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    • 23. 发明申请
    • Detection method for specific biomolecular interactions using fret between metal nanoparticle and quantum dot
    • 金属纳米粒子与量子点之间特异性生物分子相互作用的检测方法
    • US20060183247A1
    • 2006-08-17
    • US11355069
    • 2006-02-16
    • Hak-Sung KimEunkeu OhMi-Young HongDohoon LeeSunghun Nam
    • Hak-Sung KimEunkeu OhMi-Young HongDohoon LeeSunghun Nam
    • G01N33/551
    • G01N33/542A61K49/0065A61K49/0067B82Y5/00B82Y10/00B82Y30/00
    • The present invention relates to (1) a method for detecting a specific binding for bio-molecules; (2) a method for detecting a presence of target molecules within a specimen; and (3) a method for measuring a quantity of target molecules existing in a specimen, in which a pair of energy donor and energy acceptor displaying a FRET phenomenon is used to guide a specific binding between a pair of bio-molecules. According to the present invention, the process is conducted rapidly and easily without a label so as to screen a biochemical substance inhibiting a specific binding between a pair of bio-molecules in an ultra-high speed and measure a quantity of the substance and thereby, it can be applied to develop a novel drug. Further, this method can be used to analyze a characteristic such as change of the amount of carbohydrates in a glycoprotein derived from various cells as a drug candidate and thereby, is applicable for a quality control of proteins etc.
    • 本发明涉及(1)用于检测生物分子的特异性结合的方法; (2)检测试样中靶分子的存在的方法; 和(3)用于测量存在于样品中的目标分子的量的方法,其中使用一对显示FRET现象的能量供体和能量受体来引导一对生物分子之间的特异性结合。 根据本发明,该方法快速且容易地进行而没有标签,以便以超高速筛选抑制一对生物分子之间的特异性结合的生物化学物质并测量该物质的量, 它可以应用于开发新型药物。 此外,该方法可以用于分析作为候选药物的来自各种细胞的糖蛋白中的碳水化合物的量的变化,从而适用于蛋白质等的质量控制。
    • 24. 发明授权
    • Hybrid propeller shaft made of metal and composite material and method of manufacturing the same
    • 由金属和复合材料制成的混合式螺旋桨轴及其制造方法
    • US06863763B2
    • 2005-03-08
    • US10429155
    • 2003-04-30
    • Dai Gil LeeJin Kook KimHak Sung KimJong Woon Kim
    • Dai Gil LeeJin Kook KimHak Sung KimJong Woon Kim
    • F16C3/02B65H81/00
    • F16C3/026
    • The propeller shaft comprises a transmission shaft 10 consisting of a hollow metal tube 11 with excellent torque transmissibility and a composite material prepregs 12 having higher specific stiffness than a metal material and stacked to the inner surface of the metal tube, and metal yokes 40 mounted on both ends of the transmission shaft and assembled with other devices. The composite material prepregs is co-cure bonded while applying an axial compressive preload to the transmission shaft and creating a vacuum in a space between a vacuum bag inserted in the transmission shaft and the composite material prepregs of the transmission shaft. Teeth 43 or embossments 44, and adhesive-retaining grooves 45 are formed on inner surfaces of the metal yokes, so the transmission shaft is desirably compression-fitted into the metal yokes. Accordingly, the propeller shaft has advantages of securing improved impact, abrasion, and water resistance.
    • 传动轴包括由具有优良扭矩传递性的中空金属管11和与金属材料相比具有比金属材料更高的比刚度的复合材料预浸料12组成的传动轴10,并且堆叠在金属管的内表面上,金属轭40安装在 传动轴的两端,并且与其它设备组装。 复合材料预浸料在将轴向压缩预载荷施加到传动轴上并在插入传动轴的真空袋与传动轴的复合材料预浸料之间的空间中产生真空时共同固化粘合。 在金属轭的内表面上形成有齿43或凸起44以及粘合剂保持槽45,因此希望将传动轴压配合到金属轭中。 因此,传动轴具有确保改善的冲击,磨损和耐水性的优点。