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21. 发明授权

US4316898A Cephalosporins 失效
标题翻译：头孢菌素
公开(公告)号：US4316898A
公开(公告)日：1982-02-23
申请号：US151694
申请日：1980-05-20
申请人： Bernd Wetzel , Eberhard Waitun , Roland Maier , Wolfgang Rueter , Uwe Lechner , Hans Goeth
发明人： Bernd Wetzel , Eberhard Waitun , Roland Maier , Wolfgang Rueter , Uwe Lechner , Hans Goeth
IPC分类号： A61K31/545 , A61K31/546 , A61P31/04 , C07D239/46 , C07D501/20 , C07D501/36 , C07D501/57
CPC分类号： C07D239/47 , Y02P20/55
摘要： Cephalosporins of the formula ##STR1## wherein A is phenyl, 4-hydroxyphenyl, cyclohexyl, cyclohexene-1-yl, cyclohexa-1,4-diene-1-yl, 2-thienyl, 3-thienyl, 2-furyl, 3-furyl or 3,4-disubstituted phenyl, where the substituents, which may be identical to or different from each other, are each chlorine, hydroxyl or methoxy;Y is hydrogen or methoxy;D is hydrogen, hydroxyl, acetoxy, aminocarbonyloxy, pyridinium, aminocarbonyl-pyridinium or the group S-Het, where Het is 1-methyl-tetrazol-5-yl, tetrazol-5-yl, 3-methyl-1,2,4-thiadiazol-5-yl, 1,2,4-thiadiazol-5-yl, 1,3,4-thiadiazol-5-yl, 2-methyl-1,3,4-thiadiazol-5-yl, 2-methylamino-1,3,4-thiadiazol-5-yl, 2-dimethylamino-1,3,4-thiadiazol-5-yl, 2-formylamino-1,3,4-thiadiazol-5-yl, 2-acetylamino-1,3,4-thiadiazol-5-yl, 2-methyl-1,3,4-oxadiazol-5-yl, 1,2,3-triazol-4-yl or 1,2,4-triazol-3-yl;R is hydrogen, methyl, cyclopropyl, hydroxyl, methoxy, ethoxy, mercapto, morpholino, thiomorpholino, thiomorpholino-S-oxide, thiomorpholino-S,S-dioxide, ##STR2## E is hydrogen or a protective group which is easily removable in vitro or in vivo;and nontoxic, pharmacologically acceptable salts thereof.
摘要翻译：其中A为苯基，4-羟基苯基，环己基，环己烯-1-基，环己-1,4-二烯-1-基，2-噻吩基，3-噻吩基，2-呋喃基，3-甲氧基苯基，呋喃基或3,4-二取代的苯基，其中可以相同或不同的取代基各自为氯，羟基或甲氧基; Y是氢或甲氧基; D是氢，羟基，乙酰氧基，氨基羰基氧基，吡啶鎓，氨基羰基 - 吡啶鎓或S-Het基团，其中Het是1-甲基 - 四唑-5-基，四唑-5-基，3-甲基-1,2,4- 噻二唑-5-基，1,2,4-噻二唑-5-基，1,3,4-噻二唑-5-基，2-甲基-1,3,4-噻二唑-5-基，2-甲基氨基 -1,3,4-噻二唑-5-基，2-二甲基氨基-1,3,4-噻二唑-5-基，2-甲酰氨基-1,3,4-噻二唑-5-基，2-乙酰基氨基-1 ，3,4-噻二唑-5-基，2-甲基-1,3,4-恶二唑-5-基，1,2,3-三唑-4-基或1,2,4-三唑-3-基 ; R是氢，甲基，环丙基，羟基，甲氧基，乙氧基，巯基，吗啉代，硫代吗啉代，硫代吗啉代-S-氧化物，硫代吗啉代-S，S-二氧化物，E是氢或保护基，体外或体内可去除; 和无毒的药学上可接受的盐。

