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21. 发明申请

US20070205379A1 System and method for structured illumination and collection for improved optical confocality of raman fiber array spectral translator imaging and interactive raman probing 有权
标题翻译：用于结构化照明和采集的系统和方法，用于改进拉曼光纤阵列光谱翻译器成像和交互式拉曼探测的光学共焦
公开(公告)号：US20070205379A1
公开(公告)日：2007-09-06
申请号：US11712917
申请日：2007-03-02
申请人： Matthew P. Nelson , Patrick J. Treado
发明人： Matthew P. Nelson , Patrick J. Treado
IPC分类号： G01J1/58 , G02B6/06 , G01B9/10 , G01N21/64 , F21V9/16
CPC分类号： G01J3/2803 , G01J3/0221 , G01J3/44 , G01N21/474 , G01N21/55 , G01N21/645 , G01N21/6456 , G01N21/65 , G01N2021/6423 , G01N2021/6484 , G01N2201/0833 , G01N2201/0846 , G02B6/06
摘要： The disclosure relates generally to methods and apparatus for using a fiber array spectral translator-based (“FAST”) spectroscopic system for improved imaging, spectral analysis, and interactive probing of a sample. In an embodiment, the confocality of a fiber array spectral translator-based spectroscopic system is improved through the use of structured illumination and/or structured collection of photons. User input may be received and acted upon to allow a user to interactively in real time and/or near real time view and analyze specific regions of the sample.
摘要翻译：本公开一般涉及使用用于改进样品的成像，光谱分析和交互式探测的光纤阵列基于光谱转换器的（“FAST”）光谱系统的方法和装置。在一个实施例中，通过使用结构化照明和/或光子的结构化收集来提高基于光纤阵列光谱转换器的光谱系统的共焦度。可以接收用户输入并执行操作以允许用户以实时和/或接近实时的方式进行交互式查看和分析样本的特定区域。

22. 发明授权

US07057721B2 Wide field method for detecting pathogenic microorganisms 有权
标题翻译：用于检测病原微生物的广域方法
公开(公告)号：US07057721B2
公开(公告)日：2006-06-06
申请号：US10608470
申请日：2003-06-27
申请人： Charles W. Gardner, Jr. , John S. Maier , Matthew P. Nelson , Robert C. Schweitzer , Patrick J. Treado , G. Steven Vanni , Julianne Wolfe
发明人： Charles W. Gardner, Jr. , John S. Maier , Matthew P. Nelson , Robert C. Schweitzer , Patrick J. Treado , G. Steven Vanni , Julianne Wolfe
IPC分类号： G01J3/44 , G01N21/65
CPC分类号： G01J3/44 , G01J3/02 , G01J3/0272 , G01J3/10 , G01N21/35 , G01N21/3577 , G01N21/6458 , G01N21/6486 , G01N21/65 , G01N2021/6417 , G01N2021/6423 , G01N2021/656 , G01N2201/0221
摘要： Pathogenic microorganisms are detected in a wide field of view and classified by Raman light scattered light from these organisms together with digital pattern recognition of their spectral patterns.
摘要翻译：在广泛的视野中检测致病微生物，并通过来自这些生物的拉曼光散射光以及它们的光谱图案的数字图案识别来分类病原微生物。

23. 发明申请

US20120120393A1 TIME AND SPACE RESOLVED STANDOFF HYPERSPECTRAL IED EXPLOSIVES LIDAR DETECTOR 审中-公开
标题翻译：时间和空间分辨率高分辨率高分辨率激光雷达探测器
公开(公告)号：US20120120393A1
公开(公告)日：2012-05-17
申请号：US13290174
申请日：2011-11-07
申请人： Patrick J. Treado , Matthew P. Nelson , Hugh W. Hubble, II , Jason Neiss
发明人： Patrick J. Treado , Matthew P. Nelson , Hugh W. Hubble, II , Jason Neiss
IPC分类号： G01J3/44 , G01B11/24
CPC分类号： G01J3/36 , G01J3/02 , G01J3/0221 , G01J3/0264 , G01J3/2823 , G01J3/44 , G01N21/359 , G01N21/6456 , G01N21/65 , G01N21/718 , G01N2021/1738 , G01N2021/174 , G01N2021/1744
摘要： A system and method for standoff detection of explosives and explosive residue. A laser light source illuminates a target area having an unknown sample producing luminescence emitted photons, scattered photons and plasma emitted photons. A first optical system directs light to the target area. A video capture device outputs a dynamic image of the target area. A second optical system collects photons, and directs collected photons to a first two-dimensional array of detection elements and/or to a fiber array spectral translator device which device includes a two-dimensional array of optical fibers drawn into a one-dimensional fiber stack. A spectrograph is coupled to the one-dimensional fiber stack of the fiber array spectral translator device, wherein the entrance slit of the spectrograph is coupled to the one dimensional fiber stack.
摘要翻译：爆炸物和爆炸物残留物检测的系统和方法。激光源照射具有未知样品的目标区域，产生发光的光子，散射的光子和等离子体发射的光子。第一光学系统将光引导到目标区域。视频采集装置输出目标区域的动态图像。第二光学系统收集光子，并将收集的光子引导到检测元件的第一二维阵列和/或光纤阵列光谱转换器装置，该装置包括被拉入一维光纤堆叠的光纤的二维阵列。光谱仪耦合到光纤阵列光谱转换器装置的一维光纤堆叠，其中光谱仪的入口狭缝耦合到一维光纤堆叠。

