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21. 发明授权

US07727549B2 Pharmaceutical compositions for otic use 有权
标题翻译：耳用药物组合物
公开(公告)号：US07727549B2
公开(公告)日：2010-06-01
申请号：US10609975
申请日：2003-06-30
申请人： Bhagwati P. Kabra
发明人： Bhagwati P. Kabra
IPC分类号： A61K9/20
CPC分类号： A61K9/0046 , A61K9/12 , A61K9/1617 , A61K47/14
摘要： Otic compositions are disclosed. The compositions contain an otic drug and a carrier comprising a low molecular weight compound. The compositions do not drain out of the ear after administration.
摘要翻译：公开了耳用组合物。组合物含有耳用药物和包含低分子量化合物的载体。组合物在给药后不会从耳朵中排出。

22. 发明申请

US20090233890A1 LOW VISCOSITY, HIGHLY FLOCCULATED TRIAMCINOLONE ACETONIDE SUSPENSIONS FOR INTRAVITREAL INJECTION 有权
标题翻译：低粘度，高度FLOCCULATED TRIAMCINOLONE ACETONIDE悬吊用于静脉注射
公开(公告)号：US20090233890A1
公开(公告)日：2009-09-17
申请号：US12401168
申请日：2009-03-10
申请人： Bhagwati P. Kabra , Ruma Sarkar
发明人： Bhagwati P. Kabra , Ruma Sarkar
IPC分类号： A61K31/58 , A61P27/02 , A61K31/506
CPC分类号： A61K31/58 , A61K9/0048 , A61K9/10 , A61K47/34 , Y10S514/912 , Y10S514/913
摘要： Triamcinolone acetonide suspension compositions are disclosed. The suspension compositions have a relatively low viscosity and are easy to extrude through a 27- or 30-gauge needle but are highly flocculated and easily redispersed. The compositions are particularly suitable for intravitreal injection.
摘要翻译：公开了曲安奈德悬浮液组合物。悬浮液组合物具有相对较低的粘度并且容易通过27或30号针挤出，但高度絮凝并容易再分散。组合物特别适用于玻璃体内注射。

23. 发明申请

US20080241224A1 Non-Polymeric Lipophilic Pharmaceutical Implant Compositions For Intraocular Use 有权
标题翻译：用于眼内使用的非聚合物亲脂药物植入物组合物
公开(公告)号：US20080241224A1
公开(公告)日：2008-10-02
申请号：US12132003
申请日：2008-06-03
申请人： Bhagwati P. Kabra , Janet D. Howie
发明人： Bhagwati P. Kabra , Janet D. Howie
IPC分类号： A61F2/00 , A61K47/00 , A61K31/56 , A61P27/00
CPC分类号： A61K9/0051 , A61K9/1617 , A61K9/7007 , A61K31/337 , A61K47/14
摘要： Solid or semi-solid intraocular implant compositions are disclosed. The compositions contain a lipophilic compound but lack a polymeric ingredient.
摘要翻译：公开了固体或半固体眼内植入物组合物。组合物含有亲脂性化合物但缺少聚合物成分。

24. 发明授权

US06261547B1 Gelling ophthalmic compositions containing xanthan gum 有权
标题翻译：含有黄原胶的胶凝眼用组合物
公开(公告)号：US06261547B1
公开(公告)日：2001-07-17
申请号：US09448038
申请日：1999-11-23
申请人： Rajan Bawa , Rex E. Hall , Bhagwati P. Kabra , James E. Teague , Gerald D. Cagle , Kerry L. Markwardt , Mandar V. Shah
发明人： Rajan Bawa , Rex E. Hall , Bhagwati P. Kabra , James E. Teague , Gerald D. Cagle , Kerry L. Markwardt , Mandar V. Shah
IPC分类号： A61K3174
CPC分类号： A61K47/36 , A61K9/0048 , A61K31/5377 , Y10S514/912
摘要： Ophthalmic drug delivery vehicles which are administrable as a liquid and which gel upon contact with the eye are disclosed. The vehicles contain xanthan gum and an ophthalmically acceptable anesthetic agent.
摘要翻译：公开了可与液体接触并与眼睛接触凝胶的眼药物递送载体。车辆含有黄原胶和眼科可接受的麻醉剂。

