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21. 发明申请

US20090209645A1 METHODS FOR TREATING VASOMOTOR SYMPTOMS USING GABA ANALOGS IN A GASTRIC RETENTIVE DOSAGE FORM 有权
标题翻译：使用GABA模拟法治疗血管造影剂症状的方法
公开(公告)号：US20090209645A1
公开(公告)日：2009-08-20
申请号：US12368907
申请日：2009-02-10
申请人： Bret Berner , Sui Yuen Eddie Hou , Theophilus J. Gana , Marilou S. Cramer , Carl A. Pelzel
发明人： Bret Berner , Sui Yuen Eddie Hou , Theophilus J. Gana , Marilou S. Cramer , Carl A. Pelzel
IPC分类号： A61K31/195
CPC分类号： A61K31/195 , A61K9/0065 , A61K9/2031 , A61K9/2054
摘要： Methods for treating vasomotor symptoms associated with menopause are described.
摘要翻译：描述了治疗与绝经相关的血管舒缩症状的方法。

22. 发明申请

US20090176882A1 GASTRIC RETENTIVE GABAPENTIN DOSAGE FORMS AND METHODS FOR USING SAME 审中-公开
标题翻译： GASTRIC RETENTIVE GABAPENTIN剂型及其使用方法
公开(公告)号：US20090176882A1
公开(公告)日：2009-07-09
申请号：US12331184
申请日：2008-12-09
申请人： Bret Berner , Sui Yuen Eddie Hou , Theophilus J. Gana , Marilou S. Cramer
发明人： Bret Berner , Sui Yuen Eddie Hou , Theophilus J. Gana , Marilou S. Cramer
IPC分类号： A61K31/195
CPC分类号： A61K31/195 , A61K9/2009 , A61K9/2013 , A61K9/2027 , A61K9/2031 , A61K9/2054 , A61K9/284
摘要： Provided is a method of treating a patient suffering from a pain state by administering to the patient a gastric retentive dosage form of gabapentin that is capable of administration in once-daily or twice daily dosing regimens. By reducing the need to administer gabapentin from the thrice-daily administrations characteristic of immediate release gabapentin, the gastric retentive gabapentin dosage forms provided herein have the advantages of improving patient compliance for gabapentin treatment. In addition to the foregoing, the gastric retentive gabapentin dosages forms also exhibit decreased blood plasma concentrations and increased bioavailability throughout the dosing regimen.
摘要翻译：提供了一种通过向患者施用能够以每日一次或每天两次给药方案给药的加巴喷丁的胃滞留剂型来治疗患有疼痛状态的患者的方法。通过减少立即释放加巴喷丁特征的三次每日给药来管理加巴喷丁的需要，本文提供的胃保持性加巴喷丁剂型具有改善患者对加巴喷丁治疗依从性的优点。除了上述之外，胃保持性加巴喷丁剂量形式还表现出在整个给药方案中降低的血浆浓度和增加的生物利用度。

23. 发明授权

US07405238B2 Pharmacological inducement of the fed mode for enhanced drug administration to the stomach 有权
标题翻译：用于增强药物给予胃的喂养模式的药理学诱导
公开(公告)号：US07405238B2
公开(公告)日：2008-07-29
申请号：US10235076
申请日：2002-09-04
申请人： Micheline Markey , John W. Shell , Bret Berner
发明人： Micheline Markey , John W. Shell , Bret Berner
IPC分类号： A61K31/21 , A61K47/00
CPC分类号： A61K9/0065 , A61K9/209 , A61K9/5084
摘要： Drugs intended for absorption in the stomach or upper intestinal tract are administered in oral drug delivery systems in conjunction with any of various substances that have been discovered to function as potent agents for inducing the fed mode. By inducing the onset of the fed mode, these agents cause the stomach to prolong its retention of the drug delivery system, which is either large enough to be retained in the stomach during the fed mode or swells or expands to such a size upon ingestion. The fed mode inducing agents include the following compounds and their salts: glycine and glycylglycine, xylitol and related sugar alcohols, sodium and other metal docusates, β-casomorphins, α-lipoic acid and similarly structured acids, 2,2-diaryl-4-(4′-aryl-4′-hydroxypipendino)butyramides, arginine, Trp-Trp, alkylpyridinium halides, dihydroxybenzoic acids, and potent sweeteners such as aspartame, aspartic acid, acesulfame, and stevioside.
摘要翻译：预期用于在胃或上肠道中吸收的药物在口服药物递送系统中与已被发现用作诱导喂养模式的有效药剂的任何各种物质一起施用。通过诱导进食模式的发作，这些药物引起胃部延长其药物递送系统的保留，药物递送系统的大小足以在进食模式期间保留在胃中，或者在摄食时膨胀或膨胀至这样的大小。饲喂模式诱导剂包括以下化合物及其盐：甘氨酸和甘氨酰甘氨酸，木糖醇和相关糖醇，钠和其他金属多库酯，β-半胱氨酸，α-硫辛酸和类似结构的酸，2,2-二芳基-4- （4'-芳基-4'-羟基磷脂）丁酰胺，精氨酸，Trp-Trp，烷基吡啶鎓卤化物，二羟基苯甲酸，以及强效甜味剂，如阿斯巴甜，天冬氨酸，乙酰磺胺酸和甜菊苷。