24. 发明申请

US20100148073A1 System and Method for Structured Illumination and Collection for Improved Optical Confocality of Raman Fiber Array Spectral Translator Imaging and Interactive Raman Probing 有权
标题翻译：用于拉曼光纤阵列光谱转换成像和交互式拉曼探测的改进光学谐振的结构照明和采集系统和方法
公开(公告)号：US20100148073A1
公开(公告)日：2010-06-17
申请号：US12632187
申请日：2009-12-07
申请人： Matthew P. Nelson , Patrick J. Treado
发明人： Matthew P. Nelson , Patrick J. Treado
IPC分类号： G01T1/28 , G01J1/58 , G01N21/65 , G01N21/64 , G01J3/44
CPC分类号： G01J3/2803 , G01J3/0221 , G01J3/44 , G01N21/474 , G01N21/55 , G01N21/645 , G01N21/6456 , G01N21/65 , G01N2021/6423 , G01N2021/6484 , G01N2201/0833 , G01N2201/0846 , G02B6/06
摘要： The disclosure relates generally to methods and apparatus for using telescope optics and a fiber array spectral translator-based (“FAST”) spectroscopic system for improved imaging, spectral analysis, and interactive probing of a sample. In an embodiment, the confocality of a fiber array spectral translator-based spectroscopic system is improved through the use of structured illumination and/or structured collection of photons. User input may be received and acted upon to allow a user to interactively in real time and/or near real time view and analyze specific regions of the sample.
摘要翻译：本公开一般涉及用于使用望远镜光学器件的方法和装置以及用于改进样品的成像，光谱分析和交互式探测的光纤阵列光谱转换器（“FAST”）光谱系统。在一个实施例中，通过使用结构化照明和/或光子的结构化收集来提高基于光纤阵列光谱转换器的光谱系统的共焦度。可以接收用户输入并执行操作以允许用户以实时和/或接近实时的方式进行交互式查看和分析样本的特定区域。

25. 发明授权

US07692775B2 Time and space resolved standoff hyperspectral IED explosives LIDAR detection 有权
标题翻译：时间和空间解决了高光谱IED爆炸物LIDAR检测
公开(公告)号：US07692775B2
公开(公告)日：2010-04-06
申请号：US11450149
申请日：2006-06-09
申请人： Patrick J. Treado , Matthew P. Nelson , Hugh W. Hubble, II , Jason Neiss
发明人： Patrick J. Treado , Matthew P. Nelson , Hugh W. Hubble, II , Jason Neiss
IPC分类号： G01N21/00
CPC分类号： G01J3/36 , G01J3/02 , G01J3/0221 , G01J3/0264 , G01J3/2823 , G01J3/44 , G01N21/359 , G01N21/6456 , G01N21/65 , G01N21/718 , G01N2021/1738 , G01N2021/174 , G01N2021/1744
摘要： A system and method for standoff detection of explosives and explosive residue. A laser light source illuminates a target area having an unknown sample producing luminescence emitted photons, scattered photons and plasma emitted photons. A first optical system directs light to the target area. A video capture device outputs a dynamic image of the target area. A second optical system collects photons, and directs collected photons to a first two-dimensional array of detection elements and/or to a fiber array spectral translator device which device includes a two-dimensional array of optical fibers drawn into a one-dimensional fiber stack. A spectrograph is coupled to the one-dimensional fiber stack of the fiber array spectral translator device, wherein the entrance slit of the spectrograph is coupled to the one dimensional fiber stack.
摘要翻译：爆炸物和爆炸物残留物检测的系统和方法。激光源照射具有未知样品的目标区域，产生发光的光子，散射的光子和等离子体发射的光子。第一光学系统将光引导到目标区域。视频采集装置输出目标区域的动态图像。第二光学系统收集光子，并将收集的光子引导到检测元件的第一二维阵列和/或光纤阵列光谱转换器装置，该装置包括被拉入一维光纤堆叠的光纤的二维阵列。光谱仪耦合到光纤阵列光谱转换器装置的一维光纤堆叠，其中光谱仪的入口狭缝耦合到一维光纤堆叠。

