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21. 发明授权

US08436143B2 T1R taste receptors and genes encoding same 有权
公开(公告)号：US08436143B2
公开(公告)日：2013-05-07
申请号：US13288322
申请日：2011-11-03
申请人： Jon Elliot Adler , Xiaodong Li , Lena Staszewski , Shawn O'Connell , Sergey Zozulya
发明人： Jon Elliot Adler , Xiaodong Li , Lena Staszewski , Shawn O'Connell , Sergey Zozulya
IPC分类号： C07K14/705 , C07K19/00
CPC分类号： C07K14/723 , C07K14/705 , C07K2319/00 , C12Q1/6883 , G01N33/5041 , G01N33/6872 , G01N33/74 , G01N2333/726 , G06F19/12
摘要： Newly identified mammalian taste-cell-specific G protein-coupled receptors, and the genes and cDNA encoding said receptors are described. Specifically, T1R G protein-coupled receptors active in taste signaling, and the genes and cDNA encoding the same, are described, along with methods for isolating such genes and for isolating and expressing such receptors. Methods for representing taste perception of a particular taste stimulus in a mammal are also described, as are methods for generating novel molecules or combinations of molecules that elicit a predetermined taste perception in a mammal, and methods for simulating one or more tastes. Further, methods for stimulating or blocking taste perception in a mammal are also disclosed.

22. 发明授权

US08420145B2 Isosorbide derivatives and their use as flavor modifiers, tastants, and taste enhancers 有权
标题翻译：异山梨醇衍生物及其作为调味剂，促味剂和味觉增强剂的用途
公开(公告)号：US08420145B2
公开(公告)日：2013-04-16
申请号：US12396917
申请日：2009-03-03
申请人： Catherine Tachdjian , Donald S. Karanewsky , Sara L. Adamski-Werner , Jeffrey M. Yamamoto , Guy Servant
发明人： Catherine Tachdjian , Donald S. Karanewsky , Sara L. Adamski-Werner , Jeffrey M. Yamamoto , Guy Servant
IPC分类号： A23L1/22 , A23L2/56 , C07D401/02 , C07D277/20 , C07D249/04 , C07D405/02 , C07D231/10 , C07D213/02 , C07D333/10 , C07D307/04
CPC分类号： A23L1/22664 , A23L2/60 , A23L27/205 , A23L27/2052 , C07D493/04
摘要： The present invention provides isosorbide derivatives having the formula shown below and certain subgenera or species thereof, as flavor or taste modifiers, particularly, savory (“umami”) taste modifiers, savory flavoring agents and savory flavor enhancers in foods, beverages, and other comestible compositions,
摘要翻译：本发明提供了具有下列结构的异山梨醇衍生物和某些亚属或其物种，作为食品，饮料和其它可食用组合物中的风味或调味剂，特别是美味（鲜味）调味剂，咸味调味剂和咸味增味剂，

23. 发明申请

US20130071536A1 COMPOUNDS COMPRISING LINKED HETEROARYL MOIETIES AND THEIR USE AS NOVEL UMAMI FLAVOR MODIFIERS, TASTANTS AND TASTE ENHANCERS FOR COMESTIBLE COMPOSITIONS 有权
标题翻译：化合物包含链接的杂交体，并且作为新的UMAMI变形剂，TASTANTS和用于可食用组合物的增强剂
公开(公告)号：US20130071536A1
公开(公告)日：2013-03-21
申请号：US13616585
申请日：2012-09-14
申请人： Catherine TACHDJIAN , Marketa LEBL-RINNOVA , David WALLACE
发明人： Catherine TACHDJIAN , Marketa LEBL-RINNOVA , David WALLACE
IPC分类号： A23L1/226
CPC分类号： A61K9/0056 , A23L2/02 , A23L2/56 , A23L23/00 , A23L27/204 , A23L27/205 , A23L27/26 , A61K31/395 , C07D401/12 , C07D405/14
摘要： The inventions disclosed herein relate to the discovery of the use of compounds having the formula shown below and certain subgenera or species thereof, as flavor or taste modifiers, particularly, savory (“umami”) taste modifiers, savory flavoring agents and savory flavor enhancers in foods, beverages, and other comestible compositions.
摘要翻译：本文公开的发明涉及发现使用具有下述结构的化合物和某些亚属或其物种作为食品中的风味或味觉改良剂，特别是美味（鲜味）味觉调节剂，咸味调味剂和咸味增味剂，饮料和其他可食用组合物。

