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21. 发明申请

US20140044646A1 Labeled, Non-Peptidic, Multivalent Integrin Antagonist Compounds; Methods for Synthesis and Uses Thereof 有权
标题翻译：标记，非肽，多价整合素拮抗剂化合物; 其合成方法及用途
公开(公告)号：US20140044646A1
公开(公告)日：2014-02-13
申请号：US13952576
申请日：2013-07-26
申请人： The Methodist Hospital Research Institute
发明人： King Chuen Li , Zheng Li , Feng Li
IPC分类号： A61K49/00 , A61K9/127 , A61K9/51 , A61K31/505 , A61K31/506
CPC分类号： A61K49/0021 , A61K9/127 , A61K9/51 , A61K31/505 , A61K31/506 , A61K45/06 , A61K47/55 , A61K47/60 , A61K49/0052 , A61K51/0459 , C07D239/14 , C07D403/14
摘要： Disclosed are multivalent, integrin-receptor antagonists that are useful in a variety of therapeutic, prophylactic, and/or diagnostic imaging modalities. In illustrative embodiments, such compounds have been prepared and utilized in the imaging, detection, localization, and/or quantitation of one or more samples of biological interest. Similarly, these compounds, as well as formulations comprising them, find utility in the prevention, treatment, and/or amelioration of one or more symptoms of a disease, abnormal condition, dysfunction, etc., including, for example proliferative diseases such as cancer in affected animals. In certain embodiments, fluorescently- or radio-labeled-non-peptidic, multivalent integrin αvβ3 compounds are provided. Compositions including such compounds have been shown to have utility in detecting, localizing, quantitating, and/or imaging integrin αvβ3 receptor-expressing cells, including, for example, cancer cells in vitro, in vivo, and/or in situ.
摘要翻译：公开了可用于各种治疗，预防和/或诊断成像模式的多价整联蛋白 - 受体拮抗剂。在说明性实施方案中，已经制备并利用这些化合物在一种或多种生物学兴趣的样品的成像，检测，定位和/或定量中。类似地，这些化合物以及包含它们的制剂可用于预防，治疗和/或改善疾病，异常状况，功能障碍等的一种或多种症状，包括例如增殖性疾病如癌症在受影响的动物。在某些实施方案中，提供了荧光或放射性标记的非肽，多价整联蛋白α噬菌体3化合物。已经显示包含这些化合物的组合物可用于在体外，体内和/或原位检测，定位，定量和/或整合整联蛋白α1表达受体的细胞，包括例如癌细胞。

22. 发明申请

US20130293362A1 MULTI-DEGREES-OF-FREEDOM HAND CONTROLLER 审中-公开
标题翻译：多自由手控制器
公开(公告)号：US20130293362A1
公开(公告)日：2013-11-07
申请号：US13797184
申请日：2013-03-12
申请人： THE METHODIST HOSPITAL RESEARCH INSTITUTE
发明人： Scott Edward Parazynski
IPC分类号： G08C19/16
CPC分类号： G06F3/0346 , A61B5/7475 , A61B34/30 , A61B34/37 , A61B34/74 , A61B2560/0487 , G05B2219/45123 , G06F3/0338 , G08C19/16
摘要： Disclosed is a controller including a first control member, a second control member that extends from a portion of the first control member, and a controller processor that is operable to produce a rotational movement output signal in response to movement of the first control member, and a translational movement output signal in response to movement of the second control member relative to the first control member. The rotational movement output signal may be any of a pitch movement output signal, a yaw movement output signal, and a roll movement output signal, and the translational movement output signal may be any of an x-axis movement output signal, a y-axis movement output signal, and a z-axis movement output signal. In exemplary embodiments, the first control member may be gripped and moved using a single hand, and the second control member may be moved using one or more digits of the single hand, thus permitting highly intuitive, single-handed control of multiple degrees of freedom, to and including, all six degrees of rotational and translational freedom without any inadvertent cross-coupling inputs.
摘要翻译：公开了一种控制器，包括第一控制构件，从第一控制构件的一部分延伸的第二控制构件，以及可操作以响应于第一控制构件的移动产生旋转运动输出信号的控制器处理器，以及响应于第二控制构件相对于第一控制构件的移动的平移运动输出信号。旋转运动输出信号可以是音调移动输出信号，偏航运动输出信号和滚动移动输出信号中的任何一个，并且平移运动输出信号可以是x轴移动输出信号，y轴移动输出信号和z轴移动输出信号。在示例性实施例中，可以使用单手抓握和移动第一控制构件，并且可以使用单手的一个或多个数字来移动第二控制构件，从而允许对多个自由度的高度直观的单手控制，包括所有六个旋转和平移自由度，而没有任何无意的交叉耦合输入。

