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21. 发明申请

US20200053994A1 METHOD FOR ALLEVIATING PHENOTYPE OF DEGENERATIVE DISEASE DROSOPHILA MODEL BY USING LOW-DOSE RADIATION 审中-公开
公开(公告)号：US20200053994A1
公开(公告)日：2020-02-20
申请号：US16461089
申请日：2017-11-16
申请人： KOREA HYDRO & NUCLEAR POWER CO., LTD.
发明人： Seonyoung NAM , Soojin HWANG , Haemin JEONG
IPC分类号： A01K67/033 , A61N5/10 , A61P25/28
摘要： The present invention relates to a degenerative disease model Drosophila. More particularly, a technique is disclosed for alleviating the phenotypes of a degenerative disorder symptom of Drosophila. Using this technique, illumination with low dose radiation on a degenerative disease model Drosophia alleviates symptoms of the degenerative disease.

22. 发明申请

US20190279779A1 Cooling Water Reservoir And Nuclear Reactor Building Passive Cooling System Comprising Same 审中-公开
公开(公告)号：US20190279779A1
公开(公告)日：2019-09-12
申请号：US16328968
申请日：2016-10-27
申请人： KOREA HYDRO & NUCLEAR POWER CO., LTD
发明人： Hui Un HA , Sang Won LEE , Han Gon KIM
IPC分类号： G21C15/18 , B65D88/74
摘要： The purpose of the present invention is to prevent a nuclear reactor building from being pressurized and heated again when the nuclear reactor building is cooled in the event of a severe accident. The present invention comprises: a reservoir tank in which cooling water is stored; a partition part which is disposed in the reservoir tank and partitions the inside of the reservoir tank into a first storage tank and a second storage tank so as to separate the cooling water in the reservoir tank; and an inflow part which is disposed in the partition part and allows the cooling water of the second storage tank to naturally flow into the first storage tank by the difference between the water levels of the first and second storage tanks when the water level of the first storage tank is lowered.

23. 发明申请

US20190233901A1 APOPTOSIS REGULATORY GENE DETECTED IN IRRADIATED-THYMIC LYMPHOMA CELL AND METHOD FOR DETECTING SAME 审中-公开
公开(公告)号：US20190233901A1
公开(公告)日：2019-08-01
申请号：US16312126
申请日：2016-09-08
申请人： KOREA HYDRO & NUCLEAR POWER CO., LTD.
发明人： Hee Sun KIM , Hoon CHOI , Kwang Hee YANG , Yun-Mi BAEK , Dong-Kwon KEUM , Hee Youn SHIM , Byulnim HWANG
IPC分类号： C12Q1/6886 , G01N33/574
CPC分类号： C12Q1/6886 , C12Q1/68 , C12Q2600/158 , G01N33/574 , G01N33/57407
摘要： An apoptosis regulatory gene is detected in an irradiated-thymic lymphoma cell by a method for detecting such an apoptosis regulatory gene in a low-dose-rate and low-level-irradiated thymic lymphoma cell of a mouse. This has an effect of revealing the function of an apoptosis regulatory gene by means of irradiation and providing a gene profile, by detecting an apoptosis regulatory gene detected in an irradiated-thymic lymphoma cell. The detected apoptosis regulatory gene is used to construct a gene profile that can assess the dose-response relationship of industrial and healthcare workers living in a low level-radiation environment. The detected apoptosis regulatory gene can be used as an index for evaluating the extent of cancer progression and the degree of treatment in patients with thymic lymphoma. The method for detecting such an apoptosis regulatory gene is used to prepare for the prepare a composition for diagnosing thymic lymphoma and a diagnostic kit.

