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21. 发明申请

US20080175932A1 Method for Decreasing Nicotine and Other Substance Use in Humans 审中-公开
公开(公告)号：US20080175932A1
公开(公告)日：2008-07-24
申请号：US12013089
申请日：2008-01-11
申请人： Jie Wu
发明人： Jie Wu
IPC分类号： A61K36/18 , A61K31/4353 , A61P25/34 , A61P25/30 , A61P25/00
CPC分类号： A61K36/185
摘要： A method for decreasing nicotine and other substance use in humans is disclosed. Tetrahydroberberine (THB) and its analogs, l-Tetrahydropalmatine (l-THP) and l-Stepholidine (l-SPD), are present in and can be isolated from several plants in the Magnoliidae superorder. According to the disclosed method, THB and its analogs are used to block nicotine-induced DA release, and modulate heterologous or homoeric expression of human nicotinic acetylcholine receptors (nAChR) in humans. Specifically, THB exhibits bi-directory modulation of α4β2-nAChR-mediated currents induced by nicotine. THB also shows predominant inhibition on homologously expressed α7-nAChR function. Thus, according to the disclosed method, THB is used to simultaneous blockade midbrain DA system function, the brain reward center, and neuronal α4β2- and α7-nAChR function, the major nicotine targets in the brain. Therefore, THB and its analogs serve as a novel class of natural compounds to decrease nicotine dependence in humans. Furthermore other substances, such as alcohol, cocaine, and opiates, also operate by triggering the brain reward center, resulting in a cycle of substance or alcohol abuse. THB and its analogs can be used to decrease use of substances such as alcohol, cocaine, and opiates. Finally, because THB and its analogs are DA antagonists, THB and its analogs can also be used as a treatment for Parkinson's Disease, Alzheimer's Disease and Schizophrenia.

22. 发明授权

US07298191B2 Reset-free delay-locked loop 有权
标题翻译：无复位延迟锁定环路
公开(公告)号：US07298191B2
公开(公告)日：2007-11-20
申请号：US11353790
申请日：2006-02-14
申请人： Hai Jie Wu , Kiat How Tan , Chin Yeong Koh
发明人： Hai Jie Wu , Kiat How Tan , Chin Yeong Koh
IPC分类号： H03L7/06
CPC分类号： H03L7/0891 , H03L7/0812 , H03L7/10 , H03L2207/14
摘要： A delay locked loop (DLL) includes a delay unit configured to delay an input clock signal by a specified amount to produce a delayed clock signal. A phase detector receives as input the input clock signal and the delayed clock signal and outputs a signal proportional to the phase difference between the input clock signal and the delayed clock signal to provide a control voltage for adjusting the delay to the specified amount. A pulse swallower removes a pulse from the input clock signal or from the delayed clock signal to reverse the direction of the control signal.
摘要翻译：延迟锁定环（DLL）包括被配置为将输入时钟信号延迟指定量以产生延迟的时钟信号的延迟单元。相位检测器接收输入时钟信号和延迟的时钟信号作为输入，并输出与输入时钟信号和延迟的时钟信号之间的相位差成比例的信号，以提供用于将延迟调整到指定量的控制电压。脉冲吞吐器从输入时钟信号或延迟的时钟信号中去除脉冲以反转控制信号的方向。

