专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

21. 发明授权

US5102880A Substituted imidazo-fused 6-membered heterocycles as angiotensin II antagonists 失效
标题翻译：取代的咪唑并稠合的6元杂环作为血管紧张素II拮抗剂
公开(公告)号：US5102880A
公开(公告)日：1992-04-07
申请号：US755247
申请日：1991-09-05
申请人： Prasun K. Chakravarty , William J. Greenlee , Nathan B. Mantlo , Arthur A. Patchett , Thomas F. Walsh
发明人： Prasun K. Chakravarty , William J. Greenlee , Nathan B. Mantlo , Arthur A. Patchett , Thomas F. Walsh
IPC分类号： C07D471/04 , C07D473/00 , C07D473/04 , C07D473/30 , C07D473/32 , C07D473/40 , C07F9/6561
CPC分类号： C07D471/04 , C07D473/00 , C07D473/04 , C07D473/30 , C07D473/32 , C07D473/40 , C07F9/6561
摘要： Substituted Imidazo-fused 6-membered heterocycles of structural formula: ##STR1## wherein A, B, C, and D are independently carbon atoms or nitrogren atoms are angiotensin II antagonists useful in the treatment of hypertension and congestive heart failure.
摘要翻译：取代的具有结构式的咪唑稠合的6元杂环：其中A，B，C和D独立地为碳原子或硝基原子是可用于治疗高血压和充血性心力衰竭的血管紧张素II拮抗剂。

22. 发明授权

US5064825A Angiotensin II antagonists 失效
标题翻译： ANGIOTENSIN II ANTAGONISTS
公开(公告)号：US5064825A
公开(公告)日：1991-11-12
申请号：US522662
申请日：1990-05-16
申请人： Prasun K. Chakravarty , William J. Greenlee , Nathan B. Mantlo , Arthur A. Patchett , William Schoen , Thomas F. Walsh
发明人： Prasun K. Chakravarty , William J. Greenlee , Nathan B. Mantlo , Arthur A. Patchett , William Schoen , Thomas F. Walsh
IPC分类号： C07D233/88 , A61K31/415 , A61K31/55 , A61P9/00 , A61P9/12 , C07D233/90 , C07D401/02 , C07D403/02 , C07D403/10 , C07D405/02 , C07D409/02 , C07D417/02 , C07D487/04 , C07D498/04 , C07D521/00 , C07F9/6506 , C07F9/6561
CPC分类号： C07D403/10 , C07D233/90 , C07D487/04 , C07F9/65061 , C07F9/6561
摘要： Novel substituted imidazo-fused 7-member ring heterocycles of the formulae (I) and (Ia), which are useful as angiotensin II antagonists, are disclosed. ##STR1##

23. 发明授权

US06649604B2 Substituted pyridone compounds and methods of use 失效
公开(公告)号：US06649604B2
公开(公告)日：2003-11-18
申请号：US10128271
申请日：2002-04-23
申请人： Ulrike D. Spohr , Michael J. Malone , Nathan B. Mantlo , Jeffrey A. Zablocki
发明人： Ulrike D. Spohr , Michael J. Malone , Nathan B. Mantlo , Jeffrey A. Zablocki
IPC分类号： A61K3155
CPC分类号： C07D401/04 , C07D213/643 , C07D401/14 , C07D405/04 , C07D409/04 , C07D409/14 , C07D417/14 , C07D487/04
摘要： Selected novel substituted pyrimidinone and pyridone compounds are effective for prophylaxis and treatment of diseases, such as TNF-&agr;, IL-1&bgr;, IL-6 and/or IL-8 mediated diseases, and other maladies, such as pain and diabetes. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving inflammation, pain, diabetes and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

