专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

21. 发明申请

US20040235948A1 Treatment of diabetic patients with omega-3-fatty acids 审中-公开
标题翻译：用ω-3-脂肪酸治疗糖尿病患者
公开(公告)号：US20040235948A1
公开(公告)日：2004-11-25
申请号：US10792918
申请日：2004-03-05
申请人： Solvay Pharmaceuticals GmbH
发明人： Rainer Oelze , Cees-Nico Verboom
IPC分类号： A61K031/22
CPC分类号： A61K31/22 , A61K2300/00
摘要： The use of essential fatty acids with a high content of eicosapentaenoic acid ethyl ester (EPA) and/or docosahexaenoic acid ethyl ester (DHA) for preventing cardiovascular events in patients with diabetes mellitus.
摘要翻译：使用具有高含量的二十碳五烯酸乙酯（EPA）和/或二十二碳六烯酸乙酯（DHA）的必需脂肪酸用于预防糖尿病患者的心血管事件。

22. 发明申请

US20040214901A1 Trifluoroacetylalkyl-substituted phenyl, phenol and benzoyl compounds and related methods of treatment 失效
标题翻译：三氟乙酰烷基取代的苯基，苯酚和苯甲酰基化合物及相关的处理方法
公开(公告)号：US20040214901A1
公开(公告)日：2004-10-28
申请号：US10758240
申请日：2004-01-16
申请人： SOLVAY PHARMACEUTICALS GMBH
发明人： Jochen Antel , Harald Waldeck , Andreas Potthoff , Sabine Irmer , Peter-Colin Gregory
IPC分类号： A61K031/11
CPC分类号： A61K31/00 , A61K31/12 , A61K31/122
摘要： Novel and known trifluoroacetyl-substituted phenyl, phenol and benzoyl compounds for the treatment and/or inhibition of obesity and of concomitant and/or secondary diseases involved therewith, in particular metabolic syndrome and cardiovascular diseases. Novel trifluoroacetyl-substituted phenyl, phenol and benzoyl compounds, pharmaceutical preparations containing them and processes for the preparation of these compounds. Also compounds acting as inhibitors of lipase, in particular pancreatic lipase.
摘要翻译：新颖且已知的三氟乙酰基取代的苯基，苯酚和苯甲酰基化合物用于治疗和/或抑制肥胖症以及与之相关的并发症和/或继发性疾病，特别是代谢综合征和心血管疾病。新型三氟乙酰基取代的苯基，苯酚和苯甲酰基化合物，含有它们的药物制剂和这些化合物的制备方法。还有作为脂肪酶抑制剂的化合物，特别是胰脂肪酶。

23. 发明申请

US20040167213A1 Method of identifying compounds suitable for treatment and/or prophylaxis of obesity 有权
公开(公告)号：US20040167213A1
公开(公告)日：2004-08-26
申请号：US10785042
申请日：2004-02-25
申请人： Solvay Pharmaceuticals GmbH
发明人： Johannes Hebebrand , Jochen Antel , Ulf Preuschoff , Samuel David , Holger Sann , Michael Weske
IPC分类号： A61K031/255
CPC分类号： A61K31/34 , C12Q1/527 , G01N33/6893 , G01N2800/044
摘要： A method for the discovery of compounds suitable for the treatment and/or prophylaxis of obesity, in which the ability of the test compounds to inhibit de novo lipogenesis in mammals and/or man is determined. The use of compounds which are capable of inhibiting de novo lipogenesis in mammals, and which are substantially free of effects directed towards the CNS, for the preparation of pharmaceutical compositions for the treatment and/or prophylaxis of obesity, as well as for the treatment and/or inhibition of obesity, are also described.

24. 发明申请

US20030215953A1 Separation of cresol from mares' urine 失效
标题翻译：甲酚与母马尿液分离
公开(公告)号：US20030215953A1
公开(公告)日：2003-11-20
申请号：US10400936
申请日：2003-03-28
申请人： Solvay Pharmaceuticals GmbH
发明人： Heinz-Helmer Rasche , Kirsten Wilbrand , Kerstin Woltmann
IPC分类号： G01N033/00 , C07J001/00
CPC分类号： C07J1/0059 , C07J1/007 , Y10T436/203332
摘要： A method of separating cresol from mares' urine by pervaporation using pore-free polymeric silicone membranes in which starting urine solutions containing high-quality and -quantity conjugated estrogens with a reduced or substantially removed cresol content are provided which are advantageously suitable for obtaining natural mixtures of conjugated estrogens from pregnant mares' urine.
摘要翻译：提供了使用无孔聚合物硅氧烷膜通过渗透蒸发从甲苯尿中分离甲酚的方法，其中含有具有降低或基本上除去的甲酚含量的高质量和量子结合的雌激素的起始尿液溶液有利地适合于获得天然混合物的结合雌激素从怀孕母猪的尿。

