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21. 发明授权

US4703615A Multi-purpose trim and yard receptacle 失效
标题翻译：多用途装饰和码头容器
公开(公告)号：US4703615A
公开(公告)日：1987-11-03
申请号：US801078
申请日：1985-11-22
申请人： Robert C. Andrews
发明人： Robert C. Andrews
IPC分类号： A01G3/08 , A01D46/22
CPC分类号： A01G3/08
摘要： The present invention relates to a portable multi-use receptacle. The device is particularly useful as a receptacle for collecting and holding tree and shrub trimmings or leaves. The device consists of a basin-like structure having a flat rigid base. The base has an outer wall attached to the periphery thereof. The outer base has an opening therein between about 1/8 and about 1/3 of the periphery. The base has a second substantially shorter wall bridging the opening of the first wall along the periphery of the base. The base has a third wall corresponding approximately in height to the second wall. The third wall extends inward from one juncture of the first and second walls to the center portion of the base and then outward to the other juncture of the first and second walls. In this manner a walled, wedge-shaped section is defined in the base. The wedge-shaped area is removeable to obtain a walled substantially wedge-shaped opening in the base that is of a size to receive the trunk of a tree or shrub that is to be trimmed.
摘要翻译：本发明涉及便携式多用途容器。该装置特别可用作收集和保持树木和灌木饰边或叶子的容器。该装置由具有平坦刚性基座的盆状结构组成。底座具有附接到其周边的外壁。外基部具有在其周边的约1/8和约1/3之间的开口。基部具有沿基部的周边桥接第一壁的开口的第二基本上较短的壁。底座具有大致高度与第二壁对应的第三壁。第三壁从第一和第二壁的一个接合部向内延伸到基部的中心部分，然后向外延伸到第一和第二壁的另一个接合部。以这种方式，在基座中限定有楔形的楔形截面。楔形区域是可移除的，以在基座中获得一个大小为楔形的开口，该开口具有接收要修剪的树木或灌木的树干的尺寸。

22. 发明授权

US09815263B2 Method for manufacturing a thin film structural system 有权
公开(公告)号：US09815263B2
公开(公告)日：2017-11-14
申请号：US13273516
申请日：2011-10-14
申请人： Wendell Keith Belvin , David W. Sleight , John W. Connell , Thomas J. Burns , Nancy M. H. Holloway , Frank L. Palmieri , Gary A. Wainwright , Robert C. Andrews , Martin Eckhard Zander
发明人： Wendell Keith Belvin , David W. Sleight , John W. Connell , Thomas J. Burns , Nancy M. H. Holloway , Frank L. Palmieri , Gary A. Wainwright , Robert C. Andrews , Martin Eckhard Zander
IPC分类号： B29C70/74 , B32B37/14 , B32B5/18 , B32B27/28
CPC分类号： B32B37/142 , B29C70/747 , B32B5/18 , B32B27/281 , B32B2307/10 , B32B2307/302 , B32B2307/40 , B32B2310/0806 , Y10T156/10 , Y10T428/24802 , Y10T428/31504 , Y10T428/31721
摘要： A method for manufacturing a thin film structural system including a thin film structure includes depositing a reinforcing material in a liquid form in a predefined pattern on a thin film membrane, and transforming the reinforcing material in the predefined pattern to form a reinforcing element connected to the thin film membrane. The reinforcing material may be deposited in a melted form and solidified by cooling, may be transformed by a light or laser induced chemical reaction, or may be deposited and solidified such that the reinforcing element is at least partially embedded in the thin film membrane. The predefined pattern may redistribute loads around a damaged portion of the thin film structure, or define a hinge, a folding line, a stiffening feature. The reinforcing element may be electrically, optically or thermally conductive, to communicate with a device included in the system. The system may be a space structure.