22. 发明授权

US4250765A Force transmitting arrangement 失效
标题翻译：力传动装置
公开(公告)号：US4250765A
公开(公告)日：1981-02-17
申请号：US4019
申请日：1979-01-17
申请人： Bernd Niklaus , Manfred Braun , Roland Maier
发明人： Bernd Niklaus , Manfred Braun , Roland Maier
IPC分类号： B62D5/02 , B62D5/04 , F16D13/08 , F16H35/00
CPC分类号： B62D5/0439 , B62D5/0403 , F16D13/08
摘要： A force transmitting arrangement, useable as force amplifier of drive arrangements, transmits the moment of a reversible electric motor, acting as a servo motor or as a drive motor, over a friction core and a looped spring cooperating therewith to an output shaft. The looped spring has a pair of outwardly bent ends, which at the outer sides thereof drive, while taking up a tension force, an output entrainment member connected to the output shaft, whereas an input entrainment member connected with a manually operated drive, for instance the steering wheel of a motor vehicle, is located between the outwardly bent ends of the looped spring.
摘要翻译：可用作驱动装置的力放大器的力传递装置将作为伺服电动机或作为驱动电动机的可逆电动机的力矩传递到摩擦芯和与其配合的环形弹簧到输出轴。环形弹簧具有一对向外弯曲的端部，其在其外侧驱动时同时承受张力，输出夹带构件连接到输出轴，而输入夹带构件与手动操作的驱动器连接，例如机动车辆的方向盘位于环形弹簧的向外弯曲的端部之间。

23. 发明授权

US4048306A Aldehyde-erythromycylamine condensation products 失效
标题翻译：醛 - 红霉素缩合产物
公开(公告)号：US4048306A
公开(公告)日：1977-09-13
申请号：US671421
申请日：1976-03-29
申请人： Roland Maier , Eberhard Woitun , Bernd Wetzel , Wolfgang Reuter , Hanns Goeth , Uwe Lechner
发明人： Roland Maier , Eberhard Woitun , Bernd Wetzel , Wolfgang Reuter , Hanns Goeth , Uwe Lechner
IPC分类号： A61K31/70 , A61K31/7042 , A61K31/7048 , A61P31/04 , C07D295/145 , C07F9/6558 , C07F9/6561 , C07H17/08
CPC分类号： C07D295/145 , C07F9/65586 , C07F9/6561 , C07H17/08
摘要： The invention relates to novel erythromycin derivatives, and non-toxic, pharmacologically acceptable acid addition salts thereof. The compounds as well as the salts are useful as antibacterials.
摘要翻译：本发明涉及新型的红霉素衍生物及其无毒的药学上可接受的酸加成盐。化合物以及盐可用作抗细菌剂。

24. 发明申请

US20140128604A1 8-[3-AMINO-PIPERIDIN-1-YL]-XANTHINES, THE PREPARATION THEREOF AND THEIR USE AS PHARMACEUTICAL COMPOSITIONS 有权
标题翻译： 8- [3-氨基 - 哌啶-1-基] - 辛糖，其制备方法及其作为药物组合物的用途
公开(公告)号：US20140128604A1
公开(公告)日：2014-05-08
申请号：US14154885
申请日：2014-01-14
申请人： Frank HIMMELSBACH , Elke LANGKOPF , Matthias ECKHARDT , Michael MARK , Roland MAIER , Ralf LOTZ , Mohammad TADAYYON
发明人： Frank HIMMELSBACH , Elke LANGKOPF , Matthias ECKHARDT , Michael MARK , Roland MAIER , Ralf LOTZ , Mohammad TADAYYON
IPC分类号： C07D473/04
CPC分类号： C07D473/04 , C07D473/06 , C07D473/08 , C07D519/00
摘要： The present invention relates to substituted xanthines of general formula wherein R1 to R3 are as defined herein, the tautomers, the stereoisomers, the mixtures, the prodrugs thereof and the salts thereof which have valuable pharmacological properties, particularly an inhibiting effect on the activity of the enzyme dipeptidylpeptidase-IV (DPP-IV).
摘要翻译：本发明涉及通式为其中R1至R3如本文所定义的取代黄嘌呤，其互变异构体，立体异构体，混合物，其前药及其盐具有有价值的药理学性质，特别是对酶二肽肽酶-IV（DPP-IV）。

25. 发明申请

US20130165428A1 XANTHINE DERIVATIVES, THE PREPARATION THEREOF AND THEIR USE AS PHARMACEUTICAL COMPOSITIONS 审中-公开
标题翻译： XANTHINE衍生物，其制备方法及其作为药物组合物的用途
公开(公告)号：US20130165428A1
公开(公告)日：2013-06-27
申请号：US13772786
申请日：2013-02-21
申请人： Frank HIMMELSBACH , Michael MARK , Matthias ECKHARDT , Elke LANGKOPF , Roland MAIER , Ralf R.H. LOTZ
发明人： Frank HIMMELSBACH , Michael MARK , Matthias ECKHARDT , Elke LANGKOPF , Roland MAIER , Ralf R.H. LOTZ
IPC分类号： C07D473/06 , C07D473/08
CPC分类号： C07D473/08 , C07D473/04 , C07D473/06 , C07D473/10 , C07D473/12
摘要： The present invention relates to substituted xanthines of general formula wherein R1 to R4 are defined as in claim 1, the tautomers and the stereoisomers thereof, mixtures thereof, the prodrugs and the salts thereof which have valuable pharmacological properties, particularly an inhibiting effect on the activity of the enzyme dipeptidylpeptidase-IV (DPP-IV).
摘要翻译：本发明涉及通式的取代黄嘌呤：其中R 1至R 4如权利要求1所定义，其互变异构体及其立体异构体，其混合物，其前体药物及其盐具有有价值的药理学性质，特别是对活性的抑制作用的二肽基肽酶-IV（DPP-IV）。

