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21. 发明申请

US20120189643A1 Toll Like Receptor 3 Antagonists, Methods and Uses 审中-公开
标题翻译： Toll Like Receptor 3 Antagonists，Methods and Uses
公开(公告)号：US20120189643A1
公开(公告)日：2012-07-26
申请号：US13412259
申请日：2012-03-05
申请人： Jill M. Carton , Shizhong Chen , Mark Cunningham , Anuk Das , Karen Duffy , Jill M. Giles-Komar , Theresa J. Goletz , David M. Knight , Roberta Lamb , Mouhamadou L. Mbow , Kristen Picha , Gopalan Raghunathan , Lani San Mateo , Robert T. Sarisky , Vedrana Stojanovic-Susulic , Nicole Stowell , Raymond Sweet , Shanrong Zhao
发明人： Jill M. Carton , Shizhong Chen , Mark Cunningham , Anuk Das , Karen Duffy , Jill M. Giles-Komar , Theresa J. Goletz , David M. Knight , Roberta Lamb , Mouhamadou L. Mbow , Kristen Picha , Gopalan Raghunathan , Lani San Mateo , Robert T. Sarisky , Vedrana Stojanovic-Susulic , Nicole Stowell , Raymond Sweet , Shanrong Zhao
IPC分类号： A61K39/395 , C12N15/13 , C12N15/63 , C12N1/21 , A61P3/10 , C12P21/00 , C12N5/16 , A61P29/00 , A61P1/00 , A61P11/00 , C07K16/28 , C12N5/10
CPC分类号： C07K16/2866 , A61K2039/505 , C07K16/2896 , C07K2317/24 , C07K2317/74 , C07K2317/76
摘要： Toll Like Receptor 3 (TLR3) antagonists, polynucleotides encoding TLR3 antagonists or fragments thereof, and methods of making and using the foregoing are disclosed.
摘要翻译： Toll样受体3（TLR3）拮抗剂，编码TLR3拮抗剂或其片段的多核苷酸，以及制备和使用前述物质的方法。

22. 发明授权

US07993645B2 Human anti-IL-23 antibodies, compositions, methods and uses 有权
公开(公告)号：US07993645B2
公开(公告)日：2011-08-09
申请号：US12855354
申请日：2010-08-12
申请人： Jacqueline Benson , Jill Carton , Mark Cunningham , Yevgeniya I. Orlovsky , Robert Rauchenberger , Raymond Sweet
发明人： Jacqueline Benson , Jill Carton , Mark Cunningham , Yevgeniya I. Orlovsky , Robert Rauchenberger , Raymond Sweet
IPC分类号： A61K39/395
CPC分类号： C07K16/244 , A61K9/0019 , A61K9/08 , A61K39/3955 , A61K47/183 , A61K47/26 , A61K2039/505 , C07K2317/21 , C07K2317/34 , C07K2317/52 , C07K2317/55 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2319/00 , C07K2319/30
摘要： A human anti-IL-23p19 antibody, including isolated nucleic acids that encode at least one anti-IL-23p19 antibody, vectors, host cells, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices.

23. 发明授权

US07807414B2 Anti-IL-23 antibodies, compositions, methods and uses 有权
标题翻译：抗IL-23抗体，组合物，方法和用途
公开(公告)号：US07807414B2
公开(公告)日：2010-10-05
申请号：US12370872
申请日：2009-02-13
申请人： Jacqueline Benson , Mark Cunningham , Cynthia Duchala , Jill M. Giles-Komar , Jinquan Luo , Michael A. Rycyzyn , Sweet Raymond
发明人： Jacqueline Benson , Mark Cunningham , Cynthia Duchala , Jill M. Giles-Komar , Jinquan Luo , Michael A. Rycyzyn , Sweet Raymond
IPC分类号： C12N5/10 , C12N15/13 , C12N15/63
CPC分类号： A61K39/3955 , A61K39/00 , A61K45/06 , A61K2039/505 , A61K2039/55527 , A61K2039/55544 , C07K16/244 , C07K2317/30 , C07K2317/33 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C07K2319/55 , G01N33/6869 , G01N2333/54 , Y02A50/386 , Y02A50/401 , Y02A50/41 , Y02A50/412 , Y02A50/55 , Y02A50/57 , Y02A50/58
摘要： An anti-IL-23p19 antibody, including isolated nucleic acids that encode at least one anti-IL-23p19 antibody, vectors, host cells, transgenic animals or plants, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices.
摘要翻译：抗IL-23p19抗体，包括编码至少一种抗IL-23p19抗体的分离的核酸，载体，宿主细胞，转基因动物或植物及其制备和使用的方法具有在诊断和/或治疗组合物中的应用，方法和设备。

