专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

21. 发明授权

US4616018A Benzotriazolyl-4,5-dihydro-3(2H)-pyridazinones 失效
标题翻译：苯并三唑基-4,5-二氢-3（2H） - 哒嗪酮
公开(公告)号：US4616018A
公开(公告)日：1986-10-07
申请号：US749580
申请日：1985-06-27
申请人： Norbert Hauel , Volkhard Austel , Joachim Heider , Manfred Reiffen , Willi Diederen , Walter Haarman
发明人： Norbert Hauel , Volkhard Austel , Joachim Heider , Manfred Reiffen , Willi Diederen , Walter Haarman
IPC分类号： A61K31/50 , A61K31/501 , A61P7/02 , A61P9/12 , C07D237/04 , C07D249/18 , C07D401/14 , C07D403/04 , C07D403/02
CPC分类号： C07D401/14 , C07D237/04 , C07D249/18 , C07D403/04 , Y10S514/822
摘要： Compounds of the formula ##STR1## wherein R.sub.1 is hydrogen; alkyl of 1 to 7 carbon atoms; cycloalkyl of 3 to 7 carbon atoms; monosubstituted alkyl of 1 to 3 carbon atoms, where the substituent is pyridyl, methylpyridyl, phenyl, mono-, di- or trisubstituted phenyl, where the substituents on the phenyl ring, which may be identical to or different from each other, are selected from the group consisting of one amino, one dimethylamino, one to two hydroxyls, one to three methoxys and one to three halogens; .omega.-monosubstituted alkyl of 2 to 4 carbon atoms, where the substituent is hydroxyl or di(alkyl of 1 to 3 carbon atoms)amino; phenyl; monohalo-phenyl; unsubstituted or monosubstituted straight or branched alkanoyl of 1 to 6 carbon atoms, where the substituent is phenyl, methoxyphenyl or cycloalkyl of 3 to 7 carbon atoms; or unsubstituted or monosubstituted phenylsulfonyl, where the substituent is methyl or methoxy; and,R.sub.2 is hydrogen or alkyl of 1 to 3 carbon atoms; and non-toxic, pharmacologically acceptable acid addition salts thereof. The compounds as well as their salts are useful as cardiotonics, hypotensives and antithrombotics.
摘要翻译：其中R 1是氢的式IMAMA的化合物; 1至7个碳原子的烷基; 3至7个碳原子的环烷基; 其中取代基是吡啶基，甲基吡啶基，苯基，单 - ，二 - 或三取代的苯基，其中可以相同或不同的苯环上的取代基选自由一个氨基，一个二甲基氨基，一至两个羟基，一至三个甲氧基和一至三个卤素组成的组; 2至4个碳原子的ω-单取代的烷基，其中取代基是羟基或二（1至3个碳原子的烷基）氨基; 苯基; 单卤代苯基; 未取代的或单取代的1至6个碳原子的直链或支链烷酰基，其中取代基是苯基，甲氧基苯基或3-7个碳原子的环烷基; 或未取代或单取代的苯基磺酰基，其中取代基是甲基或甲氧基; R2为氢或1〜3个碳原子的烷基; 和无毒的，药学上可接受的酸加成盐。化合物及其盐可用作强心剂，低血糖剂和抗血栓药物。

