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21. 发明申请

US20060246012A1 Delivery of physiologically active compounds through an inhalation route 失效
公开(公告)号：US20060246012A1
公开(公告)日：2006-11-02
申请号：US11479509
申请日：2006-06-30
申请人： Joshua Rabinowitz , Alejandro Zaffaroni
发明人： Joshua Rabinowitz , Alejandro Zaffaroni
IPC分类号： A61K9/14 , A61L9/04
CPC分类号： A61K9/007 , A61K9/0073 , A61K9/12 , A61K31/00 , A61K31/137 , A61K31/138 , A61K31/165 , A61K31/19 , A61K31/192 , A61K31/195 , A61K31/216 , A61K31/27 , A61K31/404 , A61K31/405 , A61K31/407 , A61K31/4196 , A61K31/421 , A61K31/422 , A61K31/423 , A61K31/437 , A61K31/473 , A61K31/485 , A61K31/49 , A61K31/495 , A61K31/496 , A61K31/4985 , A61K31/501 , A61K31/519 , A61K31/53 , A61K31/551 , A61K31/5517 , A61K47/54 , A61M11/042 , A61M15/06 , A61M2205/8206 , F24V30/00 , Y10S514/923 , Y10S514/958
摘要： The present invention relates to the delivery of physiologically active compounds through an inhalation route. Specifically, it relates to aerosols containing physiologically active compounds that are used in inhalation therapy. In a method aspect of the present invention, the physiologically active compound is delivered to a patient through an inhalation route. The method comprises: a) heating a coating of a physiologically active compound, on a solid support, to form a vapor; and, b) passing air through the heated vapor to produce aerosol particles having less than 5% physiologically active compound degradation products. In a kit aspect of the present invention, a kit for delivering a physiologically active compound through an inhalation route is provided which comprises: a) a thin coating of a physiologically active compound, and b) a device for dispensing said thin coating as a condensation aerosol.

22. 发明申请

US20060233719A1 Delivery of antidepressants through an inhalation route 有权
公开(公告)号：US20060233719A1
公开(公告)日：2006-10-19
申请号：US11451853
申请日：2006-06-13
申请人： Joshua Rabinowitz , Alejandro Zaffaroni
发明人： Joshua Rabinowitz , Alejandro Zaffaroni
IPC分类号： A61K9/14 , A61L9/04 , A61K31/195
CPC分类号： A61K9/007 , A61K9/0073 , A61K9/12 , A61K31/00 , A61K31/137 , A61K31/138 , A61K31/165 , A61K31/19 , A61K31/192 , A61K31/195 , A61K31/216 , A61K31/27 , A61K31/404 , A61K31/405 , A61K31/407 , A61K31/4196 , A61K31/421 , A61K31/422 , A61K31/423 , A61K31/437 , A61K31/473 , A61K31/485 , A61K31/49 , A61K31/495 , A61K31/496 , A61K31/4985 , A61K31/501 , A61K31/519 , A61K31/53 , A61K31/551 , A61K31/5517 , A61K47/54 , A61M11/042 , A61M15/06 , A61M2205/8206 , F24V30/00 , Y10S514/923 , Y10S514/958
摘要： The present invention relates to the delivery of antidepressants through an inhalation route. Specifically, it relates to aerosols containing an antidepressant that are used in inhalation therapy. In a method aspect of the present invention, an antidepressant is administered to a patient through an inhalation route. The method comprises: a) heating a thin layer of an antidepressant, on a solid support, form a vapor; and, b) passing air through the heated vapor to produce aerosol particles having less than 5% antidepressant degradation products. In a kit aspect of the present invention, a kit for delivering an antidepressant through an inhalation route to a mammal is provided which comprises: a) a thin coating of an antidepressant composition and b) a device for dispensing said thin coating as a condensation aerosol.