24. 发明申请

US20190195249A1 METHOD AND APPARATUS FOR DIAGNOSING PNEUMATIC CONTROL VALVE BY USING POSITIONER MODEL 审中-公开
公开(公告)号：US20190195249A1
公开(公告)日：2019-06-27
申请号：US16329345
申请日：2017-08-30
申请人： KOREA HYDRO & NUCLEAR POWER CO., LTD
发明人： Yang Seok KIM , Dae Woong KIM , Bum Nyun KIM , Young Sheop PARK , Chi Yong PARK , Jong Seog KIM , Hyoung Kyun KIM , Byoung Oh LEE , Ji In KIM , Nam Woo CHOI , Yong Hoon PARK , Hee Seung CHANG , You Soo SHIN
IPC分类号： F15B19/00 , F16K31/12 , F16K37/00
CPC分类号： F15B19/005 , F15B19/00 , F16K31/12 , F16K37/00 , F16K37/0041 , F16K37/0083
摘要： Method for diagnosing a pneumatic control valve by using a positioner model includes: establishing relational expression for outputting valve stem displacement according to control pressure, the relational expression including parameters for the characteristics of a positioner, an actuator, and a valve, determining initial parameter value by adjusting the values of the parameters until the difference between a measured value for a normal operation of the pneumatic control valve and output value obtained by the relational expression is smaller than predetermined error limit, determining diagnostic parameter value by adjusting the values of the parameters until the difference between a measured value for a diagnostic operation of the pneumatic control valve and an output value obtained by the relational expression is smaller than a predetermined error limit, and comparing the initial parameter value and the diagnostic parameter value so as to determine whether the pneumatic control valve has abnormality.

25. 发明申请

US20190111131A1 ONCOGENIC RAS-INDUCED MALIGNANT CANCERIZATION INHIBITION USING LOW-DOSE RADIATION 审中-公开
公开(公告)号：US20190111131A1
公开(公告)日：2019-04-18
申请号：US16096532
申请日：2016-08-23
申请人： KOREA HYDRO & NUCLEAR POWER CO., LTD.
发明人： Seonyoung NAM , Kwang Hee YANG , Su-Jae LEE , Rae-Kwon KIM
IPC分类号： A61K41/00 , A61P35/00 , A61N5/10
摘要： The present invention relates to an apparatus for inhibiting oncogene-induced malignant carcinogenesis, including an irradiation unit for applying low-dose radiation to a subject, and to a method of inhibiting oncogene-induced malignant carcinogenesis, including applying low-dose radiation to a subject, whereby oncogene-induced malignant carcinogenesis can be inhibited by means of the apparatus and method of the present invention.

26. 发明申请

US20190071734A1 METHOD FOR DETECTING Reg3g GENE SENSITIVE TO LOW-LEVEL IONIZING RADIATION, AND GENE DETECTED BY THE METHOD 审中-公开
公开(公告)号：US20190071734A1
公开(公告)日：2019-03-07
申请号：US16193893
申请日：2018-11-16
申请人： KOREA HYDRO & NUCLEAR POWER CO., LTD.
发明人： Hee Sun KIM , Seung Jin CHOI , Moo Hyun CHOI , Jin Jong BONG , Seok Cheol SHIN
IPC分类号： C12Q1/6886 , C12Q1/6883
摘要： A method for detecting genes sensitive to low-level ionizing radiation and genes detected by the method. More specifically, genes sensitive to low-level ionizing radiation and related to suppressing thymic cancer, discovered in a carcinogenic entity and verified in a normal entity are detected by subjecting a cancerous AKR/J mouse and a normal ICR mouse to low-level radiation. Thymus is collected therefrom, immunogenic and apoptotic genes are classified via microarray processing of the thymus. The genes are amplified and the levels of gene expression are measured. Thus, a gene having a specific reaction to radiation can be accurately detected by preventing the interference of confounding variables.

27. 发明申请

US20180251856A1 METHOD FOR DETECTING Lipe GENE SENSITIVE TO HIGH-LEVEL IONIZING RADIATION 审中-公开
公开(公告)号：US20180251856A1
公开(公告)日：2018-09-06
申请号：US15956664
申请日：2018-04-18
申请人： KOREA HYDRO & NUCLEAR POWER CO., LTD
发明人： Hee Sun KIM , Seung Jin CHOI , Moo Hyun CHOI , Jin Jong BONG , Seok Cheol SHIN
IPC分类号： C12Q1/6886 , C12Q1/6883
CPC分类号： C12Q1/6886 , C12Q1/6883 , C12Q2600/158
摘要： A method for detecting genes sensitive to high-level ionizing radiation and genes detected by the method. More specifically, genes sensitive to high-level ionizing radiation discovered in a carcinogenic entity and verified in a normal entity are detected, by subjecting a cancerous AKR/J mouse and a normal ICR mouse to high-level radiation. Thymus is collected therefrom and fatty acid metabolism-related genes are classified via microarray processing of the thymus. The genes are amplified and the levels of gene expression are measured. Thus, the present invention allows a gene having a specific reaction to radiation to be accurately detected by preventing the interference of confounding variables.

