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21. 发明申请

US20090137586A1 COMPOUNDS FOR THE TREATMENT OF INFLAMMATORY DISORDERS 有权
标题翻译：用于治疗炎症性疾病的化合物
公开(公告)号：US20090137586A1
公开(公告)日：2009-05-28
申请号：US12338445
申请日：2008-12-18
申请人： Wensheng Yu , Ling Tong , Lei Chen , Joseph A. Kozlowski , Brian J. Lavey , Neng-Yang Shih , Vincent S. Madison , Guowei Zhou , Peter Orth , Zhuyan Guo , Michael K.C. Wong , De-Yi Yang , Seong Heon Kim , Bandarpalle B. Shankar , M. Arshad Siddiqui , Kristin E. Rosner , Chaoyang Dai , Janeta Popovici-Muller , Vinay M. Girijavallabhan , Dansu Li , Razia Rizvi , Aneta M. Micula , Robert Feltz
发明人： Wensheng Yu , Ling Tong , Lei Chen , Joseph A. Kozlowski , Brian J. Lavey , Neng-Yang Shih , Vincent S. Madison , Guowei Zhou , Peter Orth , Zhuyan Guo , Michael K.C. Wong , De-Yi Yang , Seong Heon Kim , Bandarpalle B. Shankar , M. Arshad Siddiqui , Kristin E. Rosner , Chaoyang Dai , Janeta Popovici-Muller , Vinay M. Girijavallabhan , Dansu Li , Razia Rizvi , Aneta M. Micula , Robert Feltz
IPC分类号： A61K31/5377 , C07D491/048 , A61K31/4355 , C07D413/14 , A61P1/00 , C07D403/06 , A61K31/4178
CPC分类号： C07D401/14 , C07D403/06 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D473/00 , C07D473/34 , C07D487/04 , C07D491/04 , C07D495/04
摘要： This invention relates to compounds of the Formula (I): or a pharmaceutically acceptable salt, solvate, ester or isomer thereof, which can be useful for the treatment of diseases or conditions mediated by MMPs, ADAMs, TACE, aggrecanase, TNF- or combinations thereof.
摘要翻译：本发明涉及式（I）化合物或其药学上可接受的盐，溶剂化物，酯或异构体，其可用于治疗由MMP，ADAM，TACE，聚集蛋白聚糖酶，TNF-或组合介导的疾病或病症其中。

22. 发明申请

US20070197564A1 Compounds for the treatment of inflammatory disorders 有权
标题翻译：用于治疗炎性疾病的化合物
公开(公告)号：US20070197564A1
公开(公告)日：2007-08-23
申请号：US11653511
申请日：2007-01-16
申请人： Brian Lavey , Joseph Kozlowski , Guowei Zhou , Ling Tong , Wensheng Yu , Michael Wong , Bandarpalle Shankar , Neng-Yang Shih , M. Siddiqui , Kristin Rosner , Chaoyang Dai , Janeta Popovici-Muller , Vinay Girijavallabhan , Dansu Li , Razia Rizvi , Lei Chen , De-Yi Yang , Robert Feltz , Seong-Heon Kim
发明人： Brian Lavey , Joseph Kozlowski , Guowei Zhou , Ling Tong , Wensheng Yu , Michael Wong , Bandarpalle Shankar , Neng-Yang Shih , M. Siddiqui , Kristin Rosner , Chaoyang Dai , Janeta Popovici-Muller , Vinay Girijavallabhan , Dansu Li , Razia Rizvi , Lei Chen , De-Yi Yang , Robert Feltz , Seong-Heon Kim
IPC分类号： A61K31/52 , C07D471/02 , A61K31/4745 , A61K31/513 , A61K31/519 , C07D473/02 , C07D487/02
CPC分类号： C07D403/14 , C07D401/06 , C07D401/14 , C07D403/06 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D473/00
摘要： This invention relates to compounds of the Formula (I): or a pharmaceutically acceptable salt, solvate or isomer thereof, which can be useful for the treatment of diseases or conditions mediated by MMPs, ADAMs, TACE, aggrecanase, TNF-α or combinations thereof.
摘要翻译：本发明涉及式（I）化合物或其药学上可接受的盐，溶剂合物或异构体，其可用于治疗由MMP，ADAM，TACE，聚集蛋白聚糖蛋白酶，TNF-α或其组合介导的疾病或病症。