25. 发明申请

US20030125349A1 Medicament containing cilansetron for the treatment of non-obstipative male irritable bowel syndrome patients 审中-公开
公开(公告)号：US20030125349A1
公开(公告)日：2003-07-03
申请号：US10347707
申请日：2003-01-22
申请人： Solvay Pharmaceuticals GmbH
发明人： Werner L. M. Cautreels , Claus Rudolf Steinborn , Heinz Guenter Krause , Steven David Caras , Egbertus Hendrikus Evert Biesheuvel , Albertus Hermannus Dirk Plekkenpol
IPC分类号： A61K031/4745
CPC分类号： A61K31/437 , A61K31/4178 , A61K31/4184 , A61K31/439 , A61K31/496 , A61K31/4985 , A61K31/538
摘要： The present invention relates to the use of cilansetron for the treatment of non-obstipative male IBS patients.

26. 发明授权

US5952327A Phosphonic acid-substituted benzazepinone-n-acetic acid derivatives process for their preparation and pharmaceutical compositions comprising them 有权
标题翻译：膦酸取代的苯并氮杂-乙酸衍生物的制备方法和包含它们的药物组合物
公开(公告)号：US5952327A
公开(公告)日：1999-09-14
申请号：US189796
申请日：1998-11-12
申请人： Harald Waldeck , Joerg Meil , Dirk Thormaehlen , Michael Wurl
发明人： Harald Waldeck , Joerg Meil , Dirk Thormaehlen , Michael Wurl
IPC分类号： A61K31/675 , A61K31/00 , A61K31/55 , A61K38/00 , A61P9/00 , A61P9/04 , A61P9/12 , C07D223/16 , C07F9/38 , C07F9/40 , C07F9/553 , C07K5/06 , C07D223/32
CPC分类号： C07K5/06191 , A61K38/00 , Y02P20/55
摘要： Compounds having NEP-inhibitory activity, corresponding to the formula I in whichR.sup.1 is hydrogen or a group forming a biolabile phosphonic acid ester,R.sup.2 is hydrogen or a group forming a biolabile phosphonic acid ester andR.sup.3 is hydrogen or a group forming a biolabile carboxylic acid esterand physiologically acceptable salts of acids of formula I, and pharmaceutical compositions comprising these compounds.
摘要翻译：具有NEP-抑制活性的化合物，其对应于其中R 1是氢的式I或形成可生物不稳定的膦酸酯的基团，R 2是氢或形成可生物不稳定的膦酸酯的基团，并且R 3是氢或形成生物不稳定羧酸的基团酸酯和式I的酸的生理上可接受的盐，以及包含这些化合物的药物组合物。

27. 发明授权

US5912235A 10, 13, 15-trioxatricyclo �9.2.1.1..sup.9.6 !-pentadecan one derivatives, method for their production and pharmaceutical compositions containing them 失效
标题翻译： 10,13,15-三氧杂三环[9.2.1.1.9.6] - 十五烷一种衍生物，其制备方法和含有它们的药物组合物
公开(公告)号：US5912235A
公开(公告)日：1999-06-15
申请号：US954891
申请日：1997-10-21
申请人： Dagmar Hoeltje , Ulf Preuschoff , Christian Eeckhout , Emil Finner
发明人： Dagmar Hoeltje , Ulf Preuschoff , Christian Eeckhout , Emil Finner
IPC分类号： A61K31/70 , A61K31/7042 , A61K31/7048 , A61P1/00 , A61P1/06 , A61P43/00 , C07H17/08 , C07H1/00
CPC分类号： C07H17/08
摘要： Ring-contracted N-demethyl-N-isopropyl-erythromycin-A-spiroacetal compounds corresponding to formula I ##STR1## having gastrointestinally effective motilin-agonistic properties and the preparation thereof.
摘要翻译：对应于具有胃肠道有效的胃动素激动性质的式I的收缩N-去甲基-N-异丙基 - 红霉素A-螺旋缩醛化合物及其制备。

28. 发明授权

US5783573A Pharmaceuticals which promote gastrointestinal blood circulation 失效
标题翻译：促进胃肠道血液循环的药物
公开(公告)号：US5783573A
公开(公告)日：1998-07-21
申请号：US929114
申请日：1997-09-15
申请人： Susanna Rozsa , Julius Gy. Papp , Dirk Thormaehlen , Harald Waldeck
发明人： Susanna Rozsa , Julius Gy. Papp , Dirk Thormaehlen , Harald Waldeck
IPC分类号： C07D223/16 , A61K31/55 , A61P1/00
CPC分类号： A61K31/55
摘要： The use is described of compounds of the general formula I ##STR1## wherein R.sup.1 represents a phenyl-lower alkyl group which can optionally be substituted in the phenyl ring by lower alkyl, lower alkoxy or halogen, or represents a naphthyl-lower alkyl group, R.sup.2 denotes hydrogen or a biolabile ester-forming group, and R.sup.3 denotes hydrogen or a biolabile ester-forming group, and physiologically acceptable salts of the acids of formula I for preparing pharmaceutical compositions for the treatment and/or prophylaxis of gastrointestinal blood circulation disturbances.
摘要翻译：描述了通式I的化合物，其中R 1表示苯基 - 低级烷基，其可以在苯环中被低级烷基，低级烷氧基或卤素任意取代，或表示萘基 - 低级烷基， R2表示氢或不生物不稳定酯形成基团，R 3表示氢或不可生物酯形成基团，以及用于制备用于治疗和/或预防胃肠道血液循环障碍的药物组合物的式I的酸的生理学上可接受的盐。

