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21. 发明授权

US07083860B2 Metallic honeycomb body having at least partially perforated sheet-metal layers 有权
标题翻译：具有至少部分穿孔的金属片层的金属蜂窝体
公开(公告)号：US07083860B2
公开(公告)日：2006-08-01
申请号：US11058991
申请日：2005-02-16
申请人： Wolfgang Maus , Rolf Brück , Peter Hirth
发明人： Wolfgang Maus , Rolf Brück , Peter Hirth
IPC分类号： F01N3/28 , B01J35/04 , B32B3/24 , B32B3/28
CPC分类号： B01J35/04 , F01N3/281 , F01N3/2821 , F01N13/008 , F01N2330/04 , F01N2330/38 , Y10T428/1234 , Y10T428/12361
摘要： A metallic honeycomb body has an axial length, a partial volume covering at least 55% of the axial length, a radial dimension of at least 20 mm, an inflow end side and an outflow end side. The honeycomb body includes sheet-metal layers structured to permit a fluid to flow through the honeycomb body in a flow direction from the inflow end side to the outflow end side. The sheet-metal layers each have a surface area, partial regions and edges at the end sides. Each of the sheet-metal layers have a multiplicity of holes formed at least in the partial regions in the partial volume. Each of the holes have a hole surface area of between 1 and 120 mm2. The sheet-metal layer surface area in the partial volume is reduced by 10 to 80% by the holes as compared to a sheet-metal layer without holes. The partial volume is disposed at a distance from each of the end sides, preventing the holes from touching and from cutting through the edges of the end sides of the sheet-metal layers.
摘要翻译：金属蜂窝体具有轴向长度，部分体积覆盖轴向长度的至少55％，径向尺寸至少为20mm，流入端侧和流出端侧。蜂窝体包括被构造成允许流体在从流入端侧到流出端侧的流动方向上流过蜂窝体的片状金属层。片状金属层各自具有表面积，端部的部分区域和边缘。每个片金属层具有至少在部分体积的部分区域中形成的多个孔。每个孔的孔表面积为1至120mm 2。与没有孔的片金属层相比，通过孔将部分体积的片金属层表面积减少10〜80％。部分容积设置在与每个端面相距一定距离处，防止孔接触和切割穿过金属片层的端侧的边缘。

22. 发明授权

US06908930B2 4-substituted 7-AZA-indolin-2-ones and their use as protein kinase inhibitors 失效
标题翻译： 4-取代的7-AZA-二氢吲哚-2-酮及其作为蛋白激酶抑制剂的用途
公开(公告)号：US06908930B2
公开(公告)日：2005-06-21
申请号：US10622787
申请日：2003-07-21
申请人： Congxin Liang , Li Sun , Chung Chen Wei , Peng Cho Tang , Gerald McMahon , Klaus Peter Hirth , Jingrong Cui
发明人： Congxin Liang , Li Sun , Chung Chen Wei , Peng Cho Tang , Gerald McMahon , Klaus Peter Hirth , Jingrong Cui
IPC分类号： A61K31/437 , A61K31/519 , A61K31/5377 , A61P1/00 , A61P1/18 , A61P3/00 , A61P5/00 , A61P9/00 , A61P11/00 , A61P11/06 , A61P13/00 , A61P15/00 , A61P19/00 , A61P25/00 , A61P35/00 , A61P37/08 , A61P43/00 , C07D471/04 , C07D487/04
CPC分类号： C07D471/04 , C07D487/04
摘要： This invention relates to 4-substituted 7-aza-indolin-2-ones and their use as protein kinase inhibitors. Particular 4-substituted 7-aza-indolin-2-ones disclosed herein are of Formula 1 and pharmaceutically acceptable salts, solvates, clathrates, and prodrugs thereof, wherein R1, R2, R3, R4, X, Y, and Z are defined herein. The invention further relates to pharmaceutical compositions and dosage forms comprising compounds of Formula 1 and to methods of their use for the treatment and/or prevention of diseases such as, but not limited to, cancer.
摘要翻译：本发明涉及4-取代的7-氮杂 - 二氢吲哚-2-酮及其作为蛋白激酶抑制剂的用途。本文公开的特定的4-取代的7-氮杂 - 二氢吲哚-2-酮是式1及其药学上可接受的盐，溶剂合物，包合物和前药，其中R 1，R 2， R 3，R 3，R 4，X，Y和Z在本文中定义。本发明还涉及包含式1化合物的药物组合物和剂型，以及它们用于治疗和/或预防疾病例如但不限于癌症的方法。