24. 发明授权

US06458813B1 Substituted pyridine compounds and methods of use 失效
公开(公告)号：US06458813B1
公开(公告)日：2002-10-01
申请号：US09932281
申请日：2001-08-17
申请人： Nathan B. Mantlo , Stephen T. Schlachter , John A. Josey
发明人： Nathan B. Mantlo , Stephen T. Schlachter , John A. Josey
IPC分类号： A61K31444
CPC分类号： C07D213/73 , C07D213/75 , C07D213/82 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D471/04 , Y10S514/886
摘要： Selected novel substituted pyridine compounds are effective for prophylaxis and treatment of diseases, such as TNF-&agr;, IL-1&bgr;, IL-6 and/or IL-8 mediated diseases, and other maladies, such as pain and diabetes. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving inflammation, pain, diabetes, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

25. 发明授权

US06440973B1 Aryl and heteroaryl substituted fused pyrrole antiinflammatory agents 失效
标题翻译：芳基和杂芳基取代的稠合吡咯抗炎剂
公开(公告)号：US06440973B1
公开(公告)日：2002-08-27
申请号：US09644102
申请日：2000-08-23
申请人： Jeffery A. Zablocki , Eugene Tarlton, Jr. , James P. Rizzi , Nathan B. Mantlo
发明人： Jeffery A. Zablocki , Eugene Tarlton, Jr. , James P. Rizzi , Nathan B. Mantlo
IPC分类号： A61K31495
CPC分类号： C07D401/04 , C07D401/14 , C07D405/14 , C07D409/14 , C07D471/04 , C07D487/04
摘要： The present invention comprises a new class of novel aryl and heteroaryl substituted fused pyrrole compounds useful for the prophylaxis and treatment of diseases or conditions, such as TNF-&agr;, IL-1&bgr;, IL-6 and/or IL-8 mediated diseases, and other maladies, such as pain and diabetes. In particular, the compounds of the invention are useful for the prophylaxis and treatment of diseases or conditions involving inflammation. Accordingly, the invention also comprises pharmaceutical compositions comprising the compounds of the invention, methods for the prophylaxis and treatment of inflammation and other maladies, such as pain and diabetes, using the compounds and compositions of the invention, and intermediates and processes useful for the preparation of compounds of the invention. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
摘要翻译：本发明包括用于预防和治疗诸如TNF-α，IL-1β，IL-6和/或IL-8介导的疾病的疾病或病症的新一类新的芳基和杂芳基取代的稠合吡咯化合物，以及其他疾病，如疼痛和糖尿病。特别地，本发明的化合物可用于预防和治疗涉及炎症的疾病或病症。因此，本发明还包括使用本发明的化合物和组合物的包含本发明化合物的药物组合物，预防和治疗炎症和其它疾病如疼痛和糖尿病的方法，以及用于制备的中间体和方法的本发明化合物。本发明还涉及制备这些化合物的方法以及在这些方法中有用的中间体。

26. 发明授权

US06410729B1 Substituted pyrimidine compounds and methods of use 失效
标题翻译：取代的嘧啶化合物及其使用方法
公开(公告)号：US06410729B1
公开(公告)日：2002-06-25
申请号：US09598740
申请日：2000-06-21
申请人： Ulrike D. Spohr , Michael J. Malone , Nathan B. Mantlo
发明人： Ulrike D. Spohr , Michael J. Malone , Nathan B. Mantlo
IPC分类号： C07D23902
CPC分类号： C07D401/04 , C07D213/643 , C07D401/14 , C07D405/04 , C07D409/04 , C07D409/14 , C07D417/14 , C07D487/04
摘要： Selected novel substituted pyrimidine compounds are effective for prophylaxis and treatment of diseases, such as TNF-&agr;, IL-1&bgr;, IL-6 and/or IL-8 mediated diseases, and other maladies, such as pain and diabetes. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving inflammation, pain, diabetes and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
摘要翻译：选择的新型取代嘧啶化合物对于预防和治疗诸如TNF-α，IL-1β，IL-6和/或IL-8介导的疾病以及其它疾病如疼痛和糖尿病等疾病是有效的。本发明包括新颖的化合物，类似物，前药和药学上可接受的盐，用于预防和治疗疾病和其它疾病或涉及炎症，疼痛，糖尿病等的疾病的药物组合物和方法。本发明还涉及制备这些化合物的方法以及在这些方法中有用的中间体。

