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21. 发明授权

US08691258B2 Anti-infective medical device 有权
标题翻译：抗感染医疗器械
公开(公告)号：US08691258B2
公开(公告)日：2014-04-08
申请号：US11008445
申请日：2004-12-09
申请人： Kenneth T. Heruth , Christopher M. Hobot , William J. Hooper , Mark S. Lent , Ruchika Singhal , Robert M. Skime , Randall V. Sparer , Maura G. Donovan , William J. Bertrand
发明人： Kenneth T. Heruth , Christopher M. Hobot , William J. Hooper , Mark S. Lent , Ruchika Singhal , Robert M. Skime , Randall V. Sparer , Maura G. Donovan , William J. Bertrand
IPC分类号： A61F13/00 , A01N25/00
CPC分类号： A61N1/05 , A61N1/0568 , A61N1/375
摘要： Implantable medical devices (IMDS) having anti-infective properties are described. Anti-infective agents are disposed in, on, or about at least a portion of a surface of the medical device. The anti-infective agents are disposed in or on a vehicle, which may be in the form of a coating layer or covering. The vehicle may be biodegradable so that, over time, the anti-infective agent is removed from a tissue location into which the device is implanted, reducing the likelihood that microorganisms resistant to the anti-infective agent will develop. IMDs having an anti-infective agent and an anti-activity agent disposed therein, thereabout, or thereon are also described. The anti-activity agent interferes with the activity of the anti-infective agent, may be released from a surface at the IMD at a time when activity of the anti-infective agent is no longer desired, and may reduce the likelihood that microorganisms resistant to the anti-infective agent will develop.
摘要翻译：描述具有抗感染性的植入式医疗装置（IMDS）。抗感染剂设置在医疗装置的表面的至少一部分上，其上或附近。抗感染剂设置在车辆中或车辆上，其可以是涂层或覆盖物的形式。载体可以是可生物降解的，使得随着时间的推移，抗感染剂从植入装置所在的组织位置移除，降低了抗感染剂抗微生物的可能性。还描述了其上设置有抗感染剂和抗活性剂的IMD，其上或其上。干扰抗感染剂的活性的抗活性剂可以在不再需要抗感染剂的活性的时候从IMD的表面释放，并且可能降低抗微生物抗性的可能性抗感染剂会发展。

22. 发明授权

US08447401B2 Collecting posture information to evaluate therapy 有权
公开(公告)号：US08447401B2
公开(公告)日：2013-05-21
申请号：US12856255
申请日：2010-08-13
申请人： Keith A. Miesel , Kenneth T. Heruth
发明人： Keith A. Miesel , Kenneth T. Heruth
IPC分类号： A61N1/36
CPC分类号： A61B5/4848 , A61B5/103 , A61B5/1116 , A61B5/4082 , A61B5/6825 , A61B5/686 , A61M5/14276 , A61N1/0531 , A61N1/0534 , A61N1/36071 , A61N1/36082 , A61N1/36514 , A61N1/36521 , A61N1/36535 , A61N1/36542 , A61N1/36557 , A61N1/37235
摘要： A medical device delivers a therapy to a patient. Posture events are identified, e.g., a posture of the patient is periodically determined and/or posture transitions by the patient are identified, and each determined posture event is associated with a current therapy parameter set. A value of at least one posture metric is determined for each of a plurality of therapy parameter sets based on the posture events associated with that therapy parameter set. A list of the therapy parameter sets is presented to a user, such as a clinician, for evaluation of the relative efficacy of the therapy parameter sets. The list may be ordered according to the one or more posture metric values to aid in evaluation of the therapy parameter sets. Where values are determined for a plurality of posture metrics, the list may be ordered according to the one of the posture metrics selected by the user.

23. 发明授权

US08246602B2 Catheters with tracking elements and permeable membranes 有权
标题翻译：导管带跟踪元件和渗透膜
公开(公告)号：US08246602B2
公开(公告)日：2012-08-21
申请号：US10873764
申请日：2004-06-22
申请人： Kenneth T. Heruth , Mark S. Lent , Justin A. Blanco
发明人： Kenneth T. Heruth , Mark S. Lent , Justin A. Blanco
IPC分类号： A61M25/00 , A61K9/22
CPC分类号： A61M25/0043 , A61M25/003 , A61M25/0105 , A61M2025/0057 , A61M2025/0166
摘要： Devices, systems and methods for delivering one or more drugs to one or more internal body locations (such as the cerebrospinal fluid) are disclosed. In various aspects, the systems and methods may involve catheters having infusion sections with permeable membranes and one or more tracking elements that may be used to place the infusions sections on the catheters in selected locations such as the spinal region.
摘要翻译：公开了用于将一种或多种药物递送到一个或多个内部身体位置（例如脑脊液）的装置，系统和方法。在各个方面，系统和方法可以包括具有可渗透膜的输注部分的导管和一个或多个跟踪元件，所述跟踪元件可用于将选定位置（例如脊柱区域）中的输液部分置于导管上。