24. 发明授权

US07790671B2 Implantable pump for protein delivery for obesity control by drug infusion into the brain 有权
标题翻译：用于通过药物输注到大脑中进行肥胖控制的蛋白质递送的可植入泵
公开(公告)号：US07790671B2
公开(公告)日：2010-09-07
申请号：US11245653
申请日：2005-10-07
申请人： Vedrana Stojanovic-Susulic , Ramakrishna Venugopalan , Mark Cunningham
发明人： Vedrana Stojanovic-Susulic , Ramakrishna Venugopalan , Mark Cunningham
IPC分类号： A61K38/00
CPC分类号： A61K38/34 , A61K47/6811 , A61K47/6849
摘要： Methods and compositions are provided for suppressing appetite by surgically implanting a drug infusion pump into a site in a subject, and delivering a stable suspension of an appetite suppressing agent a region in a central nervous system of the subject. The appetite suppressing agent binds to a target receptor on a neural cell in the central nervous system and modifies the receptor function to suppress appetite.
摘要翻译：提供了通过将药物输注泵手术植入受试者的部位来抑制食欲的方法和组合物，并且在受试者的中枢神经系统中输送食欲抑制剂的稳定的悬浮液。食欲抑制剂与中枢神经系统中的神经细胞上的靶受体结合并改变受体功能以抑制食欲。

25. 发明申请

US20100166778A1 Toll-Like Receptor 3 Antagonists 有权
标题翻译： Toll样受体3拮抗剂
公开(公告)号：US20100166778A1
公开(公告)日：2010-07-01
申请号：US12609675
申请日：2009-10-30
申请人： Mark Cunningham , Yiqing Feng , Katharine Heeringa , Jinquan Luo , Robert Rauchenberger , Mark Rutz , Lani San Mateo , Robert Sarisky , Raymond Sweet , Fang Teng , Alexey Teplyakov , Sheng-Jiun Wu
发明人： Mark Cunningham , Yiqing Feng , Katharine Heeringa , Jinquan Luo , Robert Rauchenberger , Mark Rutz , Lani San Mateo , Robert Sarisky , Raymond Sweet , Fang Teng , Alexey Teplyakov , Sheng-Jiun Wu
IPC分类号： A61K39/395 , C07K16/28 , C07K17/08 , C07H21/04 , A61P29/00 , A61P11/00 , A61P11/06 , A61P11/02 , A61P1/00 , A61P1/04 , A61P37/00 , A61P37/06 , A61P3/10 , A61P31/12 , A61P31/16
CPC分类号： C07K16/2896 , A61K39/39533 , A61K39/3955 , A61K2039/505 , C07H21/04 , C07K14/705 , C07K16/18 , C07K16/28 , C07K16/2863 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/51 , C07K2317/515 , C07K2317/52 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C07K2317/94 , C12N5/10 , C12N5/12 , C12N15/117 , C12N15/63 , C12N2310/17 , A61K39/00 , A61K2300/00
摘要： Toll Like Receptor 3 (TLR3) antibody antagonists, polynucleotides encoding TLR3 antibody antagonists or fragments thereof, and methods of making and using the foregoing are disclosed.
摘要翻译：公开了Toll样受体3（TLR3）抗体拮抗剂，编码TLR3抗体拮抗剂或其片段的多核苷酸，以及制备和使用前述物质的方法。