23. 发明授权

US08563742B2 Substituted aminothiazole derivatives, pharmaceutical compositions, and methods of use 失效
标题翻译：取代的氨基噻唑衍生物，药物组合物和使用方法
公开(公告)号：US08563742B2
公开(公告)日：2013-10-22
申请号：US12547018
申请日：2009-08-25
申请人： Adnan M. M. Mjalli , Bapu Gaddam , Robert C. Andrews , Samuel Victory , Suparna Gupta
发明人： Adnan M. M. Mjalli , Bapu Gaddam , Robert C. Andrews , Samuel Victory , Suparna Gupta
IPC分类号： A61K31/427 , C07D417/12
CPC分类号： C07D417/14 , A61K31/425 , C07D417/12
摘要： Substituted aminothiazole derivatives, methods of their preparation, pharmaceutical compositions comprising a substituted aminothiazole, and methods of use in treating human or animal disorders. The compounds may be useful as inhibitors of action of AgRP on a melanocortin receptor and thus may be useful for the management, treatment, control, or the adjunct treatment of diseases which may be responsive to the modulation of melanocortin receptors including obesity-related disorders.
摘要翻译：取代的氨基噻唑衍生物，其制备方法，包含取代的氨基噻唑的药物组合物，以及用于治疗人或动物疾病的方法。该化合物可用作AgRP对黑皮质素受体的作用的抑制剂，因此可用于治疗，治疗，控制或辅助治疗可能对黑皮质素受体（包括肥胖相关病症）的调节有反应的疾病。

24. 发明授权

US07893267B2 Benzazole derivatives, compositions, and methods of use as β-secretase inhibitors 有权
标题翻译：苯并唑衍生物，组合物和作为分泌酶抑制剂的方法
公开(公告)号：US07893267B2
公开(公告)日：2011-02-22
申请号：US11885096
申请日：2006-03-14
申请人： Adnan M. M. Mjalli , David Jones , Devi Reddy Gohimmukkula , Guoxiang Huang , Jeff Zhu , Mohan Rao , Robert C. Andrews , Tan Ren
发明人： Adnan M. M. Mjalli , David Jones , Devi Reddy Gohimmukkula , Guoxiang Huang , Jeff Zhu , Mohan Rao , Robert C. Andrews , Tan Ren
IPC分类号： C07D217/12 , A61K31/47
CPC分类号： C07D401/14 , A61K31/4725 , C07D235/30 , C07D401/04 , C07D401/12 , C07D403/12 , C07D403/14 , C07D405/14 , C07D407/14 , C07D409/14 , C07D417/04 , C07D417/14 , C07D471/04 , C07D473/00 , C07D491/04 , C07D495/04 , C07D513/04
摘要： The present invention is directed to benzazole compounds that inhibit β-site amyloid precursor protein-cleaving enzyme (BACE) and that may be useful in the treatment or prevention of diseases in which BACE is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which BACE is involved.
摘要翻译：本发明涉及抑制β-淀粉样蛋白前体蛋白切割酶（BACE）的苯扎唑化合物，其可用于治疗或预防BACE所涉及的疾病如阿尔茨海默氏病。本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及BACE的疾病中的用途。

25. 发明申请

US20100056587A1 Substituted Aminothiazole Derivatives, Pharmaceutical Compositions, And Methods Of Use 失效
标题翻译：取代的氨基噻唑衍生物，药物组合物和使用方法
公开(公告)号：US20100056587A1
公开(公告)日：2010-03-04
申请号：US12547018
申请日：2009-08-25
申请人： Adnan M. M. Mjalli , Bapu Gaddam , Robert C. Andrews , Samuel Victory , Suparna Gupta
发明人： Adnan M. M. Mjalli , Bapu Gaddam , Robert C. Andrews , Samuel Victory , Suparna Gupta
IPC分类号： A61K31/427 , C07D409/12 , C07D409/14
CPC分类号： C07D417/14 , A61K31/425 , C07D417/12
摘要： Substituted aminothiazole derivatives, methods of their preparation, pharmaceutical compositions comprising a substituted aminothiazole, and methods of use in treating human or animal disorders. The compounds may be useful as inhibitors of action of AgRP on a melanocortin receptor and thus may be useful for the management, treatment, control, or the adjunct treatment of diseases which may be responsive to the modulation of melanocortin receptors including obesity-related disorders.
摘要翻译：取代的氨基噻唑衍生物，其制备方法，包含取代的氨基噻唑的药物组合物，以及用于治疗人或动物疾病的方法。该化合物可用作AgRP对黑皮质素受体的作用的抑制剂，因此可用于治疗，治疗，控制或辅助治疗可能对黑皮质素受体（包括肥胖相关病症）的调节有反应的疾病。