23. 发明申请

US20060276506A1 Compounds for the treatment of inflammatory disorders 有权
公开(公告)号：US20060276506A1
公开(公告)日：2006-12-07
申请号：US11333663
申请日：2006-01-17
申请人： Wensheng Yu , Ling Tong , Lei Chen , Joseph Kozlowski , Brian Lavey , Neng-Yang Shih , Vincent Madison , Guowei Zhou , Peter Orth , Zhuyan Guo , Michael Wong , De-Yi Yang , Seong Kim , Bandarpalle Shankar , M. Siddiqui , Kristin Rosner , Chaoyang Dai , Umar Mansoor , Janeta Popovici-Muller , Vinay Girijavallabhan , Dansu Li
发明人： Wensheng Yu , Ling Tong , Lei Chen , Joseph Kozlowski , Brian Lavey , Neng-Yang Shih , Vincent Madison , Guowei Zhou , Peter Orth , Zhuyan Guo , Michael Wong , De-Yi Yang , Seong Kim , Bandarpalle Shankar , M. Siddiqui , Kristin Rosner , Chaoyang Dai , Umar Mansoor , Janeta Popovici-Muller , Vinay Girijavallabhan , Dansu Li
IPC分类号： A61K31/4709 , A61K31/4245 , A61K31/4178 , C07D413/14 , C07D403/02
CPC分类号： C07D403/06 , C07D401/14 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D473/00 , C07D473/34 , C07D487/04 , C07D491/04 , C07D495/04
摘要： This invention relates to compounds of the Formula (I): or a pharmaceutically acceptable salt, solvate, ester or isomer thereof, which can be useful for the treatment of diseases or conditions mediated by MMPs, ADAMs, TACE, aggrecanase, TNF- or combinations thereof.

24. 发明授权

US09273040B2 Benzoxazolinone compounds with selective activity in voltage-gated sodium channels 有权
标题翻译：在电压门控钠通道中具有选择性活性的苯并恶唑啉酮化合物
公开(公告)号：US09273040B2
公开(公告)日：2016-03-01
申请号：US14353488
申请日：2012-10-26
申请人： Mark E. Layton , Joseph E. Pero , Hannah Fiji , Michael J. Kelly, III , Pablo de Leon , Michael A. Rossi , Kevin F. Gilbert , Anthony J. Roecker , Zhijian Zhao , Swati I P. Mercer , Scott Wolkenberg , James Mulhearn , Lianyun Zhao , Dansu Li
发明人： Mark E. Layton , Joseph E. Pero , Hannah Fiji , Michael J. Kelly, III , Pablo de Leon , Michael A. Rossi , Kevin F. Gilbert , Anthony J. Roecker , Zhijian Zhao , Swati I P. Mercer , Scott Wolkenberg , James Mulhearn , Lianyun Zhao , Dansu Li
IPC分类号： A61K31/00 , C07D417/12 , C07D417/14 , C07D451/02 , C07D471/04 , C07D491/107 , C07D493/10
CPC分类号： C07D417/12 , C07D417/14 , C07D451/02 , C07D471/04 , C07D491/107 , C07D493/10
摘要： Disclosed are compounds of Formula (A) or a salt thereof, wherein “Het”, Ra, and Rb are defined herein, which have properties for blocking Nav 1.7 ion channels found in peripheral and sympathetic neurons. Also described are pharmaceutical formulations comprising the compounds of Formula (A) or their salts, and methods of treating neuropathic pain disorders using the same.
摘要翻译：公开了式（A）的化合物或其盐，其中“Het”，Ra和Rb在本文中定义，其具有用于阻断在外周和交感神经元中发现的Nav 1.7离子通道的性质。还描述了包含式（A）化合物或其盐的药物制剂，以及使用其制备神经性疼痛障碍的方法。