27. 发明授权

US06333341B1 Substituted pyridine compounds and methods of use 失效
标题翻译：取代的吡啶化合物及其使用方法
公开(公告)号：US06333341B1
公开(公告)日：2001-12-25
申请号：US09642860
申请日：2000-08-21
申请人： Nathan B. Mantlo , Stephen T. Schlachter , John A. Josey
发明人： Nathan B. Mantlo , Stephen T. Schlachter , John A. Josey
IPC分类号： A61K314427
CPC分类号： C07D213/73 , C07D213/75 , C07D213/82 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D471/04 , Y10S514/886
摘要： Selected novel substituted pyridine compounds are effective for prophylaxis and treatment of diseases, such as TNF-&agr;, IL-1&bgr;, IL-6 and/or IL-8 mediated diseases, and other maladies, such as pain and diabetes. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving inflammation, pain, diabetes, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
摘要翻译：选择的新型取代的吡啶化合物对于诸如TNF-α，IL-1β，IL-6和/或IL-8介导的疾病以及其它疾病如疼痛和糖尿病等疾病的预防和治疗是有效的。本发明包括新颖的化合物，类似物，前药和药学上可接受的盐，用于预防和治疗疾病和其它疾病或涉及炎症，疼痛，糖尿病，癌症等疾病的药物组合物和方法。本发明还涉及制备这些化合物的方法以及在这些方法中有用的中间体。

28. 发明授权

US5837719A 2,5-substituted aryl pyrroles, compositions containing such compounds and methods of use 失效
标题翻译： 2,5-取代的芳基吡咯，含有这些化合物的组合物和使用方法
公开(公告)号：US5837719A
公开(公告)日：1998-11-17
申请号：US694143
申请日：1996-08-08
申请人： Stephen E. de Laszlo , Nigel J. Liverton , Gerald S. Ponticello , Harold G. Selnick , Nathan B. Mantlo
发明人： Stephen E. de Laszlo , Nigel J. Liverton , Gerald S. Ponticello , Harold G. Selnick , Nathan B. Mantlo
IPC分类号： C07D401/04 , C07D401/14 , C07D403/04 , C07D409/14 , A01N43/40 , C07D401/00
CPC分类号： C07D401/04 , C07D401/14 , C07D403/04 , C07D409/14
摘要： The present invention addresses 2, 5-substituted aryl pyrroles of the formula: ##STR1## or a pharmaceutically acceptable salts thereof, as well as compositions containing such compounds and methods of treatment. The compounds are useful for treating Cytokine mediated diseases, which refers to diseases or conditions in which excessive or unregulated production or activity of one or more cytokines occurs. Interleukin-1 (IL-1), Interleukin-6 (IL-6), Interleukin-8 (IL-8) and Tumor Necrosis Factor (TNF) are cytokines which are involved in immunoregulation and other physiological conditions, such as inflammation. The compounds also have glucagon antagonist activity.
摘要翻译：本发明涉及下式的2,5-取代芳基吡咯啉或其药学上可接受的盐，以及含有这些化合物的组合物和治疗方法。该化合物可用于治疗细胞因子介导的疾病，其涉及发生一种或多种细胞因子的过量或不调节的产生或活性的疾病或病症。白细胞介素-1（IL-1），白细胞介素-6（IL-6），白细胞介素-8（IL-8）和肿瘤坏死因子（TNF）是参与免疫调节和其他生理条件如炎症的细胞因子。该化合物还具有胰高血糖素拮抗剂活性。

