The oligosaccharides of formula (I) are useful as antithrombotic agents.
摘要翻译：本发明涉及式（I）的十糖：其中Ac表示乙酰基，R表示式-OH或-OSO 3 - 基团，其酸形式或其任何一种药学上可接受的盐的形式，以及到他们的准备过程。式（I）的寡糖可用作抗血栓形成剂。

28. 发明授权

US08071570B2 Mixtures of polysaccharides derived from heparin, their preparation and pharmaceutical compositions containing them 有权
标题翻译：衍生自肝素的多糖的混合物，其制备物和含有它们的药物组合物
公开(公告)号：US08071570B2
公开(公告)日：2011-12-06
申请号：US13103960
申请日：2011-05-09
申请人： Christian Viskov , Vesna Biberovic , Pierre Mourier , Luc Grondard
发明人： Christian Viskov , Vesna Biberovic , Pierre Mourier , Luc Grondard
IPC分类号： A61K31/727 , C08B37/10 , C07H5/06
CPC分类号： C08B37/0078
摘要： The present invention relates to mixtures of polysaccharides derived from heparin having a mean molecular weight of 1500 to 3000 Daltons and an anti-Xa/anti-IIa ratio greater than 30, their method of preparation and pharmaceutical compositions containing them.
摘要翻译：本发明涉及平均分子量为1500〜3000道尔顿，抗Xa /抗-IIa比大于30的肝素多糖的混合物，其制备方法和含有它们的药物组合物。

29. 发明授权

US07956046B2 Oligosaccharide mixtures derived from heparin, preparation thereof and pharmaceutical compositions containing them 有权
标题翻译：衍生自肝素的寡糖混合物，其制备物和含有它们的药物组合物
公开(公告)号：US07956046B2
公开(公告)日：2011-06-07
申请号：US10899618
申请日：2004-07-27
申请人： Volker Laux , Pierre Mourier , Christian Viskov
发明人： Volker Laux , Pierre Mourier , Christian Viskov
IPC分类号： A61K31/715 , C07H1/00
CPC分类号： C08B37/0078
摘要： Oligosaccharide mixtures comprising anti-Xa activities of from 190 IU/mg to 450 IU/mg and anti-IIa activities of less than 0.2 IU/mg; and having constituent oligosaccharides with an average molecular weight of from 1800 to 2400 Daltons, constituent oligosaccharides comprise from 2 to 16 saccharide units, a 4,5-unsaturated uronic acid 2-O-sulfate unit at one end, and comprising at least one ΔIIa-IIs-Is hexasaccharide sequence are described. Processes for preparing the oligosaccharide mixtures, pharmaceutical compositions and articles of manufacture comprising the oligosaccharide mixtures are described. Methods of treatment and prevention comprising administering the oligosaccharide mixtures are described.
摘要翻译：包含190 IU / mg至450 IU / mg的抗Xa活性和小于0.2 IU / mg的抗IIa活性的寡糖混合物; 并且具有平均分子量为1800至2400道尔顿的构成寡糖，构成寡糖包含2至16个糖单元，一端为4个不饱和糖醛酸2-O-硫酸酯单元，并且包含至少一个Dgr ; IIa-IIs-是六糖序列。描述了制备包含寡糖混合物的寡糖混合物，药物组合物和制品的方法。描述了施用寡糖混合物的治疗和预防方法。

30. 发明申请

US20080182820A1 Mixtures of sulfated oligosaccharides 有权
标题翻译：硫酸化低聚糖的混合物
公开(公告)号：US20080182820A1
公开(公告)日：2008-07-31
申请号：US11882607
申请日：2007-08-02
申请人： Christian Viskov
发明人： Christian Viskov
IPC分类号： A61K31/727 , C08B37/10 , A61P9/00
CPC分类号： C08B37/0078
摘要： The present invention relates to mixtures of polysaccharides derived from heparin having a mean molecular weight of 1500 to 3000 Daltons and an anti-Xa/anti-IIa ratio greater than 30, their method of preparation and pharmaceutical compositions containing them.
摘要翻译：本发明涉及平均分子量为1500〜3000道尔顿，抗Xa /抗-IIa比大于30的肝素的多糖混合物，其制备方法和含有它们的药物组合物。

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