28. 发明申请

US20180251855A1 METHOD FOR DETECTING Ppargc1a GENE SENSITIVE TO HIGH-LEVEL IONIZING RADIATION 审中-公开
公开(公告)号：US20180251855A1
公开(公告)日：2018-09-06
申请号：US15956658
申请日：2018-04-18
申请人： KOREA HYDRO & NUCLEAR POWER CO., LTD
发明人： Hee Sun KIM , Seung Jin CHOI , Moo Hyun CHOI , Jin Jong BONG , Seok Cheol SHIN
IPC分类号： C12Q1/6886 , C12Q1/6883
CPC分类号： C12Q1/6886 , C12Q1/6883 , C12Q2600/158
摘要： A method for detecting genes sensitive to high-level ionizing radiation and genes detected by the method. More specifically, genes sensitive to high-level ionizing radiation discovered in a carcinogenic entity and verified in a normal entity are detected, by subjecting a cancerous AKR/J mouse and a normal ICR mouse to high-level radiation. Thymus is collected therefrom and fatty acid metabolism-related genes are classified via microarray processing of the thymus. The genes are amplified and the levels of gene expression are measured. Thus, the present invention allows a gene having a specific reaction to radiation to be accurately detected by preventing the interference of confounding variables.

29. 发明申请

US20180237865A1 METHOD FOR DETECTING Acsl1 GENE SENSITIVE TO HIGH-LEVEL IONIZING RADIATION 审中-公开
公开(公告)号：US20180237865A1
公开(公告)日：2018-08-23
申请号：US15956661
申请日：2018-04-18
申请人： KOREA HYDRO & NUCLEAR POWER CO., LTD
发明人： Hee Sun KIM , Seung Jin CHOI , Moo Hyun CHOI , Jin Jong BONG , Seok Cheol SHIN
IPC分类号： C12Q1/6886 , C12Q1/6883
CPC分类号： C12Q1/6886 , C12Q1/6883 , C12Q2600/158
摘要： A method for detecting genes sensitive to high-level ionizing radiation and genes detected by the method. More specifically, genes sensitive to high-level ionizing radiation discovered in a carcinogenic entity and verified in a normal entity are detected, by subjecting a cancerous AKR/J mouse and a normal ICR mouse to high-level radiation. Thymus is collected therefrom and fatty acid metabolism-related genes are classified via microarray processing of the thymus. The genes are amplified and the levels of gene expression are measured. Thus, the present invention allows a gene having a specific reaction to radiation to be accurately detected by preventing the interference of confounding variables.

30. 发明授权

US10036732B2 Ultrasonic inspection device for small bore pipes 有权
公开(公告)号：US10036732B2
公开(公告)日：2018-07-31
申请号：US15033065
申请日：2014-08-19
申请人： KOREA HYDRO & NUCLEAR POWER CO., LTD
发明人： Byoung Sik Yoon , Yong Sik Kim , Jeong Seok Lee , Tae Hun Lee
IPC分类号： G01N29/04 , G01N29/265 , G01N29/22
CPC分类号： G01N29/041 , G01N29/043 , G01N29/223 , G01N29/225 , G01N29/265 , G01N2291/0258 , G01N2291/0289 , G01N2291/044 , G01N2291/2634 , G01N2291/267
摘要： The present invention relates to an ultrasonic inspection device for small bore pipes comprising: a first arc-shaped frame part and a second arc-shaped frame part which surround the circumference of a pipe when combined with the pipe, and which have one side thereof rotationally connected to each other by means of a rotary connecting pin; an adjustment part that connects the other side of the first arc-shaped frame part and the other side of the second arc-shaped frame part to each other and is capable of adjusting the diameter of the bore formed by the first arc-shaped frame part and the second arc-shaped frame part according to the diameter of the pipe; a probe fixing part for fixing a probe to the first arc-shaped frame part such that the probe comes into contact with the surface of the pipe; an encoder part which is provided to the second arc-shaped frame part and maintains an encoder at a predetermined distance from the pipe; and a plurality of roller parts which are provided to the first arc-shaped frame part and the second arc-shaped frame part and rotate around the circumference of the pipe contacting the pipe in a state where the first arc-shaped frame part and the second arc-shaped frame part are connected to each other. The present invention includes two arc-shaped frame parts which surround the circumference of a pipe and is able to adjust the diameter of the bore of a ring-shaped frame part obtained according to connection of the two arc-shaped frame parts, and thus is applicable irrespective of the diameter of the pipe within a predetermined range, thereby improving work convenience and reducing costs.

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