29. 发明授权

US5792778A 2-substituted aryl pyrroles, compositions containing such compounds and methods of use 失效
标题翻译： 2-取代的芳基吡咯，含有这些化合物的组合物和使用方法
公开(公告)号：US5792778A
公开(公告)日：1998-08-11
申请号：US694008
申请日：1996-08-08
申请人： Stephen E. de Laszlo , Nigel J. Liverton , Gerald S. Ponticello , Harold G. Selnick , Nathan B. Mantlo
发明人： Stephen E. de Laszlo , Nigel J. Liverton , Gerald S. Ponticello , Harold G. Selnick , Nathan B. Mantlo
IPC分类号： C07D401/04 , C07D401/14 , C07D403/04 , A61K31/40 , A61K31/44 , A61K31/445 , C07D207/325 , C07D213/06 , C07D295/06 , C07D213/33
CPC分类号： C07D401/04 , C07D401/14 , C07D403/04
摘要： The present invention addresses 2-substituted aryl pyrroles, as well as compositions containing such compounds and methods of treatment. Cytokine mediated diseases refers to diseases or conditions in which excessive or unregulated production or activity of one or more cytokines occurs. Interleukin-1 (IL-1), Interleukin-6 (IL-6), Interleukin-8 (IL-8) and Tumor Necrosis Factor (TNF) are cytokines which are involved.
摘要翻译：本发明涉及2-取代的芳基吡咯，以及含有这些化合物的组合物和处理方法。细胞因子介导的疾病是指发生一种或多种细胞因子过度或不规律的生产或活性的疾病或病症。白细胞介素-1（IL-1），白细胞介素-6（IL-6），白细胞介素-8（IL-8）和肿瘤坏死因子（TNF）是涉及的细胞因子。

30. 发明授权

US5776954A Substituted pyridyl pyrroles, compositions containing such compounds and methods of use 失效
标题翻译：取代的吡啶基吡咯，含有这些化合物的组合物和使用方法
公开(公告)号：US5776954A
公开(公告)日：1998-07-07
申请号：US742428
申请日：1996-10-30
申请人： Stephen E. de Laszlo , Linda L. Chang , Dooseop Kim , Nathan B. Mantlo
发明人： Stephen E. de Laszlo , Linda L. Chang , Dooseop Kim , Nathan B. Mantlo
IPC分类号： C07D401/04 , C07D401/14 , C07D403/04 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , A61K31/44
CPC分类号： C07D401/04 , C07D401/14 , C07D403/04 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14
摘要： The present invention addresses substituted pyridyl pyrroles, as well as compositions containing such compounds and methods of treatment. The compounds in the present invention are glucagon antagonists and inhibitors of the biosynthesis and action of TNF-.alpha. and IL1. The compounds block the action of glucagon at its receptors and thereby decrease the levels of plasma glucose. The instant pyrroles are also inhibitors of TNF-.alpha. and IL1 and may be used as antidiabetic agents as well as other cytokine mediated diseases. Cytokine mediated diseases refers to diseases or conditions in which excessive or unregulated production of one or more cytokines occurs. Interleukin-1 (IL-1) and Tumor Necrosis Factor (TNF) are cytokines produced by a variety of cells, which are involved in immunoregulation and other physiological conditions, such as inflammation.
摘要翻译：本发明涉及取代的吡啶基吡咯，以及含有这些化合物的组合物和处理方法。本发明中的化合物是胰高血糖素拮抗剂和TNF-α和IL1的生物合成和作用的抑制剂。该化合物阻断胰高血糖素受体的作用，从而降低血浆葡萄糖的水平。即时吡咯也是TNF-α和IL1的抑制剂，可用作抗糖尿病药物和其他细胞因子介导的疾病。细胞因子介导的疾病是指发生一种或多种细胞因子的过量或不稳定的产生的疾病或病症。白细胞介素-1（IL-1）和肿瘤坏死因子（TNF）是由各种细胞产生的细胞因子，其涉及免疫调节和其它生理条件如炎症。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式