23. 发明申请

US20130288215A1 METHODS FOR USING VIRTUAL PATIENT MEDICAL DATA IN EDUCATION, DIAGNOSIS AND TREATMENT 审中-公开
标题翻译：使用虚拟病人医学数据进行教育，诊断和治疗的方法
公开(公告)号：US20130288215A1
公开(公告)日：2013-10-31
申请号：US13804680
申请日：2013-03-14
申请人： The Methodist Hospital Research Institute
发明人： Edward Brian Butler , Craig Peter Fischer
IPC分类号： G09B23/28 , G06F19/00
CPC分类号： G09B23/28 , A61B34/25 , G06F19/321 , G06F19/3481 , G06Q10/10 , G06Q50/22 , G16H10/60 , G16H50/20 , G16H50/50
摘要： Systems, methods and apparatuses for generating and using representations of individual or aggregate human medical data.
摘要翻译：用于生成和使用单个或总体人体医学数据的表示的系统，方法和装置。

24. 发明申请

US20230119855A1 HYDROGEL DEVICES AND METHODS OF MAKING AND USE THEREOF 有权
公开(公告)号：US20230119855A1
公开(公告)日：2023-04-20
申请号：US17873553
申请日：2022-07-26
申请人： The Methodist Hospital System
发明人： Aldona Jedrysiak Spiegel
IPC分类号： A61L27/52 , A61L27/38 , A61L27/54
摘要： Disclosed herein are hydrogel devices and methods of making an use thereof. The devices can comprise: a continuous hydrogel matrix; a first chamber in the hydrogel matrix; and a second chamber in the hydrogel matrix; wherein the first chamber and the second chamber are each independently perfusable; wherein the first chamber is fluidly independent from the second chamber; wherein the first chamber is configured to be at least partially filled with adipose tissue; wherein the second chamber is configured to be at least partially filled with an oxygenated fluid; wherein the first chamber is defined by a first border; wherein the second chamber is defined by a second border; and wherein the first chamber and the second chamber are spaced apart from each other by an average distance of from 50 micrometers (microns, μm) to 800 μm as measured from the first border to the second border.

25. 发明申请

US20230047159A1 REGULATORY T CELL (TREG) COMPOSITIONS AND METHODS FOR TREATING NEURODEGENERATIVE DISEASE 有权
公开(公告)号：US20230047159A1
公开(公告)日：2023-02-16
申请号：US17292423
申请日：2020-12-04
申请人： THE METHODIST HOSPITAL
发明人： Stanley Hersh APPEL , Jason Robert THONHOFF , David Robert BEERS , Aaron Drew THOME
IPC分类号： A61K35/17 , C12N5/0783 , A01N1/02 , A61P25/28
摘要： Disclosed are improved methods for manufacturing large-scale populations of robust, highly pure, and functional T regulatory cells (Tregs). Also disclosed are expanded Treg populations, cryopreserved Treg populations and methods and uses of these cells in compositions formulated for treating one or more mammalian diseases, including, for example, treatment, prophylaxis, and/or amelioration of one or more symptoms of a human neurodegenerative disorder. In particular, the compositions and methods provided herein find clinical use in the treatment and amelioration of one or more symptoms of amyotrophic lateral sclerosis (ALS), Alzheimer's disease, and other neurological diseases and disorders.

26. 发明授权

US11523886B2 Systems and methods for computer-aided orthognathic surgical planning 有权
公开(公告)号：US11523886B2
公开(公告)日：2022-12-13
申请号：US16326458
申请日：2017-08-21
申请人： THE METHODIST HOSPITAL SYSTEM
发明人： James Jiong Xia , Jaime Gateno , Peng Yuan
IPC分类号： A61C13/00 , A61B34/10 , A61B34/20 , G06T7/00
摘要： Systems and methods for orthognathic surgical planning are described herein. An example computer-implemented method can include generating a composite three-dimensional (3D) model of a subject's skull, defining a global reference frame for the composite 3D model, performing a cephalometric analysis on the composite 3D model to quantify at least one geometric property of the subject's skull, performing a virtual osteotomy to separate the composite 3D model into a plurality of segments, performing a surgical simulation using the osteotomized segments, and designing a surgical splint or template for the subject.

