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21. 发明申请

US20130197499A1 BALLOON DESIGN TO ENHANCE COOLING UNIFORMITY 有权
标题翻译：气球设计，以加强冷却均匀性
公开(公告)号：US20130197499A1
公开(公告)日：2013-08-01
申请号：US13360430
申请日：2012-01-27
申请人： Jean-Pierre LALONDE , Scott W. DAVIE , Dan WITTENBERGER
发明人： Jean-Pierre LALONDE , Scott W. DAVIE , Dan WITTENBERGER
IPC分类号： A61B18/02
CPC分类号： A61B18/02 , A61B18/1492 , A61B2018/0022 , A61B2018/00255 , A61B2018/00375 , A61B2018/00577 , A61B2018/00648 , A61B2018/00791 , A61B2018/00994 , A61B2018/0212 , A61B2018/0268 , A61B2018/0275 , A61B2090/064
摘要： A device, system, and method for enhancing cooling uniformity and efficiency of cryogenic fluids and providing a treatment element the shape of which can be adjusted for multiple purposes. The device may include a balloon catheter and fluid dispersion element, the fluid dispersion element directing the flow of coolant from a fluid injection element the interior wall of the balloon. The method of changing the shape of the treatment element may include retracting and extending a shaft to which the distal neck of a balloon is coupled, so that the balloon goes from a first shape to a second shape.
摘要翻译：一种用于增强低温流体的冷却均匀性和效率的装置，系统和方法，并提供一种处理元件，其形状可以被调整用于多种目的。该装置可以包括球囊导管和流体分散元件，流体分散元件将来自流体注射元件的冷却剂流引导到气囊的内壁。改变处理元件的形状的方法可以包括缩回和延伸气球的远端颈部所连接的轴，使得气球从第一形状变为第二形状。

22. 发明申请

US20120245574A1 Spray nozzle design for a catheter 有权
标题翻译：导管喷嘴设计
公开(公告)号：US20120245574A1
公开(公告)日：2012-09-27
申请号：US13071594
申请日：2011-03-25
申请人： Jean-Pierre Lalonde
发明人： Jean-Pierre Lalonde
IPC分类号： A61B18/02
CPC分类号： A61B18/02 , A61B2018/0022 , A61B2018/00255 , A61B2018/00351 , A61B2018/00577 , A61B2018/0212 , A61B2018/0262
摘要： A catheter-based medical device including controlled refrigerant dispersion is disclosed. The device includes a fluid injection tube that carries refrigerant from a coolant supply to the distal portion of the device. A fluid dispersion unit is disposed on the distal end of the fluid tube to control the angle of distribution for refrigerant that is expelled from the fluid injection tube. Controlling the angle of distribution for the refrigerant facilitates dispersion of the fluid in a predetermined spray pattern. The disclosure further relates to cryoablation treatment systems incorporating such a catheter, and to cryoablation treatment methods for tissue treatment to address various conditions suitably treatable with cryoablation.
摘要翻译：公开了一种包括受控的制冷剂分散体的基于导管的医疗装置。该装置包括将制冷剂从冷却剂供应运送到装置的远端部分的流体注入管。流体分散单元设置在流体管的远端，以控制从流体注入管排出的制冷剂的分配角度。控制制冷剂的分配角度促进流体以预定的喷雾模式的分散。本公开还涉及包含这种导管的冷冻消融治疗系统，以及用于组织治疗的冷冻消融治疗方法，以解决适合于冷冻消融治疗的各种状况。

23. 发明授权

US08043284B2 Cryosurgical catheter 有权
公开(公告)号：US08043284B2
公开(公告)日：2011-10-25
申请号：US12792376
申请日：2010-06-02
申请人： John W. Lehmann , Dan Wittenberger , Claudia Luckge , Jean-Pierre Lalonde , Cristian Petre , Domenic Santoianni
发明人： John W. Lehmann , Dan Wittenberger , Claudia Luckge , Jean-Pierre Lalonde , Cristian Petre , Domenic Santoianni
IPC分类号： A61B18/02
CPC分类号： A61B18/02 , A61B2017/00243 , A61B2017/00292 , A61B2017/00973 , A61B2018/00095 , A61B2018/0212 , A61F2007/0298 , A61M25/0029 , A61M2025/0039 , Y10S977/906
摘要： A cryogenic catheter includes an outer flexible member having at least one cryogenic fluid path through the flexible member. The at least one fluid path is defined by a plurality of flexible members disposed within the outer flexible member.

