会员体验
专利管家(专利管理)
工作空间(专利管理)
风险监控(情报监控)
数据分析(专利分析)
侵权分析(诉讼无效)
联系我们
交流群
官方交流:
QQ群: 891211   
微信请扫码    >>>
现在联系顾问~
热词
    • 22. 发明授权
    • Farnesyl transferase inhibitors, their preparation, the pharmaceutical
compositions which contain them and their use in the preparation of
medicaments
    • 法呢基转移酶抑制剂,它们的制备,含有它们的药物组合物及其在制备药物中的用途
    • US6013662A
    • 2000-01-11
    • US999408
    • 1997-12-29
    • Jean-Dominique BourzatAlain Commer.cedilla.onNorbert DereuPatrick MaillietFabienne Sounigo-ThompsonJean-Paul MartinMarc CapetMichel Cheve
    • Jean-Dominique BourzatAlain Commer.cedilla.onNorbert DereuPatrick MaillietFabienne Sounigo-ThompsonJean-Paul MartinMarc CapetMichel Cheve
    • C07D209/56C07D209/72C07D401/12C07D403/04C07D405/04C07D405/14C07D409/04C07D409/12C07D409/14A01N43/38C07D235/08C07D401/08
    • C07D401/12C07D209/56C07D209/72C07D403/04C07D405/04C07D405/14C07D409/04C07D409/12C07D409/14
    • Novel products of formula (I), their preparation, the pharmaceutical compositions which contain them and their use in the preparation of medicaments. ##STR1## In the formula (I), the following substituents are among the preferred: Ar represents a substituted or condensed phenyl radical or a polycyclic or heterocyclic aromatic radical, R represents a radical of general formula --(CH.sub.2).sub.m --X.sub.1 --(CH.sub.2).sub.n --Z in which X.sub.1 =single bond, O, S; m=0, 1; n=0, 1, 2; it being possible for the CH.sub.2 radicals to be substituted; Z represents carboxyl, COOR.sub.6 (R.sub.6 =alkyl), CON(R.sub.7)(R.sub.8) (R.sub.7 =hydrogen or alkyl and R.sub.8 =hydrogen, hydroxyl, arylsulphonyl, heterocyclyl, optionally substituted amino, optionally substituted alkyloxy or optionally substituted alkyl), PO(OR.sub.9).sub.2 (R.sub.9 =hydrogen or alkyl), an --NH--CO--T (T=hydrogen or optionally substituted alkyl) radical, or elsea ##STR2## radical, R.sub.1 and R.sub.2 =hydrogen or halogen or alkyl, alkyloxy which is optionally substituted, alkylthio, alkyloxycarbonyl or else R.sub.1 and R.sub.2, at the ortho position with respect to one another, form an optionally substituted heterocycle containing 1 or 2 heteroatoms, R.sub.3 and R.sub.4 =hydrogen or halogen or alkyl, alkenyl, alkyloxy, alkylthio, carboxyl or alkyloxycarbonyl, R.sub.5 =hydrogen, alkyl, alkylthio, X=O or S or --NH--, --CO--, methylene, vinyldiyl, alkene-1,1-diyl or cycloalkane-1,1-diyl, and Y=O or S, in the racemic form, as well as the optical isomers (diastereomers and enantiomers) and the salts of the product of formula (I). The compounds of formula (I) are farnesyl transferase inhibitors which exhibit notable antitumor and antileukemic properties.
    • 式(I)的新产品,其制备方法,含有它们的药物组合物及其在制备药物中的用途。 在式(I)中,以下取代基是优选的:Ar表示取代或稠合的苯基或多环或杂环芳族基,R表示通式 - (CH 2)m -X1(CH 2)n Z 其中X1 =单键,O,S; m = 0,1, n = 0,1,2; CH2基可以被取代; Z代表羧基,COOR6(R6 =烷基),CON(R7)(R8)(R7 =氢或烷基,R8 =氢,羟基,芳基磺酰基,杂环基,任选取代的氨基,任选取代的烷氧基或任选取代的烷基),PO OR 9)2(R 9 =氢或烷基),-NH-CO-T(T =氢或任选取代的烷基)基团,或者基团,R 1和R 2 =氢或卤素或任选被取代的烷基, 烷基硫代,烷氧基羰基,或者R1和R2相对于彼此的邻位,形成任选取代的含有1或2个杂原子的杂环,R 3和R 4 =氢或卤素或烷基,烯基,烷氧基,烷硫基,羧基或烷氧基羰基, R5 =氢,烷基,烷硫基,X = O或S或-NH-,-CO-,亚甲基,乙烯基二烯基,烯-1,1-二基或环烷烃-1,1-二基,Y = O或S 外消旋形式,以及光学异构体(非对映异构体和对映体)和式(I)的产物的盐。 式(I)化合物是具有显着的抗肿瘤和抗白血病性质的法呢基转移酶抑制剂。
    • 23. 发明授权
    • Pre-stretched film, and apparatus and method for outer packaging
    • 预拉伸膜,以及用于外包装的装置和方法
    • US5953888A
    • 1999-09-21
    • US887
    • 1997-12-30
    • Jean-Paul Martin-CocherJaconelli Georges
    • Jean-Paul Martin-CocherJaconelli Georges
    • B65B21/14B29C55/06B65B11/04B65B11/28B65B17/02B65D71/00B65D75/00B65B53/00
    • B65B11/045B29C55/06B65D71/0088B65D75/006B65D2571/00018B65D2571/00043B65D2571/00055B65D2571/00067
    • The present invention relates to a pre-stretched film, and to apparatus and a method of applying outer packaging to packages and to loads, optimized as a function of the structure and in particular the shape of the package or the load, in particular a palletized load, and also as a function of the transport and handling that the package or the load must be capable of withstanding without the outer packaging being dislocated. According to the invention, a stretchable film is stretched over at least one roller having a diameter that varies along its axis of rotation so as to form parallel longitudinal zones in the film that have different degrees of stretching. These zones make it possible, in particular, to track the external outlines of objects to be packaged and/or to provide locally-reinforced bonding, or on the contrary to present surfaces that are more relaxed. The present invention applies in particular to packaging and grouping together loads that may optionally be palletized. The main application of the present invention lies in grouping together bottles of beverages.
    • 本发明涉及预拉伸膜,以及将外包装应用于包装和负载的装置和方法,其根据结构,特别是包装或负载的形状,特别是码垛 并且还作为包装或负载必须能够承受而不会使外包装脱位的运输和处理的函数。 根据本发明,可拉伸薄膜在至少一个具有沿着其旋转轴线变化的直径的滚子上被拉伸,从而在膜中形成具有不同拉伸程度的平行纵向区域。 这些区域特别地可以跟踪要包装的物体的外部轮廓和/或提供局部加强的粘合,或者与更放松的现有表面相反。 本发明特别适用于将可选择地被托盘化的载荷组合在一起。 本发明的主要应用在于将饮料瓶分组在一起。