24. 发明授权

US08338115B2 Assays for detecting T2R76 taste modulatory compounds 有权
标题翻译：检测T2R76味道调节化合物的方法
公开(公告)号：US08338115B2
公开(公告)日：2012-12-25
申请号：US12413102
申请日：2009-03-27
申请人： Jon Elliot Adler , Alexey Pronin , Huixian Tang
发明人： Jon Elliot Adler , Alexey Pronin , Huixian Tang
IPC分类号： G01N33/567 , C07K14/705
CPC分类号： C07K14/705 , A61K38/00
摘要： Isolated nucleic acids encoding T2R76 polypeptides, recombinantly expressed T2R76 polypeptides, heterologous expression systems for recombinant expression of T2R76 polypeptides, assay methods employing the same, and methods for altering taste perception via administration of a T2R76 modulator. These T22R76 polypeptides can be expressed alone or co-expressed with another T2R polypeptide, preferably a different human T2R polypeptide.
摘要翻译：编码T2R76多肽的分离的核酸，重组表达的T2R76多肽，用于重组表达T2R76多肽的异源表达系统，使用该多肽的测定方法以及通过施用T2R76调节剂改变味觉的方法。这些T22R76多肽可以单独表达或与另一个T2R多肽，优选不同的人T2R多肽共表达。

25. 发明授权

US08323912B2 Methods of screening heteromeric T1R2/T1R3 receptors which modulate sweet taste signaling 有权
标题翻译：筛选调节甜味信号的异源性T1R2 / T1R3受体的方法
公开(公告)号：US08323912B2
公开(公告)日：2012-12-04
申请号：US13023502
申请日：2011-02-08
申请人： Mark Zoller , Xiaodong Li , Lena Staszewski , Shawn O'Connell , Sergey Zozulya , Jon Elliot Adler , Hong Xu , Fernando Echeverri
发明人： Mark Zoller , Xiaodong Li , Lena Staszewski , Shawn O'Connell , Sergey Zozulya , Jon Elliot Adler , Hong Xu , Fernando Echeverri
IPC分类号： G01N33/567 , C07K1/00 , C07K14/00 , C07K17/00
CPC分类号： G01N33/5008 , C12N2503/00 , C12N2510/00 , C40B30/04 , G01N33/6872 , G01N2333/726 , G01N2500/10
摘要： The present invention relates to the discovery that the T1R receptors assemble to form functional taste receptors. Particularly, it has been discovered that co-expression of T1R1 and T1R3 results in a taste receptor that responds to umami taste stimuli, including monosodium glutamate. Also, it has been discovered that co-expression of the T1R2 and T1R3 receptors results in a taste receptor that responds to sweet taste stimuli including naturally occurring and artificial sweeteners.Also the present invention relates to the use of hetero-oligomeric taste receptors comprising T1R1/T1R3 and T1R2/T1R3 in assays to identify compounds that respectively respond to umami taste stimuli and sweet taste stimuli.Further, the invention relates to the constitutive of cell lines that stably or transiently co-express a combination of T1R1 and T1R3; or T1R2 and T1R3; under constitutive or inducible conditions. The use of these cells lines in cell-based assays to identify umami and sweet taste modulatory compounds is also provided, particularly high throughput screening assays that detect receptor activity by use of fluorometric imaging.Finally, the invention relates to the discovery that some compounds, e.g., lactisole, inhibit both the activities of human T1R2/T1R3 and T1R1/T1R3 receptors, and accordingly the sweet and umami taste, suggesting that these receptors may be the only sweet and umami receptors.
摘要翻译：本发明涉及T1R受体组装形成功能性味觉受体的发现。特别地，已经发现，T1R1和T1R3的共表达导致对鲜味刺激（包括谷氨酸钠）起反应的味觉感受器。此外，已经发现，T1R2和T1R3受体的共表达导致对包括天然存在的和人造甜味剂的甜味刺激有反应的味觉受体。本发明还涉及在测定中使用包含T1R1 / T1R3和T1R2 / T1R3的异低聚味觉感受器来鉴定分别响应于鲜味刺激和甜味刺激的化合物。此外，本发明涉及稳定或瞬时共表达T1R1和T1R3的组合的细胞系的组成; 或T1R2和T1R3; 在组成型或诱导性条件下。还提供了在基于细胞的测定中使用这些细胞系以鉴定鲜味和甜味调节化合物，特别是通过使用荧光成像检测受体活性的高通量筛选测定。最后，本发明涉及一些发现，一些化合物，例如乳酸，抑制人T1R2 / T1R3和T1R1 / T1R3受体的活性，因此抑制甜味和鲜味，这表明这些受体可能是唯一的甜味和鲜味受体。

