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21. 发明授权

US11478422B2 Film formulations containing dexmedetomidine and methods of producing them 有权
公开(公告)号：US11478422B2
公开(公告)日：2022-10-25
申请号：US16931630
申请日：2020-07-17
申请人： BioXcel Therapeutics, Inc. , ARx, LLC
发明人： Vasukumar Kakumanu , David Christian Hanley , Frank Yocca , Chetan Dalpatbhai Lathia , Scott David Barnhart
IPC分类号： A61K9/00 , A61K47/38 , A61K9/70 , A61K31/4174 , A61P25/22 , A61K47/34
摘要： Disclosed herein is a self-supporting, dissolvable, film containing dexmedetomidine or a pharmaceutically acceptable salt thereof. The film is administered orally to treat various conditions, particularly agitation, by transmucosal delivery of the active agent.

22. 发明申请

US20200000717A1 FILM FORMULATIONS CONTAINING DEXMEDETOMIDINE AND METHODS OF PRODUCING THEM 审中-公开
公开(公告)号：US20200000717A1
公开(公告)日：2020-01-02
申请号：US16453679
申请日：2019-06-26
申请人： BioXcel Therapeutics, Inc. , ARx, LLC
发明人： Vasukumar KAKUMANU , David Christian HANLEY , Frank YOCCA , Chetan Dalpatbhai LATHIA , Scott David BARNHART
IPC分类号： A61K9/00 , A61K31/4174 , A61K9/70 , A61K47/38 , A61K47/34 , A61P25/22
摘要： Disclosed herein is a self-supporting, dissolvable, film containing dexmedetomidine or a pharmaceutically acceptable salt thereof. The film is administered orally to treat various conditions, particularly agitation, by transmucosal delivery of the active agent.

23. 发明申请

US20170087084A1 PRODUCTION OF UNIT DOSE CONSTRUCTS 审中-公开
公开(公告)号：US20170087084A1
公开(公告)日：2017-03-30
申请号：US15371951
申请日：2016-12-07
申请人： ARx, LLC
发明人： Matthew K. MUSHO , John H. LIND , Scott D. BARNHART
IPC分类号： A61K9/00 , A61K47/38 , A61K47/34
CPC分类号： A61K9/006 , A61K9/7007 , A61K47/34 , A61K47/38
摘要： Dissolvable unit dose constructs and their method of manufacture are disclosed in which the unit dose constructs are formed of a composition including a polymer matrix that includes a water soluble polymer, active ingredient, and a liquid carrier. The composition is deposited directly, such as by stenciling, to form individual unit doses without the need to cut and convert long, continuous rolls of film.

24. 发明授权

US11559484B2 Film formulations containing dexmedetomidine and methods of producing them 有权
公开(公告)号：US11559484B2
公开(公告)日：2023-01-24
申请号：US17103013
申请日：2020-11-24
申请人： BioXcel Therapeutics, Inc. , ARx, LLC
发明人： Vasukumar Kakumanu , David Christian Hanley , Frank Yocca , Chetan Dalpatbhai Lathia , Scott David Barnhart
IPC分类号： A61K9/00 , A61K47/38 , A61K31/4174 , A61P25/22 , A61K47/34 , A61K9/70
摘要： Disclosed herein is a self-supporting, dissolvable, film containing dexmedetomidine or a pharmaceutically acceptable salt thereof. The film is administered orally to treat various conditions, particularly agitation, by transmucosal delivery of the active agent.

25. 发明授权

US11497711B2 Film formulations containing dexmedetomidine and methods of producing them 有权
公开(公告)号：US11497711B2
公开(公告)日：2022-11-15
申请号：US17560392
申请日：2021-12-23
申请人： BioXcel Therapeutics, Inc. , ARx, LLC
发明人： Vasukumar Kakumanu , David Christian Hanley , Frank Yocca , Chetan Dalpatbhai Lathia , Scott David Barnhart
IPC分类号： A61P25/22 , A61K47/38 , A61K9/70 , A61K9/00 , A61K31/4174 , A61K47/34
摘要： Disclosed herein is a self-supporting, dissolvable, film containing dexmedetomidine or a pharmaceutically acceptable salt thereof. The film is administered orally to treat various conditions, particularly agitation, by transmucosal delivery of the active agent.

26. 发明申请

US20210077388A1 FILM FORMULATIONS CONTAINING DEXMEDETOMIDINE AND METHODS OF PRODUCING THEM 有权
公开(公告)号：US20210077388A1
公开(公告)日：2021-03-18
申请号：US17103013
申请日：2020-11-24
申请人： BioXcel Therapeutics, Inc. , ARx, LLC
发明人： Vasukumar Kakumanu , David Christian Hanley , Frank Yocca , Chetan Dalpatbhai Lathia , Scott David Barnhart
IPC分类号： A61K9/00 , A61K31/4174 , A61P25/22 , A61K47/38 , A61K47/34 , A61K9/70
摘要： Disclosed herein is a self-supporting, dissolvable, film containing dexmedetomidine or a pharmaceutically acceptable salt thereof. The film is administered orally to treat various conditions, particularly agitation, by transmucosal delivery of the active agent.