24. 发明申请

US20120150258A1 COLLECTING POSTURE AND ACTIVITY INFORMATION TO EVALUATE THERAPY 有权
标题翻译：收集治疗和活动信息以评估治疗
公开(公告)号：US20120150258A1
公开(公告)日：2012-06-14
申请号：US13401348
申请日：2012-02-21
申请人： Keith A. Miesel , Kenneth T. Heruth , Gregory F. Molnar
发明人： Keith A. Miesel , Kenneth T. Heruth , Gregory F. Molnar
IPC分类号： A61N1/372
CPC分类号： A61B5/103 , A61B5/0205 , A61B5/1116 , A61B5/4082 , A61B5/4094 , A61B5/6804 , A61B5/6825 , A61B5/686 , A61N1/0529 , A61N1/0531 , A61N1/0534 , A61N1/36071 , A61N1/36082 , A61N1/36585 , A61N1/37235 , G06F19/00
摘要： A medical device, programmer, or other computing device may determine values of one or more activity and, in some embodiments, posture metrics for each therapy parameter set used by the medical device to deliver therapy. The metric values for a parameter set are determined based on signals generated by the sensors when that therapy parameter set was in use. Activity metric values may be associated with a postural category in addition to a therapy parameter set, and may indicate the duration and intensity of activity within one or more postural categories resulting from delivery of therapy according to a therapy parameter set. A posture metric for a therapy parameter set may indicate the fraction of time spent by the patient in various postures when the medical device used a therapy parameter set. The metric values may be used to evaluate the efficacy of the therapy parameter sets.
摘要翻译：医疗设备，程序员或其他计算设备可以确定一个或多个活动的值，并且在一些实施例中，确定由医疗设备用于递送治疗的每个治疗参数集的姿势度量。当参数组被使用时，基于由传感器产生的信号来确定参数集的度量值。除了治疗参数集之外，活动度量值可以与姿势类别相关联，并且可以指示根据治疗参数集合递送治疗产生的一个或多个姿势类别内的活动的持续时间和强度。用于治疗参数组的姿势度量可以指示当医疗装置使用治疗参数集时患者在各种姿势中花费的时间的分数。度量值可用于评估治疗参数组的功效。

25. 发明申请

US20100274106A1 DETECTING SLEEP 审中-公开
标题翻译：检测睡眠
公开(公告)号：US20100274106A1
公开(公告)日：2010-10-28
申请号：US12828981
申请日：2010-07-01
申请人： Kenneth T. Heruth , Keith A. Miesel
发明人： Kenneth T. Heruth , Keith A. Miesel
IPC分类号： A61B5/00
CPC分类号： G06F19/3481 , A61B5/0205 , A61B5/4809 , A61M5/14276 , A61M2005/1726 , A61M2230/10 , A61M2230/40 , A61M2230/62 , A61M2230/63 , A61N1/36078 , A61N1/36135 , G16H40/63
摘要： A system includes one or more sensors and a processor. Each of the sensors generates a signal as a function of at least one physiological parameter of a patient that may discernibly change when the patient is asleep. The processor monitors the physiological parameters, and determines whether the patient is asleep based on the parameters. In some embodiments, the processor determines plurality of sleep metric values, each of which indicates a probability of the patient being asleep, based on each of a plurality of physiological parameters. The processor may average or otherwise combine the plurality of sleep metric values to provide an overall sleep metric value that is compared to a threshold value in order to determine whether the patient is asleep.
摘要翻译：系统包括一个或多个传感器和处理器。每个传感器产生作为患者的至少一个生理参数的函数的信号，当患者睡着时可以明显改变。处理器监视生理参数，并根据参数确定患者是否睡着了。在一些实施例中，处理器基于多个生理参数中的每一个来确定多个睡眠度量值，每个休眠度量值指示患者睡眠的概率。处理器可以平均或以其他方式组合多个睡眠度量值以提供与阈值进行比较的整体睡眠度量值，以便确定患者是否睡着了。

