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    • 21. 发明授权
    • Solvent system enhancing the solubility of pharmaceuticals for
encapsulation
    • 溶剂体系提高药物的包封溶解度
    • US5360615A
    • 1994-11-01
    • US890285
    • 1992-05-26
    • Man S. YuFoo S. HomSibaprasanna ChakrabartiChong-Heng HuangMahendra Patel
    • Man S. YuFoo S. HomSibaprasanna ChakrabartiChong-Heng HuangMahendra Patel
    • A61K9/08A61K9/00A61K9/20A61K9/48A61K9/66A61K45/00A61K47/00A61K47/04A61K47/32A61K47/34
    • A61K9/2009A61K9/2031A61K9/485A61K9/4858A61K9/4866
    • This invention relates to a solvent system for enhancing the solubility of an acidic, basic, or amphoteric pharmaceutical agent to produce a highly concentrated solution suitable for softgel filling or two piece encapsulation. The solvent system comprises polyethylene glycol containing 0.2-1.0 mole equivalents of an ionizing agent per mole equivalent pharmaceutical agent and 1-20% water. Glycerin or polyvinylpyrrolidone may be added to further enhance the solubility of certain drugs. The disclosed solvent system is capable of enhancing solubilities of pharmaceutical agents 40-400%.The ionizing agent functions by causing partial ionization (neutralization) of the free pharmaceutical agent. When the pharmaceutical agent is acidic, the ionizing agent is preferably a hydroxide ion species, whereas when the pharmaceutical agent is basic, the ionizing agent is preferably a hydrogen ion species. For amphoteric pharmaceutical agents, either hydroxide ion or hydrogen ion sources may be utilized to effect partial ionization.The disclosed solvent system is useful because it not only provides for the enhancement or improvement of bioavailability of acidic, basic and amphoteric pharmaceutical agents by delivering them already in solution, but it also provides for a highly concentrated solution capable of encapsulation in a small enough vessel to permit easy swallowing.The highly concentrated solid solutions of the present invention are also useful for conversion into tablets and as veterinary spot and pour on preparations.
    • 本发明涉及一种用于增强酸性,碱性或两性药剂在产生适于软胶囊填充或两片封装的高度浓缩溶液中的溶解度的溶剂体系。 溶剂系统包含每摩尔当量药剂和1-20%水含有0.2-1.0摩尔当量离子化剂的聚乙二醇。 可以加入甘油或聚乙烯吡咯烷酮以进一步提高某些药物的溶解度。 所公开的溶剂系统能够提高40-400%的药剂的溶解度。 电离剂通过引起游离药剂的部分电离(中和)起作用。 当药剂为酸性时,电离剂优选为氢氧根离子,而当药剂为碱性时,电离剂优选为氢离子。 对于两性药剂,可以使用氢氧根离子或氢离子源来实现部分电离。 所公开的溶剂系统是有用的,因为它不仅通过将其输送到溶液中来提供酸性,碱性和两性药物的生物利用度的增强或改善,而且还提供能够在足够小的容器中包封的高度浓缩的溶液 容易吞咽。 本发明的高度浓缩的固体溶液也可用于转化成片剂和兽药斑点并倒入制剂上。
    • 28. 发明申请
    • ELECTRONIC DEVICE USING FASTENER FOR FIXING
    • 使用紧固件固定的电子设备
    • US20130100614A1
    • 2013-04-25
    • US13588628
    • 2012-08-17
    • Yi-Fei YuYuan-Heng Huang
    • Yi-Fei YuYuan-Heng Huang
    • H05K7/20
    • H01L23/4093H01L2924/0002H01L2924/00
    • An electronic device includes a circuit board, a communication chip, a ceramic heat sink and an elastic fastener. The circuit board has first and second fixing members. The communication chip is disposed on the circuit board. The ceramic heat sink disposed on the communication chip has first and second lateral sides. The elastic fastener includes a first extension portion, a second extension portion and a clamping portion. The first extension portion extending to the first fixing member from the first lateral side is engaged with the first fixing member to generate a first fastening force. The second extension portion extending to the second fixing member from the second lateral side is engaged with the second fixing member to generate a second fastening force. The clamping portion applies a force on the ceramic heat sink to tightly press the ceramic heat sink on the communication chip.
    • 电子设备包括电路板,通信芯片,陶瓷散热器和弹性紧固件。 电路板具有第一和第二固定构件。 通信芯片设置在电路板上。 布置在通信芯片上的陶瓷散热片具有第一和第二侧面。 弹性紧固件包括第一延伸部分,第二延伸部分和夹紧部分。 从第一侧面延伸到第一固定构件的第一延伸部分与第一固定构件接合以产生第一紧固力。 从第二侧面延伸到第二固定构件的第二延伸部分与第二固定构件接合以产生第二紧固力。 夹紧部分在陶瓷散热器上施加一个力,以将通信芯片上的陶瓷散热片紧压。
    • 30. 发明授权
    • Liquid crystal display
    • 液晶显示器
    • US08405807B2
    • 2013-03-26
    • US12702305
    • 2010-02-09
    • Ting-Yi ChoChin-An TsengYen-Heng HuangChia-Hui PaiWen-Hsien TsengChung-Kai ChenChung-Yi Chiu
    • Ting-Yi ChoChin-An TsengYen-Heng HuangChia-Hui PaiWen-Hsien TsengChung-Kai ChenChung-Yi Chiu
    • G02F1/1343G02F1/1335G02F1/1337G02F1/1339
    • G02F1/13394G02F1/133514G02F1/136213G02F2001/136222
    • A liquid crystal display including an active device array substrate, an opposite substrate disposed above the active device array substrate, a liquid crystal layer disposed between the active device array substrate and the opposite substrate, and spacers is provided. The active device array substrate includes a substrate, pixels, a first dielectric layer and color filter patterns. Each pixel includes a first active device, a first pixel electrode and a capacitor electrode. The capacitor electrode and the first pixel electrode constitute a storage capacitor. The first dielectric layer covers the first active device. The color filter patterns are disposed on the first dielectric layer. Each of the color filter patterns has a first opening disposed above the capacitor electrode to expose the first dielectric layer above the capacitor electrode. Each first pixel electrode is respectively disposed on one of the color filters and within the corresponding first opening.
    • 提供一种液晶显示器,包括有源器件阵列基板,设置在有源器件阵列基板上方的相对基板,设置在有源器件阵列基板和相对基板之间的液晶层和间隔件。 有源器件阵列衬底包括衬底,像素,第一介电层和滤色器图案。 每个像素包括第一有源器件,第一像素电极和电容器电极。 电容电极和第一像素电极构成存储电容器。 第一介电层覆盖第一有源器件。 滤色器图案设置在第一电介质层上。 每个滤色器图案具有设置在电容器电极上方的第一开口,以暴露电容器电极上方的第一介电层。 每个第一像素电极分别设置在一个滤色器上并在相应的第一开口内。