25. 发明授权

US09242995B2 Isoxazolopyridine orexin receptor antagonists 有权
标题翻译：异氮杂吡啶食欲素受体拮抗剂
公开(公告)号：US09242995B2
公开(公告)日：2016-01-26
申请号：US14354392
申请日：2012-10-19
申请人： Dansu Li , Anthony J. Roecker
发明人： Dansu Li , Anthony J. Roecker
IPC分类号： C07D498/04
CPC分类号： C07D498/04
摘要： The present invention is directed to isoxazolopyndine compounds which are antagonists of orexin receptors. The present invention is also directed to uses of the isoxazolopyndine compounds described herein in the treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The present invention is also directed to pharmaceutical compositions comprising these compounds. The present invention is also directed to uses of these pharmaceutical compositions in the prevention or treatment of such diseases in which orexin receptors are involved.
摘要翻译：本发明涉及作为食欲肽受体拮抗剂的异恶唑嘌呤类化合物。本发明还涉及本文所述的异恶唑嘌呤类化合物在治疗或预防涉及食欲素受体的神经和精神疾病和疾病中的用途。本发明还涉及包含这些化合物的药物组合物。本发明还涉及这些药物组合物在预防或治疗涉及食欲素受体的疾病中的用途。

26. 发明授权

US07879890B2 Compounds for the treatment of inflammatory disorders 有权
标题翻译：用于治疗炎性疾病的化合物
公开(公告)号：US07879890B2
公开(公告)日：2011-02-01
申请号：US12338445
申请日：2008-12-18
申请人： Wensheng Yu , Ling Tong , Lei Chen , Joseph A. Kozlowski , Brian J. Lavey , Neng-Yang Shih , Vincent S. Madison , Guowei Zhou , Peter Orth , Zhuyan Guo , Michael K. C. Wong , De-Yi Yang , Seong Heon Kim , Bandarpalle B. Shankar , M. Arshad Siddiqui , Kristin E. Rosner , Chaoyang Dai , Janeta Popovici-Muller , Vinay M. Girijavallabhan , Dansu Li , Razia Rizvi , Aneta M. Micula , Robert Feltz
发明人： Wensheng Yu , Ling Tong , Lei Chen , Joseph A. Kozlowski , Brian J. Lavey , Neng-Yang Shih , Vincent S. Madison , Guowei Zhou , Peter Orth , Zhuyan Guo , Michael K. C. Wong , De-Yi Yang , Seong Heon Kim , Bandarpalle B. Shankar , M. Arshad Siddiqui , Kristin E. Rosner , Chaoyang Dai , Janeta Popovici-Muller , Vinay M. Girijavallabhan , Dansu Li , Razia Rizvi , Aneta M. Micula , Robert Feltz
IPC分类号： A61K31/416 , A61K31/428
CPC分类号： C07D401/14 , C07D403/06 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D473/00 , C07D473/34 , C07D487/04 , C07D491/04 , C07D495/04
摘要： This invention relates to compounds of the Formula (I): or a pharmaceutically acceptable salt, solvate, ester or isomer thereof, which can be useful for the treatment of diseases or conditions mediated by MMPs, ADAMs, TACE, aggrecanase, TNF- or combinations thereof.
摘要翻译：本发明涉及式（I）化合物或其药学上可接受的盐，溶剂化物，酯或异构体，其可用于治疗由MMP，ADAM，TACE，聚集蛋白聚糖酶，TNF-或组合介导的疾病或病症其中。