23. 发明申请

US20070252633A1 RATE-BASED SENSORS FOR ADVANCED REAL-TIME ANALYSIS AND DIAGNOSTICS 失效
标题翻译：基于速率的传感器，用于高级实时分析和诊断
公开(公告)号：US20070252633A1
公开(公告)日：2007-11-01
申请号：US11534412
申请日：2006-09-22
申请人： Jay Frankel , Majid Keyhani , Rao Arimilli , Jie Wu
发明人： Jay Frankel , Majid Keyhani , Rao Arimilli , Jie Wu
IPC分类号： G06G7/18 , H03K3/011
CPC分类号： G01D1/10
摘要： The invention provides a universal rate-based transducer for advancing diagnostic and predictive analyses of low frequency physical phenomena, such as associated with heat and mass transfer, solid and fluid mechanics, pressure and seismic analysis. In many applications, such as in the fire metrology, aerospace, security and defense sectors, rate information is crucial for reaching fast and reliable diagnosis and prediction. In one preferred embodiment, the invention comprises a universal voltage rate sensor interface that accurately recovers the instantaneous heating/cooling rate, dT/dt. Upon appropriate calibration, this sensor interface allows real-time extraction of rates associated with many physical quantities of interest (e.g., temperature, heat flux, concentration, strain, stress, pressure, intensity, etc.).
摘要翻译：本发明提供了一种通用的速率传感器，用于进行低频物理现象的诊断和预测分析，例如与热和质量传递，固体和流体力学，压力和地震分析相关联。在许多应用中，例如在火力计量，航空航天，安防和国防领域，速率信息对于快速可靠的诊断和预测至关重要。在一个优选实施例中，本发明包括通用电压速率传感器接口，其精确地恢复瞬时加热/冷却速率dT / dt。通过适当的校准，该传感器接口允许实时提取与许多感兴趣的物理量相关的速率（例如，温度，热通量，浓度，应变，应力，压力，强度等）。

24. 发明申请

US20070123539A1 Treatment of Restenosis and Stenosis with Dasatinib 审中-公开
标题翻译：用达沙替尼治疗再狭窄和狭窄
公开(公告)号：US20070123539A1
公开(公告)日：2007-05-31
申请号：US11551116
申请日：2006-10-19
申请人： Jie Wu , Zhengming Chen , Kapil Bhalla
发明人： Jie Wu , Zhengming Chen , Kapil Bhalla
IPC分类号： A61K31/506
CPC分类号： A61K31/506
摘要： A method for treating or inhibiting artery obstructive disease, such as restenosis after angioplasty and stenting procedures and stenosis after coronary artery bypass surgery, in a subject by administering to the subject a therapeutically effective amount of dasatinib or a derivative thereof Also provided are drug-eluting medical devices, including stents, having a therapeutically effective amount of dasatinib.
摘要翻译：用于治疗或抑制动脉阻塞性疾病的方法，例如血管成形术和冠状动脉搭桥术后的再狭窄，以及冠状动脉搭桥手术后的狭窄，通过向受试者施用治疗有效量的达沙替尼或其衍生物。还提供了药物洗脱具有治疗有效量的达沙替尼的医疗装置，包括支架。

25. 发明申请

US20060069664A1 Method and system for processing queries intiated by users of mobile devices 有权
标题翻译：用于处理移动设备用户所提出的查询的方法和系统
公开(公告)号：US20060069664A1
公开(公告)日：2006-03-30
申请号：US10957115
申请日：2004-09-30
申请人： Benjamin Ling , Jie Wu , Jian Deng , Hanping Feng
发明人： Benjamin Ling , Jie Wu , Jian Deng , Hanping Feng
IPC分类号： G06F17/30
CPC分类号： G06F17/30867 , G06F17/30979 , G06F17/30991 , H04L51/066 , H04W4/14 , H04W48/16
摘要： In one embodiment, a method for processing queries initiated by users of mobile devices includes receiving an incoming message containing a query initiated be a user of a mobile device, and extracting the query from the received message. The message further includes obtaining a result of the query and creating an outgoing message with the result of the query for delivery to the mobile device.
摘要翻译：在一个实施例中，用于处理由移动设备的用户发起的查询的方法包括：接收包含作为移动设备的用户的发起的查询的传入消息，以及从所接收的消息中提取查询。该消息还包括获得查询的结果并创建具有用于传送到移动设备的查询结果的传出消息。