24. 发明申请

US20070184104A1 Gastric retentive gabapentin dosage forms and methods for using same 审中-公开
标题翻译：胃保持性加巴喷丁剂型及其使用方法
公开(公告)号：US20070184104A1
公开(公告)日：2007-08-09
申请号：US11648134
申请日：2006-12-29
申请人： Bret Berner , Sui Yuen Eddie Hou , Theophilus Gana , Marilou Cramer
发明人： Bret Berner , Sui Yuen Eddie Hou , Theophilus Gana , Marilou Cramer
IPC分类号： A61K9/22 , A61K31/195 , A61K9/52
CPC分类号： A61K9/5047 , A61K31/195
摘要： Provided is a method of treating a patient suffering from a pain state by administering to the patient a gastric retentive dosage form of gabapentin that is capable of administration in once-daily or twice daily dosing regimens. By reducing the need to administer gabapentin from the thrice-daily administrations characteristic of immediate release gabapentin, the gastric retentive gabapentin dosage forms provided herein have the advantages of improving patient compliance for gabapentin treatment. In addition to the foregoing, the gastric retentive gabapentin dosages forms also exhibit decreased blood plasma concentrations and increased bioavailability throughout the dosing regimen.
摘要翻译：提供了一种通过向患者施用能够以每日一次或每天两次给药方案给药的加巴喷丁的胃滞留剂型来治疗患有疼痛状态的患者的方法。通过减少立即释放加巴喷丁特征的三次每日给药来管理加巴喷丁的需要，本文提供的胃保持性加巴喷丁剂型具有改善患者对加巴喷丁治疗依从性的优点。除了上述之外，胃保持性加巴喷丁剂量形式还表现出在整个给药方案中降低的血浆浓度和增加的生物利用度。

25. 发明授权

US06723340B2 Optimal polymer mixtures for gastric retentive tablets 有权
标题翻译：用于胃滞留片的最佳聚合物混合物
公开(公告)号：US06723340B2
公开(公告)日：2004-04-20
申请号：US10029134
申请日：2001-10-25
申请人： Gloria Gusler , Bret Berner , Mei Chau , Aimee Padua
发明人： Gloria Gusler , Bret Berner , Mei Chau , Aimee Padua
IPC分类号： A61K922
CPC分类号： A61K9/0065 , A61K9/2031 , A61K9/2054
摘要： Unit dosage form tablets for the delivery of pharmaceuticals are formed of the pharmaceutical dispersed in a solid unitary matrix that is formed of a combination of poly(ethylene oxide) and hydroxypropyl methylcellulose. The combination offers unique benefits in terms of release rate control and reproducibility while allowing both swelling of the tablet to effect gastric retention and gradual disintegration of the tablet to clear the tablet from the gastrointestinal tract after release of the drug has occurred.
摘要翻译：用于递送药物的单位剂型片剂由分散在由聚（环氧乙烷）和羟丙基甲基纤维素的组合形成的固体单一基质中的药物形成。该组合在释放速率控制和再现性方面提供了独特的益处，同时允许片剂的膨胀在药物释放后发生胃液滞留和逐渐崩解片剂以从胃肠道中清除片剂。

26. 发明授权

US06595919B2 Device for signal processing for measurement of physiological analytes 有权
标题翻译：用于测量生理分析物的信号处理装置
公开(公告)号：US06595919B2
公开(公告)日：2003-07-22
申请号：US09794783
申请日：2001-02-27
申请人： Bret Berner , Timothy C. Dunn , Kathleen C. Farinas , Michael D. Garrison , Ronald T. Kurnik , Matthew J. Lesho , Russell O. Potts , Janet A. Tamada , Michael J. Tierney
发明人： Bret Berner , Timothy C. Dunn , Kathleen C. Farinas , Michael D. Garrison , Ronald T. Kurnik , Matthew J. Lesho , Russell O. Potts , Janet A. Tamada , Michael J. Tierney
IPC分类号： A61B500
CPC分类号： A61B5/1477 , A61B5/14532 , A61B5/14542 , A61B5/1486 , G06F19/00
摘要： A method is provided for continually or continuously measuring the concentration of target chemical analytes present in a biological system, and processing analyte-specific signals to obtain a measurement value that is closely correlated with the concentration of the target chemical analyte in the biological system. One important application of the invention involves a method for signal processing in a system for monitoring blood glucose values.
摘要翻译：提供了用于连续或连续地测量存在于生物系统中的目标化学分析物的浓度的方法，并且处理分析物特异性信号以获得与生物系统中的目标化学分析物的浓度密切相关的测量值。本发明的一个重要应用涉及用于监测血糖值的系统中的信号处理方法。