26. 发明授权

US08598353B2 Benzazole derivatives, compositions, and methods of use as β-secretase inhibitors 失效
标题翻译：苯并唑衍生物，组合物和用作β-分泌酶抑制剂的方法
公开(公告)号：US08598353B2
公开(公告)日：2013-12-03
申请号：US12950718
申请日：2010-11-19
申请人： Adnan M. M. Mjalli , David R. Jones , Devi Reddy Gohimukkula , Guoxiang Huang , Jeff J. Zhu , Mohan Rao , Robert C. Andrews , Tan Ren
发明人： Adnan M. M. Mjalli , David R. Jones , Devi Reddy Gohimukkula , Guoxiang Huang , Jeff J. Zhu , Mohan Rao , Robert C. Andrews , Tan Ren
IPC分类号： C07D401/12 , A61K31/4725
CPC分类号： C07D401/14 , A61K31/4725 , C07D235/30 , C07D401/04 , C07D401/12 , C07D403/12 , C07D403/14 , C07D405/14 , C07D407/14 , C07D409/14 , C07D417/04 , C07D417/14 , C07D471/04 , C07D473/00 , C07D491/04 , C07D495/04 , C07D513/04
摘要： The present invention is directed to benzazole compounds that inhibit β-site amyloid precursor protein-cleaving enzyme (BACE) and that may be useful in the treatment or prevention of diseases in which BACE is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which BACE is involved.
摘要翻译：本发明涉及抑制β-位淀粉样蛋白前体蛋白切割酶（BACE）的苯并唑化合物，其可用于治疗或预防BACE所涉及的疾病如阿尔茨海默氏病。本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及BACE的疾病中的用途。

27. 发明授权

US07776919B2 Carboxamide derivatives as therapeutic agents 失效
标题翻译：甲酰胺衍生物作为治疗剂
公开(公告)号：US07776919B2
公开(公告)日：2010-08-17
申请号：US12019045
申请日：2008-01-24
申请人： Adnan M. M. Mjalli , Robert C. Andrews , Ramesh Gopalaswamy , Christopher L. Wysong
发明人： Adnan M. M. Mjalli , Robert C. Andrews , Ramesh Gopalaswamy , Christopher L. Wysong
IPC分类号： A01N37/18 , C07C237/00 , C07C233/00 , C07C235/00
CPC分类号： C07D231/12 , C07C235/38 , C07C237/20 , C07C271/22 , C07C2601/08 , C07C2603/18 , C07D207/16 , C07D211/34 , C07D217/26 , C07D233/56 , C07D249/08 , C07D309/04
摘要： This invention provides certain compounds, methods of their preparation, pharmaceutical compositions comprising the compounds, and their use in treating human or animal disorders. The compounds of the invention are useful as modulators of the interaction between the receptor for advanced glycated end products (RAGE) and its ligands, such as advanced glycated end products (AGEs), S100/calgranulin/EN-RAGE, β-amyloid and amphoterin, and for the management, treatment, control, or as an adjunct treatment for diseases in humans caused by RAGE. Such diseases or disease states include acute and chronic inflammation, the development of diabetic late complications such as increased vascular permeability, nephropathy, atherosclerosis, and retinopathy, the development of Alzheimer's disease, erectile dysfunction, and tumor invasion and metastasis.
摘要翻译：本发明提供某些化合物，其制备方法，包含该化合物的药物组合物及其在治疗人或动物疾病中的用途。本发明的化合物可用作晚期糖基化终产物（RAGE）的受体与其配体如晚期糖基化终产物（AGE），S100 /钙粒蛋白/ EN-RAGE，淀粉样蛋白和两性霉素，以及由RAGE引起的人类疾病的管理，治疗，控制或辅助治疗。这些疾病或疾病状态包括急性和慢性炎症，糖尿病晚期并发症的发展，例如血管通透性增加，肾病，动脉粥样硬化和视网膜病变，阿尔茨海默病的发展，勃起功能障碍和肿瘤侵袭和转移。