26. 发明授权

US06926780B2 Method of surface self-nanocrystallization of metallic materials 有权
标题翻译：金属材料表面自我纳米化方法
公开(公告)号：US06926780B2
公开(公告)日：2005-08-09
申请号：US10202241
申请日：2002-07-23
申请人： Tianying Xiong , Tiefan Li , Jie Wu , Huazi Jin , Minjie Wu , Jinsheng Chen , Ming Li
发明人： Tianying Xiong , Tiefan Li , Jie Wu , Huazi Jin , Minjie Wu , Jinsheng Chen , Ming Li
IPC分类号： C21D7/06 , C23C24/04 , C21D1/74
CPC分类号： C21D7/06 , C21D2201/03 , C23C24/04
摘要： The present invention relates to a method of surface treatment of metallic materials, more particularly, to a method of the surface self-nanocrystallization of metallic materials by the bombarding of supersonic fine particles. The method comprises the step of bombarding the surface of metallic substrate material with fine particles at supersonic speed of 300-1200 m/s carried by a compressed gas, which is ejected from a nozzle. The present method can be used for the surface self-nanocrystallization of metallic parts with a complicated structure or a large area, and the nanometer layer obtained is homogeneous. In addition, it can be operated in a simple way with low energy consumption, low cost, high efficiency of production and high surface nanocrystallization rate of from 1 cm2 to 10 cm2/min.
摘要翻译：金属材料的表面处理方法技术领域本发明涉及一种金属材料的表面处理方法，更具体地说，涉及通过轰击超音速微粒而使金属材料的表面自纳晶化的方法。该方法包括用喷射器喷射的压缩气体携带的300-1200m / s超声速度的细颗粒轰击金属基材表面的步骤。本方法可以用于具有复杂结构或大面积的金属部件的表面自纳米结构，并且所获得的纳米层是均匀的。另外，能够以低能耗，低成本，高效率的生产和1cm 2〜10cm 2以上的高表面纳米化速度的简单方式进行操作 > / min。

27. 发明公开

US20230181519A1 Compositions And Methods For Treating Nicotine-Related Disorders And Symptoms Using Dihydromyricetin 审中-公开
公开(公告)号：US20230181519A1
公开(公告)日：2023-06-15
申请号：US17548550
申请日：2021-12-12
申请人： Jie Wu
发明人： Jie Wu
IPC分类号： A61K31/353 , A61P25/34
CPC分类号： A61K31/353 , A61P25/34
摘要： The invention relates to pharmaceutical compositions comprising dihydromyricetin, methods for making such compositions, and methods for using such compositions to treat nicotine-related disorders and habits, such as nicotine addiction, nicotine withdrawal symptoms and the reduction and/or cessation of smoking, vaping, patch, and/or chewing tobacco products.

28. 发明申请

US20200207903A1 AQUEOUS POLYURETHANE DISPERSION ADHESIVE COMPOSITIONS 审中-公开
公开(公告)号：US20200207903A1
公开(公告)日：2020-07-02
申请号：US16612535
申请日：2017-05-11
申请人： Chenyan Bai , Zhaohui Qu , Jie Wu , Kalyan Sehanobish , Hongyu Chen , Xinchun Liu , Chao Zhang
发明人： Chenyan Bai , Zhaohui Qu , Jie Wu , Kalyan Sehanobish , Hongyu Chen , Xinchun Liu , Chao Zhang
IPC分类号： C08G18/10 , C08G18/28 , C08G18/32 , C08G18/73 , C08G18/76 , C08G18/75 , C09J175/06 , C09J175/08 , B32B7/12
摘要： An aqueous polyurethane dispersion compositions are disclosed. The compositions include a polyurethane prepolymer dispersed in an aqueous medium, the polyurethane prepolymer comprising an isocyanate and a crystalline polyester polyol having a hydroxyl content of 20 to 150 mg KOH/g and a melt temperature of less than or equal to 90° C. Methods of forming a laminate are also disclosed. The methods include providing an aqueous polyurethane dispersion, applying the polyurethane dispersion to a surface of the first substrate, bringing the side of the first substrate into contract with a surface of the second substrate, and curing the aqueous dispersion, thereby laminating the first substrate to the second substrate. Laminates formed by the methods and including the compositions are also disclosed.