22. 发明授权

US4379788A 2-Phenyl-pyrimidones 失效
标题翻译： 2-苯基 - 嘧啶酮
公开(公告)号：US4379788A
公开(公告)日：1983-04-12
申请号：US327348
申请日：1981-12-04
申请人： Joachim Heider , Volkhard Austel , Wolfgang Eberlein , Rudolf Kadatz , Christian Lillie
发明人： Joachim Heider , Volkhard Austel , Wolfgang Eberlein , Rudolf Kadatz , Christian Lillie
IPC分类号： C07D239/88 , A61K31/513 , A61P9/00 , C07D213/82 , C07D239/91 , C07D265/22 , C07D471/04 , C07D498/04 , A61K31/505
CPC分类号： C07D213/82 , C07D239/91 , C07D265/22 , C07D471/04
摘要： Compounds of the formula ##STR1## wherein A and B, together with each other and the respective carbon atoms to which they are attached, form a phenyl or pyridine ring;R.sub.1 is hydrogen, halogen, amino, nitro, alkyl of 1 to 3 carbon atoms or alkoxy of 1 to 3 carbon atoms;R.sub.2 is hydrogen or alkoxy of 1 to 3 carbon atoms;D is alkylene of 3 to 4 carbon atoms or hydroxy(alkylene of 3 to 4 carbon atoms);R.sub.3 and R.sub.5, which may be identical to or different from each other, are each hydrogen or alkyl of 1 to 3 carbon atoms;R.sub.4 is hydrogen or alkoxy of 1 to 3 carbon atoms; andR.sub.6 is straight or branched alkyl of 1 to 6 carbon atoms or --E--R.sub.7 ;where E is straight alkylene of 2 to 4 carbon atoms or hydroxy-substituted straight alkylene of 2 to 4 carbon atoms, andR.sub.7 is ##STR2## where R.sub.8 and R.sub.9 are each hydrogen, alkyl of 1 to 3 carbon atoms or alkoxy of 1 to 3 carbon atoms;and non-toxic, pharmacologically acceptable acid addition salts thereof formed with inorganic or organic acids; the compounds as well as their salts are useful as hypotensives, antiarrhythmics and .beta.-receptor-blockers.
摘要翻译：其中A和B与它们相连的相互连接的碳原子一起形成苯基或吡啶环; R 1是氢，卤素，氨基，硝基，1至3个碳原子的烷基或1至3个碳原子的烷氧基; R2是氢或1〜3个碳原子的烷氧基; D是3至4个碳原子的亚烷基或羟基（3至4个碳原子的亚烷基）; R 3和R 5可以相同或不同，分别为氢或1-3个碳原子的烷基; R4是氢或1〜3个碳原子的烷氧基; R6是1-6个碳原子的直链或支链烷基或-E-R7; 其中E是2至4个碳原子的直链亚烷基或2至4个碳原子的羟基取代的直链亚烷基，并且R 7是R 8和R 9各自为氢，1至3个碳原子的烷基或1至 3个碳原子; 和与无机或有机酸形成的无毒的，药学上可接受的酸加成盐; 化合物及其盐可用作低血糖，抗心律失常药和β-受体阻滞剂。

23. 发明授权

US4361563A Pyridazinone-substituted benzimidazoles and salts 失效
标题翻译：哒嗪酮取代的苯并咪唑和盐
公开(公告)号：US4361563A
公开(公告)日：1982-11-30
申请号：US259537
申请日：1981-05-01
申请人： Volkhard Austel , Joachim Heider , Wolfgang Eberlein , Willi Diederen , Walter Haarmann
发明人： Volkhard Austel , Joachim Heider , Wolfgang Eberlein , Willi Diederen , Walter Haarmann
IPC分类号： A61K31/50 , C07D235/18 , C07D237/04 , C07D403/04
CPC分类号： C07D237/04 , A61K31/50 , C07D235/18 , Y10S514/822
摘要： Compounds of the formula ##STR1## wherein R.sub.1 is hydrogen; trifluoromethyl; alkyl of 1 to 11 carbon atoms; cycloalkyl of 3 to 7 carbon atoms; hydroxyl; alkoxy of 1 to 6 carbon atoms; mercapto; (alkyl of 1 to 6 carbon atoms)-mercapto; phenyl-(alkyl of 1 to 3 carbon atoms); phenyl; or mono-, di- or tri-substituted phenyl, where the substituents, which may be identical to or different from each other, are each halogen, alkyl of 1 to 4 carbon atoms, (alkyl of 1 to 6 carbon atoms)-sulfinyl, hydroxyl, alkoxy of 1 to 6 carbon atoms, mercapto or (alkyl of 1 to 6 carbon atoms)-mercapto;R.sub.2 is hydrogen, alkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 6 carbon atoms or phenyl-(alkyl of 1 to 3 carbon atoms); andR.sub.3 is alkyl of 1 to 6 carbon atoms; optically active antipodes thereof; and non-toxic, pharmaceutically acceptable acid addition salts of said compounds or of said optically active antiposed. The compounds are useful as cardiotonics and antithrombotics.
摘要翻译：其中R 1是氢的式IMAMA的化合物; 三氟甲基 1至11个碳原子的烷基; 3至7个碳原子的环烷基; 羟; 1至6个碳原子的烷氧基; 巯基（1-6个碳原子的烷基） - 巯基; 苯基 - （1至3个碳原子的烷基）; 苯基; 或单取代，二取代或三取代的苯基，其中可以相同或不同的取代基各自为卤素，具有1至4个碳原子的烷基，（1至6个碳原子的烷基） - 亚磺酰基，羟基，1至6个碳原子的烷氧基，巯基或（1至6个碳原子的烷基） - 巯基; R2是氢，1至6个碳原子的烷基，3至6个碳原子的环烷基或苯基 - （1至3个碳原子的烷基）; 且R 3为1至6个碳原子的烷基; 光学活性对映体; 和所述化合物或所述光学活性药物的无毒的药学上可接受的酸加成盐。这些化合物可用作强心剂和抗血栓药物。