28. 发明授权

US07737285B2 Azole derivatives and fused bicyclic azole derivatives as therapeutic agents 有权
标题翻译：唑衍生物和稠合双环唑衍生物作为治疗剂
公开(公告)号：US07737285B2
公开(公告)日：2010-06-15
申请号：US11800085
申请日：2007-05-03
申请人： Adnan M. M. Mjalli , Robert C. Andrews , Ramesh Gopalaswamy , Anitha Hari , Kwasi A. Avor , Ghassan Qabaja , Xiao-Chuan Guo , Suparna Gupta , David R. Jones , Xin Chen
发明人： Adnan M. M. Mjalli , Robert C. Andrews , Ramesh Gopalaswamy , Anitha Hari , Kwasi A. Avor , Ghassan Qabaja , Xiao-Chuan Guo , Suparna Gupta , David R. Jones , Xin Chen
IPC分类号： C07D233/61 , A01N43/50
CPC分类号： C07D233/64 , C07D235/08 , C07D235/12 , C07D235/14 , C07D235/18 , C07D235/30 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/04 , C07D405/12 , C07D413/12 , C07D453/02
摘要： This invention provides certain compounds, methods of their preparation, pharmaceutical compositions comprising the compounds, and their use in treating human or animal disorders. The compounds of the invention are useful as modulators of the interaction between the receptor for advanced glycated end products (RAGE) and its ligands, such as advanced glycated end products (AGEs), S100/calgranulin/EN-RAGE, β-amyloid and amphoterin, and for the management, treatment, control, or as an adjunct treatment for diseases in humans caused by RAGE. Such diseases or disease states include acute and chronic inflammation, the development of diabetic late complications such as increased vascular permeability, nephropathy, atherosclerosis, and retinopathy, the development of Alzheimer's disease, erectile dysfunction, and tumor invasion and metastasis.
摘要翻译：本发明提供某些化合物，其制备方法，包含该化合物的药物组合物及其在治疗人或动物疾病中的用途。本发明的化合物可用作晚期糖基化终产物（RAGE）的受体与其配体如晚期糖基化终产物（AGE），S100 /钙粒蛋白/ EN-RAGE，淀粉样蛋白和两性霉素，以及由RAGE引起的人类疾病的管理，治疗，控制或辅助治疗。这些疾病或疾病状态包括急性和慢性炎症，糖尿病晚期并发症的发展，例如血管通透性增加，肾病，动脉粥样硬化和视网膜病变，阿尔茨海默病的发展，勃起功能障碍和肿瘤侵袭和转移。

