专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

21. 发明授权

US07842819B2 Derivatives for modulation of ion channels 有权
标题翻译：用于离子通道调制的衍生物
公开(公告)号：US07842819B2
公开(公告)日：2010-11-30
申请号：US11584961
申请日：2006-10-23
申请人： Esther Martinborough , Andreas P. Termin , Timothy D. Neubert , Nicole Zimmermann , Corey Don Gutierrez
发明人： Esther Martinborough , Andreas P. Termin , Timothy D. Neubert , Nicole Zimmermann , Corey Don Gutierrez
IPC分类号： C07D209/02 , A61K31/40
CPC分类号： C07D401/08 , C07D207/10 , C07D207/12 , C07D211/54 , C07D401/06 , C07D401/12 , C07D403/06 , C07D403/08
摘要： Sulfonamide derivatives act as ion channel antagonists. The compositions are useful for treating or relieving pain-related conditions.
摘要翻译：磺酰胺衍生物作为离子通道拮抗剂。该组合物可用于治疗或缓解疼痛相关病症。

22. 发明申请

US20100160316A1 QUINAZOLINES USEFUL AS MODULATORS OF ION CHANNELS 失效
公开(公告)号：US20100160316A1
公开(公告)日：2010-06-24
申请号：US12714871
申请日：2010-03-01
申请人： Jesus E. Gonzalez, III , Dean M. Wilson , Andreas P. Termin , Peter D. J. Grootenhuis , Yulian Zhang , Benjamin J. Petzoldt , Lev Tyler Dewey Fanning , Timothy D. Neubert , Roger D. Tung , Esther Martinborough , Nicole Zimmerman
发明人： Jesus E. Gonzalez, III , Dean M. Wilson , Andreas P. Termin , Peter D. J. Grootenhuis , Yulian Zhang , Benjamin J. Petzoldt , Lev Tyler Dewey Fanning , Timothy D. Neubert , Roger D. Tung , Esther Martinborough , Nicole Zimmerman
IPC分类号： A61K31/5377 , C07D239/86 , A61K31/517 , C07D239/88 , C07D413/10 , A61K31/496 , A61P19/10 , A61P19/02 , A61P17/02 , A61P21/00 , A61P13/02 , A61P11/00 , C07D403/04
CPC分类号： C07D239/91 , C07D239/94 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D409/04 , C07D409/12 , C07D413/12 , C07D417/12 , C07D471/04 , C07D487/04
摘要： The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels and calcium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.

23. 发明申请

US20100087479A1 Compositions Useful as Inhibitors of Voltage-Gated Sodium Channels 有权
标题翻译：用作电压门控钠通道抑制剂的组合物
公开(公告)号：US20100087479A1
公开(公告)日：2010-04-08
申请号：US12556845
申请日：2009-09-10
申请人： Jesus E. Gonzalez, III , Andreas P. Termin , Esther Martinborough , Nicole Zimmerman
发明人： Jesus E. Gonzalez, III , Andreas P. Termin , Esther Martinborough , Nicole Zimmerman
IPC分类号： A61K31/4725 , C12N5/02 , A61K31/427 , A61K31/433 , A61K31/4709
CPC分类号： C04B35/632 , C07C311/46 , C07C311/51 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07D209/80 , C07D209/92 , C07D213/76 , C07D231/38 , C07D231/42 , C07D237/20 , C07D237/22 , C07D239/42 , C07D239/47 , C07D239/52 , C07D239/545 , C07D239/69 , C07D241/22 , C07D261/16 , C07D263/50 , C07D277/52 , C07D277/82 , C07D285/125 , C07D285/135 , C07D295/26 , C07D401/12 , C07D403/12 , C07D405/12 , C07D405/14 , C07D407/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D417/14 , C07D513/04
摘要： The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
摘要翻译：本发明涉及可用作电压门控钠通道抑制剂的化合物。本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种疾病的方法。

24. 发明授权

US5514594A Method for measurement of no contents 失效
标题翻译：没有内容的测量方法
公开(公告)号：US5514594A
公开(公告)日：1996-05-07
申请号：US262627
申请日：1994-06-20
申请人： Andreas P. Termin
发明人： Andreas P. Termin
IPC分类号： G01N31/00 , G01N33/00
CPC分类号： G01N31/005 , G01N33/0037 , Y10T436/177692 , Y10T436/178459
摘要： The present invention relates to a method and a device for the measurement of NO contents in liquids using an inert carder gas. The device consists of a micro reaction part FIG. 1 which is divided into an inert gas inlet nozzle 1, the microreaction vessel 2 with frit 3, at least one inlet nozzle for the injection of the liquid to be analyzed 4, as well as a cooled outlet nozzle for the inert gas loaded with NO 5, and a detector 6, with which the NO content of the inset liquid is measured and evaluated, and where the NO.sub.2 - ions present in the solution are reduced back to NO using a reaction mixture consisting out of 1,1'-dimethylferrocene in acetonitrile in an acidic medium, preferably perchloric acid.
摘要翻译：本发明涉及使用惰性卡尔斯气体测量液体中的NO含量的方法和装置。该装置由微反应部分构成。 1，其分为惰性气体入口喷嘴1，具有玻璃料3的微反应容器2，用于注入待分析液体4的至少一个入口喷嘴，以及用于负载NO的惰性气体的冷却出口喷嘴 5和检测器6，用于测量和评估插入液体的NO含量，并且使用由1,1'-二甲基二茂铁组成的反应混合物将溶液中存在的NO 2 - 离子还原为NO 乙腈在酸性介质中，优选高氯酸。