24. 发明申请

US20100286677A1 CRYOSURGICAL CATHETER 有权
公开(公告)号：US20100286677A1
公开(公告)日：2010-11-11
申请号：US12792376
申请日：2010-06-02
申请人： John W. LEHMANN , Dan WITTENBERGER , Claudia LÜCKGE , Jean-Pierre LALONDE , Cristian PETRE , Domenic SANTOIANNI
发明人： John W. LEHMANN , Dan WITTENBERGER , Claudia LÜCKGE , Jean-Pierre LALONDE , Cristian PETRE , Domenic SANTOIANNI
IPC分类号： A61B18/02
CPC分类号： A61B18/02 , A61B2017/00243 , A61B2017/00292 , A61B2017/00973 , A61B2018/00095 , A61B2018/0212 , A61F2007/0298 , A61M25/0029 , A61M2025/0039 , Y10S977/906
摘要： A cryogenic catheter includes an outer flexible member having at least one cryogenic fluid path through the flexible member. The at least one fluid path is defined by a plurality of flexible members disposed within the outer flexible member.

25. 发明申请

US20080077124A1 CLOSED LOOP CATHETER COOLANT SYSTEM 有权
标题翻译：封闭式导管冷却系统
公开(公告)号：US20080077124A1
公开(公告)日：2008-03-27
申请号：US11948321
申请日：2007-11-30
申请人： Jean-Pierre LALONDE , Marwan ABBOUD
发明人： Jean-Pierre LALONDE , Marwan ABBOUD
IPC分类号： A61B18/02
CPC分类号： A61B18/02 , A61B2017/00092 , A61B2017/00119 , A61B2018/0212 , A61B2018/0262 , A61F7/12
摘要： A coolant system for a cryoablation or treatment probe such as a mapping or ablation catheter, or a treatment wand, includes a compressor and condenser having a low pressure inlet side and a high pressure outlet side, wherein the outlet side passes through a heat exchanger and is cooled by the inlet side and conditioned for injection to a catheter inlet. A vacuum return system connectable to the catheter outlet draws thermally expended coolant from the catheter and returns it to the low pressure inlet side. A motorized pressure regulator between the heat exchanger and the catheter inlet determines the pressure of coolant passing into the catheter and thus regulates the cooling rate for a selected mapping or ablation regimen. The low pressure compressor inlet supply preferentially conditions the pressurized coolant to ambient temperature or lower before injection into the catheter, allowing the coolant to travel through the body at ambient before expansion in the tip. In a preferred embodiment, a coolant reservoir feeds into the low pressure inlet side and receives a return flow of excess fluid from a branch off the outlet side of the compressor. The vacuum return assures that coolant does not leak into the blood stream, and preferably various check valves and bypass valves operate in the event of pressure buildup to return fluid to either the inlet or supply from different points along the loop. The coolant mixture preferably has a boiling point of approximately −60° Fahrenheit at about 1-2 bar, and may be compressed to several hundred psi. The entire system is amenable to microprocessor control for providing ablation cooling cycles to operate the catheter tip in accordance with a selected protocol, and for effecting system functions such as recharging and venting of the supply, and shutting down during nonuse or upon occurrence of a fault condition.
摘要翻译：用于冷冻消融或治疗探针如冷凝或消融导管或治疗棒的冷却剂系统包括具有低压入口侧和高压出口侧的压缩机和冷凝器，其中出口侧通过热交换器和通过入口侧冷却并调节注射到导管入口。可连接到导管出口的真空返回系统从导管吸出热消耗的冷却剂并将其返回到低压入口侧。热交换器和导管入口之间的电动压力调节器确定冷却剂通过导管的压力，从而调节所选择的定位或消融方案的冷却速率。低压压缩机入口供应优选地将加压的冷却剂调节到环境温度或更低温度，然后注入导管，允许冷却剂在环境温度下在尖端中膨胀之前穿过身体。在优选实施例中，冷却剂储存器进入低压入口侧并接收来自压缩机出口侧的分支的多余流体的回流。真空回流确保冷却剂不会泄漏到血液中，并且优选地，在压力累积的情况下，各种止回阀和旁通阀操作，以将流体从沿着回路的不同点返回到入口或供应源。冷却剂混合物优选在约1-2巴下具有约-60华氏度的沸点，并且可以压缩至几百磅/平方英寸。整个系统适于微处理器控制，以根据所选择的方案提供消融冷却循环来操作导管尖端，并且用于实现系统功能，例如电源的再充电和排气，以及在不使用或发生故障时关闭。条件。