27. 发明授权

US07772263B2 Compounds for the treatment of inflammatory disorders 有权
公开(公告)号：US07772263B2
公开(公告)日：2010-08-10
申请号：US12364845
申请日：2009-02-03
申请人： Brian J. Lavey , Joseph A. Kozlowski , Guowei Zhou , Ling Tong , Wensheng Yu , Michael K. C. Wong , Bandarpalle B. Shankar , Neng-Yang Shih , M. Arshad Siddiqui , Kristin E. Rosner , Chaoyang Dai , Janeta Popovici-Muller , Vinay M. Girijavallabhan , Dansu Li , Razia Rizvi , Lei Chen , De-Yi Yang , Robert Feltz , Seong Heon Kim
发明人： Brian J. Lavey , Joseph A. Kozlowski , Guowei Zhou , Ling Tong , Wensheng Yu , Michael K. C. Wong , Bandarpalle B. Shankar , Neng-Yang Shih , M. Arshad Siddiqui , Kristin E. Rosner , Chaoyang Dai , Janeta Popovici-Muller , Vinay M. Girijavallabhan , Dansu Li , Razia Rizvi , Lei Chen , De-Yi Yang , Robert Feltz , Seong Heon Kim
IPC分类号： A61K31/427 , A61K31/4164 , A61K31/4375
CPC分类号： C07D403/14 , C07D401/06 , C07D401/14 , C07D403/06 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D473/00
摘要： This invention relates to compounds of the Formula (I): or a pharmaceutically acceptable salt, solvate or isomer thereof, which can be useful for the treatment of diseases or conditions mediated by MMPs, ADAMs, TACE, aggrecanase, TNF-α or combinations thereof.

28. 发明申请

US20100145048A1 COMPOUNDS FOR THE TREATMENT OF INFLAMMATORY DISORDERS 失效
标题翻译：用于治疗炎症性疾病的化合物
公开(公告)号：US20100145048A1
公开(公告)日：2010-06-10
申请号：US12582341
申请日：2009-10-20
申请人： Zhuyan Guo , Peter Orth , Zhaoning Zhu , Robert D. Mazzola , Tin-Yau Chan , Henry A. Vaccaro , Brian McKittrick , Joseph A. Kozlowski , Brian J. Lavey , Guowei Zhou , Sunil Paliwal , Shing-Chun Wong , Neng-Yang Shih , Pauline C. Ting , Kristin E. Rosner , Gerald W. Shipps, JR. , M. Arshad Siddiqui , David B. Belanger , Chaoyang Dai , Dansu Li , Vinay M. Girijavallabhan , Janeta Popovici-Muller , Wensheng Yu , Lianyun Zhao
发明人： Zhuyan Guo , Peter Orth , Zhaoning Zhu , Robert D. Mazzola , Tin-Yau Chan , Henry A. Vaccaro , Brian McKittrick , Joseph A. Kozlowski , Brian J. Lavey , Guowei Zhou , Sunil Paliwal , Shing-Chun Wong , Neng-Yang Shih , Pauline C. Ting , Kristin E. Rosner , Gerald W. Shipps, JR. , M. Arshad Siddiqui , David B. Belanger , Chaoyang Dai , Dansu Li , Vinay M. Girijavallabhan , Janeta Popovici-Muller , Wensheng Yu , Lianyun Zhao
IPC分类号： C07D405/12 , C07D417/12 , C07D413/14 , C07D409/12
CPC分类号： C07D409/14 , C07C235/06 , C07C235/08 , C07C235/10 , C07C2601/08 , C07D207/20 , C07D207/26 , C07D209/44 , C07D215/14 , C07D217/06 , C07D263/32 , C07D295/185 , C07D307/52 , C07D333/20 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04 , C07D471/10 , C07D487/04 , C07D513/04
摘要： This invention relates to compounds of the Formula (I): or a pharmaceutically acceptable salt, solvate or isomer thereof, which can be useful for the treatment of diseases or conditions mediated by MMPs, ADAMs, TACE, TNF-α or combinations thereof.
摘要翻译：本发明涉及式（I）化合物或其药学上可接受的盐，溶剂合物或异构体，其可用于治疗由MMP，ADAM，TACE，TNF-α或其组合介导的疾病或病症。

