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21. 发明申请

US20130146910A1 LIGHT EMITTING DIODE CHIP 有权
标题翻译：发光二极管芯片
公开(公告)号：US20130146910A1
公开(公告)日：2013-06-13
申请号：US13581417
申请日：2011-02-15
申请人： Markus Maute , Karl Engl , Stefanie Rammelsberger , Nikolaus Gmeinwieser , Johann Eibl
发明人： Markus Maute , Karl Engl , Stefanie Rammelsberger , Nikolaus Gmeinwieser , Johann Eibl
IPC分类号： H01L33/60
CPC分类号： H01L33/60 , H01L33/20 , H01L33/382 , H01L33/405 , H01L33/46 , H01L33/54 , H01L2924/0002 , H01L2924/00
摘要： A light emitting diode chip includes a semiconductor layer sequence, the semiconductor layer sequence having an active layer that generates electromagnetic radiation, wherein the light emitting diode chip has a radiation exit area at a front side. At a rear side lying opposite the radiation exit area, the light emitting diode chip has, at least in regions, a mirror layer containing silver. A functional layer that reduces corrosion and/or improves adhesion of the mirror layer is arranged on the mirror layer, wherein a material from which the functional layer is formed is also distributed in the entire mirror layer. The material of the functional layer has a concentration gradient in the mirror layer, wherein the concentration of the material of the functional layer in the mirror layer decreases proceeding from the functional layer in the direction toward the semiconductor layer sequence.
摘要翻译：发光二极管芯片包括半导体层序列，所述半导体层序列具有产生电磁辐射的有源层，其中所述发光二极管芯片在前侧具有辐射出射区域。在与辐射出口区域相对的后侧，发光二极管芯片至少在区域中具有含有银的镜面层。降低镜面层的腐蚀和/或改善粘合性的功能层被布置在镜面层上，其中形成功能层的材料也分布在整个镜面层中。功能层的材料在镜面层中具有浓度梯度，其中镜面层中的功能层的材料的浓度从功能层朝向半导体层序列的方向减小。

22. 发明授权

US08425947B2 Fibrinogen-based tissue adhesive containing an elastase inhibitor 有权
标题翻译：含有弹性蛋白酶抑制剂的基于纤维蛋白原的组织粘合剂
公开(公告)号：US08425947B2
公开(公告)日：2013-04-23
申请号：US13021551
申请日：2011-02-04
申请人： Heinz Redl , Johann Eibl , Irmgard Schlag
发明人： Heinz Redl , Guenther Schlag , Johann Eibl
IPC分类号： A01N65/00
CPC分类号： A61L24/106
摘要： The present invention provides a fibrinogen-based tissue adhesive which contains an elastase inhibitor.
摘要翻译：本发明提供含有弹性蛋白酶抑制剂的纤维蛋白原组织粘合剂。

23. 发明申请

US20110009324A1 Stable Therapeutic Proteins 审中-公开
标题翻译：稳定的治疗蛋白
公开(公告)号：US20110009324A1
公开(公告)日：2011-01-13
申请号：US12879821
申请日：2010-09-10
申请人： Johann Eibl
发明人： Johann Eibl
IPC分类号： A61K38/36 , A61K38/37 , A61P7/04 , C07K14/75 , C07K14/755
CPC分类号： A61K38/37 , A61K38/36 , A61K38/363
摘要： The invention relates to storable medicaments produced from pharmaceutical active ingredient preparations which are virus safe. Said medicaments contain at least one intact therapeutic protein obtained from plasma or by means of genetic engineering, as an active pharmaceutical substance. Said active ingredient preparations contain active enzymes, especially proteases, which are either free or bound to the substrates thereof and act against the therapeutic protein(s) present.
摘要翻译：本发明涉及由病毒安全的药用活性成分制剂制备的可储存药物。所述药物含有至少一种从血浆或通过基因工程获得的完整治疗蛋白质作为活性药物。所述活性成分制剂含有活性酶，特别是蛋白酶，它们与其底物游离或结合，并且对抗存在的治疗性蛋白质。