26. 发明授权

US06635053B1 Cooling system 有权
标题翻译：冷却系统
公开(公告)号：US06635053B1
公开(公告)日：2003-10-21
申请号：US09638208
申请日：2000-08-11
申请人： Jean-Pierre Lalonde , Marwan Abboud , Rachid Mahrouche , Dan Wittenberger
发明人： Jean-Pierre Lalonde , Marwan Abboud , Rachid Mahrouche , Dan Wittenberger
IPC分类号： A61B1818
CPC分类号： A61B18/02 , A61B2017/00084 , A61B2017/00092 , A61B2017/00119 , A61B2017/00199 , A61B2018/0212 , A61B2018/0262 , A61B2018/0268
摘要： A cryogenic medical system includes a medical device and a console connectable to the medical device at a connection point. The console controls the temperature of the medical device. The console includes a first cooling system directing coolant to the medical device at a first temperature along a coolant supply line and a second cooling system chilling the coolant within the coolant supply line to a temperature below the first temperature before the coolant reaches the connection point.
摘要翻译：低温医疗系统包括在连接点处可连接到医疗装置的医疗装置和控制台。控制台控制医疗设备的温度。所述控制台包括第一冷却系统，所述第一冷却系统沿着冷却剂供应管线在第一温度下将冷却剂引导至所述医疗设备;以及第二冷却系统，在所述冷却剂到达所述连接点之前将所述冷却剂供应管线内的冷却剂冷却至低于所述第一温度的温

27. 发明授权

US06602247B2 Apparatus and method for performing a treatment on a selected tissue region 有权
公开(公告)号：US06602247B2
公开(公告)日：2003-08-05
申请号：US10016190
申请日：2002-03-12
申请人： Jean-Pierre Lalonde
发明人： Jean-Pierre Lalonde
IPC分类号： A61B1818
CPC分类号： A61M25/0029 , A61B5/042 , A61B18/02 , A61B2017/00243 , A61B2017/00292 , A61B2017/00973 , A61B2017/22051 , A61B2018/00095 , A61B2018/0022 , A61B2018/0212 , A61B2018/0262 , A61F2007/0298 , A61M2025/0037 , A61M2025/0039 , Y10S977/906
摘要： A cryogenic catheter includes an outer flexible member having at least one cryogenic fluid path through the flexible member. The at least one fluid path is defined by a plurality of flexible members disposed within the outer flexible member.

28. 发明授权

US06589234B2 Cryogenic medical device with high pressure resistance tip 有权
标题翻译：具有高耐压端头的低温医疗器械
公开(公告)号：US06589234B2
公开(公告)日：2003-07-08
申请号：US09965208
申请日：2001-09-27
申请人： Jean-Pierre Lalonde , Marwan Abboud , Constantin Bogdan Ciobotaru
发明人： Jean-Pierre Lalonde , Marwan Abboud , Constantin Bogdan Ciobotaru
IPC分类号： A61B1818
CPC分类号： A61B18/02 , A61B2018/0212 , A61B2018/0268
摘要： The present invention provides a medical device to cold treat desired regions. An injection tube with an open distal end is disposed inside of a catheter tube, defining a return lumen therein. A supply of cryogenic fluid, regulated by a controller mechanism coupled to the device, flows through the injection tube and into the distal tip portion of the catheter tube, whereupon the fluid is returned from the catheter through the return lumen. The expansion and evaporation of cryogenic fluid inside the device serves to cool the surrounding areas external to and proximate the distal end of the device. An additional restriction tube is provided in the length of the catheter tube to regulate the pressure of the flow of cryogen therethrough so as to create higher operating pressures in the distal end of the device and thereby enhance the cooling power and temperature stability of the device at a lower range of fluid flow rates without reaching the triple point of the cryogenic fluid.
摘要翻译：本发明提供一种用于冷处理所需区域的医疗装置。具有开口远端的注射管设置在导管管内部，在其中限定回流腔。由连接到装置的控制器机构调节的低温流体的供应流过注射管并进入导管管的远侧末端部分，于是流体从导管通过返回内腔返回。装置内的低温流体的膨胀和蒸发用于冷却装置的远端外部和附近的周围区域。在导管的长度上设置一个附加的限制管，用于调节制冷剂流过的压力，从而在装置的远端产生更高的操作压力，从而提高装置的冷却功率和温度稳定性较低的流体流速范围，而不达到低温流体的三重点。