24. 发明授权

US4154837A (Aminoalkoxy-aryl)-substituted isoquinolinones and naphthydrinones and salts thereof, and hypotensive compositions and methods employing them 失效
标题翻译：（氨基烷氧基 - 芳基） - 取代的异喹啉酮和萘啶酮及其盐，以及使用它们的低血压组合物和方法
公开(公告)号：US4154837A
公开(公告)日：1979-05-15
申请号：US867308
申请日：1978-01-06
申请人： Joachim Heider , Volkhard Austel , Wolfgang Eberlein , Rudolf Kadatz , Jurgen Dammgen , Walter Kobinger , Christian Lillie
发明人： Joachim Heider , Volkhard Austel , Wolfgang Eberlein , Rudolf Kadatz , Jurgen Dammgen , Walter Kobinger , Christian Lillie
IPC分类号： A61K31/444 , A61K31/47 , A61K31/472 , A61P9/00 , A61P9/12 , C07D217/24 , C07D471/04
CPC分类号： C07D471/04 , C07D217/24
摘要： Compounds of the formula ##STR1## wherein A is benzo, mono-, di- or tri-substituted benzo, the substituents being selected from the group consisting of lower alkoxy, amino and nitro, or pyrido;R.sub.1 is hydrogen or lower alkyl;R.sub.2 is alkyl of 1 to 6 carbon atoms or --X--R.sub.6, where X is straight alkylene of 1 to 4 carbon atoms or hydroxy-substituted straight alkylene of 1 to 4 carbon atoms; andR.sub.6 is amino; carbalkoxy of 2 to 6 carbon atoms; phenyl; mono-, di- or tri-substituted phenyl, the substituents being selected from the group consisting of lower alkyl and lower alkoxy; phenoxy; or mono-, di- or tri-substituted phenoxy, the substituents being selected from the group consisting of lower alkyl and lower alkoxy;R.sub.3 is hydrogen or hydroxyl;R.sub.4 is hydrogen, lower alkyl or lower alkoxy;R.sub.5 is hydrogen or lower alkyl; andN is 0, 1 or 2;And non-toxic, pharmacologically acceptable acid addition salts thereof. The compounds as well as the salts are useful as antiarrhythmics, .beta.-adrenergic-receptor blockers and anti-anginous agents.
摘要翻译：其中A是苯并，一或二取代或三取代的苯并，其取代基选自低级烷氧基，氨基和硝基，或吡啶并。 R1是氢或低级烷基; R2是1至6个碳原子的烷基或-X-R6，其中X是1至4个碳原子的直链亚烷基或1至4个碳原子的羟基取代的直链亚烷基; R6为氨基; 2至6个碳原子的烷氧基; 苯基; 单取代，二取代或三取代的苯基，所述取代基选自低级烷基和低级烷氧基; 苯氧基或单 - ，二 - 或三 - 取代的苯氧基，所述取代基选自低级烷基和低级烷氧基; R3是氢或羟基; R4是氢，低级烷基或低级烷氧基; R5是氢或低级烷基; 和N IS 0，1或2; 和非毒性，药理学上可接受的酸添加量。化合物和盐可用作抗心律失常药，β-肾上腺素能受体阻断剂和抗麻痹剂。