26. 发明申请

US20120252782A1 Xanthine Derivatives, the Preparation Thereof and Their Use as Pharmaceutical Compositions 审中-公开
公开(公告)号：US20120252782A1
公开(公告)日：2012-10-04
申请号：US13523938
申请日：2012-06-15
申请人： Frank HIMMELSBACH , Michael MARK , Matthias ECKHARDT , Elke LANGKOPF , Roland MAIER , Ralf R.H. LOTZ
发明人： Frank HIMMELSBACH , Michael MARK , Matthias ECKHARDT , Elke LANGKOPF , Roland MAIER , Ralf R.H. LOTZ
IPC分类号： A61K31/522 , A61K31/55 , C07D473/06 , A61K31/5377 , A61P3/10 , A61P3/00 , A61P3/08 , A61P3/06 , A61P19/02 , A61P9/10 , A61P3/04 , A61P37/06 , A61P19/10 , A61K31/538 , C07D473/08
CPC分类号： C07D473/08 , C07D473/04 , C07D473/06 , C07D473/10 , C07D473/12
摘要： The present invention relates to substituted xanthines of general formula wherein R1 to R4 are defined as in claim 1, the tautomers and the stereoisomers thereof, mixtures thereof, the prodrugs and the salts thereof which have valuable pharmacological properties, particularly an inhibiting effect on the activity of the enzyme dipeptidylpeptidase-IV (DPP-IV).

27. 发明授权

US08178541B2 8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions 有权
标题翻译： 8- [3-氨基 - 哌啶-1-基] - 黄嘌呤，其制备及其作为药物组合物的用途
公开(公告)号：US08178541B2
公开(公告)日：2012-05-15
申请号：US12143128
申请日：2008-06-20
申请人： Frank Himmelsbach , Elke Langkopf , Matthias Eckhardt , Michael Mark , Roland Maier , Ralf Lotz , Mohammad Tadayyon
发明人： Frank Himmelsbach , Elke Langkopf , Matthias Eckhardt , Michael Mark , Roland Maier , Ralf Lotz , Mohammad Tadayyon
IPC分类号： A61K31/522 , A61P3/10 , A61P3/04 , C07D473/06 , C07D519/00 , A61P19/02
CPC分类号： C07D473/04 , C07D473/06 , C07D473/08 , C07D519/00
摘要： The present invention relates to substituted xanthines of general formula wherein R1 to R3 are as defined herein, the tautomers, the stereoisomers, the mixtures, the prodrugs thereof and the salts thereof which have valuable pharmacological properties, particularly an inhibiting effect on the activity of the enzyme dipeptidylpeptidase-IV (DPP-IV).
摘要翻译：本发明涉及通式为其中R1至R3如本文所定义的取代黄嘌呤，其互变异构体，立体异构体，混合物，其前药及其盐具有有价值的药理学性质，特别是对酶二肽肽酶-IV（DPP-IV）。

28. 发明申请

US20110144083A1 Xanthine Derivatives, the Preparation Thereof and Their Use as Pharmaceutical Compositions 审中-公开
标题翻译：黄嘌呤衍生物，其制备及其作为药物组合物的用途
公开(公告)号：US20110144083A1
公开(公告)日：2011-06-16
申请号：US13032686
申请日：2011-02-23
申请人： Frank HIMMELSBACH , Michael MARK , Matthias ECKHARDT , Elke LANGKOPF , Roland MAIER , Ralf R. H. LOTZ
发明人： Frank HIMMELSBACH , Michael MARK , Matthias ECKHARDT , Elke LANGKOPF , Roland MAIER , Ralf R. H. LOTZ
IPC分类号： A61K31/551 , C07D473/08 , A61K31/522 , A61P3/10 , A61P3/04 , A61P5/50 , A61P3/06 , A61P19/02 , A61P19/10 , A61P37/06 , A61K31/5355
CPC分类号： C07D473/08 , C07D473/04 , C07D473/06 , C07D473/10 , C07D473/12
摘要： The present invention relates to substituted xanthines of general formula wherein R1 to R4 are defined as in claim 1, the tautomers and the stereoisomers thereof, mixtures thereof, the prodrugs and the salts thereof which have valuable pharmacological properties, particularly an inhibiting effect on the activity of the enzyme dipeptidylpeptidase-IV (DPP-IV).
摘要翻译：本发明涉及通式的取代黄嘌呤：其中R 1至R 4如权利要求1所定义，其互变异构体及其立体异构体，其混合物，其前体药物及其盐具有有价值的药理学性质，特别是对活性的抑制作用的二肽基肽酶-IV（DPP-IV）。