23. 发明授权

US06696448B2 3-(piperazinylbenzylidenyl)-2-indolinone compounds and derivatives as protein tyrosine kinase inhibitors 失效
标题翻译： 3-（哌嗪基亚苄基）-2-二氢吲哚酮化合物和衍生物作为蛋白质酪氨酸激酶抑制剂
公开(公告)号：US06696448B2
公开(公告)日：2004-02-24
申请号：US10201593
申请日：2002-07-24
申请人： Peng Cho Tang , Li Sun , Gerald McMahon , Laura Kay Shawver , Klaus Peter Hirth
发明人： Peng Cho Tang , Li Sun , Gerald McMahon , Laura Kay Shawver , Klaus Peter Hirth
IPC分类号： A61K31496
CPC分类号： G06F13/4045
摘要： The present invention relates to novel 3-(piperazinyl-benylidenyl)-2-indolinone compounds and derivatives and physiologically acceptable salts thereof which are expected to modulate the activity of protein tyrosine kinases and therefore to be useful in the prevention and treatment of protein tyrosine kinase related cellular disorders such as cancer.
摘要翻译：本发明涉及新的3-（哌嗪基 - 亚烯基）-2-二氢吲哚酮化合物及其衍生物及其生理上可接受的盐，其预期调节蛋白酪氨酸激酶的活性，因此可用于预防和治疗蛋白质酪氨酸激酶相关的细胞病症如癌症。

24. 发明授权

US06656435B1 Honeycomb body with adsorber material, in particular, for a hydrocarbon trap 有权
标题翻译：具有吸附材料的蜂窝体，特别是用于烃阱
公开(公告)号：US06656435B1
公开(公告)日：2003-12-02
申请号：US09677325
申请日：2000-09-29
申请人： Rolf Brück , Peter Hirth
发明人： Rolf Brück , Peter Hirth
IPC分类号： B01D5372
CPC分类号： B01D53/02 , B01D53/945 , B01D53/9486 , B01D2253/25 , B01D2253/30 , B01D2253/306 , B01D2253/3425 , B01D2257/702 , B01D2258/01 , B01D2259/4516 , B01D2259/4566 , B01J35/0006 , B01J35/04 , F01N3/0807 , F01N3/0835 , F01N13/0097 , Y02A50/2324 , Y02T10/20 , Y02T10/22
摘要： A honeycomb body includes separating walls defining channels for channelling a gas, and an adsorber material disposed on at least part of the separating walls. The inner cross-section and number of channels define a specific geometric surface area (GSA) of the honeycomb body, and they are at least partially separated from one another by separating walls. The material and thickness of the walls define a specific heat capacity with regard to the geometric unit area. The honeycomb body has an adsorption material provided especially for hydrocarbon adsorption. The specific GSA of the body is greater than or equal to 37.5 m K/J, preferably, ≧40, and, particularly, >60, the GSA being divided by the specific heat capacity (cp) with regard to the area, measured at room temperature without absorption material and eventual other coatings. The body can additionally have a catalytically active coating that, at least, is oxidative. The body is preferably constructed of sheet metal layers having a thickness of ≦40 &mgr;m with more than 450 cpsi, especially more than 540 cpsi. A hydrocarbon trap of such dimensions can be used for the purification of motor vehicle exhaust gases to reduce the emission of pollutants during the cold-start phase.
摘要翻译：蜂窝体包括限定用于引导气体的通道的分离壁和设置在分隔壁的至少一部分上的吸附材料。内部横截面和通道数限定了蜂窝体的特定几何表面积（GSA），并且它们通过分隔壁至少部分地彼此分离。壁的材料和厚度相对于几何单位面积确定了比热容。蜂窝体具有特别用于烃吸附的吸附材料。身体的特定GSA大于或等于37.5米K / J，优选≥40，特别是> 60，GSA除以相对于面积的比热容（cp），测量在室温下没有吸收材料和最终的其他涂层。身体还可以具有至少氧化的催化活性涂层。本体优选地由具有大于450cpsi，特别是大于540cpsi的厚度<=40μm的金属板构成。这种尺寸的碳氢化合物阱可以用于汽车尾气净化，以减少冷启动阶段污染物的排放。