29. 发明授权

US5677297A Benzazepine-, benzoxazepine- and benzothiazepine-n-acetic acid derivatives, process for their preparation and pharmaceutical compositions containing them 失效
标题翻译：苯扎西平 - ，苯并氧氮杂和苯并硫氮杂_-乙酸衍生物，其制备方法和含有它们的药物组合物
公开(公告)号：US5677297A
公开(公告)日：1997-10-14
申请号：US620213
申请日：1996-03-22
申请人： Harald Waldeck , Dagmar Hoeltje , Josef Messinger , Jochen Antel , Michael Wurl , Dirk Thormaehlen
发明人： Harald Waldeck , Dagmar Hoeltje , Josef Messinger , Jochen Antel , Michael Wurl , Dirk Thormaehlen
IPC分类号： C07D223/16 , A61K31/33 , A61K31/423 , A61K31/428 , A61K31/55 , A61K31/554 , A61K38/00 , A61K38/05 , A61P7/10 , A61P9/00 , A61P43/00 , C07D267/14 , C07D281/10 , C07K5/078 , C07D487/00
CPC分类号： C07K5/06139 , A61K38/00
摘要： Compounds with neutral endopeptidase (NEP) inhibitory activity corresponding to the formula I ##STR1## in which R.sup.1 is a lower alkoxy-lower-alkyl group whose lower alkoxy radical is substituted by a lower alkoxy group, or a phenyl-lower-alkyl or phenyloxy-lower-alkyl group which can optionally be substituted in the phenyl ring by lower alkyl, lower alkoxy or halogen, or a naphthyl-lower-alkyl group, A is CH.sub.2, O or S, R.sup.2 is hydrogen or halogen, R.sup.3 is hydrogen or halogen, R.sup.4 is hydrogen or a group forming a biolabile ester, and R.sup.5 is hydrogen or a group forming a biolabile ester, and the physiologically acceptable acid addition salts thereof.
摘要翻译：具有对应于式I的中性内肽酶（NEP）抑制活性的化合物其中R1是低级烷氧基被低级烷氧基取代的低级烷氧基 - 低级烷基或苯基 - 低级烷基或苯基氧基 - 低级烷基，其可以被苯环中的低级烷基，低级烷氧基或卤素或萘基 - 低级烷基任意取代，A是CH 2，O或S，R 2是氢或卤素，R 3是氢或卤素，R 4为氢或形成不可生物酯的基团，R 5为氢或形成不可生物酯的基团及其生理上可接受的酸加成盐。

30. 发明授权

US08017351B2 Amylases for pharmaceutical use 失效
标题翻译：药用淀粉酶
公开(公告)号：US08017351B2
公开(公告)日：2011-09-13
申请号：US11917551
申请日：2006-06-16
申请人： Allan Svendsen , Peter Collin Gregory
发明人： Allan Svendsen , Peter Collin Gregory
IPC分类号： C12Q1/40 , C12N9/28
CPC分类号： C12N9/2417
摘要： The pharmaceutical use of amylases related to Bacillus alpha-amylases of SEQ ID NOs: 1-3, optionally in combination with a lipase and/or a protease. Examples of medical indications are: Treatment of digestive disorders, pancreatic exocrine insufficiency (PEI), pancreatitis, cystic fibrosis, diabetes type I, and/or diabetes type II. The amylases of SEQ ID NOs: 1-3 are variants of amylases from Bacillus stearothermophilus, Bacillus licheniformis and Bacillus sp. The amylases of the invention have an improved efficacy in vivo, an improved pH-profile, a high specific activity, and/or an improved starch degradation profile.
摘要翻译：与SEQ ID NO：1-3的芽孢杆菌α-淀粉酶相关的淀粉酶的药物用途，任选地与脂肪酶和/或蛋白酶组合。医学适应症的例子有：消化系统疾病，胰腺外分泌功能不全（PEI），胰腺炎，囊性纤维化，I型糖尿病和/或II型糖尿病的治疗。 SEQ ID NO：1-3的淀粉酶是来自嗜热脂肪芽孢杆菌，地衣芽孢杆菌和芽孢杆菌属的淀粉酶的变体。本发明的淀粉酶在体内具有改善的功效，改善的pH分布，高比活性和/或改进的淀粉降解特征。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式