27. 发明申请

US20210402199A1 METHOD AND APPARATUS FOR ONCOMAGNETIC TREATMENT 有权
公开(公告)号：US20210402199A1
公开(公告)日：2021-12-30
申请号：US17293461
申请日：2019-11-13
申请人： THE METHODIST HOSPITAL
发明人： Santosh Anand Helekar , David Stuart Baskin , Martyn Alun Sharpe , Kumar Pichumani
IPC分类号： A61N2/00 , A61K31/19 , A61K31/20 , A61N2/12
摘要： To disrupt mitochondrial function in certain cells, controlling hardware causes a magnet to oscillate so as to generate an oscillating magnetic field. The oscillating magnetic field is applied to a volume of tissue including cells with degraded mitochondria to trigger apoptosis in the cells with degraded mitochondria.

28. 发明申请

US20210383910A1 SYSTEM AND METHOD FOR AUTOMATICALLY AND CONTINUOUSLY MONITORING MEDICATION DELIVERY TO A PATIENT 有权
公开(公告)号：US20210383910A1
公开(公告)日：2021-12-09
申请号：US17290823
申请日：2019-10-31
申请人： The Methodist Hospital
发明人： Brian PARRISH
IPC分类号： G16H20/13 , G16H10/60 , G16H70/40
摘要： A system for automatically monitoring the delivery of medication to a patient, the system comprising: an electronic medical record containing information regarding the medical condition of the patient; a prescription order identifying a medication to be delivered to the patient; a database identifying contraindications and warnings for specific medications; a rules engine for determining the appropriateness of a medication vis-a-vis a medical condition of a patient; and a central processing unit (CPU) configured to (i) provide the prescription order and the electronic medical record of the patient to the rules engine, (ii) receive a determination from the rules engine regarding the appropriateness of the prescription order vis-a-vis the medical condition of the patient, and (iii) mark the electronic medical record with an indication regarding the appropriateness of the prescription order vis-a-vis the medical condition of the patient.

29. 发明申请

US20210380683A1 MODULATION OF IRF-4 AND USES THEREOF 有权
公开(公告)号：US20210380683A1
公开(公告)日：2021-12-09
申请号：US17046843
申请日：2019-04-12
申请人： THE METHODIST HOSPITAL SYSTEM
发明人： Wenhao CHEN , Xian Chang LI
IPC分类号： C07K16/28 , A61K35/17 , A61P37/06
摘要： Disclosed are methods and compositions for inhibiting IRF4 in T-cells, thereby improving transplant outcomes or treating an autoimmune disease such as a myelination disorder. Thus, disclosed are methods to improve a transplant outcome in a recipient of a transplant comprising inhibiting IRF4 in T-cells of the recipient, thereby improving the transplant outcome. In some embodiments, IRF4 can be inhibited by administering an IRF4 inhibitor (e.g., trametinib or anti-IRF4 siRNA), and/or by adoptive transfer of T-cells having IRF4 inhibition. In some embodiments, the T-cells are CD4+ Tcells, and the infiltration thereof into a transplant can be reduced. Also disclosed are methods of treating a subject with a myelination disorder (e.g., multiple sclerosis or encephalomyelitis) comprising inhibiting IRF4.

30. 发明申请

US20210361167A1 SIGNAL ISOLATION MAGNETIC RESONANCE IMAGE (SIMRI) AND METHODS THEREOF 有权
公开(公告)号：US20210361167A1
公开(公告)日：2021-11-25
申请号：US17277034
申请日：2019-09-17
申请人： Tatiana WOLFE , Caio C. QUINI , Philip J. HORNER , Matthew K. K. HOGAN , THE METHODIST HOSPITAL SYSTEM
发明人： Tatiana WOLFE , Caio C. QUINI , Philip J. HORNER , Matthew K. HOGAN
IPC分类号： A61B5/00 , A61B5/055 , G01R33/50 , G01R33/56 , G01R33/563 , G16H30/20 , G16H30/40
摘要： The exemplified system and method facilitate an objective, non-invasive measurement of myelin quality and integrity in living brains based on isolation of myelin-specific magnetic relaxation constants in k-space. The system uses magnetic resonance (MR) signals to select signatures specific to, or associated with, myelin and its structure and to then encode the selected signatures into an image or model to which the quantitative myelin health information can be co-registered with 2D, 3D visualization, and tractography of the myelin-signal isolated MR information. The system also sets a model for digital hierarchical learning of biomedical signals in MR, and beyond, based on experimental data in which it executes the herein described signal isolation operations.

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