27. 发明授权

US6144869A Monitoring of physiological analytes 有权
公开(公告)号：US6144869A
公开(公告)日：2000-11-07
申请号：US309727
申请日：1999-05-11
申请人： Bret Berner , Chia-Ming Chiang , Michael D. Garrison , Janan Jona , Russell O. Potts , Janet A. Tamada , Michael J. Tierney
发明人： Bret Berner , Chia-Ming Chiang , Michael D. Garrison , Janan Jona , Russell O. Potts , Janet A. Tamada , Michael J. Tierney
IPC分类号： G01N27/28 , A61B5/00 , A61B5/145 , A61B5/1477 , A61N1/30 , G01N27/327 , A61B5/05
CPC分类号： A61B5/1486 , A61B5/14532 , C12Q1/006 , A61B5/150022 , A61B5/150091 , A61B5/157 , A61N1/30
摘要： Methods and devices are provided for measuring the concentration of target chemical analytes present in a biological system. Device configuration and/or measurement techniques are employed in order to reduce the effect of interfering species on sensor sensitivity. One important application of the invention involves a method and device for monitoring blood glucose values.

28. 发明授权

US4792450A Device for controlled release drug delivery 失效
标题翻译：控释药物输送装置
公开(公告)号：US4792450A
公开(公告)日：1988-12-20
申请号：US875824
申请日：1986-06-18
申请人： Agis F. Kydonieus , Bret Berner
发明人： Agis F. Kydonieus , Bret Berner
IPC分类号： A61K9/70 , A61K47/32 , A61K9/00 , A61L15/03
CPC分类号： A61K9/7084 , A61K47/32 , Y10S514/874 , Y10S514/944 , Y10S514/947
摘要： A device for the controlled release and delivery of a pharmacologically active agent, comprising a vinyl gel layer and a pharmacologically active agent uniformly dispersed in the layer in a pharmacologically effective amount, the vinyl layer comprising a polyvinyl chloride resin, a primary plasticizer for the polyvinyl chloride resin, and an organic, nonvolatile gel forming additive in an amount sufficient to form a gel.
摘要翻译：用于控制释放和递送药理活性剂的装置，其包含以药理学有效量均匀分散在该层中的乙烯基凝胶层和药理活性剂，所述乙烯基层包含聚氯乙烯树脂，用于聚乙烯醇的主要增塑剂氯化物树脂和有效的非挥发性凝胶形成添加剂，其量足以形成凝胶。

29. 发明授权

US08333992B2 Gastric retained gabapentin dosage form 有权
公开(公告)号：US08333992B2
公开(公告)日：2012-12-18
申请号：US13560938
申请日：2012-07-27
申请人： Bret Berner , Sui Yuen Eddie Hou , Gloria M. Gusler
发明人： Bret Berner , Sui Yuen Eddie Hou , Gloria M. Gusler
IPC分类号： A61K9/22 , A61K9/24 , A61K9/52
CPC分类号： A61K9/0065 , A61K9/0002 , A61K9/2031 , A61K9/2054 , A61K9/48 , A61K31/195 , A61K31/197 , A61K45/06
摘要： A method of treatment for epilepsy and other disease states is described, which comprises the delivery of gabapentin in a gastric retained dosage form.

30. 发明授权

US08333991B2 Gastric retained gabapentin dosage form 有权
标题翻译：胃保留加巴喷丁剂型
公开(公告)号：US08333991B2
公开(公告)日：2012-12-18
申请号：US13553622
申请日：2012-07-19
申请人： Bret Berner , Sui Yuen Eddie Hou , Gloria M. Gusler
发明人： Bret Berner , Sui Yuen Eddie Hou , Gloria M. Gusler
IPC分类号： A61K9/22 , A61K9/24 , A61K9/52
CPC分类号： A61K9/0065 , A61K9/0002 , A61K9/2031 , A61K9/2054 , A61K9/48 , A61K31/195 , A61K31/197 , A61K45/06
摘要： A method of treatment for epilepsy and other disease states is described, which comprises the delivery of gabapentin in a gastric retained dosage form.
摘要翻译：描述了治疗癫痫和其他疾病状态的方法，其包括在胃保留剂型中递送加巴喷丁。

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