29. 发明授权

US06283959B1 Endovascular cryotreatment catheter 有权
公开(公告)号：US06283959B1
公开(公告)日：2001-09-04
申请号：US09378972
申请日：1999-08-23
申请人： Jean Pierre Lalonde , Robert Martin , Claudia Lueckge , Leonilda Capuano , John W. Lehmann , Daniel Nahon
发明人： Jean Pierre Lalonde , Robert Martin , Claudia Lueckge , Leonilda Capuano , John W. Lehmann , Daniel Nahon
IPC分类号： A61B1818
CPC分类号： A61B18/02 , A61B2017/22001 , A61B2017/22051 , A61B2017/22054 , A61B2017/22069 , A61B2018/0022 , A61B2018/0212 , A61B2018/0262 , A61B2018/0268
摘要： A catheter is attached to an elongated catheter body adapted for endovascular insertion with a balloon assembly at its distal end. Coolant injected through the catheter body may, in different embodiments, directly cool tissue contacting the balloon, or may cool a separate internal chamber. In the first case, the coolant also inflates the balloon, and spent coolant is returned to the handle via a return passage extending through the body of the catheter. A valve may regulate back pressure in the return passage to coordinate the flow of coolant into and out of the balloon so as to both inflate the balloon and achieve cryogenic cooling at the surface of the balloon. The coolant is biologically safe, and may be liquid carbon dioxide. Plural balloons may be provided adjacent the cooling segment, and one balloon may be shaped to treat the ostium of a vessel. Preferably, thermal conductivity of the balloon wall is enhanced by inclusion of thermally conductive material, such as metal, which may be introduced as a component of a composite elastomer material, or as a patterned metal layer that defines a pattern of thermally conductive treatment regions of the balloon surface. Patterns formed by printing, lithography or other means with copper, silver or other highly thermally conductive material enhance through-conduction characteristics of the wall so icing preferentially occurs to stimulate tissue destruction and vascular regeneration. Suitable patterns include spirals, dots, arrays of separated segments, or meandering curves which allow expansion of the balloon body without introducing delamination, localized stress cracking or separation of the balloon material. The conductive patterns may include patterns such as waffle-iron or other arrays of small lesions that are effective to treat the endovascular wall. When separate media are used for cooling and for balloon expansion, the cooling chamber may have a large diameter, and the balloon may form a thin shell or cuff. In that case, the balloon may be quickly inflated with a medium such as a saline to provide a quickly deployed and compliant contact structure of excellent conductivity.

30. 发明授权

US09439707B2 Spray nozzle design for a catheter 有权
标题翻译：导管喷嘴设计
公开(公告)号：US09439707B2
公开(公告)日：2016-09-13
申请号：US13071594
申请日：2011-03-25
申请人： Jean-Pierre Lalonde
发明人： Jean-Pierre Lalonde
IPC分类号： A61B18/02 , A61B18/00
CPC分类号： A61B18/02 , A61B2018/0022 , A61B2018/00255 , A61B2018/00351 , A61B2018/00577 , A61B2018/0212 , A61B2018/0262
摘要： A catheter-based medical device including controlled refrigerant dispersion is disclosed. The device includes a fluid injection tube that carries refrigerant from a coolant supply to the distal portion of the device. A fluid dispersion unit is disposed on the distal end of the fluid tube to control the angle of distribution for refrigerant that is expelled from the fluid injection tube. Controlling the angle of distribution for the refrigerant facilitates dispersion of the fluid in a predetermined spray pattern. The disclosure further relates to cryoablation treatment systems incorporating such a catheter, and to cryoablation treatment methods for tissue treatment to address various conditions suitably treatable with cryoablation.
摘要翻译：公开了一种包括受控的制冷剂分散体的基于导管的医疗装置。该装置包括将制冷剂从冷却剂供应运送到装置的远端部分的流体注入管。流体分散单元设置在流体管的远端，以控制从流体注入管排出的制冷剂的分配角度。控制制冷剂的分配角度促进流体以预定的喷雾模式的分散。本公开还涉及包含这种导管的冷冻消融治疗系统，以及用于组织治疗的冷冻消融治疗方法，以解决适合于冷冻消融治疗的各种状况。

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