29. 发明授权

US07714013B2 Azole derivatives and fused bicyclic azole derivatives as therapeutic agents 有权
公开(公告)号：US07714013B2
公开(公告)日：2010-05-11
申请号：US11511163
申请日：2006-08-28
申请人： Adnan M. M. Mjalli , Robert C. Andrews , Ramesh Gopalaswamy , Anitha Hari , Kwasi A. Avor , Ghassan Qabaja , Xiao-Chuan Guo , Suparna Gupta , David R. Jones , Xin Chen
发明人： Adnan M. M. Mjalli , Robert C. Andrews , Ramesh Gopalaswamy , Anitha Hari , Kwasi A. Avor , Ghassan Qabaja , Xiao-Chuan Guo , Suparna Gupta , David R. Jones , Xin Chen
IPC分类号： A61K31/4164 , A61K31/4178 , C07D233/64 , C07D403/02
CPC分类号： C07D233/64 , C07D235/08 , C07D235/12 , C07D235/14 , C07D235/18 , C07D235/30 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/04 , C07D405/12 , C07D413/12 , C07D453/02
摘要： This invention provides certain compounds, methods of their preparation, pharmaceutical compositions comprising the compounds, and their use in treating human or animal disorders. The compounds of the invention are useful as modulators of the interaction between the receptor for advanced glycated end products (RAGE) and its ligands, such as advanced glycated end products (AGEs), S100/calgranulin/EN-RAGE, β-amyloid and amphoterin, and for the management, treatment, control, or as an adjunct treatment for diseases in humans caused by RAGE. Such diseases or disease states include acute and chronic inflammation, the development of diabetic late complications such as increased vascular permeability, nephropathy, atherosclerosis, and retinopathy, the development of Alzheimer's disease, erectile dysfunction, and tumor invasion and metastasis.

30. 发明授权

US07361678B2 Azole derivatives and fused bicyclic azole derivatives as therapeutic agents 有权
标题翻译：唑衍生物和稠合双环唑衍生物作为治疗剂
公开(公告)号：US07361678B2
公开(公告)日：2008-04-22
申请号：US10382203
申请日：2003-03-05
申请人： Adnan M. M. Mjalli , Robert C. Andrews , Ramesh Gopalaswamy , Anitha Hari , Kwasi S. Avor , Ghassan Qabaja , Xiao-Chuan Guo , Suparna Gupta , David R. Jones , Xin Chen
发明人： Adnan M. M. Mjalli , Robert C. Andrews , Ramesh Gopalaswamy , Anitha Hari , Kwasi S. Avor , Ghassan Qabaja , Xiao-Chuan Guo , Suparna Gupta , David R. Jones , Xin Chen
IPC分类号： A61K31/4164 , A61K31/4178 , C07D233/64 , C07D403/02
CPC分类号： C07D233/64 , C07D235/08 , C07D235/12 , C07D235/14 , C07D235/18 , C07D235/30 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/04 , C07D405/12 , C07D413/12 , C07D453/02
摘要： This invention provides certain compounds, methods of their preparation, pharmaceutical compositions comprising the compounds, and their use in treating human or animal disorders. The compounds of the invention are useful as modulators of the interaction between the receptor for advanced glycated end products (RAGE) and its ligands, such as advanced glycated end products (AGEs), S100/calgranulin/EN-RAGE, β-amyloid and amphoterin, and for the management, treatment, control, or as an adjunct treatment for diseases in humans caused by RAGE. Such diseases or disease states include acute and chronic inflammation, the development of diabetic late complications such as increased vascular permeability, nephropathy, atherosclerosis, and retinopathy, the development of Alzheimer's disease, erectile dysfunction, and tumor invasion and metastasis.
摘要翻译：本发明提供某些化合物，其制备方法，包含该化合物的药物组合物及其在治疗人或动物疾病中的用途。本发明的化合物可用作晚期糖基化终产物（RAGE）的受体与其配体如晚期糖基化终产物（AGE），S100 /钙粒蛋白/ EN-RAGE，β-淀粉样蛋白和两性蛋白之间相互作用的调节剂，以及由RAGE引起的人类疾病的管理，治疗，控制或辅助治疗。这些疾病或疾病状态包括急性和慢性炎症，糖尿病晚期并发症的发展，例如血管通透性增加，肾病，动脉粥样硬化和视网膜病变，阿尔茨海默病的发展，勃起功能障碍和肿瘤侵袭和转移。

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