25. 发明授权

US5763198A Screening assays for compounds 失效
标题翻译：化合物的筛选试验
公开(公告)号：US5763198A
公开(公告)日：1998-06-09
申请号：US279321
申请日：1994-07-22
申请人： Klaus Peter Hirth , Harald App , Jianming Tsai
发明人： Klaus Peter Hirth , Harald App , Jianming Tsai
IPC分类号： G01N33/68 , G01N33/543
CPC分类号： G01N33/6842 , G01N33/68 , G01N2333/9121
摘要： The invention is directed to rapid and quantitative assay systems for screening test compounds for their ability to modulate tyrosine kinase or phosphatase activities involved in signal transduction by determining the tyrosine phosphorylation state of a protein substrate using an anti-phosphotyrosine antibody and an antibody specific for the protein substrate. These assays may be practiced in a whole cell or cell-free system. The assays can be used to identify test compounds for use in therapeutic applications to disease processes in which tyrosine kinase or phosphatase activity in a signal transduction pathway contributes to a pathological process.
摘要翻译：本发明涉及快速和定量的测定系统，用于通过使用抗磷酸酪氨酸抗体和特异于抗磷酸酪氨酸抗体测定蛋白质底物的酪氨酸磷酸化状态来筛选测试化合物的调节酪氨酸激酶或参与信号转导的磷酸酶活性的能力蛋白质底物。这些测定可以在整个细胞或无细胞系统中实施。该测定可用于鉴定用于治疗应用于疾病过程的测试化合物，其中信号转导途径中的酪氨酸激酶或磷酸酶活性有助于病理过程。

26. 发明授权

US5734710A Communication system having a service feature which can be activated and/or deactivated 失效
标题翻译：具有可被激活和/或去激活的服务特征的通信系统
公开(公告)号：US5734710A
公开(公告)日：1998-03-31
申请号：US502982
申请日：1995-07-17
申请人： Peter Hirth , Hans-Dietmar Schulz
发明人： Peter Hirth , Hans-Dietmar Schulz
IPC分类号： H04M3/54 , H04M3/42
CPC分类号： H04M3/54
摘要： The invention relates to a communication system comprising a first subscriber line for a first user terminal to which subscriber line a service feature functioning in a service switching point is assigned, which feature can be activated and/or deactivated from the first subscriber line by the first user terminal. A remote control of the first user terminal via a second user terminal of a second subscriber line is provided to activate and/or deactivate the service feature.
摘要翻译：本发明涉及一种通信系统，该通信系统包括用于第一用户终端的第一用户线，用户线在业务交换点中运行的服务特征被分配给该用户线，该特征可以通过第一用户线从第一用户线激活和/或去激活用户终端。提供经由第二用户线路的第二用户终端的第一用户终端的远程控制以激活和/或停用服务特征。

27. 发明授权

US09010086B2 Device and method for treating exhaust gas containing soot particles and motor vehicle having the device and carrying out the method 有权
标题翻译：用于处理含有烟灰颗粒的废气和具有该装置并执行该方法的机动车辆的装置和方法
公开(公告)号：US09010086B2
公开(公告)日：2015-04-21
申请号：US13419633
申请日：2012-03-14
申请人： Wolfgang Maus , Peter Hirth , Rolf Brück
发明人： Wolfgang Maus , Peter Hirth , Rolf Brück
IPC分类号： F01N3/00 , F01N3/027 , B01D46/00 , B03C3/013 , B03C3/12 , B03C3/38 , B03C3/49 , B03C3/68 , F01N3/01 , F01N3/023
CPC分类号： F01N3/0275 , B01D46/0032 , B03C3/013 , B03C3/12 , B03C3/383 , B03C3/49 , B03C3/68 , B03C2201/30 , F01N3/01 , F01N3/0231
摘要： A device for treating exhaust gas containing soot particles, includes at least one ionization element for ionizing soot particles and at least one separation device having a surface precipitator for depositing ionized soot particles. The at least one surface precipitator includes at least two at least partially electrically conductive neutralization regions that are electrically insulated from each other in order to neutralize ionized soot particles. A method for converting soot particles of an exhaust gas includes applying different electric potentials. A motor vehicle includes the device and carries out the method.
摘要翻译：一种用于处理含有烟灰颗粒的废气的装置，包括至少一个用于电离烟灰颗粒的电离元件和至少一个具有用于沉积电离烟灰颗粒的表面沉淀器的分离装置。所述至少一个表面沉淀器包括至少两个至少部分导电的中和区域，它们彼此电绝缘以中和电离烟灰颗粒。用于转换废气的烟尘颗粒的方法包括施加不同的电位。机动车辆包括该装置并执行该方法。

