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21. 发明公开

US20240226448A9 MICRO-VOLUME INJECTORS WITH DOSE GUIDANCE AND METHODS FOR USE 审中-公开
公开(公告)号：US20240226448A9
公开(公告)日：2024-07-11
申请号：US18239055
申请日：2023-08-28
申请人： ALTAVIZ, LLC
发明人： John C. Huculak , Jack R. Auld , Hien Nguyen , Tammo Heeren , Matthew McCawley , Eric Anderfaas , John C. Dunne, JR.
IPC分类号： A61M5/315 , A61F9/00 , A61M5/24 , A61M5/28
CPC分类号： A61M5/31568 , A61F9/0008 , A61M5/24 , A61M5/281 , A61M5/3157 , A61M5/31581 , A61M2205/3306 , A61M2205/3317 , A61M2205/3368 , A61M2205/3584 , A61M2205/502 , A61M2205/52 , A61M2205/581 , A61M2205/584 , A61M2205/587
摘要： Injector devices and methods for using them to deliver medicament into a patient's body, e.g., sub-retinally within an eye, are provided. The injector includes a cartridge including a piston slidably disposed within an interior for delivering medicament within the interior through an outlet, and a driver including a plunger coupled to the piston, a source of pressurized fluid, and an actuator member for opening a flow path at least partially between the source and the plunger to advance the plunger and piston to deliver medicament from the interior. One or more sensors are operatively coupled to the plunger to measure displacement of the plunger, a processor is coupled to the sensor(s) for analyzing sensor signals to measure volume of medicament delivered from the interior, and an output device, e.g., one or more LEDs or speakers, provide outputs related to the volume of medicament delivered.

22. 发明授权

US11738154B2 Micro-volume injectors with dose guidance and methods for use 有权
公开(公告)号：US11738154B2
公开(公告)日：2023-08-29
申请号：US17019133
申请日：2020-09-11
申请人： ALTAVIZ, LLC
发明人： John C. Huculak , Jack R. Auld , Hien Nguyen , Tammo Heeren , Matthew McCawley , Eric Anderfaas , John C. Dunne, Jr.
IPC分类号： A61M5/315 , A61M5/24 , A61M5/28 , A61F9/00
CPC分类号： A61M5/31568 , A61F9/0008 , A61M5/24 , A61M5/281 , A61M5/3157 , A61M5/31581 , A61M2205/3306 , A61M2205/3317 , A61M2205/3368 , A61M2205/3584 , A61M2205/502 , A61M2205/52 , A61M2205/581 , A61M2205/584 , A61M2205/587
摘要： Injector devices and methods for using them to deliver medicament into a patient's body, e.g., sub-retinally within an eye, are provided. The injector includes a cartridge including a piston slidably disposed within an interior for delivering medicament within the interior through an outlet, and a driver including a plunger coupled to the piston, a source of pressurized fluid, and an actuator member for opening a flow path at least partially between the source and the plunger to advance the plunger and piston to deliver medicament from the interior. One or more sensors are operatively coupled to the plunger to measure displacement of the plunger, a processor is coupled to the sensor(s) for analyzing sensor signals to measure volume of medicament delivered from the interior, and an output device, e.g., one or more LEDs or speakers, provide outputs related to the volume of medicament delivered.

23. 发明授权

US10912883B2 Gas-powered fluid injection system 有权
公开(公告)号：US10912883B2
公开(公告)日：2021-02-09
申请号：US16180001
申请日：2018-11-04
申请人： ALTAVIZ, LLC
发明人： Matthew McCawley , Andrew Schieber , Matthew Flowers , Jack R. Auld , Marcus Souza
IPC分类号： A61M37/00 , A61M5/155 , A61M5/20 , A61M5/48 , A61M5/315 , A61M5/24 , A61M5/14
摘要： Gas-powered fluid injection systems and methods are disclosed, e.g., for delivering fluids into a patient's body. An injection device comprises a driver housing which forms and/or encloses a gas pressure source, an actuation piston driven by the gas pressure source and a hydraulic fluid pressurized by movement of the actuation piston. The hydraulic fluid flows through an adjustable valve into a plunger lumen which pushes a plunger of a fluid dispensing device, such as a syringe, to dispense an injection fluid, such as a medicament. The injection device has a movable plunger sleeve which receives the plunger of the fluid dispensing device. The plunger sleeve is moved during the activation and de-activation of the injection device such that it relieves residual pressure in the fluid dispensing device thereby preventing the fluid dispensing device from continuing to dispense injection fluid after the injection device has been de-actuated.