25. 发明授权

US3948898A 1,3-Dioxo-2-aminoalkyl-4,4-dimethyl-isoquinolines and salts thereof 失效
标题翻译： 1,3-二氧代-2-氨基烷基-4,4-二甲基 - 异喹啉及其盐
公开(公告)号：US3948898A
公开(公告)日：1976-04-06
申请号：US503072
申请日：1974-09-04
申请人： Eberhard Kutter , Volkard Austel , Wolfgang Eberlein , Joachim Heider
发明人： Eberhard Kutter , Volkard Austel , Wolfgang Eberlein , Joachim Heider
IPC分类号： C07D217/04 , A61K31/47 , A61K31/472 , A61K31/4725 , A61P9/06 , A61P9/12 , A61P25/20 , C07D217/24 , C07D401/06 , C07D401/12 , C07D217/16
CPC分类号： C07D217/24 , Y10S514/821
摘要： Compounds of the formula ##SPC1##Wherein R.sub.1 is hydrogen, halogen, methoxy or methylthioR.sub.2 is hydrogen or methoxy,n is 2 or 3, andA is ##SPC2##Or ##SPC3##Where R.sub.3 is hydrogen or methyl,R.sub.4 is pyridyl, methy-pyridyl, phenyl, chlorophenyl, trifluoromethyl-phenyl, tolyl, xylyl, ethyl-phenyl, diethyl-phenyl, methoxy-phenyl or dimethoxy-phenyl, andR.sub.5 and R.sub.6, which may be identical to or different from each other, are each hydrogen or methoxy,And non-toxic, pharmacologically acceptable acid addition salts thereof; the compounds as well as the salts are useful as hypotensives, sedatives, antiarrhythmics and bradycardiacs.
摘要翻译：式WHEREIN R 1是氢，卤素，甲氧基或甲硫基R 2的化合物是氢或甲氧基，N IS 2 OR 3，A是或R 3是氢或甲基，R 4是吡啶基，甲基 - 吡啶基，苯基，氯苯基，三氟甲基苯基，甲苯基，二甲苯基，乙基 - 苯基，二乙基 - 苯基，甲氧基 - 苯基或二甲氧基 - 苯基，以及可以相同或不同的R5和R6各自为氢或甲氧基。非 - 药理学上可接受的酸添加剂; 该化合物作为盐类有效地用作高血压药物，消炎药，抗精神病药和溴氰菊酯。

26. 发明授权

US07705151B2 1,6 Naphthridines useful as inhibitors of SYK kinase 有权
标题翻译： 1,6萘吡啶可用作SYK激酶抑制剂
公开(公告)号：US07705151B2
公开(公告)日：2010-04-27
申请号：US12399292
申请日：2009-03-06
申请人： Charles L. Cywin , Scott E. Jakes , Joachim Heider , Mark A. Bobko , Renee L. Des Jarlais , Mark Player , James Rinker , Michael Winters , Bao-ping Zhao
发明人： Charles L. Cywin , Scott E. Jakes , Joachim Heider , Mark A. Bobko , Renee L. Des Jarlais , Mark Player , James Rinker , Michael Winters , Bao-ping Zhao
IPC分类号： C07D471/02 , C07D413/00
CPC分类号： C07D471/04
摘要： Disclosed are compounds of formula (I): wherein R3, R5, R7 and R8 are defined herein, which are useful as inhibitors SYK kinase and are thus useful for treating diseases resulting from inappropriate mast cell activation, which include allergic and inflammatory diseases. Also disclosed are pharmaceutical compositions comprising these compounds and processes for preparing these compounds.
摘要翻译：公开了式（I）的化合物：其中R 3，R 5，R 7和R 8在本文中定义，其可用作抑制剂SYK激酶，因此可用于治疗由不适当的肥大细胞活化引起的疾病，包括过敏性和炎性疾病。还公开了包含这些化合物的药物组合物和制备这些化合物的方法。

27. 发明授权

US07678911B2 1,6 naphthyridines useful as inhibitors of SYK kinase 有权
标题翻译：可用作SYK激酶抑制剂的1,6-萘啶
公开(公告)号：US07678911B2
公开(公告)日：2010-03-16
申请号：US12014190
申请日：2008-01-15
申请人： Charles L. Cywin , Scott E. Jakes , Joachim Heider , Mark A. Bobko , Renee L. Des Jarlais , Mark Player , James Rinker , Michael Winters , Bao-ping Zhao
发明人： Charles L. Cywin , Scott E. Jakes , Joachim Heider , Mark A. Bobko , Renee L. Des Jarlais , Mark Player , James Rinker , Michael Winters , Bao-ping Zhao
IPC分类号： C07D471/02 , C07D413/00
CPC分类号： C07D471/04
摘要： Disclosed are compounds of formula (I): wherein R3, R5, R7 and R8 are defined herein, which are useful as inhibitors SYK kinase and are thus useful for treating diseases resulting from inappropriate mast cell activation, which include allergic and inflammatory diseases. Also disclosed are pharmaceutical compositions comprising these compounds and processes for preparing these compounds.
摘要翻译：公开了式（I）的化合物：其中R 3，R 5，R 7和R 8在本文中定义，其可用作抑制剂SYK激酶，因此可用于治疗由不适当的肥大细胞活化引起的疾病，包括过敏性和炎性疾病。还公开了包含这些化合物的药物组合物和制备这些化合物的方法。