26. 发明授权

US07551821B2 Chemical imaging fiberscope 有权
标题翻译：化学成像纤维镜
公开(公告)号：US07551821B2
公开(公告)日：2009-06-23
申请号：US11744797
申请日：2007-05-04
申请人： Patrick J. Treado , Matthew P. Nelson , Scott A. Keitzer , Ryan D. Smith
发明人： Patrick J. Treado , Matthew P. Nelson , Scott A. Keitzer , Ryan D. Smith
IPC分类号： G02B6/06 , G01J3/44 , A61B1/06
CPC分类号： G02B6/06 , A61B1/00165 , A61B1/043 , A61B1/063 , A61B1/0638 , A61B1/0646 , A61B1/07 , A61B5/0075 , A61B5/0084 , G01J3/02 , G01J3/0208 , G01J3/0218 , G01J3/0227 , G01J3/024 , G01J3/0256 , G01J3/0262 , G01J3/0286 , G01J3/44 , G01J2003/1213
摘要： A fiberscope device is disclosed which is suitable for video imaging, laser Raman spectroscopy and laser Raman spectroscopic (i.e. chemical) imaging. The fiberscope design minimizes fiber background interference arising from the laser delivery fiber optic and the coherent fiber optic light gathering bundle while maintaining high light throughput efficiency through the use of integrated spectral filters. In the fiberscope design, the laser delivery fiber optic is offset from the coherent fiber optic light gathering bundle. The laser delivery field is captured entirely by the light gathering field of view of the coherent fiber bundle. The fiberscope incorporates spectral filter optical elements that provide environmental insensitivity, particularly to temperature and moisture. The fiberscope is suited to the analysis of a wide range of condensed phase materials (solids and liquids), including the analysis of biological materials such as breast tissue lesions and arterial plaques, in such a manner to delineate abnormal from normal tissues.
摘要翻译：公开了适用于视频成像，激光拉曼光谱和激光拉曼光谱（即化学）成像的纤维内窥镜装置。纤维镜设计可以最大限度地减少激光传输光纤和相干光纤采集光束产生的光纤背景干扰，同时通过使用集成光谱滤波器保持高光通量效率。在纤维镜设计中，激光传输光纤与相干光纤聚光束偏移。激光输送场完全由相干光纤束的聚光场捕获。纤维镜包含光谱滤光器光学元件，其提供环境不敏感性，特别是对温度和湿度。纤维内窥镜适用于分析各种凝聚相材料（固体和液体），包括分析生物材料如乳房组织损伤和动脉斑块，以便从正常组织中描绘异常。

27. 发明授权

US07420679B2 Method and apparatus for extended hyperspectral imaging 有权
标题翻译：用于扩展高光谱成像的方法和装置
公开(公告)号：US07420679B2
公开(公告)日：2008-09-02
申请号：US11229539
申请日：2005-09-20
申请人： Patrick J. Treado , Charles W. Gardner, Jr. , Matthew P. Nelson
发明人： Patrick J. Treado , Charles W. Gardner, Jr. , Matthew P. Nelson
IPC分类号： G01J3/51 , G01N21/31
CPC分类号： G01N21/255
摘要： The disclosure relates to method and apparatus for obtaining a multimodal hyperspectral image of a sample for widefield spectral analysis. An apparatus according to one embodiment may include a plurality of optical lenses configured to interchangeably receive photons and focus the photons; a plurality of tunable filters positioned in a filter housing, each tunable filter selectively receiving the focused dispersed photons from one of the plurality of optical lenses, each tunable filter providing wavelength-selective filtered photons; a first optical camera and a second optical cameras for selectively receiving the wavelength-selective filtered photons from each of the plurality of tunable filters and combining said filtered photons to form a hyperspectral spatially accurate, wavelength-resolved image of the sample.
摘要翻译：本公开涉及用于获得用于宽带光谱分析的样品的多峰高光谱图像的方法和装置。根据一个实施例的装置可以包括多个配置成可互换地接收光子并聚焦光子的光学透镜; 多个可调滤光器，其位于过滤器壳体中，每个可调谐滤光器选择性地从多个光学透镜中的一个透镜接收聚焦的分散的光子，每个可调谐滤光器提供波长选择性滤光的光子; 第一光学摄像机和第二光学摄像机，用于从多个可调谐滤光器中的每一个选择性地接收波长选择性滤波的光子，并组合所述滤波的光子以形成样品的高光谱空间准确的波长分辨图像。