24. 发明授权

US07494971B2 Pharmaceutical preparations and medicines capable of generating, and/or containing, thrombin 有权
标题翻译：能够产生和/或含有凝血酶的药物制剂和药物
公开(公告)号：US07494971B2
公开(公告)日：2009-02-24
申请号：US11041165
申请日：2005-01-21
申请人： Johann Eibl
发明人： Johann Eibl
IPC分类号： A61K38/36 , C07K14/00
CPC分类号： A61K38/36 , A61K2300/00
摘要： The invention relates to a pharmaceutical active ingredient preparation for producing a medicament that contains thrombin or has a thrombin-generating capacity and compositions comprising thereof. The inventive preparation contains: (A) prothrombin obtained from plasma or by means of genetic engineering (coagulation factor II), (B) coagulation factors V, VIII, IX, X obtained from plasma or by means of genetic engineering, which can be at least partially in the activated state, and coagulation factor Xla obtained from plasma or by means of genetic engineering, and (C) phospholipids which are safe from prions and contribute to the clotting process, said phospholipids being optionally contained in liposomes.
摘要翻译：本发明涉及一种用于生产含有凝血酶或具有凝血酶生成能力的药物的药物活性成分制剂及其组合物。本发明的制剂包含：（A）从血浆或通过基因工程（凝血因子II）获得的凝血酶原，（B）从血浆或通过遗传工程获得的凝血因子V，VIII，IX，X，其可以在至少部分为活化状态，以及由血浆或通过遗传工程获得的凝血因子Xla，和（C）磷酸蛋白，其从朊病毒中是安全的并且有助于凝血过程，所述磷脂任选地包含在脂质体中。

25. 发明授权

US07459295B2 Fibrinogen-based tissue adhesive containing an elastase inhibitor 有权
标题翻译：含有弹性蛋白酶抑制剂的基于纤维蛋白原的组织粘合剂
公开(公告)号：US07459295B2
公开(公告)日：2008-12-02
申请号：US11443925
申请日：2006-05-30
申请人： Heinz Redl , Gunther Schlag , Johann Eibl
发明人： Heinz Redl , Gunther Schlag , Johann Eibl
IPC分类号： C12N9/00
CPC分类号： A61L24/106
摘要： The present invention provides a fibrinogen-based tissue adhesive which contains an elastase inhibitor.
摘要翻译：本发明提供含有弹性蛋白酶抑制剂的纤维蛋白原组织粘合剂。

26. 发明授权

US06953837B2 Factor VIII/vWF complexes and compositions 有权
标题翻译：因子VIII / vWF复合物和组合物
公开(公告)号：US06953837B2
公开(公告)日：2005-10-11
申请号：US10003621
申请日：2001-11-02
申请人： Artur Mitterer , Bernhard Fischer , Öyvind L. Schönberger , Kathrin Thomas-Urban , Friedrich Dorner , Johann Eibl
发明人： Artur Mitterer , Bernhard Fischer , Öyvind L. Schönberger , Kathrin Thomas-Urban , Friedrich Dorner , Johann Eibl
IPC分类号： A61K38/43 , A61K38/00 , A61K38/37 , A61P7/04 , C07K1/18 , C07K14/755 , C12P21/04 , C07K1/00
CPC分类号： A61K38/37 , C07K14/755
摘要： There is disclosed a method of recovering factor VIII/vWF-complex which is characterized in that factor VIII/vWF-complex from a protein solution is bound to a cation exchanger and is recovered by step-wise elution of factor VIII/vWF-complex, which particularly contains high-molecular vWF multimers, as well as a factor VIII/vWF-complex obtainable by means of cation exchange chromatography.
摘要翻译：公开了一种回收因子VIII / vWF-复合物的方法，其特征在于将来自蛋白质溶液的因子VIII / vWF-复合物结合到阳离子交换剂并通过逐步洗脱因子VIII / vWF-复合物来回收，其特别包含高分子vWF多聚体，以及通过阳离子交换层析可获得的因子VIII / vWF-络合物。

27. 发明申请

US20050209154A1 Stable factor VIII/von Willebrand factor complex 有权
标题翻译：稳定因子VIII / von Willebrand因子复合物
公开(公告)号：US20050209154A1
公开(公告)日：2005-09-22
申请号：US11132326
申请日：2005-05-19
申请人： Bernhard Fischer , Artur Mitterer , Friedrich Dorner , Johann Eibl
发明人： Bernhard Fischer , Artur Mitterer , Friedrich Dorner , Johann Eibl
IPC分类号： A61K38/43 , A61K31/00 , A61K38/37 , A61P7/00 , A61P7/04 , C07K1/18 , C07K1/22 , C07K14/745 , C07K14/755
CPC分类号： C07K14/755 , Y10S514/834 , Y10T436/25375
摘要： There are disclosed a stable factor VIII/vWF-complex, particularly comprising high-molecular vWF multimers, being free from low-molecular vWF molecules and from proteolytic vWF degradation products, as well as a method of producing this complex.
摘要翻译：公开了稳定的因子VIII / vWF-复合物，特别是包含不含低分子vWF分子和蛋白水解vWF降解产物的高分子vWF多聚体，以及生产该复合物的方法。