29. 发明授权

US07696212B2 Xanthine derivatives, the preparation thereof and their use as pharmaceutical compositions 有权
标题翻译：黄嘌呤衍生物，其制备及其作为药物组合物的用途
公开(公告)号：US07696212B2
公开(公告)日：2010-04-13
申请号：US12331720
申请日：2008-12-10
申请人： Frank Himmelsbach , Elke Langkopf , Matthias Eckhardt , Roland Maier , Ralf Lotz , Michael Mark , Mohammad Tadayyon
发明人： Frank Himmelsbach , Elke Langkopf , Matthias Eckhardt , Roland Maier , Ralf Lotz , Michael Mark , Mohammad Tadayyon
IPC分类号： C07D473/06 , C07D519/00 , A61K31/522 , A61K31/538 , A61K31/536 , A61K31/5415 , A61K31/5513 , A61P3/10 , A61P3/04
CPC分类号： C07D473/06
摘要： Disclosed are substituted xanthines of general formula wherein R1 to R4 are defined hereinbelow, the tautomers, the stereoisomers, the mixtures thereof, the prodrugs thereof and the salts thereof, which have valuable pharmacological properties, particularly an inhibitory effect on the activity of the enzyme dipeptidylpeptidase-IV (DPP-IV).
摘要翻译：公开了以下通式的取代黄嘌呤：其中R1至R4定义如下，其互变异构体，立体异构体，其混合物，其前体药物及其盐具有有价值的药理学性质，特别是对酶二肽基肽酶的活性的抑制作用 -IV（DPP-IV）。

30. 发明授权

US07569574B2 Purine derivatives, the preparation thereof and their use as pharmaceutical compositions 有权
标题翻译：嘌呤衍生物，其制备及其作为药物组合物的用途
公开(公告)号：US07569574B2
公开(公告)日：2009-08-04
申请号：US10634047
申请日：2003-08-04
申请人： Roland Maier , Frank Himmelsbach , Matthias Eckhardt , Elke Langkopf , Michael Mark , Ralf R. H. Lotz
发明人： Roland Maier , Frank Himmelsbach , Matthias Eckhardt , Elke Langkopf , Michael Mark , Ralf R. H. Lotz
IPC分类号： C07D473/30 , C07D473/18 , C07D473/04 , C07D473/06 , A61K31/522 , A61P3/10 , A61P3/04
CPC分类号： C07D473/30
摘要： The invention relates to new purine derivatives of general formula wherein R1 to R4 are defined as in the claims, the tautomers, the stereoisomers, the mixtures, the prodrugs thereof and the salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases which have valuable pharmacological properties, particularly an inhibiting effect on the activity of the enzyme dipeptidylpeptidase-IV (DPP-IV), the preparation thereof, the use thereof for the prevention or treatment of diseases or conditions associated with an increased DPP-IV activity or capable of being prevented or alleviated by reducing the DPP-IV activity, particularly type I or type II diabetes mellitus, the pharmaceutical compositions containing a compound of general formula (I) or a physiologically acceptable salt thereof as well as processes for the preparation thereof.
摘要翻译：本发明涉及通式的新嘌呤衍生物，其中R 1至R 4如权利要求中所定义，互变异构体，立体异构体，混合物，其前药及其盐，特别是其与无机或有机酸的生理学上可接受的盐或具有有价值的药理学性质的碱基，特别是对二肽基肽酶-IV（DPP-IV）的活性的抑制作用，其制备方法，其用于预防或治疗与增加的DPP-IV活性有关的疾病或病症的用途或能够通过减少DPP-IV活性（特别是I型或II型糖尿病）来预防或缓解含有通式（I）化合物或其生理学上可接受的盐的药物组合物及其制备方法。

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