23. 发明申请

US20060233717A1 Delivery of compounds for the treatment of headache through an inhalation route 有权
公开(公告)号：US20060233717A1
公开(公告)日：2006-10-19
申请号：US11385992
申请日：2006-03-21
申请人： Ron Hale , Joshua Rabinowitz , Dennis Solas , Alejandro Zaffaroni
发明人： Ron Hale , Joshua Rabinowitz , Dennis Solas , Alejandro Zaffaroni
IPC分类号： A61K9/14 , A61L9/04 , B29B9/00 , A61K31/405
CPC分类号： A61K9/007 , A61K9/0073 , A61K31/405 , Y10S514/958
摘要： The present invention relates to the delivery of migraine headache drugs through an inhalation route. Specifically, it relates to aerosols containing migraine headache drugs that are used in inhalation therapy.

24. 发明申请

US20060177382A1 Delivery of antiemetics through an inhalation route 有权
公开(公告)号：US20060177382A1
公开(公告)日：2006-08-10
申请号：US11398383
申请日：2006-04-04
申请人： Joshua Rabinowitz , Alejandro Zaffaroni
发明人： Joshua Rabinowitz , Alejandro Zaffaroni
IPC分类号： A61K9/14 , A61L9/04
CPC分类号： A61K9/007 , A61K9/0073 , A61K9/12 , A61K31/00 , A61K31/137 , A61K31/138 , A61K31/165 , A61K31/19 , A61K31/192 , A61K31/195 , A61K31/216 , A61K31/27 , A61K31/404 , A61K31/405 , A61K31/407 , A61K31/4196 , A61K31/421 , A61K31/422 , A61K31/423 , A61K31/437 , A61K31/473 , A61K31/485 , A61K31/49 , A61K31/495 , A61K31/496 , A61K31/4985 , A61K31/501 , A61K31/519 , A61K31/53 , A61K31/551 , A61K31/5517 , A61K47/54 , A61M11/042 , A61M15/06 , A61M2205/8206 , F24V30/00 , Y10S514/923 , Y10S514/958
摘要： The present invention relates to the delivery of antiemetics through an inhalation route. Specifically, it relates to aerosols containing antiemetics that are used in inhalation therapy. In a method aspect of the present invention, an antiemetic is delivered to a patient through an inhalation route. The method comprises: a) heating a thin layer of an antiemetic, on a solid support, to form a vapor; and, b) passing air through the heated vapor to produce aerosol particles having less than 5% antiemetic degradation products. In a kit aspect of the present invention, a kit for delivering an antiemetic through an inhalation route is provided which comprises: a) a thin layer of an antiemetic drug and b) a device for dispensing said thin layer an antiemetic as a condensation aerosol.

