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21. 发明授权

US06021354A Single pass lead and method of use 有权
标题翻译：单通铅和使用方法
公开(公告)号：US06021354A
公开(公告)日：2000-02-01
申请号：US224739
申请日：1998-12-31
申请人： Eduardo N. Warman , Matthew D. Bonner
发明人： Eduardo N. Warman , Matthew D. Bonner
IPC分类号： A61N1/05
CPC分类号： A61N1/056
摘要： A cardiac pacing lead for pacing the atria and a method of its use. The lead is provided with a mechanism for maintaining an atrial pacing electrode adjacent stimulable tissue in a patient's superior vena cava and an additional electrode locatable in the right ventricle or elsewhere when the atrial electrode is so located. One such mechanism for maintaining the atrial electrode's position may be a lead body displaying pre-formed laterally extending curves sized to span a patient's superior vena cava, with the atrial electrode located thereon.
摘要翻译：用于起搏心房的心脏起搏线及其使用方法。该引线设置有用于将心房起搏电极维持在患者上腔静脉中的可刺激组织旁边的机构，以及当心房电极如此定位时位于右心室或别处的附加电极。用于维持心房电极的位置的一种这样的机构可以是引导体，其显示预先形成的横向延伸的曲线，其尺寸跨越患者的上腔静脉，心房电极位于其上。

22. 发明授权

US5968086A Pacing and cardioversion lead systems with shared lead conductors 失效
标题翻译：起搏和心脏复律引导系统具有共用引线导体
公开(公告)号：US5968086A
公开(公告)日：1999-10-19
申请号：US28143
申请日：1998-02-23
申请人： Matthew D. Bonner , Adrianus P. Donders
发明人： Matthew D. Bonner , Adrianus P. Donders
IPC分类号： A61N1/05
CPC分类号： A61N1/056 , A61N1/0563
摘要： An implantable electrical lead having an elongated insulative lead body carrying a cardioversion/defibrillation electrode and a sensing electrode spaced from the cardioversion/defibrillation electrode. A diode enclosure is mounted in the lead body between the cardioversion/defibrillation electrode and the sensing electrode, the diode enclosure having conductive end walls and including a diode or diodes therein coupled between the conductive end walls. The enclosure is also provided with a feedthrough tube extending through said enclosure, passing through the end walls. An elongated conductor extends through the lead body and through the feedthrough tube of said enclosure and is electrically coupled to the sensing electrode. The cardioversion/defibrillation electrode and the sensing electrode are each electrically coupled to one of the conductive end walls of the diode enclosure.
摘要翻译：一种可植入电引线，其具有承载心脏复律/除颤电极的细长绝缘引线体和与心脏复律/除颤电极间隔开的感测电极。二极管外壳安装在心脏复律电极和感测电极之间的引线主体中，二极管外壳具有导电端壁并且包括耦合在导电端壁之间的二极管或二极管。外壳还设置有穿过所述外壳延伸穿过端壁的馈通管。细长的导体延伸穿过引线主体并穿过所述外壳的馈通管并且电耦合到感测电极。心脏复律/除颤电极和感测电极各自电耦合到二极管外壳的导电端壁之一。

23. 发明授权

US10112045B2 Implantable medical device fixation 有权
公开(公告)号：US10112045B2
公开(公告)日：2018-10-30
申请号：US13284761
申请日：2011-10-28
申请人： Thomas A. Anderson , Douglas D. Nippoldt , Richard W. Swenson, III , Vladimir Grubac , Matthew D. Bonner , Raymond W. Usher , Arshad A. Alfoqaha
发明人： Thomas A. Anderson , Douglas D. Nippoldt , Richard W. Swenson, III , Vladimir Grubac , Matthew D. Bonner , Raymond W. Usher , Arshad A. Alfoqaha
IPC分类号： A61B5/02 , A61N1/05 , A61N1/372 , A61N1/375 , A61N1/362
摘要： An assembly includes an implantable medical device (IMD) including a conductive housing, and a fixation element assembly attached to the IMD. The fixation element assembly includes a set of active fixation tines and an insulator to electrically isolate the set of active fixation tines from the conductive housing of the implantable medical device. The active fixation tines in the set are deployable from a spring-loaded position in which distal ends of the active fixation tines point away from the implantable medical device to a hooked position in which the active fixation tines bend back towards the implantable medical device. The active fixation tines are configured to secure the implantable medical device to a patient tissue when deployed while the distal ends of the active fixation tines are positioned adjacent to the patient tissue.