29. 发明申请

US20170191856A1 Interchangeable Face Gauge For An Automobile 审中-公开
公开(公告)号：US20170191856A1
公开(公告)日：2017-07-06
申请号：US15295516
申请日：2016-10-17
申请人： Enrique J. Baiz , Osvaldo Izquierdo , Cheng Jie Wu
发明人： Enrique J. Baiz , Osvaldo Izquierdo , Cheng Jie Wu
IPC分类号： G01D13/04 , B60K35/00
CPC分类号： G01D13/04 , B60K35/00 , B60K37/02 , B60K2370/151 , B60K2370/156 , B60K2370/34 , B60K2370/688 , B60K2370/691 , B60K2370/698 , B60K2370/81 , B60K2370/828 , B60K2370/91
摘要： An interchangeable face gauge structure for automobile gauges comprises a gauge body, a face gauge, a retainer ring and an outer cover. The gauge body and outer cover are combined by means of assembling, which causes the outer cover to be dismountable from and re-mountable on the gauge body. The face gauge is additionally mounted on the surface of the light directing panel on the gauge body, which allows the face gauge to be replaceable with one of the type to the liking of the user after the outer cover is dismounted from the gauge body, improving the variability and visual effect of the gauge body. Further, with the convenience of the outer cover being easily mountable on the gauge body, the user is allowed to replace and mount parts by themselves, adding to the practicality of the structure.

30. 发明授权

US09174969B2 Indoline scaffold SHP-2 inhibitors and cancer treatment method 有权
标题翻译：吲哚酚支架SHP-2抑制剂和癌症治疗方法
公开(公告)号：US09174969B2
公开(公告)日：2015-11-03
申请号：US13055113
申请日：2009-07-21
申请人： Jie Wu , Nicholas J. Lawrence , Said M. Sebti
发明人： Jie Wu , Nicholas J. Lawrence , Said M. Sebti
IPC分类号： A61K31/496 , C07D209/08 , C07D215/36 , C07D405/06
CPC分类号： C07D405/06 , C07D209/08 , C07D215/36
摘要： The subject invention concerns methods and compounds for inhibiting Shp2. In one embodiment, a compound of the invention has a chemical structure as shown in formula I or II: wherein X, Y, and Z are independently N or S; R1 is cycloalkyl, heterocycloalkyl, aryl, or heteroaryl, any of which can be optionally substituted with one or more of halogen; alkyl; heteroalkyl; —COOH; —C(R3)3, wherein R3 can independently be any of —H or halogen; or —OR4, wherein R4 can be any of H, alkyl, or heteroalkyl; R2 is alkyl, alkylcarbonyl, heteroalkylcarbonyl, aryl, arylcarbonyl, heterocycloalkylcarbonyl, cycloalkylcarbonyl, or —C(O)NR6R7, any of which can be optionally substituted with one or more of halogen; alkyl; heteroalkyl; carbonyl; —OR4, wherein R4 can be —H, alkyl, or heteroalkyl; —OH; —C(R3)3, wherein R3 can independently be any of —H or halogen; aryl, which can be substituted with one or more of halogen or —OR4; heterocycloalkyl; or —C(O)OR5, wherein R5 can be —H or alkyl; R6 and R7 are independently —H, alkyl, heteroalkyl, aryl, or heteroaryl; and R′ is H or alkyl; or a pharmaceutically acceptable salt or hydrate thereof.
摘要翻译：本发明涉及抑制Shp2的方法和化合物。在一个实施方案中，本发明的化合物具有如式I或II所示的化学结构：其中X，Y和Z独立地为N或S; R 1是环烷基，杂环烷基，芳基或杂芳基，其中任何一个可以任选被一个或多个卤素取代; 烷基; 杂烷基; -COOH; -C（R 3）3，其中R 3可以独立地为-H或卤素; 或-OR 4，其中R 4可以是H，烷基或杂烷基中的任何一个; R 2是烷基，烷基羰基，杂烷基羰基，芳基，芳基羰基，杂环烷基羰基，环烷基羰基或-C（O）NR 6 R 7，其中任何一个可以任选被一个或多个卤素取代; 烷基; 杂烷基; 羰; -OR4，其中R4可以是-H，烷基或杂烷基; -哦; -C（R 3）3，其中R 3可以独立地为-H或卤素; 芳基，其可被一个或多个卤素或-OR 4取代; 杂环烷基; 或-C（O）OR 5，其中R 5可以是-H或烷基; R6和R7独立地是-H，烷基，杂烷基，芳基或杂芳基; 和R'是H或烷基; 或其药学上可接受的盐或水合物。

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