25. 发明申请

US20050089479A1 Delivery of sedative-hypnotics through an inhalation route 有权
标题翻译：通过吸入路线输送镇静催眠药
公开(公告)号：US20050089479A1
公开(公告)日：2005-04-28
申请号：US10749537
申请日：2003-12-30
申请人： Joshua Rabinowitz , Alejandro Zaffaroni
发明人： Joshua Rabinowitz , Alejandro Zaffaroni
IPC分类号： A61K9/12 , A61K9/00 , A61K9/72 , A61K31/00 , A61K31/13 , A61K31/137 , A61K31/138 , A61K31/165 , A61K31/167 , A61K31/19 , A61K31/192 , A61K31/216 , A61K31/27 , A61K31/40 , A61K31/403 , A61K31/404 , A61K31/4045 , A61K31/405 , A61K31/407 , A61K31/4196 , A61K31/421 , A61K31/422 , A61K31/423 , A61K31/437 , A61K31/439 , A61K31/4402 , A61K31/4418 , A61K31/4525 , A61K31/4545 , A61K31/46 , A61K31/473 , A61K31/48 , A61K31/485 , A61K31/49 , A61K31/495 , A61K31/496 , A61K31/4985 , A61K31/501 , A61K31/505 , A61K31/519 , A61K31/53 , A61K31/5415 , A61K31/55 , A61K31/551 , A61K31/5513 , A61K31/5517 , A61K45/00 , A61K47/48 , A61M11/00 , A61P15/10 , A61P21/02 , A61P25/06 , A61P25/08 , A61P25/16 , A61P25/18 , A61P25/20 , A61P25/22 , A61P25/24 , A61P25/32 , A61P29/00 , A61P31/04 , A61P37/08 , A61P43/00 , C07D471/04 , C07D487/04 , F24V30/00 , A61L9/04 , A61K9/14
CPC分类号： A61K9/007 , A61K9/0073 , A61K9/12 , A61K31/00 , A61K31/137 , A61K31/138 , A61K31/165 , A61K31/19 , A61K31/192 , A61K31/195 , A61K31/216 , A61K31/27 , A61K31/404 , A61K31/405 , A61K31/407 , A61K31/4196 , A61K31/421 , A61K31/422 , A61K31/423 , A61K31/437 , A61K31/473 , A61K31/485 , A61K31/49 , A61K31/495 , A61K31/496 , A61K31/4985 , A61K31/501 , A61K31/519 , A61K31/53 , A61K31/551 , A61K31/5517 , A61K47/54 , A61M11/042 , A61M15/06 , A61M2205/8206 , F24V30/00 , Y10S514/923 , Y10S514/958
摘要： The present invention relates to the delivery of sedative-hypnotics through an inhalation route. Specifically, it relates to aerosols containing sedative-hypnotics that are used in inhalation therapy. In a method aspect of the present invention, a sedative-hypnotic drug is administered to a patient through an inhalation route. The method comprises: a) heating a composition, wherein the composition comprises a sedative-hypnotic, to form a vapor; and, b) allowing the vapor to cool, thereby forming a condensation aerosol comprising particles with less than 5% sedative-hypnotic drug degradation products. In a kit aspect of the present invention, a kit for delivering a sedative-hypnotic through an inhalation route is provided which comprises: a) a thin coating of a sedative-hypnotic drug composition and b) a device for dispensing said thin coating as a condensation aerosol.
摘要翻译：本发明涉及通过吸入途径递送镇静催眠药。具体地说，它涉及用于吸入治疗的含有镇静催眠药的气溶胶。在本发明的方法方面，通过吸入途径向患者施用镇静催眠药物。该方法包括：a）加热组合物，其中所述组合物包含镇静催眠剂，以形成蒸气; 和b）允许蒸气冷却，从而形成包含具有小于5％镇静催眠药物降解产物的颗粒的凝结气雾剂。在本发明的试剂盒方面，提供了一种用于通过吸入途径输送镇静催眠药物的试剂盒，其包括：a）镇静催眠药物组合物的薄涂层和b）用于将所述薄涂层分配为冷凝气溶胶。

26. 发明授权

US5851801A Method of preparing polypeptide binding compositions derived from immunoglobulin variable regions 失效
标题翻译：制备衍生自免疫球蛋白可变区的多肽结合组合物的方法
公开(公告)号：US5851801A
公开(公告)日：1998-12-22
申请号：US460892
申请日：1995-06-05
申请人： Kevin W. Moore , Alejandro Zaffaroni
发明人： Kevin W. Moore , Alejandro Zaffaroni
IPC分类号： C12N15/09 , A61K38/00 , A61K39/395 , A61P37/00 , C07H21/04 , C07K1/22 , C07K14/00 , C07K16/00 , C07K19/00 , C12N1/00 , C12N15/00 , C12N15/10 , C12P21/00 , C12P21/08 , C12R1/125 , C12R1/19 , C12R1/865 , G01N33/531 , G01N33/577 , C12N15/13
CPC分类号： G01N33/531 , C07K16/00 , C12N15/10 , A61K38/00 , C07K2317/622 , Y10S424/801 , Y10S530/808 , Y10S530/809 , Y10S530/866 , Y10S530/867 , Y10S930/30
摘要： Proteinaceous binding compositions are prepared employing hybrid DNA technology, where the variable region polypeptides of immunoglobulins are substantially reproduced to provide relatively small protein molecules having binding specificity and lacking the undesirable aspects of the heavy regions of immunoglobulins. The compositions find a wide range of use, particularly for physiological purposes for diagnosis and therapy. The binding compositions may be modified by labeling with radioisotopes, fluorescers, and toxins for specific applications in diagnosis or therapy.
摘要翻译：使用杂交DNA技术制备蛋白质结合组合物，其中基本上复制了免疫球蛋白的可变区多肽，以提供具有结合特异性的较小蛋白质分子并且缺乏免疫球蛋白重区域的不期望的方面。该组合物发现广泛的用途，特别是用于诊断和治疗的生理目的。可以通过用放射性同位素，荧光剂和毒素标记用于诊断或治疗中的特定应用来修饰结合组合物。