29. 发明申请

US20100120838A1 COMPOUNDS FOR THE TREATMENT OF INFLAMMATORY DISORDERS 有权
标题翻译：用于治疗炎症性疾病的化合物
公开(公告)号：US20100120838A1
公开(公告)日：2010-05-13
申请号：US12690633
申请日：2010-01-20
申请人： Brian J. Lavey , Joseph A. Kozlowski , Guowei Zhou , Ling Tong , Wensheng Yu , Michael K. C. Wong , Shankar B. Bandarpalle , Neng-Yang Shih , M. Arshad Siddiqui , Kristin E. Rosner , Chaoyang Dai , Janeta Popovici-Muller , Vinay M. Girijavallabhan , Dansu Li , Aneta M. Micula , Seong Heon Kim , De-Yi Yang , Razia Rizvi
发明人： Brian J. Lavey , Joseph A. Kozlowski , Guowei Zhou , Ling Tong , Wensheng Yu , Michael K. C. Wong , Shankar B. Bandarpalle , Neng-Yang Shih , M. Arshad Siddiqui , Kristin E. Rosner , Chaoyang Dai , Janeta Popovici-Muller , Vinay M. Girijavallabhan , Dansu Li , Aneta M. Micula , Seong Heon Kim , De-Yi Yang , Razia Rizvi
IPC分类号： A61K31/4178 , A61K31/437 , A61K31/4439 , C07D491/048 , C07D471/04 , C07D401/14 , C07D403/06 , A61P3/00 , A61P29/00 , A61P11/00
CPC分类号： C07D403/14 , C07D401/06 , C07D401/14 , C07D403/06 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D473/00
摘要： This invention relates to compounds of the Formula (I): or a pharmaceutically acceptable salt, solvate or isomer thereof, which can be useful for the treatment of diseases or conditions mediated by MMPs, ADAMs, TACE, aggrecanase, TNF-α or combinations thereof.
摘要翻译：本发明涉及式（I）化合物或其药学上可接受的盐，溶剂合物或异构体，其可用于治疗由MMP，ADAM，TACE，聚集蛋白聚糖蛋白酶，TNF-α或其组合介导的疾病或病症。

30. 发明授权

US07683088B2 Compounds for the treatment of inflammatory disorders 有权
标题翻译：用于治疗炎性疾病的化合物
公开(公告)号：US07683088B2
公开(公告)日：2010-03-23
申请号：US11653798
申请日：2007-01-16
申请人： Brian J. Lavey , Joseph A. Kozlowski , Guowei Zhou , Ling Tong , Wensheng Yu , Michael K. C. Wong , Bandarpalle B. Shankar , Neng-Yang Shih , M. Arshad Siddiqui , Kristin E. Rosner , Chaoyang Dai , Janeta Popovici-Muller , Vinay M. Girijavallabhan , Dansu Li , Aneta M. Micula , Seong-Heon Kim , De-Yi Yang , Razia Rizvi
发明人： Brian J. Lavey , Joseph A. Kozlowski , Guowei Zhou , Ling Tong , Wensheng Yu , Michael K. C. Wong , Bandarpalle B. Shankar , Neng-Yang Shih , M. Arshad Siddiqui , Kristin E. Rosner , Chaoyang Dai , Janeta Popovici-Muller , Vinay M. Girijavallabhan , Dansu Li , Aneta M. Micula , Seong-Heon Kim , De-Yi Yang , Razia Rizvi
IPC分类号： A61K31/4166 , A61K31/4035 , A61K31/343 , C07D233/02 , C07D209/46 , C07D307/87
CPC分类号： C07D403/14 , C07D401/06 , C07D401/14 , C07D403/06 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D473/00
摘要： This invention relates to compounds of the Formula (I): or a pharmaceutically acceptable salt, solvate or isomer thereof, which can be useful for the treatment of diseases or conditions mediated by MMPs, ADAMs, TACE, aggrecanase, TNF-α or combinations thereof.
摘要翻译：本发明涉及式（I）化合物或其药学上可接受的盐，溶剂合物或异构体，其可用于治疗由MMP，ADAM，TACE，聚集蛋白聚糖蛋白酶，TNF-α或其组合介导的疾病或病症。

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