25. 发明授权

US08883766B2 Ion channel modulators and methods of use 有权
标题翻译：离子通道调节剂和使用方法
公开(公告)号：US08883766B2
公开(公告)日：2014-11-11
申请号：US13457855
申请日：2012-04-27
申请人： Esther Martinborough , Tim Neubert , Tara Whitney , Danielle Lehsten , Tara Hampton , Nicole Zimmermann , Andreas P. Termin
发明人： Esther Martinborough , Tim Neubert , Tara Whitney , Danielle Lehsten , Tara Hampton , Nicole Zimmermann , Andreas P. Termin
IPC分类号： A61K31/63 , A61K31/655 , C07D209/42 , C07D215/06 , C07D405/12 , C07D209/08 , C07D401/06 , C07D401/04 , C07D215/233 , C07D317/60 , C07C311/51 , C07C311/53
CPC分类号： C07D209/08 , C07C311/51 , C07C311/53 , C07C2602/08 , C07D209/42 , C07D215/06 , C07D215/233 , C07D317/60 , C07D401/04 , C07D401/06 , C07D405/12
摘要： In general, the invention relates to compounds useful as ion channel modulators. It has now been found that compounds of this invention, and pharmaceutically acceptable compositions thereof, are useful as inhibitors of voltage-gated sodium channels.
摘要翻译：通常，本发明涉及可用作离子通道调节剂的化合物。现在已经发现，本发明的化合物及其药学上可接受的组合物可用作电压门控钠通道的抑制剂。

26. 发明授权

US08357702B2 Bicyclic derivatives as modulators of voltage gated ion channels 有权
标题翻译：双环衍生物作为电压门控离子通道的调制器
公开(公告)号：US08357702B2
公开(公告)日：2013-01-22
申请号：US13537903
申请日：2012-06-29
申请人： Timothy Donald Neubert , Aarti Sameer Kawatkar , Esther Ann Martinborough , Andreas P. Termin , Nicole Hilgraf
发明人： Timothy Donald Neubert , Aarti Sameer Kawatkar , Esther Ann Martinborough , Andreas P. Termin , Nicole Hilgraf
IPC分类号： C07D417/12 , C07D215/36 , C07D215/38 , A61K31/4709
CPC分类号： C07D417/12 , C07D277/52
摘要： Bicyclic derivatives useful as ion channel antagonists are disclosed herein. The compositions thereof are useful for treating or relieving pain-related conditions.
摘要翻译：本文公开了用作离子通道拮抗剂的双环衍生物。其组合物可用于治疗或缓解疼痛相关病症。

27. 发明申请

US20120283243A1 Spiroindoline Modulators of Muscarinic Receptors 失效
标题翻译：毒蕈碱受体的螺二氢吲哚调节剂
公开(公告)号：US20120283243A1
公开(公告)日：2012-11-08
申请号：US13546185
申请日：2012-07-11
申请人： Lewis R. Makings , Miguel Garcia-Guzman Blanco , Dennis J. Hurley , Ioana Drutu , Gabriel Raffai , Daniele M. Bergeron , Akiko Nakatani , Andreas P. Termin , Alina Silina
发明人： Lewis R. Makings , Miguel Garcia-Guzman Blanco , Dennis J. Hurley , Ioana Drutu , Gabriel Raffai , Daniele M. Bergeron , Akiko Nakatani , Andreas P. Termin , Alina Silina
IPC分类号： A61K31/438 , C07D401/04 , C07D491/107 , A61K31/439 , A61K31/55 , A61P27/06 , A61P3/10 , A61P25/28 , A61P25/18 , A61P25/24 , A61P25/16 , C07D221/20 , A61P25/00
CPC分类号： C07D401/06 , A61K31/435 , A61K31/438 , A61K31/4747 , A61K31/55 , C07D221/20 , C07D223/32 , C07D405/04 , C07D405/06 , C07D405/12 , C07D451/02 , C07D451/04 , C07D471/10 , C07D491/10
摘要： The present invention relates to modulators of muscarinic receptors. The present invention also provides compositions comprising such modulators, and methods therewith for treating muscarinic receptor mediated diseases.
摘要翻译：本发明涉及毒蕈碱受体的调节剂。本发明还提供包含这种调节剂的组合物，及其用于治疗毒蕈碱受体介导的疾病的方法。