28. 发明授权

US06562598B1 Factor X deletion mutants and analogues thereof 有权
标题翻译：因子X缺失突变体及其类似物
公开(公告)号：US06562598B1
公开(公告)日：2003-05-13
申请号：US09367777
申请日：1999-11-18
申请人： Michele Himmelspach , Michael Pfleiderer , Falko-Guenter Falkner , Johann Eibl , Friedrich Dorner , Uwe Schlokat
发明人： Michele Himmelspach , Michael Pfleiderer , Falko-Guenter Falkner , Johann Eibl , Friedrich Dorner , Uwe Schlokat
IPC分类号： C12P2106
CPC分类号： C12N9/6432 , A61K38/00 , C12Y304/21006
摘要： Factor X&Dgr; analogues are provided, as well as pharmaceutical preparations containing such analogues and methods of preparing such analogues. The factor X&Dgr; analogues have a deletion of the amino acids Arg180 to Arg234 and a modification in the region of the amino acid sequence between Gly173 and Arg179 of the factor X amino acid sequence. Such analogues can include a processing site not normally present in factor X, thus allowing for selective conversion of the analogue to an active form. The analogues and preparations have utility in the treatment of a number of blood coagulation disorders.
摘要翻译：提供因子XDELTA类似物，以及含有此类类似物的药物制剂和制备此类类似物的方法。因子XDELTA类似物具有氨基酸Arg180至Arg234的缺失和在因子X氨基酸序列的Gly173和Arg179之间的氨基酸序列区域的修饰。这样的类似物可以包括通常不存在于因子X中的处理位点，从而允许将类似物选择性转化为活性形式。类似物和制剂可用于治疗许多凝血障碍。

29. 发明授权

US06414125B1 Method of chromatographically purifying or fractionating, respectively, von Willebrand factor from a VWF-containing starting material 失效
$Method of chromatographically purifying or fractionating, respectively, von Willebrand factor from a VWF-containing starting material$
标题翻译：分别从含VWF的起始材料中色谱纯化或分馏von Willebrand因子的方法
公开(公告)号：US06414125B1
公开(公告)日：2002-07-02
申请号：US09355865
申请日：1999-10-21
申请人： Juergen Siekmann , Peter Turecek , Hans-Peter Schwarz , Johann Eibl , Bernhard Fischer , Artur Mitterer , Friedrich Dorner
发明人： Juergen Siekmann , Peter Turecek , Hans-Peter Schwarz , Johann Eibl , Bernhard Fischer , Artur Mitterer , Friedrich Dorner
IPC分类号： A23J100
CPC分类号： C07K14/755
摘要： Disclosed is a method of chromatographically purifying or fractionating, respectively, von Willebrand factor (vWF) from a vWF-containing starting material, comprising the following steps: adsorbing the vWF from the starting material on avid collagen immobilized on a carrier, separating the non-adsorbed portion and, optionally, washing the carrier, eluting the vWF from immobilized collagen, and recovering the purified vWF, as well as a pharmaceutical preparation comprising biologically active vWF which is bound to collagen in a stable manner.
摘要翻译：公开了一种从含有vWF的原料分别纯化或分馏von Willebrand因子（vWF）的方法，其包括以下步骤：将起始材料的vWF吸附在固定在载体上的avid胶原上，吸附部分和任选地洗涤载体，从固定化胶原洗脱vWF，并回收纯化的vWF，以及包含以稳定方式与胶原结合的生物活性vWF的药物制剂。

30. 发明授权

US06210929B1 Fusion protein comprising a furin derivative or a derivative of a furin analogue and a heterologous sequence 失效
标题翻译：包含弗林蛋白酶衍生物或弗林素类似物衍生物和异源序列的融合蛋白
公开(公告)号：US06210929B1
公开(公告)日：2001-04-03
申请号：US08753247
申请日：1996-11-22
申请人： Uwe Schlokat , Bernhard Fischer , Falko-Guenter Falkner , Friedrich Dorner , Johann Eibl
发明人： Uwe Schlokat , Bernhard Fischer , Falko-Guenter Falkner , Friedrich Dorner , Johann Eibl
IPC分类号： C12N1562
CPC分类号： C07K14/755 , A61K38/00 , C07K2319/00 , C12N9/6454
摘要： Fusion proteins of an optionally C-terminally deleted furin derivative, or of a derivative of a furin analogue, and a heterologous sequence, methods of preparing the same and methods of recovering proproteins from proteins by using the proproteins according to the invention are described.
摘要翻译：描述了任选C末端缺失的弗林蛋白酶衍生物，弗林蛋白酶类似物衍生物和异源序列的融合蛋白，其制备方法以及通过使用本发明的蛋白从蛋白质中回收蛋白质的方法。

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