26. 发明授权

US07813803B2 Regional therapies for treatment of pain 有权
标题翻译：治疗疼痛的区域疗法
公开(公告)号：US07813803B2
公开(公告)日：2010-10-12
申请号：US11374852
申请日：2006-03-14
申请人： Kenneth T. Heruth , Mark S. Lent , Ruchika Singhal , Michael J. Schendel , Gary W. King
发明人： Kenneth T. Heruth , Mark S. Lent , Ruchika Singhal , Michael J. Schendel , Gary W. King
IPC分类号： A61N1/34
CPC分类号： A61M5/14276 , A61M5/172 , A61M5/1723 , A61M2205/054 , A61M2205/3523 , A61N1/025 , A61N1/36071 , A61N1/372 , A61N1/37229
摘要： Enhanced therapies for treating pain are described. The therapies include subcutaneous stimulation of tissue in proximity to a source of pain at low frequencies (less than about 20 Hz) and high frequencies (greater than about 50 Hz). The subcutaneous stimulation may be applied in proximity to a structure in the back, such as discs, facet joints, nerve roots or ganglions, sympathetic chain, ligaments, muscles, and the like. Subcutaneous stimulation at high and low frequencies applied in combination with epidural stimulation is also described.
摘要翻译：描述了治疗疼痛的增强疗法。这些疗法包括在低频（小于约20Hz）和高频（大于约50Hz）的疼痛源附近皮下刺激组织。皮下刺激可以应用在背部的结构附近，例如盘，小关节，神经根或神经节，交感神经链，韧带，肌肉等。还描述了与硬膜外刺激组合施加的高频和低频下的皮下刺激。

27. 发明授权

US07805196B2 Collecting activity information to evaluate therapy 有权
标题翻译：收集活动信息以评估治疗
公开(公告)号：US07805196B2
公开(公告)日：2010-09-28
申请号：US11691411
申请日：2007-03-26
申请人： Keith A. Miesel , Kenneth T. Heruth
发明人： Keith A. Miesel , Kenneth T. Heruth
IPC分类号： A61N1/36
CPC分类号： A61N1/3615 , A61B5/1116 , A61B5/1118 , A61B5/4082 , A61B5/4094 , A61B2562/0219 , A61N1/36003 , A61N1/36096
摘要： A medical device delivers a therapy to a patient. The medical device or another device may periodically determine an activity level of the patient, and associate each determined activity level with a current therapy parameter set. A value of at least one activity metric is determined for each of a plurality of therapy parameter sets based on the activity levels associated with that therapy parameter set. A list of the therapy parameter sets is presented to a user, such as a clinician, for evaluation of the relative efficacy of the therapy parameter sets. The list may be ordered according to the one or more activity metric values to aid in evaluation of the therapy parameter sets. Where values are determined for a plurality of activity metrics, the list may be ordered according to the one of the activity metrics selected by the user.
摘要翻译：医疗设备向患者传递治疗。医疗装置或其他装置可以周期性地确定患者的活动水平，并将每个确定的活动水平与当前治疗参数组相关联。基于与该治疗参数组相关联的活动水平，为多个治疗参数组中的每一个确定至少一个活动度量的值。将治疗参数组的列表呈现给诸如临床医师的用户，用于评估治疗参数组的相对功效。该列表可以根据一个或多个活动度量值来排序以帮助评估治疗参数集。在确定多个活动度量的值的情况下，可以根据用户选择的活动度量中的一个排序列表。

