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21. 发明申请

US20050277761A1 POTASSIUM CHANNEL INTERACTORS POLYPEPTIDES AND USES THEREOF 有权
标题翻译：钾通道相互作用聚合物及其用途
公开(公告)号：US20050277761A1
公开(公告)日：2005-12-15
申请号：US10118590
申请日：2002-04-08
申请人： Kenneth Rhodes , Maria Betty , Huai-Ping Ling , Wenqian An
发明人： Kenneth Rhodes , Maria Betty , Huai-Ping Ling , Wenqian An
IPC分类号： A61K38/00 , C07K14/47 , C12N15/12 , C07H21/04 , C07K14/705
CPC分类号： C07K14/47 , A61K38/00
摘要： The invention provides isolated nucleic acids molecules, designated PCIP nucleic acid molecules, which encode proteins that bind potassium channels and modulate potassium channel mediated activities. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing PCIP nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a PCIP gene has been introduced or disrupted. The invention still further provides isolated PCIP proteins, fusion proteins, antigenic peptides and anti-PCIP antibodies. Diagnostic methods utilizing compositions of the invention are also provided.
摘要翻译：本发明提供分离的核酸分子，指定的PCIP核酸分子，其编码结合钾通道的蛋白质并调节钾通道介导的活性。本发明还提供了反义核酸分子，含有PCIP核酸分子的重组表达载体，已经引入了表达载体的宿主细胞，以及其中引入或破坏了PCIP基因的非人转基因动物。本发明还进一步提供了分离的PCIP蛋白，融合蛋白，抗原肽和抗PCIP抗体。还提供了利用本发明组合物的诊断方法。

22. 发明授权

US5650492A P-40 homodimer of interleukin-12 失效
标题翻译：白细胞介素-12的P-40同型二聚体
公开(公告)号：US5650492A
公开(公告)日：1997-07-22
申请号：US424682
申请日：1995-04-18
申请人： Maurice Kent Gately , John Hakimi , Ping Ling
发明人： Maurice Kent Gately , John Hakimi , Ping Ling
IPC分类号： A61K38/00 , A61K38/19 , A61K38/20 , A61P3/08 , A61P9/00 , A61P29/00 , A61P37/06 , A61P43/00 , C07K1/22 , C07K14/52 , C07K14/54 , C07K19/00 , C12N5/10 , C12N15/00 , C12N15/09 , C12N15/24 , C12P21/02
CPC分类号： C07K14/5434 , A61K38/00 , Y10S930/141
摘要： Analysis of the culture media of p40-transfected COS cells indicated the presence of 40 kDa monomers and 80 kDa disulfide-linked homodimers. Examination of partially purified p40 recombinant proteins demonstrated that only the homodimer but not the monomer binds to the IL-12 receptor. Partially purified 80 kDa homodimer inhibited [.sup.125 I]IL-12 binding to PHA-activated human lymphoblasts with an IC.sub.50 of 80 ng/ml, which is similar to the IC.sub.50 value (20 ng/ml) for the human IL-12 heterodimer. Although neither the 40 kDa monomer nor the 80 kDa dimer could stimulate human PHA-blast proliferation, the 80 kDa dimer inhibited IL-12-induced proliferation in a dose-dependent manner with an IC.sub.50 of 1 .mu.g/ml. The IL-12 p40 subunit contains the essential epitopes for receptor binding, but they are only active when p40 is covalently associated with a second protein such as p35 or p40. When p40 is associated with the p35 subunit, the heterodimer acts as an agonist mediating biologic activity. When p40 associates with itself, the homodimer behaves as an antagonist.
摘要翻译： p40转染的COS细胞的培养基的分析表明存在40kDa的单体和80kDa的二硫键连接的同型二聚体。部分纯化的p40重组蛋白的检查证明只有同源二聚体而不是单体与IL-12受体结合。部分纯化的80kDa同源二聚体抑制[125 I] IL-12与PHA激活的人类淋巴母细胞结合，IC 50为80ng / ml，其与人IL-12异源二聚体的IC 50值（20ng / ml）相似。尽管40kDa单体和80kDa二聚体都不能刺激人类PHA-blast增殖，但是80kDa二聚体以IC50为1μg/ ml以剂量依赖的方式抑制IL-12诱导的增殖。 IL-12 p40亚基含有受体结合的必需表位，但是当p40与第二种蛋白如p35或p40共价结合时，它们仅具有活性。当p40与p35亚基相关时，异源二聚体起介导生物活性的作用。当p40与其自身相关时，同型二聚体表现为拮抗剂。

23. 外观设计

USD365243S Display framework for cd boxes 失效
公开(公告)号：USD365243S
公开(公告)日：1995-12-19
申请号：US30146
申请日：1994-11-08
申请人： Ping-Ling Kwa
设计人： Ping-Ling Kwa

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