26. 发明授权

US07659250B2 BMP-7 variant compositions, methods and uses 失效
标题翻译： BMP-7变体组合物，方法和用途
公开(公告)号：US07659250B2
公开(公告)日：2010-02-09
申请号：US11760146
申请日：2007-06-08
申请人： Bernard Amegadzie , Mark Cunningham , Haimanti Dorai , Jeffrey Luo , Juliane Mills , Bethany Swencki-Underwood
发明人： Bernard Amegadzie , Mark Cunningham , Haimanti Dorai , Jeffrey Luo , Juliane Mills , Bethany Swencki-Underwood
IPC分类号： A61K38/16 , A61K38/17 , A61K38/18 , C07K14/00 , C07K14/435 , C07K14/46 , C07K14/465 , C07K14/47 , C07K14/475 , C07K14/51
CPC分类号： C07K14/51 , A61K38/00
摘要： Human Bone Morphogenic Protein 7 (hBMP-7) variant peptide chains, nucleic acids encoding these peptide chains, and methods of making and using the foregoing are disclosed.
摘要翻译：公开了人骨形态发生蛋白7（hBMP-7）变体肽链，编码这些肽链的核酸，以及制备和使用前述物质的方法。

27. 发明申请

US20090186020A1 Melanocortin Receptor Binding Mimetibodies, Compositions, Methods and Uses 有权
标题翻译：黑皮质素受体结合模拟物，组合物，方法和用途
公开(公告)号：US20090186020A1
公开(公告)日：2009-07-23
申请号：US11929046
申请日：2007-10-30
申请人： Mark Cunningham , Vedrana Stojanovic-Susulic , Karyn O'Neil , Chichi Huang , Jeffrey Luo
发明人： Mark Cunningham , Vedrana Stojanovic-Susulic , Karyn O'Neil , Chichi Huang , Jeffrey Luo
IPC分类号： A61K39/395 , C07K16/00 , C07H21/04 , C12N15/63 , C12N5/10 , C12P21/06 , C12N5/02
CPC分类号： A61K38/34 , A61K47/6811 , C07H21/04 , C07K14/68 , C07K16/00 , C07K2317/56 , C07K2317/64 , C07K2318/10 , C07K2319/00
摘要： Melanocortin receptor binding mimetibody polypeptides are disclosed. Polynucleotides encoding these polypeptides, cells comprising these polynucleotides or expressing the mimetibodies, and methods of making and using the forgoing are also disclosed.
摘要翻译：公开了黑皮质素受体结合模拟体多肽。还公开了编码这些多肽的多核苷酸，包含这些多核苷酸的细胞或表达模拟物，以及制备和使用前述方法。

28. 发明申请

US20090162371A1 Anti-IL-23 Antibodies, Compositions, Methods and Uses 有权
标题翻译：抗IL-23抗体，组合物，方法和用途
公开(公告)号：US20090162371A1
公开(公告)日：2009-06-25
申请号：US12370872
申请日：2009-02-13
申请人： Jacqueline Benson , Mark Cunningham , Cynthia Duchala , Jill M. Giles-Komar , Jinquan Luo , Michael A. Rycyzyn , Sweet Raymond
发明人： Jacqueline Benson , Mark Cunningham , Cynthia Duchala , Jill M. Giles-Komar , Jinquan Luo , Michael A. Rycyzyn , Sweet Raymond
IPC分类号： A61K39/395 , C07K16/18 , C12N15/11 , C12N15/00 , C12N1/21 , C12N5/06 , C12P21/02 , G01N33/53
CPC分类号： A61K39/3955 , A61K39/00 , A61K45/06 , A61K2039/505 , A61K2039/55527 , A61K2039/55544 , C07K16/244 , C07K2317/30 , C07K2317/33 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C07K2319/55 , G01N33/6869 , G01N2333/54 , Y02A50/386 , Y02A50/401 , Y02A50/41 , Y02A50/412 , Y02A50/55 , Y02A50/57 , Y02A50/58
摘要： An anti-IL-23p19 antibody, including isolated nucleic acids that encode at least one anti-IL-23p19 antibody, vectors, host cells, transgenic animals or plants, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices.
摘要翻译：抗IL-23p19抗体，包括编码至少一种抗IL-23p19抗体的分离的核酸，载体，宿主细胞，转基因动物或植物及其制备和使用的方法具有在诊断和/或治疗组合物中的应用，方法和设备。