25. 发明授权

US5827835A Thermally-gelling emulsions 失效
标题翻译：热胶凝乳液
公开(公告)号：US5827835A
公开(公告)日：1998-10-27
申请号：US758787
申请日：1996-12-03
申请人： Bhagwati P. Kabra
发明人： Bhagwati P. Kabra
IPC分类号： A61K9/00 , A61K47/38 , A61K31/715 , A01N43/04 , C08B11/00 , C08B11/08
CPC分类号： A61K47/38 , A61K9/0014 , A61K9/0048
摘要： Thermally gelling emulsion compositions which reversibly increase in either loss modulus or storage modulus, or both, upon contact with the eye, skin, mucous membrane or body cavity are disclosed. The emulsion compositions contain one or more nonionic substituted cellulose ethers and do not require a charged surfactant or a pH-sensitive polymer for such increase in loss modulus or storage modulus, or both, upon administration. In one embodiment, the compositions gel upon instillation in the eye.
摘要翻译：公开了在与眼睛，皮肤，粘膜或体腔接触时可逆地增加损失模量或储能模量或两者的热胶凝乳剂组合物。乳液组合物含有一种或多种非离子取代的纤维素醚，并且在给药时不需要带电荷的表面活性剂或pH敏感性聚合物来增加损失模量或储能模量，或两者。在一个实施方案中，组合物滴注在眼睛中凝胶化。

26. 发明授权

US08722735B2 Pharmaceutical compositions having desirable bioavailability 有权
标题翻译：药物组合物具有理想的生物利用度
公开(公告)号：US08722735B2
公开(公告)日：2014-05-13
申请号：US13252255
申请日：2011-10-04
申请人： Bhagwati P. Kabra , Nuria Carreras , Mónica Cuchi , Francisco Javier Galán , Mridvika , Elena González Puig , Nuria Jiménez , Carmen Martinez
发明人： Bhagwati P. Kabra , Nuria Carreras , Mónica Cuchi , Francisco Javier Galán , Mridvika , Elena González Puig , Nuria Jiménez , Carmen Martinez
IPC分类号： A01N37/08 , A61K31/215 , A61K47/44 , A61K31/5575 , A61K9/00
CPC分类号： A61K31/216 , A61K9/0048 , A61K31/215 , A61K31/535 , A61K31/542 , A61K31/5575 , A61K45/06 , A61K47/44 , Y02A50/465 , A61K2300/00
摘要： The present invention is directed to the provision of pharmaceutical compositions. The compositions include a therapeutic agent and a relatively low amount of surfactant for providing higher bioavailability of the therapeutic agent. The compositions are particularly desirable as ophthalmic compositions in which the therapeutic agent is a prostaglandin such as travoprost and the surfactant is a vegetable oil such as castor oil.
摘要翻译：本发明涉及药物组合物的提供。组合物包括治疗剂和相对少量的表面活性剂以提供较高的治疗剂的生物利用度。作为其中治疗剂是前列腺素如曲伏前列素并且表面活性剂是植物油如蓖麻油的眼用组合物，组合物是特别理想的。

27. 发明授权

US08450287B2 Topical ophthalmic compositions containing tobramycin and dexamethasone 有权
标题翻译：含有妥布霉素和地塞米松的局部眼用组合物
公开(公告)号：US08450287B2
公开(公告)日：2013-05-28
申请号：US13311716
申请日：2011-12-06
申请人： Bhagwati P. Kabra
发明人： Bhagwati P. Kabra
IPC分类号： A61K31/70 , A61K31/74
CPC分类号： A61K47/36 , A61K9/0048 , A61K31/70 , A61K31/74 , Y10S514/912 , A61K2300/00
摘要： Ophthalmic pharmaceutical compositions containing tobramycin, dexamethasone and deacetylated xanthan gum are described. The compositions provide longer ocular retention for enhanced ocular bioavailability of tobramycin and dexamethasone. In a preferred embodiment, the compositions also provide for improved suspension of dexamethasone. The concentration of ionizable species in the compositions is controlled so as to prevent precipitation of the xanthan gum as a result of ionic interactions between tobramycin and xanthan gum, while allowing for a restoration of viscosity upon topical application of the compositions to the eye. The use of deacetylated xanthan gum is disclosed, so as to avoid formulation instability caused by pH drift during storage.
摘要翻译：描述含有妥布霉素，地塞米松和脱乙酰化黄原胶的眼药物组合物。组合物提供更长的眼睛保留量以增强妥布霉素和地塞米松的眼部生物利用度。在优选的实施方案中，组合物还提供地塞米松的改善的悬浮液。控制组合物中可离子化物质的浓度，以防止由于妥布霉素和黄原胶之间的离子相互作用而使黄原胶沉淀，同时允许在将组合物局部施用于眼睛时恢复粘度。公开了使用去乙酰化的黄原胶，以避免在储存期间由pH漂移引起的制剂不稳定性。