27. 发明申请

US20200000708A1 DISPENSING METHOD FOR PRODUCING DISSOLVABLE UNIT DOSE FILM CONSTRUCTS 审中-公开
公开(公告)号：US20200000708A1
公开(公告)日：2020-01-02
申请号：US16453432
申请日：2019-06-26
申请人： ARx, LLC
发明人： Scott D. BARNHART , Eric LAKATOSH , William C. BAER , Abraham ANONUEVO
IPC分类号： A61K9/00
摘要： Dissolvable unit dose film constructs are made by providing a muco-adhesive composition including a muco-adhesive polymer matrix in which the muco-adhesive polymer matrix has a water-soluble polymer, water-dispersible polymer, water-swellable polymer, or combinations thereof and a liquid carrier. The method further includes drying the muco-adhesive composition to remove at least a portion of the liquid carrier, forming a muco-adhesive film substrate, forming a composition for an active layer, the composition including a polymer matrix in which the polymer matrix for the active layer composition includes a water-soluble polymer, water-dispersible polymer, water-swellable polymer, or combinations thereof, an active ingredient and a liquid carrier. The method further includes depositing the composition for the active layer onto the muco-adhesive substrate as a plurality of individual volumes and removing the liquid carrier from the plurality of deposited individual volumes to form a plurality of dissolvable film active layers on the muco-adhesive substrate.

28. 发明申请

US20170246108A1 PRODUCTION OF UNIT DOSE CONSTRUCTS 审中-公开
公开(公告)号：US20170246108A1
公开(公告)日：2017-08-31
申请号：US15597498
申请日：2017-05-17
申请人： ARx, LLC
发明人： Matthew K. Musho , John H. Lind , Scott D. Barnhart
IPC分类号： A61K9/00 , A61K47/38 , A61K47/34
CPC分类号： A61K9/006 , A61K9/7007 , A61K47/34 , A61K47/38
摘要： Dissolvable unit dose constructs and their method of manufacture are disclosed in which the unit dose construct is formed by providing a first composition including a water soluble polymer and a liquid carrier, depositing the first composition onto a substrate, providing a second composition including a water soluble polymer and a liquid carrier, applying the second composition at a discrete location overlying the first composition by microdeposition; and removing at least a portion of the liquid carrier from the first composition to form the unit dose construct.

29. 发明授权

US09662301B2 Production of unit dose constructs 有权
公开(公告)号：US09662301B2
公开(公告)日：2017-05-30
申请号：US15371915
申请日：2016-12-07
申请人： ARx, LLC
发明人： Matthew K. Musho , John H. Lind , Scott D. Barnhart
IPC分类号： A61K9/00 , A61K9/70
CPC分类号： A61K9/006 , A61K9/7007 , A61K47/34 , A61K47/38
摘要： Dissolvable unit dose constructs and their method of manufacture are disclosed in which the unit dose constructs are formed of a composition including a polymer matrix that includes a water soluble polymer, active ingredient, and a liquid carrier. The composition is deposited directly, such as by stenciling, to form individual unit doses without the need to cut and convert long, continuous rolls of film.

30. 发明申请

US20160175296A1 Method of producing uniform buprenorphine-containing formulations 审中-公开
标题翻译：制备均匀含丁丙诺啡的制剂的方法
公开(公告)号：US20160175296A1
公开(公告)日：2016-06-23
申请号：US14757886
申请日：2015-12-23
申请人： ARx, LLC
发明人： William Curtis Baer, II , Michael Joseph Passariello
IPC分类号： A61K31/485 , A61K9/70
CPC分类号： A61K31/485 , A61K9/0056 , A61K9/006 , A61K9/08 , A61K9/7015 , A61K31/00 , A61K47/26
摘要： A method of forming a liquid formulation includes preparing a mixture and adding a second component to the mixture to form the liquid formulation. The mixture includes water, a film-forming polymer, a buffer, and a first component. The first component is an active ingredient including buprenorphine or a sweetener. The second component is the active ingredient comprising buprenorphine or the sweetener. Adding the second component is the last step in creating the liquid formulation. If the first component is the active ingredient, the second component is the sweetener. If the first component is the sweetener, the second component is the active ingredient. A method of forming a water-disintegrable film includes casting a formulation film from the liquid formulation and drying the formulation film to form the water-disintegrable film. A film formulation and a water-disintegrable film are also disclosed.
摘要翻译：形成液体制剂的方法包括制备混合物并向混合物中加入第二组分以形成液体制剂。混合物包括水，成膜聚合物，缓冲剂和第一组分。第一组分是包括丁丙诺啡或甜味剂的活性成分。第二组分是包含丁丙诺啡或甜味剂的活性成分。添加第二个组分是创建液体制剂的最后一步。如果第一组分是活性成分，则第二组分是甜味剂。如果第一组分是甜味剂，则第二组分是活性成分。形成水崩解膜的方法包括从液体制剂中浇铸制剂膜并干燥制剂膜以形成水崩解膜。还公开了薄膜配方和水解性薄膜。

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