29. 发明申请

US20070218064A1 HUMAN ANTI-IL-23 ANTIBODIES, COMPOSITIONS, METHODS AND USES 有权
标题翻译：人类抗IL-23抗体，组合物，方法和用途
公开(公告)号：US20070218064A1
公开(公告)日：2007-09-20
申请号：US11617503
申请日：2006-12-28
申请人： Jacqueline Benson , Jill Carton , Mark Cunningham , Yevgeniya Orlovsky , Robert Rauchenberger , Raymond Sweet
发明人： Jacqueline Benson , Jill Carton , Mark Cunningham , Yevgeniya Orlovsky , Robert Rauchenberger , Raymond Sweet
IPC分类号： A61K39/395 , C07K16/24 , C07H21/04 , C12P21/06 , C12N5/06
CPC分类号： C07K16/244 , A61K9/0019 , A61K9/08 , A61K39/3955 , A61K47/183 , A61K47/26 , A61K2039/505 , C07K2317/21 , C07K2317/34 , C07K2317/52 , C07K2317/55 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2319/00 , C07K2319/30
摘要： A human anti-IL-23p19 antibody, including isolated nucleic acids that encode at least one anti-IL-23p19 antibody, vectors, host cells, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices.
摘要翻译：人抗IL-23p19抗体，包括编码至少一种抗IL-23p19抗体的分离的核酸，载体，宿主细胞及其制备和使用方法在诊断和/或治疗组合物，方法和装置中的应用。

30. 发明授权

US06687745B1 System and method for delivering a graphical user interface of remote applications over a thin bandwidth connection 有权
标题翻译：通过薄带宽连接传送远程应用程序的图形用户界面的系统和方法
公开(公告)号：US06687745B1
公开(公告)日：2004-02-03
申请号：US09599382
申请日：2000-06-22
申请人： Louis M. Franco , Frank Leon Rose , Philip S. J. Brittan , Mark Cunningham , Alex Bulkin , Mat Baskin , Greg Blonder
发明人： Louis M. Franco , Frank Leon Rose , Philip S. J. Brittan , Mark Cunningham , Alex Bulkin , Mat Baskin , Greg Blonder
IPC分类号： G06F1516
CPC分类号： H04L67/42 , G06F8/60 , G06F9/54 , H04L29/06 , H04L51/06 , H04L67/025 , H04L67/14 , H04L67/34 , H04L67/36 , H04L69/329
摘要： A method and system are disclosed for delivering interactive links for presenting applications and second information at a client computer from remote sources in a network-configured computer processing system. In one embodiment, the method includes retrieving over a first communication connection, in response to a request of a client computer, informational content having computer program code embedded therein, and executing the embedded computer program code for establishing a second communication connection to an application server. The method further includes retrieving over the second communication connection first information including presentational information for presenting the application and the second information. The method also includes presenting the application and the second information based upon the presentational information, and storing on the client computer an interactive link for selectively re-establishing the second communication connection to the application server for retrieving the first information and presenting the application and the second information on an as-needed basis. Preferably, the storing of the interactive link includes downloading a graphical representation of the interactive link and storing a file containing information representing an operating environment of the client computer and a network address of the application server.
摘要翻译：公开了一种方法和系统，用于在网络配置的计算机处理系统中从远程源提供用于在客户端计算机上呈现应用和第二信息的交互式链接。在一个实施例中，该方法包括响应于客户端计算机的请求检索第一通信连接，其中嵌入有计算机程序代码的信息内容，以及执行用于建立到应用服务器的第二通信连接的嵌入式计算机程序代码。该方法还包括通过第二通信连接检索第一信息，包括用于呈现应用程序的显示信息和第二信息。该方法还包括基于该展示信息呈现应用程序和第二信息，并在客户端计算机上存储交互式链接，用于选择性地重新建立到应用服务器的第二通信连接，用于检索第一信息并呈现应用程序和根据需要提供第二个信息。优选地，交互式链接的存储包括下载交互式链接的图形表示，并且存储包含表示客户端计算机的操作环境的信息的文件和应用服务器的网络地址。

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