24. 发明授权

US08758365B2 Implant system including guiding accessory and methods of use 有权
标题翻译：植入系统包括引导配件和使用方法
公开(公告)号：US08758365B2
公开(公告)日：2014-06-24
申请号：US13197156
申请日：2011-08-03
申请人： Matthew D. Bonner , Vladimir P. Nikolski
发明人： Matthew D. Bonner , Vladimir P. Nikolski
IPC分类号： A61B19/00
CPC分类号： A61N1/056 , A61N1/37205 , A61N1/3756
摘要： A guiding accessory, for use in conjunction with a guidewire and a catheter of an implant system, facilitates passage of an elongate and flexible conductor of a relatively compact therapy delivery device to an implant site, for example, within the cardiac venous system, when a therapy generator of the device is held within a distal portion of the catheter, and the catheter, device and guiding accessory are advanced along the guidewire. The guiding accessory includes a helically extending wall that forms a lumen within which the device conductor and guidewire extend. After advancing the catheter, guiding accessory and device to the implant site, the helically extending wall is unwound from around the device conductor, for removal, preferably, by pulling proximally on a tension line, which is attached to a proximal end of the wall.
摘要翻译：用于与导线和植入物系统的导管一起使用的引导附件有助于使相对紧凑的治疗递送装置的细长柔性导体通过例如心脏静脉系统内的植入部位，该装置的治疗发生器被保持在导管的远端部分内，并且导管，装置和导向附件沿着导丝线前进。引导配件包括螺旋形延伸的壁，其形成设备导体和导丝延伸的管腔。在推进导管之后，引导附件和装置到植入部位，螺旋形延伸的壁从装置导体周围展开，以便优选地通过在附着在壁的近端的张力线上向近侧拉动来移除。

25. 发明授权

US08623010B2 Cardiac mapping instrument with shapeable electrode 有权
标题翻译：具有可塑电极的心脏测绘仪
公开(公告)号：US08623010B2
公开(公告)日：2014-01-07
申请号：US12480926
申请日：2009-06-09
申请人： Jon M. Ocel , Roderick E. Briscoe , David E. Francischelli , Scott E. Jahns , James R. Keogh , Katherine S. Jolly , Matthew D. Bonner
发明人： Jon M. Ocel , Roderick E. Briscoe , David E. Francischelli , Scott E. Jahns , James R. Keogh , Katherine S. Jolly , Matthew D. Bonner
IPC分类号： A61B18/14
CPC分类号： A61B5/042 , A61B5/7475 , A61B18/14 , A61B2017/2927 , A61B2018/1472 , A61N1/056
摘要： An instrument including an elongated shaft and a non-conductive handle is disclosed. The shaft defines a proximal section and a distal section. The distal section forms an electrically conductive tip. Further, the shaft is adapted to be transitionable from a straight state to a first bent state. The shaft is capable of independently maintaining the distinct shapes associated with the straight state and the first bent state. The handle is rigidly coupled to the proximal section of the shaft. The instrument is useful for epicardial pacing and/or mapping of the heart for temporary pacing on a beating heart, for optimizing the placement of ventricular leads for the treatment of patients with congestive heart failure and ventricular dysynchrony and/or for use in surgical ablation procedures.
摘要翻译：公开了一种包括细长轴和非导电手柄的仪器。轴限定近端部分和远端部分。远侧部分形成导电尖端。此外，轴适于从直状态转变到第一弯曲状态。轴能够独立地保持与直线状态和第一弯曲状态相关联的不同形状。手柄刚性地联接到轴的近端部分。该仪器可用于心脏起搏和/或心脏在心脏跳动中临时起搏的作用，以优化用于治疗患有充血性心力衰竭和心室异常不适和/或用于外科手术切除手术的患者的心室导线的放置。