28. 发明申请

US20070188747A1 SYSTEM AND METHOD FOR IMAGE RECONSTRUCTION IN A FIBER ARRAY SPECTRAL TRANSLATOR SYSTEM 有权
标题翻译：一种光纤阵列传输系统中图像重构的系统与方法
公开(公告)号：US20070188747A1
公开(公告)日：2007-08-16
申请号：US11674552
申请日：2007-02-13
申请人： Matthew P. Nelson , Jason H. Neiss , Patrick J. Treado
发明人： Matthew P. Nelson , Jason H. Neiss , Patrick J. Treado
IPC分类号： G01D18/00 , G01J3/00 , G01C19/00
CPC分类号： G01J3/02 , G01J3/0218 , G01J3/0221 , G01J3/28 , G01J3/2803 , G01J3/2823 , G01N21/255 , G01N21/274 , G01N2201/0833
摘要： The disclosure relates generally to methods and apparatus for spectral calibration of a spectroscopic system which includes a fiber array spectral translator. One embodiment relates to a method for obtaining a first image of a known substance using a photon detector and a fiber array spectral translator having plural fibers, wherein the first image comprises at least one pixel; providing a second image of the substance wherein the second image comprises at least one pixel; comparing the first image with the second image; and adjusting at least one pixel of the first image based on the comparison of images to thereby obtain an adjusted image.
摘要翻译：本公开一般涉及包括光纤阵列光谱转换器的光谱系统的光谱校准的方法和装置。一个实施例涉及一种使用光子检测器和具有多个光纤的光纤阵列光谱转换器获得已知物质的第一图像的方法，其中第一图像包括至少一个像素; 提供所述物质的第二图像，其中所述第二图像包括至少一个像素; 将第一图像与第二图像进行比较; 以及基于图像的比较来调整第一图像的至少一个像素，从而获得调整后的图像。

29. 发明授权

US07256875B2 Method for detection of pathogenic microorganisms 有权
标题翻译：检测病原微生物的方法
公开(公告)号：US07256875B2
公开(公告)日：2007-08-14
申请号：US11440845
申请日：2006-05-25
申请人： John S. Maier , Charles W. Gardner, Jr. , Matthew P. Nelson , Robert C. Schweitzer , Patrick J. Treado , G. Steven Vanni , Julianne Wolfe
发明人： John S. Maier , Charles W. Gardner, Jr. , Matthew P. Nelson , Robert C. Schweitzer , Patrick J. Treado , G. Steven Vanni , Julianne Wolfe
IPC分类号： G01J3/44 , G01N21/65
CPC分类号： G01N21/6486 , G01J3/02 , G01J3/0218 , G01J3/2823 , G01J3/44 , G01N21/31 , G01N21/33 , G01N21/359 , G01N21/645 , G01N21/6456 , G01N21/6458 , G01N21/65 , G01N2021/1736 , G01N2021/6421 , G01N2021/6423 , G01N2021/656
摘要： A method for the detection and identification of pathogenic microorganisms using Raman scattered light and transmitted light in the near infrared spectral region. The method may include passing the Raman scattered light and transmitted light through a FAST fiber array spectral translator.
摘要翻译：一种使用拉曼散射光和近红外光谱区域的透射光检测和鉴定病原微生物的方法。该方法可以包括使拉曼散射光和透射光通过FAST光纤阵列光谱转换器。

30. 发明授权

US07239383B2 Method and apparatus for spectral modulation compensation 有权
标题翻译：光谱调制补偿的方法和装置
公开(公告)号：US07239383B2
公开(公告)日：2007-07-03
申请号：US10879632
申请日：2004-06-30
申请人： John S. Maier , Jason N. Neiss , Shona Stewart , Matthew P. Nelson , Joseph Demuth , Patrick J. Treado
发明人： John S. Maier , Jason N. Neiss , Shona Stewart , Matthew P. Nelson , Joseph Demuth , Patrick J. Treado
IPC分类号： G01J3/44
CPC分类号： G01N21/65 , G01J3/0297 , G01J3/44 , G01N2021/656
摘要： The embodiments disclosed herein generally relate to identifying and removing background noise in spectroscopic imaging of a sample. Because white-light has essentially constant intensity at every wavelength, background noise caused by white light can be identified and removed from spectroscopic measurements including Raman spectroscopy. Thus, once the Raman spectrum for a sample is obtained, it may be corrected to remove the white-light dispersive spectrum in accordance with the embodiments disclosed herein.
摘要翻译：本文公开的实施例通常涉及在样本的光谱成像中识别和去除背景噪声。因为白光在每个波长处具有基本恒定的强度，所以可以从包括拉曼光谱的光谱测量中识别和去除由白光引起的背景噪声。因此，一旦获得样品的拉曼光谱，就可以根据本文公开的实施方案来校正其去除白光色散谱。

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