28. 发明授权

US07321041B2 1,6 Naphthyridines useful as inhibitors of SYK kinase 有权
标题翻译： 1,6萘吡啶可用作SYK激酶的抑制剂
公开(公告)号：US07321041B2
公开(公告)日：2008-01-22
申请号：US10413980
申请日：2003-04-15
申请人： Charles L. Cywin , Scott E. Jakes , Joachim Heider , Mark A. Bobko , Renee L. Des Jarlais , Mark Player , James Rinker , Michael Winters , Bao-ping Zhao
发明人： Charles L. Cywin , Scott E. Jakes , Joachim Heider , Mark A. Bobko , Renee L. Des Jarlais , Mark Player , James Rinker , Michael Winters , Bao-ping Zhao
IPC分类号： C07D471/02
CPC分类号： C07D471/04
摘要： Disclosed are compounds of formula (I): wherein R3, R5, R7 and R8 are defined herein, which are useful as inhibitors SYK kinase and are thus useful for treating diseases resulting from inappropriate mast cell activation, which include allergic and inflammatory diseases. Also disclosed are pharmaceutical compositions comprising these compounds and processes for preparing these compounds.
摘要翻译：公开了式（I）的化合物：其中R 3，R 5，R 7和R 8是其可用作抑制剂SYK激酶，因此可用于治疗由不适当的肥大细胞活化引起的疾病，包括过敏性和炎性疾病。还公开了包含这些化合物的药物组合物和制备这些化合物的方法。

29. 发明授权

US5175157A Cyclic amine derivatives, pharmaceutical compositions containing these compounds and methods for preparing them 失效
标题翻译：环胺衍生物，含有这些化合物的药物组合物及其制备方法
公开(公告)号：US5175157A
公开(公告)日：1992-12-29
申请号：US725855
申请日：1991-07-03
申请人： Manfred Psiorz , Joachim Heider , Andreas Bomhard , Manfred Reiffen , Norbert Hauel , Klaus Noll , Berthold Narr , Christian Lillie , Walter Kobinger , Jurgen Dammgen
发明人： Manfred Psiorz , Joachim Heider , Andreas Bomhard , Manfred Reiffen , Norbert Hauel , Klaus Noll , Berthold Narr , Christian Lillie , Walter Kobinger , Jurgen Dammgen
IPC分类号： C07D223/16 , C07D401/06 , C07D401/14 , C07D403/06 , C07D403/14 , C07D405/14 , C07D409/14 , C07D491/04
CPC分类号： C07D223/16 , C07D401/06 , C07D401/14 , C07D403/06 , C07D403/14 , C07D405/14 , C07D409/14 , C07D491/04
摘要： Disclosed are new cyclic amine derivatives of the formula I ##STR1## wherein the substituents are defined in the specification. These compounds are useful as for treating sinus tachycardia.
摘要翻译：公开了式I（I）的新的环胺衍生物，其中取代基在说明书中定义。这些化合物可用于治疗窦性心动过速。

30. 发明授权

US5116986A Heteroaromatic amine derivatives 失效
标题翻译：异构胺衍生物
公开(公告)号：US5116986A
公开(公告)日：1992-05-26
申请号：US696677
申请日：1991-05-07
申请人： Andreas Bomhard , Joachim Heider , Manfred Psiorz , Norbert Hauel , Berthold Narr , Klaus Noll , Christian Lillie , Walter Kobinger , Willi Diederen
发明人： Andreas Bomhard , Joachim Heider , Manfred Psiorz , Norbert Hauel , Berthold Narr , Klaus Noll , Christian Lillie , Walter Kobinger , Willi Diederen
IPC分类号： A61K31/40 , A61K31/403 , A61K31/4035 , A61K31/44 , A61K31/4427 , A61K31/443 , A61K31/4433 , A61K31/47 , A61K31/472 , A61P9/00 , A61P9/08 , A61P9/10 , C07D209/44 , C07D209/46 , C07D209/48 , C07D217/04 , C07D217/08 , C07D217/14 , C07D217/22 , C07D217/24 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D491/04 , C07D491/056
CPC分类号： C07D209/48 , C07D209/44 , C07D209/46 , C07D217/14 , C07D217/24 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D417/12 , C07D491/04
摘要： The present invention relates to new heteroaromatic amine derivatives of general formula ##STR1## wherein the substituents are defined hereinbelow, which have valuable pharmacological properties, particularly a heart rate lowering activity and a positive inotropic activity.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式