26. 发明申请

US20130035748A1 IMPLANT SYSTEM INCLUDING GUIDING ACCESSORY AND METHODS OF USE 有权
标题翻译：包括引导附件和使用方法的植入系统
公开(公告)号：US20130035748A1
公开(公告)日：2013-02-07
申请号：US13197156
申请日：2011-08-03
申请人： Matthew D. Bonner , Vladimir P. Nikolski
发明人： Matthew D. Bonner , Vladimir P. Nikolski
IPC分类号： A61F2/84
CPC分类号： A61N1/056 , A61N1/37205 , A61N1/3756
摘要： A guiding accessory, for use in conjunction with a guidewire and a catheter of an implant system, facilitates passage of an elongate and flexible conductor of a relatively compact therapy delivery device to an implant site, for example, within the cardiac venous system, when a therapy generator of the device is held within a distal portion of the catheter, and the catheter, device and guiding accessory are advanced along the guidewire. The guiding accessory includes a helically extending wall that forms a lumen within which the device conductor and guidewire extend. After advancing the catheter, guiding accessory and device to the implant site, the helically extending wall is unwound from around the device conductor, for removal, preferably, by pulling proximally on a tension line, which is attached to a proximal end of the wall.
摘要翻译：用于与导线和植入物系统的导管一起使用的引导附件有助于使相对紧凑的治疗递送装置的细长柔性导体通过例如心脏静脉系统内的植入部位，该装置的治疗发生器被保持在导管的远端部分内，并且导管，装置和导向附件沿着导丝线前进。引导配件包括螺旋形延伸的壁，其形成设备导体和导丝延伸的管腔。在推进导管之后，引导附件和装置到植入部位，螺旋形延伸的壁从装置导体周围展开，以便优选地通过在附着在壁的近端的张力线上向近侧拉动来移除。

27. 发明申请

US20120172690A1 IMPLANTABLE MEDICAL DEVICE FIXATION 审中-公开
标题翻译：可植入医疗器械固定
公开(公告)号：US20120172690A1
公开(公告)日：2012-07-05
申请号：US13284761
申请日：2011-10-28
申请人： Thomas A. Anderson , Douglas D. Nippoldt , Richard W. Swenson, III , Vladimir Grubac , Matthew D. Bonner , Raymond W. Usher , Arshad A. Alfoqaha
发明人： Thomas A. Anderson , Douglas D. Nippoldt , Richard W. Swenson, III , Vladimir Grubac , Matthew D. Bonner , Raymond W. Usher , Arshad A. Alfoqaha
IPC分类号： A61B5/145 , A61B19/00 , A61N1/36 , A61N1/365 , A61B5/04 , A61N1/05
CPC分类号： A61N1/0573 , A61N1/362 , A61N1/37205 , A61N1/37518 , A61N1/3756
摘要： An assembly includes an implantable medical device (IMD) including a conductive housing, and a fixation element assembly attached to the IMD. The fixation element assembly includes a set of active fixation tines and an insulator to electrically isolate the set of active fixation tines from the conductive housing of the implantable medical device. The active fixation tines in the set are deployable from a spring-loaded position in which distal ends of the active fixation tines point away from the implantable medical device to a hooked position in which the active fixation tines bend back towards the implantable medical device. The active fixation tines are configured to secure the implantable medical device to a patient tissue when deployed while the distal ends of the active fixation tines are positioned adjacent to the patient tissue.
摘要翻译：组件包括可植入医疗装置（IMD），其包括导电外壳和连接到IMD的固定元件组件。固定元件组件包括一组主动固定齿和绝缘体，用于将一组主动固定齿与可植入医疗装置的导电外壳电隔离。组合中的主动固定齿可从弹簧加载位置展开，其中主动固定尖端的远端尖端远离可植入医疗装置指向钩状位置，在该位置，主动固定齿可向着可植入医疗装置弯回。主动固定齿构造成在展开时将可植入医疗装置固定到患者组织，同时活动固定齿的远端定位成与患者组织相邻。