24. 发明申请

US20190175825A1 GAS-POWERED FLUID INJECTION SYSTEM 审中-公开
公开(公告)号：US20190175825A1
公开(公告)日：2019-06-13
申请号：US16180001
申请日：2018-11-04
申请人： ALTAVIZ, LLC
发明人： Matthew McCawley , Andrew Scheiber , Matthew Flowers , Jack R. Auld , Marcus Souza
IPC分类号： A61M5/155 , A61M5/315
摘要： Gas-powered fluid injection systems and methods are disclosed, e.g., for delivering fluids into a patient's body. An injection device comprises a driver housing which forms and/or encloses a gas pressure source, an actuation piston driven by the gas pressure source and a hydraulic fluid pressurized by movement of the actuation piston. The hydraulic fluid flows through an adjustable valve into a plunger lumen which pushes a plunger of a fluid dispensing device, such as a syringe, to dispense an injection fluid, such as a medicament. The injection device has a movable plunger sleeve which receives the plunger of the fluid dispensing device. The plunger sleeve is moved during the activation and de-activation of the injection device such that it relieves residual pressure in the fluid dispensing device thereby preventing the fluid dispensing device from continuing to dispense injection fluid after the injection device has been de-actuated.

25. 发明申请

US20170325995A1 INTRAOCULAR GAS INJECTOR 审中-公开
公开(公告)号：US20170325995A1
公开(公告)日：2017-11-16
申请号：US15640141
申请日：2017-06-30
申请人： Altaviz, LLC
发明人： Jack R. Auld , John C. Huculak , Christopher L. McCollam
IPC分类号： A61F9/007 , A61M5/31 , A61M5/315
CPC分类号： A61F9/007 , A61F9/00727 , A61M5/3145 , A61M5/31553 , A61M5/3156 , A61M5/3158 , A61M5/31596 , A61M2005/3128 , A61M2202/02 , A61M2210/0612
摘要： A gas mixture apparatus includes a measurement control system, an activation system, a pressurized chamber with one or more gases, and a mixing chamber. The apparatus can also include additional pressure regulation control systems. The gas mixture apparatus can be used to introduce and automatically perform the steps to achieve a desired concentration of the one or more gases contained in the pressurized chamber. The gas mixture apparatus can include the pressurized chamber within the apparatus itself such that no external devices are necessary for introducing the one or more gases into the mixing chamber.

26. 发明授权

US08998983B2 Intraocular lens inserters 有权
标题翻译：人工晶体插入器
公开(公告)号：US08998983B2
公开(公告)日：2015-04-07
申请号：US14291743
申请日：2014-05-30
申请人： Altaviz, LLC
发明人： Jack R. Auld
IPC分类号： A61F2/16
CPC分类号： A61F2/167 , A61F2/1662 , A61F2/1678 , A61F9/007
摘要： An intraocular lens inserter can include an energy storage portion, an actuator portion, and a lens support portion. The energy storage portion can include a compressible energy storage device, such as a compressible fluid, springs, and other devices. The inserter can include an actuator portion operating with a substantially incompressible fluid, such as liquids or other noncompressible fluids. The actuator can be configured to provide an operator with control over the release of energy from the energy storage portion so as to move a plunger for the discharge of a lens from an intraocular lens cartridge.
摘要翻译：眼内透镜插入器可以包括能量存储部分，致动器部分和透镜支撑部分。能量存储部分可以包括可压缩能量存储装置，例如可压缩流体，弹簧和其它装置。插入器可以包括用基本上不可压缩的流体操作的致动器部分，例如液体或其它不可压缩的流体。致动器可以被配置为向操作者提供对来自能量存储部分的能量释放的控制，以便移动用于从眼内透镜盒排出镜头的柱塞。

27. 发明申请

US20130345619A1 INTRAOCULAR GAS INJECTOR 有权
公开(公告)号：US20130345619A1
公开(公告)日：2013-12-26
申请号：US13916536
申请日：2013-06-12
申请人： Altaviz, LLC
发明人： Jack R. Auld , John C. Huculak , Christopher L. McCollam
IPC分类号： A61F9/007
CPC分类号： A61F9/007 , A61F9/00727 , A61M5/3145 , A61M5/31596 , A61M2005/3128 , A61M2202/02 , A61M2210/0612
摘要： A gas mixture apparatus includes a measurement control system, an activation system, a pressurized chamber with one or more gases, and a mixing chamber. The apparatus can also include additional pressure regulation control systems. The gas mixture apparatus can be used to introduce and automatically perform the steps to achieve a desired concentration of the one or more gases contained in the pressurized chamber. The gas mixture apparatus can include the pressurized chamber within the apparatus itself such that no external devices are necessary for introducing the one or more gases into the mixing chamber.