26. 发明授权

US08247184B2 Assays using chimeric T1R polypeptides for identifying putative taste modulatory compounds 有权
标题翻译：使用嵌合T1R多肽鉴定推定的口味调节化合物的测定
公开(公告)号：US08247184B2
公开(公告)日：2012-08-21
申请号：US13020068
申请日：2011-02-03
申请人： Xiaodong Li , Feng Zhang , Hong Xu , Qing Li
发明人： Xiaodong Li , Feng Zhang , Hong Xu , Qing Li
IPC分类号： G01N33/53 , G01N33/567 , C12N1/00 , C12N5/07 , C12N5/10
CPC分类号： C07K14/705 , G01N33/566 , G01N2333/726 , G01N2500/02 , G01N2500/10
摘要： This invention relates to chimeric taste receptors comprising the extracellular portion of one T1R or a variant or fragment thereof, either T1R1 or T1R2, and the transmembrane portion of another T1R or a variant or fragment thereof, either T1R1 or T1R2, preferably associated with a T1R3 polypeptide and a suitable G protein. These chimeric taste receptors and cells which express such chimeric taste receptors are useful in assays for identifying sweet and umami ligands as well in assays for identifying sweet and umami enhancers. Additionally, these chimeric taste receptors and cells which express same can be used to map and determine where specific sweet and umami ligands interact with their respective receptors and to elucidate the mechanism of receptor activation.
摘要翻译：本发明涉及包含一个T1R的细胞外部分或其变体或片段T1R1或T1R2的嵌合味觉感受器，以及T1R1或其变体或片段的跨膜部分，T1R1或T1R2，优选与T1R3相关多肽和合适的G蛋白。这些嵌合味觉受体和表达这种嵌合味觉受体的细胞可用于鉴定甜味和鲜味配体的测定以及用于鉴定甜味和鲜味增强剂的测定中。此外，这些嵌合味觉受体和表达相同的细胞可以用于绘制和确定特定甜味和鲜味配体与其各自受体相互作用的位置，并阐明受体活化的机制。

27. 发明授权

US08173373B2 Methods of screening T1R1/T1R3 heteromeric receptors for compounds that modulate umami taste signaling 有权
标题翻译：筛选调节鲜味信号的化合物的T1R1 / T1R3异聚受体的方法
公开(公告)号：US08173373B2
公开(公告)日：2012-05-08
申请号：US12270846
申请日：2008-11-13
申请人： Mark Zoller , Xiaodong Li , Lena Staszewski , Shawn O'Connell , Sergey Zozulya , Jon Elliot Adler , Hong Xu , Fernando Echeverri
发明人： Mark Zoller , Xiaodong Li , Lena Staszewski , Shawn O'Connell , Sergey Zozulya , Jon Elliot Adler , Hong Xu , Fernando Echeverri
IPC分类号： G01N33/53 , G01N33/567
CPC分类号： G01N33/5041 , A01K2217/05 , C07K14/705 , C07K2319/00 , C12Q1/6876 , C12Q2600/124 , C12Q2600/158 , G01N33/5008 , G01N33/566 , G01N2333/4719 , G01N2333/705 , G01N2333/726 , G01N2500/04
摘要： Methods for screening compounds that modulate umami taste signaling in taste cells are provided. These methods comprise contacting a compound with hetero-oligomeric taste transduction G-protein coupled receptors that respond to umami taste stimuli, and determining whether the compound binds to and/or affects the activity of the hetero-oligomeric umami receptor.
摘要翻译：提供了筛选在味细胞中调节鲜味信号的化合物的方法。这些方法包括使化合物与响应于鲜味刺激的异低聚味道转导性G蛋白偶联受体接触，并确定该化合物是否结合和/或影响异源寡聚体受体的活性。