28. 发明申请

US20100121362A1 VESSEL SUPPORT DEVICE AND METHOD OF VESSEL HARVESTING 审中-公开
标题翻译：船舶支持装置和船舶收集方法
公开(公告)号：US20100121362A1
公开(公告)日：2010-05-13
申请号：US12689357
申请日：2010-01-19
申请人： Cynthia T. Clague , Michael J. Hobday , Raymond W. Usher , Roderick E. Briscoe , Katherine S. Olig , Ana R. Menk , Christopher P. Olig , Eric A. Meyer , Steven C. Christian , Thomas P. Daigle , Robert H. Reetz , Jeffrey D. Sandstrom , James R. Keogh , Matthew D. Bonner , Scott E. Jahns , Philip J. Haarstad
发明人： Cynthia T. Clague , Michael J. Hobday , Raymond W. Usher , Roderick E. Briscoe , Katherine S. Olig , Ana R. Menk , Christopher P. Olig , Eric A. Meyer , Steven C. Christian , Thomas P. Daigle , Robert H. Reetz , Jeffrey D. Sandstrom , James R. Keogh , Matthew D. Bonner , Scott E. Jahns , Philip J. Haarstad
IPC分类号： A61B17/22 , A61M25/00
CPC分类号： A61B17/32 , A61B17/00008 , A61B17/3205 , A61B17/32053 , A61B2017/320064
摘要： Embodiments of the invention provide a vessel support system and a method of vessel harvesting. The system can include a cutting device, a catheter adapted to be inserted into a section of the vessel in order to support the vessel as the cutting device is advanced over the vessel, and a cannula adapted to be coupled to the vessel and adapted to receive the catheter as the catheter is inserted into the section of the vessel. The method can include orienting a cutting device coaxially with the cannula and the catheter and advancing the cutting device over the cannula, the catheter, and the section of the vessel in order to core out the section of the vessel and a portion of the surrounding tissue.
摘要翻译：本发明的实施例提供了一种血管支持系统和血管收集方法。该系统可以包括切割装置，适于插入到容器的一部分中的导管，以便当切割装置前进在容器上时支撑容器，以及适于联接到容器并适于接收的套管作为导管的导管插入血管的部分。该方法可以包括将切割装置与套管和导管同轴定向，并将切割装置推进套管，导管和容器的部分，以便将血管的一部分和周围组织的一部分。