28. 发明公开

US20240131269A1 MICRO-VOLUME INJECTORS WITH DOSE GUIDANCE AND METHODS FOR USE 审中-公开
公开(公告)号：US20240131269A1
公开(公告)日：2024-04-25
申请号：US18239055
申请日：2023-08-27
申请人： ALTAVIZ, LLC
发明人： John C. Huculak , Jack R. Auld , Hien Nguyen , Tammo Heeren , Matthew McCawley , Eric Anderfaas , John C. Dunne, JR.
IPC分类号： A61M5/315 , A61F9/00 , A61M5/24 , A61M5/28
CPC分类号： A61M5/31568 , A61F9/0008 , A61M5/24 , A61M5/281 , A61M5/3157 , A61M5/31581 , A61M2205/3306 , A61M2205/3317 , A61M2205/3368 , A61M2205/3584 , A61M2205/502 , A61M2205/52 , A61M2205/581 , A61M2205/584 , A61M2205/587
摘要： Injector devices and methods for using them to deliver medicament into a patient's body, e.g., sub-retinally within an eye, are provided. The injector includes a cartridge including a piston slidably disposed within an interior for delivering medicament within the interior through an outlet, and a driver including a plunger coupled to the piston, a source of pressurized fluid, and an actuator member for opening a flow path at least partially between the source and the plunger to advance the plunger and piston to deliver medicament from the interior. One or more sensors are operatively coupled to the plunger to measure displacement of the plunger, a processor is coupled to the sensor(s) for analyzing sensor signals to measure volume of medicament delivered from the interior, and an output device, e.g., one or more LEDs or speakers, provide outputs related to the volume of medicament delivered.

29. 发明公开

US20230173184A1 GAS POWERED AUTO-INJECTORS AND METHODS FOR USE 审中-公开
公开(公告)号：US20230173184A1
公开(公告)日：2023-06-08
申请号：US18076335
申请日：2022-12-06
申请人： ALTAVIZ, LLC
发明人： Matthew McCawley , Jack R. Auld
IPC分类号： A61M5/20 , A61M5/32
CPC分类号： A61M5/2046 , A61M5/322 , A61M2005/208
摘要： An auto-injector includes a drive assembly within a housing carrying a syringe including a needle adjacent an activation cap within the housing's distal end. The drive assembly includes a first chamber carrying a gas canister, a plunger within a second chamber coupled to the syringe, and proximal and distal chambers. The activation cap is pressed against a subject's skin to direct the drive assembly proximally to open an outlet of the canister to release pressurized gas into the first chamber, whereupon the gas enters the proximal chamber to generate a distal force to advance the drive assembly to direct the needle into the subject and enters the second chamber to advance the plunger to deliver agents from the syringe into the subject. After the plunger advances, the gas enters the distal chamber to generate a proximal force to retract the drive assembly to direct the needle back into the housing.

30. 发明申请

US20230119081A1 DRIVE MODULES FOR INJECTORS, AND SYSTEMS AND METHODS FOR USING SUCH DRIVE MODULES 有权
公开(公告)号：US20230119081A1
公开(公告)日：2023-04-20
申请号：US17965707
申请日：2022-10-13
申请人： ALTAVIZ, LLC
发明人： Matthew McCawley , Jack R. Auld
IPC分类号： A61M5/20 , A61M5/315 , A61M5/32
摘要： An injection device for delivering an agent into a patient’s body including a drive module and an injector module. The drive module includes a canister and puncture mechanism in a first chamber, a plunger in a second chamber communicating with the first chamber, and an actuator that moves the puncture mechanism to cause a puncture pin thereon to penetrate a septum of the canister and cause the gas within the canister to flow through the first chamber into the second chamber. The plunger includes a proximal end including a piston and a distal end and is configured such that gas entering the second chamber causes the plunger to move from an initial position to an extended position for delivering one or more agents from the injector module, the piston including one or more passages that allow gas from the canister to pass through the piston into the second chamber around the plunger.

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