28. 发明授权

US07775993B2 Detecting sleep 有权
标题翻译：检测睡眠
公开(公告)号：US07775993B2
公开(公告)日：2010-08-17
申请号：US11081786
申请日：2005-03-16
申请人： Kenneth T. Heruth , Keith A. Miesel
发明人： Kenneth T. Heruth , Keith A. Miesel
IPC分类号： A61B5/103 , A61B5/117 , A61B5/08 , A61B5/05
CPC分类号： G06F19/3481 , A61B5/0205 , A61B5/4809 , A61M5/14276 , A61M2005/1726 , A61M2230/10 , A61M2230/40 , A61M2230/62 , A61M2230/63 , A61N1/36078 , A61N1/36135 , G06F19/00 , G16H40/63
摘要： A system includes one or more sensors and a processor. Each of the sensors generates a signal as a function of at least one physiological parameter of a patient that may discernibly change when the patient is asleep. The processor monitors the physiological parameters, and determines whether the patient is asleep based on the parameters. In some embodiments, the processor determines plurality of sleep metric values, each of which indicates a probability of the patient being asleep, based on each of a plurality of physiological parameters. The processor may average or otherwise combine the plurality of sleep metric values to provide an overall sleep metric value that is compared to a threshold value in order to determine whether the patient is asleep.
摘要翻译：系统包括一个或多个传感器和处理器。每个传感器产生作为患者的至少一个生理参数的函数的信号，当患者睡着时可以明显改变。处理器监视生理参数，并根据参数确定患者是否睡着了。在一些实施例中，处理器基于多个生理参数中的每一个来确定多个睡眠度量值，每个休眠度量值指示患者睡眠的概率。处理器可以平均或以其他方式组合多个睡眠度量值以提供与阈值进行比较的整体睡眠度量值，以便确定患者是否睡着了。

29. 发明授权

US07590453B2 Collecting activity information to evaluate incontinence therapy 有权
标题翻译：收集活动信息以评估失禁治疗
公开(公告)号：US07590453B2
公开(公告)日：2009-09-15
申请号：US11796811
申请日：2007-04-30
申请人： Kenneth T. Heruth , Keith A. Miesel
发明人： Kenneth T. Heruth , Keith A. Miesel
IPC分类号： A61N1/36
CPC分类号： A61M5/1723 , A61B5/0031 , A61B5/02055 , A61B5/0476 , A61B5/0488 , A61B5/1118 , A61B5/1455 , A61B5/6814 , A61B5/6826 , A61B5/6831 , A61B5/6838 , A61B2562/0219 , A61M5/14276 , A61N1/36071 , A61N1/365 , A61N1/36521 , A61N1/36542 , A61N1/36557
摘要： A medical device delivers a therapy to a patient. The medical device may periodically determine an activity level of the patient, and associate each determined activity level with a current therapy parameter set. A value of at least one activity metric is determined for each of a plurality of therapy parameter sets based on the activity levels associated with that therapy parameter set. A list of the therapy parameter sets is presented to a user, such as a clinician, for evaluation of the relative efficacy of the therapy parameter sets. The list may be ordered according to the one or more activity metric values to aid in evaluation of the therapy parameter sets. Where values are determined for a plurality of activity metrics, the list may be ordered according to the one of the activity metrics selected by the user.
摘要翻译：医疗设备向患者传递治疗。医疗设备可以周期性地确定患者的活动水平，并将每个确定的活动水平与当前治疗参数组相关联。基于与该治疗参数组相关联的活动水平，为多个治疗参数组中的每一个确定至少一个活动度量的值。将治疗参数组的列表呈现给诸如临床医师的用户，用于评估治疗参数组的相对功效。该列表可以根据一个或多个活动度量值来排序以帮助评估治疗参数集。在确定多个活动度量的值的情况下，可以根据用户选择的活动度量中的一个排序列表。

30. 发明申请

US20080167637A1 Method and apparatus for aneurismal treatment 审中-公开
标题翻译：用于动脉瘤治疗的方法和装置
公开(公告)号：US20080167637A1
公开(公告)日：2008-07-10
申请号：US11549379
申请日：2006-10-13
申请人： Sonny Yamasaki , Kenneth T. Heruth , James K. Carney , Mark L. Stiger
发明人： Sonny Yamasaki , Kenneth T. Heruth , James K. Carney , Mark L. Stiger
IPC分类号： A61M31/00
CPC分类号： A61B17/12022 , A61B17/12113 , A61B17/12136 , A61B17/12186 , A61B17/12195 , A61L24/001 , A61L24/06
摘要： An irritant or polymer is dispensed to the inner surface area of an aneurysm to exert a contractile force on the inner surface area of the aneurysm, thereby shrinking the aneurysm. As a result, the artery wall at the aneurysm site is strengthened, the risk of rupture is decreased, and at least a partial cure for the expansion of the arterial wall at the aneurysm site is provided.
摘要翻译：刺激物或聚合物被分配到动脉瘤的内表面区域以在动脉瘤的内表面区域施加收缩力，从而使动脉瘤收缩。结果，动脉瘤部位的动脉壁被加强，破裂的风险降低，并且提供至少部分治愈动脉瘤部位的动脉壁的膨胀。

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