27. 发明授权

US5284660A Delayed onset transdermal delivery device 失效
标题翻译：延迟发作透皮递送装置
公开(公告)号：US5284660A
公开(公告)日：1994-02-08
申请号：US933423
申请日：1992-08-21
申请人： Eun Soo Lee , Felix Theeuwes , Patrick S. L. Wong , Su Il Yum , Robert M. Gale , Alejandro Zaffaroni
发明人： Eun Soo Lee , Felix Theeuwes , Patrick S. L. Wong , Su Il Yum , Robert M. Gale , Alejandro Zaffaroni
IPC分类号： A61K9/00 , A61K9/22 , A61K9/70 , A61F13/00
CPC分类号： A61K9/7084 , A61K9/7069 , A61K9/7092
摘要： A diffusional drug delivery device is described which can provide for delayed onset of therapeutic effect and for delivery of the therapeutic agent in predetermined temporal patterns at optimum rates. Delay means are provided between the agent reservoir and the surface through which the agent is released by diffusion to delay the release of agent at a therapeutic rate for predetermined times after application. Suitable means include a delay membrane disposed between the releasing surface and the agent reservoir, which membrane is preferably free of undissolved agent and/or is initially impermeable to the agent and thereafter becomes permeable. One or more agent chambers defined by one or more of such membranes may be provided, whereby agents are released in predetermined temporal patterns at optimal release rates. Delayed permeability enables programmed washout periods to be obtained from the sequential and concurrent application of devices for the administration of drugs, such as nitrates, to which patients may develop a tolerance on continuous administration over extended time periods.
摘要翻译：描述了扩散药物递送装置，其可以提供治疗效果的延迟开始和以最佳速率以预定时间模式递送治疗剂。在药剂储存器和通过扩散释放药剂的表面之间提供延迟装置，以在施用后以治疗速率延迟药剂释放预定时间。合适的方法包括设置在释放表面和药剂储存器之间的延迟膜，该膜优选不含未溶解的试剂和/或最初不能渗透到试剂中，然后变得可渗透。可以提供由一种或多种这样的膜限定的一个或多个试剂室，由此以最佳释放速率以预定的时间模式释放试剂。延迟渗透性使得能够从连续和同时使用用于施用诸如硝酸盐的药物的装置获得程序性洗脱期，患者可以在延长的时间段内持续施用耐受性。

28. 发明授权

US4642334A Hybrid DNA prepared binding composition 失效
标题翻译：杂交DNA制备结合组成
公开(公告)号：US4642334A
公开(公告)日：1987-02-10
申请号：US558551
申请日：1983-12-05
申请人： Kevin W. Moore , Alejandro Zaffaroni
发明人： Kevin W. Moore , Alejandro Zaffaroni
IPC分类号： C12N15/09 , A61K38/00 , A61K39/395 , A61P37/00 , C07H21/04 , C07K1/22 , C07K14/00 , C07K16/00 , C07K19/00 , C12N1/00 , C12N15/00 , C12N15/10 , C12P21/00 , C12P21/08 , C12R1/125 , C12R1/19 , C12R1/865 , G01N33/531 , G01N33/577
CPC分类号： G01N33/531 , C07K16/00 , C12N15/10 , A61K38/00 , C07K2317/622 , Y10S424/801 , Y10S530/808 , Y10S530/809 , Y10S530/866 , Y10S530/867 , Y10S930/30
摘要： Proteinaceous binding compositions are prepared employing hybrid DNA techogy, where the variable region polypeptides of immunoglobulins are substantially reproduced to provide relatively small protein molecules having binding specificity and lacking the undesirable aspects of the heavy regions of immunoglobulins. The compositions find a wide range of use, particularly for physiological purposes for diagnosis and therapy. The binding compositions may be modified by labeling with radioisotopes, fluorescers, and toxins for specific applications in diagnosis or therapy.
摘要翻译：使用杂交DNA技术制备蛋白质结合组合物，其中基本上复制了免疫球蛋白的可变区多肽，以提供具有结合特异性的较小蛋白质分子并且缺乏免疫球蛋白重区域的不期望的方面。该组合物发现广泛的用途，特别是用于诊断和治疗的生理目的。可以通过用放射性同位素，荧光剂和毒素标记用于诊断或治疗中的特定应用来修饰结合组合物。