29. 发明申请

US20100063475A1 DEVICES AND METHODS FOR INTERSTITIAL INJECTION OF BIOLOGIC AGENTS INTO TISSUE 有权
标题翻译：用于生物组织的内部注射用于组织的装置和方法
公开(公告)号：US20100063475A1
公开(公告)日：2010-03-11
申请号：US12621037
申请日：2009-11-18
申请人： Scott E. Jahns , Gary S. Oehme , Matthew D. Bonner , James R. Keogh
发明人： Scott E. Jahns , Gary S. Oehme , Matthew D. Bonner , James R. Keogh
IPC分类号： A61M31/00 , A61M5/32
CPC分类号： A61B17/3478 , A61B17/00234 , A61B17/205 , A61B2017/00247 , A61B2017/00876 , A61B2017/2936 , A61B2017/2943 , A61B2017/306 , A61B2018/00392 , A61B2090/034 , A61M5/32 , A61M2025/0086 , A61M2025/0087
摘要： Apparatus and methods for injecting biological agents into tissue. Devices are provided having elongate shafts and distal injection heads for transversely driving needles into tissue and injecting medical agents into the tissue through the needles. A longitudinal force directed along the shaft can be translated to a needle driving force transverse to the shaft. Some devices provide controllably variable needle penetration depth. Devices include mechanical needle drivers utilizing four link pantographs, rack and pinions, and drive yokes for driving a first needle bearing body toward a second tissue contacting body. Other devices include inflatable members for driving and retracting needles. Still other devices include magnets for biasing the needles in extended and/or retracted positions. The invention includes minimally invasive methods for epicardially injecting cardiocyte precursor cells into infarct myocardial tissue.
摘要翻译：将生物制剂注入组织的装置和方法。设备具有细长的轴和远端注射头，用于将针横向驱动到组织中，并通过针将药剂注射到组织中。沿着轴引导的纵向力可以平移到与轴垂直的针驱动力。一些装置提供可控的可变针穿透深度。设备包括利用四个连杆缩放仪，齿条和小齿轮的机械针驱动器和用于将第一滚针轴承体朝向第二组织接触体驱动的驱动轭。其他装置包括用于驱动和缩回针的可充气构件。还有其它装置包括用于在延伸和/或缩回位置偏置针的磁体。本发明包括用心外膜将心脏细胞前体细胞注入梗死心肌组织的微创方法。

30. 发明授权

US07628780B2 Devices and methods for interstitial injection of biologic agents into tissue 有权
标题翻译：将生物制剂间插注入组织的装置和方法
公开(公告)号：US07628780B2
公开(公告)日：2009-12-08
申请号：US11000798
申请日：2004-11-30
申请人： Matthew D. Bonner , Paul T. Rothstein , Prasanga D. Hiniduma-Lokuge , James R. Keogh , Raymond W. Usher , Scott Eric Jahns , Victor T. Chen
发明人： Matthew D. Bonner , Paul T. Rothstein , Prasanga D. Hiniduma-Lokuge , James R. Keogh , Raymond W. Usher , Scott Eric Jahns , Victor T. Chen
IPC分类号： A61M31/00 , A61B17/32
CPC分类号： A61B17/3478 , A61B17/00234 , A61B17/205 , A61B2017/00243 , A61B2017/00247 , A61B2017/2926 , A61B2017/2936 , A61B2017/2943 , A61B2017/306 , A61B2018/00392 , A61B2090/034 , A61M25/0084
摘要： Apparatus and methods for injecting biological agents into tissue. Devices are provided having elongate shafts and distal injection heads for driving needles into tissue and injecting medical agents into the tissue through the needles. A longitudinal force directed along the shaft can be translated to a needle driving force. Some devices provide controllably variable needle penetration depth. Devices include mechanical needle drivers utilizing four link pantographs, rack and pinions, and drive yokes for driving a first needle bearing body toward a second tissue contacting body. Other devices include inflatable members for driving and retracting needles. Still other devices include magnets for biasing the needles in extended and/or retracted positions. The invention includes minimally invasive methods for epicardially injecting cardiocyte precursor cells into infarct myocardial tissue.
摘要翻译：将生物制剂注入组织的装置和方法。设备具有细长轴和远端注射头，用于将针驱动到组织中，并通过针将药剂注射到组织中。沿着轴引导的纵向力可以转换成针驱动力。一些装置提供可控的可变针穿透深度。设备包括利用四个连杆缩放仪，齿条和小齿轮的机械针驱动器和用于将第一滚针轴承体朝向第二组织接触体驱动的驱动轭。其他装置包括用于驱动和缩回针的可充气构件。还有其它装置包括用于在延伸和/或缩回位置偏置针的磁体。本发明包括用心外膜将心脏细胞前体细胞注入梗死心肌组织的微创方法。

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