28. 发明申请

US20120238578A1 COMPOSITIONS USEFUL AS INHIBITORS OF VOLTAGE-GATED SODIUM CHANNELS 有权
标题翻译：组合物作为电压门控通道的抑制剂有用
公开(公告)号：US20120238578A1
公开(公告)日：2012-09-20
申请号：US13478538
申请日：2012-05-23
申请人： Jesus E. Gonzalez, III , Andreas P. Termin , Esther Martinborough , Nicole Zimmerman
发明人： Jesus E. Gonzalez, III , Andreas P. Termin , Esther Martinborough , Nicole Zimmerman
IPC分类号： A61K31/427 , A61K31/428 , A61K31/4245 , A61K31/517 , A61K31/53 , A61K31/498 , A61K31/4725 , A61P25/00 , A61P19/02 , A61P25/06 , A61P25/08 , A61P25/28 , A61P25/18 , A61P25/22 , A61P25/24 , A61P9/06 , A61P25/14 , A61P1/00 , C12N5/071 , A61K31/4709
CPC分类号： C07D417/14 , C04B35/632 , C07C311/46 , C07C311/51 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07D209/80 , C07D209/92 , C07D213/76 , C07D231/38 , C07D231/42 , C07D237/20 , C07D237/22 , C07D239/42 , C07D239/47 , C07D239/52 , C07D239/545 , C07D239/69 , C07D241/22 , C07D261/16 , C07D263/50 , C07D277/52 , C07D277/82 , C07D285/125 , C07D285/135 , C07D295/26 , C07D401/12 , C07D403/12 , C07D405/12 , C07D405/14 , C07D407/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D513/04
摘要： The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
摘要翻译：本发明涉及可用作电压门控钠通道抑制剂的化合物。本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种疾病的方法。

29. 发明授权

US08268818B2 Inhibitors of C-MET and uses thereof 失效
标题翻译： C-MET抑制剂及其用途
公开(公告)号：US08268818B2
公开(公告)日：2012-09-18
申请号：US12438995
申请日：2007-09-04
申请人： Tiansheng Wang , Jeremy Green , Brian Ledford , François Maltais , Andreas P. Termin , Mark Cornebise , Jonathan Parsons , Adam Tanner , James Westcott
发明人： Tiansheng Wang , Jeremy Green , Brian Ledford , François Maltais , Andreas P. Termin , Mark Cornebise , Jonathan Parsons , Adam Tanner , James Westcott
IPC分类号： A61K31/427 , A61K31/454 , A61K31/495 , A61K31/497 , C07D413/14 , C07D405/14 , C07D277/44
CPC分类号： C07D417/04
摘要： The present invention relates to compounds useful as inhibitors of PI3K, particularly of PI3Kγ. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
摘要翻译：本发明涉及可用作PI3K抑制剂，特别是PI3Kγ的化合物。本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。

30. 发明申请

US20120178713A1 PHENYL SULPHONAMIDES AS MODULATORS OF ION CHANNELS 有权
标题翻译：作为离子通道调节剂的苯乙烯磺酸盐
公开(公告)号：US20120178713A1
公开(公告)日：2012-07-12
申请号：US13419936
申请日：2012-03-14
申请人： Esther Martinborough , Lev T.D. Fanning , Urvi Sheth , Dean Wilson , Andreas P. Termin , Timothy D. Neubert , Nicole Hilgraf , Tara Leanne Hampton , Tara Whitney , Aarti Sameer Kawatkar , Danielle Lehsten , Dean Stamos , Jinglan Zhou , Vijayalaksmi Arumugam , Corey Anderson
发明人： Esther Martinborough , Lev T.D. Fanning , Urvi Sheth , Dean Wilson , Andreas P. Termin , Timothy D. Neubert , Nicole Hilgraf , Tara Leanne Hampton , Tara Whitney , Aarti Sameer Kawatkar , Danielle Lehsten , Dean Stamos , Jinglan Zhou , Vijayalaksmi Arumugam , Corey Anderson
IPC分类号： A61K31/496 , C07D403/12 , A61K31/506 , C07D417/14 , A61K31/501 , A61K31/454 , C07D471/04 , A61K31/437 , A61K31/427 , C07F7/02 , A61K31/695 , C07D413/14 , A61K31/5377 , A61P35/00 , A61P19/02 , A61P25/06 , A61P25/08 , A61P25/28 , A61P25/22 , A61P25/24 , A61P1/00 , A61P13/02 , C07D417/12
CPC分类号： C07D417/12 , C07D239/42 , C07D401/12 , C07D405/12 , C07D417/14 , C07D471/10 , C07D491/10
摘要： The present invention relates to phenyl sulfonamides useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders, including for example the treatment of pain.
摘要翻译：本发明涉及可用作离子通道抑制剂的苯基磺酰胺。本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种疾病（包括例如治疗疼痛）的方法。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式