28. 发明授权

US08138322B2 Human T1R2 nucleic acid sequences and polypeptides 有权
标题翻译：人T1R2核酸序列和多肽
公开(公告)号：US08138322B2
公开(公告)日：2012-03-20
申请号：US12177925
申请日：2008-07-23
申请人： Jon Elliot Adler , Xiaodong Li , Lena Staszewski , Shawn O'Connell , Sergey Zozulya
发明人： Jon Elliot Adler , Xiaodong Li , Lena Staszewski , Shawn O'Connell , Sergey Zozulya
IPC分类号： C12N15/12 , C12N15/62 , C07K14/705
CPC分类号： C07K14/723 , C07K14/705 , C07K2319/00 , C12Q1/6883 , G01N33/5041 , G01N33/6872 , G01N33/74 , G01N2333/726 , G06F19/12
摘要： Binding assays for identifying compounds that modulate human T1R2 polypeptide associated taste are disclosed. These assays detect the specific binding of compounds to a human T1R2 polypeptide or the modulation of the specific binding of a compound that specifically binds to a human T1R2 polypeptide. The binding assays may include the use of detectable labels, e.g., radionuclides, enzymes, fluorophases, and the like. Compounds identified in these binding assays have putative application as T1R2 taste modulators, particularly sweet taste, and potentially are useful additives in compositions for human or animal consumption.
摘要翻译：公开了用于鉴定调节人类T1R2多肽相关味道的化合物的结合测定法。这些测定法检测化合物与人T1R2多肽的特异性结合，或调节与人T1R2多肽特异性结合的化合物的特异性结合。结合测定可以包括使用可检测的标记，例如放射性核素，酶，氟化酶等。在这些结合测定中鉴定的化合物具有T1R2味道调节剂，特别是甜味的推定应用，并且潜在地是用于人或动物消费的组合物中有用的添加剂。

29. 发明授权

US08017751B2 hT2R54 receptor polypeptides and nucleic acid sequences 有权
标题翻译： hT2R54受体多肽和核酸序列
公开(公告)号：US08017751B2
公开(公告)日：2011-09-13
申请号：US12133155
申请日：2008-06-04
申请人： Jon Elliot Adler
发明人： Jon Elliot Adler
IPC分类号： C12N15/12 , C07K14/705
CPC分类号： G01N33/74 , A01K2217/05 , A61K38/00 , C07H21/04 , C07K14/705 , C07K2319/00 , G01N33/566 , G01N33/582 , G01N2333/726 , G01N2500/00 , G01N2500/04
摘要： Functional assays that detect the effect of a particular compound or compounds on the activation of at least one human T2R polypeptide are provided. These assays include e.g., assays which detect the effect of said compound on intracellular calcium, second messengers such as cAMP, cGMP, current e.g., by use of voltage-clamp or patch-clamp, techniques, fluorescence polarization or FRET assays, and the like. These assays are useful in identifying compounds that putatively elicit or modulate (inhibit or enhance) bitter taste in human subjects, e.g. bitter taste blockers. The effect of identified compounds on taste may be further evaluated in human or animal taste tests.
摘要翻译：提供检测特定化合物或化合物对至少一种人T2R多肽的活化的影响的功能测定。这些测定包括例如检测所述化合物对细胞内钙的影响的测定法，第二信使例如cAMP，cGMP，例如通过使用电压钳或膜片钳，技术，荧光偏振或FRET测定等等。这些测定可用于鉴定在人类受试者中假定诱导或调节（抑制或增强）苦味的化合物，例如，苦味抑制剂。鉴定的化合物对味道的影响可以在人或动物味道测试中进一步评估。

30. 发明申请

US20110212856A1 HUMAN T2R RECEPTORS RECOGNIZING A CLASS OF BITTER MOLECULES FROM COFFEE 有权
标题翻译：人类T2R受体识别来自咖啡的一类双歧杆菌分子
公开(公告)号：US20110212856A1
公开(公告)日：2011-09-01
申请号：US13094974
申请日：2011-04-27
申请人： Xiaodong Li , Hong Xu , Qing Li , Huixian Tang
发明人： Xiaodong Li , Hong Xu , Qing Li , Huixian Tang
IPC分类号： C40B30/04 , G01N33/68
CPC分类号： C07K14/705 , G01N33/566 , G01N2333/726 , G01N2500/00 , G01N2500/10 , Y10S514/974
摘要： The present invention relates to the discovery that specific human taste receptors in the T2R taste receptor family respond to particular bitter compounds, i.e., chlorogenic lactone compounds that contribute at least partially to the bitter taste of many coffee beverages. The present invention further relates to the use of these receptors in assays for identifying ligands that modulate the activation of these taste receptors by chlorogenic lactones and related compounds and which may be used as additives and/or removed from foods, beverages and medicinals in order to modify (block) T2R-associated bitter taste. A preferred embodiment is the use of the identified compounds as additives in coffee and coffee-flavored foods, beverages and medicinals.
摘要翻译：本发明涉及T2R味觉受体家族中的特定人味受体对特定苦味化合物的反应的发现，即，至少部分地促成许多咖啡饮料的苦味的绿色内酯化合物。本发明还涉及这些受体在测定中用于鉴定调节绿色内酯和相关化合物来调节这些味觉受体的活化并可以用作添加剂和/或从食品，饮料和药物中去除的配体的用途，以便修改（阻断）T2R相关的苦味。优选的实施方案是使用所鉴定的化合物作为咖啡和咖啡风味食品，饮料和药物中的添加剂。

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