29. 发明授权

US4352791A Potassium replacement therapy 失效
标题翻译：钾替代疗法
公开(公告)号：US4352791A
公开(公告)日：1982-10-05
申请号：US257540
申请日：1981-04-27
申请人： Alejandro Zaffaroni , John Fara
发明人： Alejandro Zaffaroni , John Fara
IPC分类号： A61K33/14 , A61K31/60
CPC分类号： A61K33/14
摘要： A composition is disclosed comprising potassium chloride and a therapeutically acceptable salicylate salt or salicylic acid. The composition is useful for potassium therapy.
摘要翻译：公开了包含氯化钾和治疗上可接受的水杨酸盐或水杨酸的组合物。该组合物可用于钾疗法。

30. 发明授权

US4135514A Osmotic releasing system for administering ophthalmic drug to eye of animal 失效
标题翻译：渗透性释放系统，用于将眼药物用于动物眼
公开(公告)号：US4135514A
公开(公告)日：1979-01-23
申请号：US775989
申请日：1977-03-09
申请人： Alejandro Zaffaroni , Alan S. Michaels , Felix Theeuwes
发明人： Alejandro Zaffaroni , Alan S. Michaels , Felix Theeuwes
IPC分类号： A61F6/14 , A61F9/00 , A61K9/00 , A61M31/00
CPC分类号： A61K9/0051 , A61F6/14 , A61F6/144 , A61F9/0017 , A61K9/0004 , A61K9/0039
摘要： An osmotic device for releasing a useful agent at different release rate patterns from the device in a selected environment is disclosed. The device is comprised of a wall surrounding and forming a compartment as a means for containing a useful agent and having a passageway for releasing the agent. The wall is comprised in at least a part of a material permeable to an external fluid and impermeable to the agent. A layer of a pattern rate controlling material that erodes in a selected environment for changing the release rate pattern of the device is carried on the semipermeable wall distant from the compartment. The agent is soluble in the fluid and exhibits an osmotic pressure gradient across the semipermeable wall against the fluid, or the agent has limited solubility and is admixed with an osmotically effective solute soluble in the fluid that exhibits an osmotic pressure gradient across the semipermeable wall against the fluid. In operation, agent is released from the device at different release rate patterns by the pattern rate controlling material eroding at a controlled rate to increase the amount of fluid available to the semipermeable wall for imbibition, which fluid is imbibed through the wall into the compartment producing a solution of the soluble agent or a solution of the osmotically effective solute containing the agent which is released through the passageway to the exterior of the device at a rate controlled by the permeability of the semipermeable wall and the osmotic pressure gradient across the wall of the device.
摘要翻译：公开了一种用于在所选环境中从设备以不同释放速率模式释放有用试剂的渗透装置。该装置包括围绕并形成隔室的壁，作为用于容纳有用试剂并具有用于释放试剂的通道的装置。所述壁包括在对外部流体可渗透并且对所述试剂不可渗透的材料的至少一部分中。在选择的环境中侵蚀以改变装置的释放速率图案的图案速率控制材料层被承载在远离隔室的半透壁上。该试剂可溶于流体并且表现出跨越半透性壁抵抗流体的渗透压梯度，或者该试剂具有有限的溶解度，并且与可溶于流体的渗透压有效溶质混合，该溶质表现出穿过半透壁的渗透压梯度，抵抗流体。在操作中，通过模式速率控制材料以受控的速率以不同的释放速率模式从设备释放试剂，以增加半渗透壁可用于吸入的流体的量，该流体通过壁被吸入隔室产生将可溶性试剂或含有该试剂的渗透有效溶质的溶液的溶液以通过该通道释放的渗透压力通过半透壁的渗透率和穿过该壁的渗透压梯度设备。

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