28. 发明申请

US20120115829A1 Low Viscosity, Highly Flocculated Triamcinolone Acetonide Suspensions for Intravitreal Injection 审中-公开
公开(公告)号：US20120115829A1
公开(公告)日：2012-05-10
申请号：US13352043
申请日：2012-01-17
申请人： Bhagwati P. Kabra , Ruma Sarkar
发明人： Bhagwati P. Kabra , Ruma Sarkar
IPC分类号： A61K31/58 , A61P27/02 , A61K31/496
CPC分类号： A61K31/58 , A61K9/0048 , A61K9/10 , A61K47/34 , Y10S514/912 , Y10S514/913
摘要： Triamcinolone acetonide suspension compositions are disclosed. The suspension compositions have a relatively low viscosity and are easy to extrude through a 27- or 30-gauge needle but are highly flocculated and easily redispersed. The compositions are particularly suitable for intravitreal injection.

29. 发明授权

US08128960B2 Low viscosity, highly flocculated triamcinolone acetonide suspensions for intravitreal injection 有权
标题翻译：低粘度，高度絮凝的曲安奈德悬浮液用于玻璃体内注射
公开(公告)号：US08128960B2
公开(公告)日：2012-03-06
申请号：US12401168
申请日：2009-03-10
申请人： Bhagwati P. Kabra , Ruma Sarkar
发明人： Bhagwati P. Kabra , Ruma Sarkar
IPC分类号： A61K9/14
CPC分类号： A61K31/58 , A61K9/0048 , A61K9/10 , A61K47/34 , Y10S514/912 , Y10S514/913
摘要： Triamcinolone acetonide suspension compositions are disclosed. The suspension compositions have a relatively low viscosity and are easy to extrude through a 27- or 30-gauge needle but are highly flocculated and easily redispersed. The compositions are particularly suitable for intravitreal injection.
摘要翻译：公开了曲安奈德悬浮液组合物。悬浮液组合物具有相对较低的粘度并且容易通过27或30号针挤出，但高度絮凝并容易再分散。组合物特别适用于玻璃体内注射。

30. 发明授权

US08101582B2 Topical ophthalmic compositions containing tobramycin and dexamethasone 有权
标题翻译：含有妥布霉素和地塞米松的局部眼用组合物
公开(公告)号：US08101582B2
公开(公告)日：2012-01-24
申请号：US12841414
申请日：2010-07-22
申请人： Bhagwati P. Kabra
发明人： Bhagwati P. Kabra
IPC分类号： A61K31/70 , A61K31/74
CPC分类号： A61K47/36 , A61K9/0048 , A61K31/70 , A61K31/74 , Y10S514/912 , A61K2300/00
摘要： Ophthalmic pharmaceutical compositions containing tobramycin, dexamethasone and deacetylated xanthan gum are described. The compositions provide longer ocular retention for enhanced ocular bioavailability of tobramycin and dexamethasone. In a preferred embodiment, the compositions also provide for improved suspension of dexamethasone. The concentration of ionizable species in the compositions is controlled so as to prevent precipitation of the xanthan gum as a result of ionic interactions between tobramycin and xanthan gum, while allowing for a restoration of viscosity upon topical application of the compositions to the eye. The use of deacetylated xanthan gum is disclosed, so as to avoid formulation instability caused by pH drift during storage.
摘要翻译：描述含有妥布霉素，地塞米松和脱乙酰化黄原胶的眼药物组合物。组合物提供更长的眼睛保留量以增强妥布霉素和地塞米松的眼部生物利用度。在优选的实施方案中，组合物还提供地塞米松的改善的悬浮液。控制组合物中可离子化物质的浓度，以防止由于妥布霉素和黄原胶之间的离子相互作用而使黄原胶沉淀，同时允许在将组合物局部施用于眼睛时恢复粘度。公开了使用去乙酰化的黄原胶，以避免在储存期间由pH漂移引起的制剂不稳定性。

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