28. 发明授权

US08771821B2 Honeycomb body with flexible connecting points, exhaust-gas treatment unit and motor vehicle 有权
标题翻译：蜂窝体具有柔性连接点，废气处理单元和机动车辆
公开(公告)号：US08771821B2
公开(公告)日：2014-07-08
申请号：US12869856
申请日：2010-08-27
申请人： Rolf Brück , Peter Hirth , Kait Althöfer , Wolfgang Maus
发明人： Rolf Brück , Peter Hirth , Kait Althöfer , Wolfgang Maus
IPC分类号： B01D53/92 , F01N3/022
CPC分类号： F01N3/281 , F01N2260/10 , F01N2330/02 , F01N2330/44 , Y02A50/2322
摘要： A honeycomb body is formed of at least one at least partially structured sheet-metal foil and has a plurality of channels. The sheet-metal foil has a course or profile direction and includes top-side connecting points and bottom-side connecting points to itself or to at least one additional smooth sheet-metal foil or structured sheet-metal foil. At least the top-side connecting points or bottom-side connecting points form a curved connection line and expansion joints between the respective connection points of the curved connection line. An exhaust-gas treatment unit and a motor vehicle are also provided.
摘要翻译：蜂窝体由至少一个至少部分结构的片状金属箔形成并且具有多个通道。片状金属箔具有路线或轮廓方向，并且包括自身的顶侧连接点和底侧连接点，或者至少一个附加光滑的金属箔或结构的片状金属箔。至少顶侧连接点或底侧连接点在弯曲连接线的相应连接点之间形成弯曲连接线和伸缩接头。还提供废气处理单元和机动车辆。

29. 发明授权

US08615985B2 Method and device for providing a gas flow containing a reducing agent 有权
标题翻译：用于提供含有还原剂的气流的方法和装置
公开(公告)号：US08615985B2
公开(公告)日：2013-12-31
申请号：US12416364
申请日：2009-04-01
申请人： Rolf Brück , Peter Hirth , Thomas Härig , Marc Brugger
发明人： Rolf Brück , Peter Hirth , Thomas Härig , Marc Brugger
IPC分类号： F01N3/00 , F01N3/10 , F01N3/04
CPC分类号： F01N3/2066 , F01N2240/40 , F01N2610/02 , F01N2610/10 , Y02A50/2325 , Y02T10/24
摘要： A method for providing a reducing agent-containing gas flow in the exhaust system of an internal combustion engine includes providing at least one reducing agent precursor, evaporating the precursor to provide a gas flow, at least partially heating the gas flow to temperatures of at least 250° C., at least partially converting the precursor in the gas flow to a reducing agent and adding the reducing agent-containing gas flow to the exhaust of the engine. The method and a device provide a reducing agent-containing gas flow in a quantity being easily controllable and adaptable to dynamic changes especially in exhaust systems of mobile applications such as automobiles. A temperature of a first zone is kept at 150° C. or just below while a temperature of a second zone is kept at more than 300° C. A hydrolysis catalytic converter is hardly cooled upon receiving the precursor as a vapor, positively affecting the method.
摘要翻译：一种用于在内燃机的排气系统中提供含还原剂的气流的方法，包括提供至少一种还原剂前体，蒸发前体以提供气流，至少部分地将气流加热到至少 250℃，至少部分地将气流中的前体转化为还原剂，并将含还原剂的气流加入到发动机的排气中。该方法和装置提供了一种易于控制并适应动态变化的量的还原剂气体流，特别是在诸如汽车的移动应用的排气系统中。第一区域的温度保持在150℃或刚好在第二区域的温度保持在大于300℃的温度。水解催化转化器在接收作为蒸汽的前体时几乎不被冷却，从而对方法。

30. 发明授权

US08357332B2 Device and method for evaporating a reactant 有权
标题翻译：用于蒸发反应物的装置和方法
公开(公告)号：US08357332B2
公开(公告)日：2013-01-22
申请号：US12417190
申请日：2009-04-02
申请人： Rolf Brück , Peter Hirth , Thomas Härig , Marc Brugger
发明人： Rolf Brück , Peter Hirth , Thomas Härig , Marc Brugger
IPC分类号： B01D50/00
CPC分类号： F01N3/2066 , B01B1/005 , F01N2240/40 , F01N2610/02 , F01N2610/10 , F01N2610/14 , H05B3/40 , H05B2203/02 , Y02T10/24
摘要： A device for evaporating at least one of the following reactants: a reducing agent precursor solution and a reducing agent precursor, includes at least one electrically heatable heating zone having at least one electrically operable heating element with a heating resistor that is self-regulated about a significant temperature. A method and the device for evaporating a reactant allow a simple control of an evaporation process, especially of a urea/water solution, to provide a reducing agent, especially in an SCR process. The heating resistors have a significant temperature that corresponds to a control temperature of the heating resistor. The need for additional control electronics can be removed by adjusting a correspondingly steep curve within a range.
摘要翻译：用于蒸发以下反应物中的至少一种的装置：还原剂前体溶液和还原剂前体，包括至少一个电可加热加热区，其具有至少一个电可操作的加热元件，该加热电阻器具有自调节显着的温度。用于蒸发反应物的方法和装置允许简单地控制蒸发过程，特别是尿素/水溶液，以提供还原剂，特别是在SCR方法中。加热电阻器具有对应于加热电阻器的控制温度的显着温度。可以通过在一个范围内调整相应的陡峭曲线来消除对附加控制电子设备的需求。

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