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11. 发明授权

US11278568B2 In situ preparation of cyano-bridged metal nanoparticles within a biocompatible reverse micellar system 有权
公开(公告)号：US11278568B2
公开(公告)日：2022-03-22
申请号：US15742719
申请日：2016-07-08
申请人： MEDESIS PHARMA , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , UNIVERSITE DE MONTPELLIER
发明人： Jean-Claude Maurel , Elsa Compte , Cyril Lavaud , Yannick Guari , Joulia Guari , Jérôme Long
IPC分类号： A61K33/32 , A61K9/107 , A61K31/28 , A61K9/51 , A61K47/28 , A61K31/26 , A61K47/10 , A61K9/00 , A61K33/26 , A61K33/30 , A61K47/24
摘要： The present invention relates to a method for in situ preparation of cyano-bridged coordination polymers as metal nanoparticles within a biocompatible reverse micellar system by mixing at least two reverse micellar systems, each one containing at least one metal salt precursor. The invention also relates to the stabilization of theses nanoparticles by using a biocompatible reverse micellar system. This system takes part of the synthesis as a nanoreactor which comprises at least an acylglycerol, a sterol, lecithin, ethanol and water for the preparation of stable cyano-bridged metal nanoparticles without any use of additional stabilizer agent.

12. 发明申请

US20220016132A1 BISMUTH-THIOLS AS ANTISEPTICS FOR BIOMEDICAL USES, INCLUDING TREATMENT OF BACTERIAL BIOFILMS AND OTHER USES 有权
公开(公告)号：US20220016132A1
公开(公告)日：2022-01-20
申请号：US17181781
申请日：2021-02-22
申请人： Microbion Corporation
发明人： Brett Hugh James BAKER , Philip DOMENICO
IPC分类号： A61K31/555 , A61K9/06 , A61K9/10 , A61K9/70 , A61K31/095 , A61K31/29 , A61K33/245 , A61K9/00 , A61K31/28 , A61K45/06 , A61K9/16 , A61K31/496 , A61K31/545 , A61K31/546 , A61K31/65 , A61K31/7004 , A61K31/7036 , A61K38/14
摘要： Compositions and methods, including novel homogeneous microparticulate suspensions, are described for treating natural surfaces that contain bacterial biofilm, including unexpected synergy or enhancing effects between bismuth-thiol (BT) compounds and certain antibiotics, to provide formulations including antiseptic formulations. Previously unpredicted antibacterial properties and anti-biofilm properties of disclosed BT compounds and BT compound-plus-antibiotic combinations are also described, including preferential efficacies of certain such compositions for treating certain gram-positive bacterial infections, and distinct preferential efficacies of certain such compositions for treating certain gram-negative bacterial infections.

13. 发明授权

US11186553B2 Metal complex formulations 有权
公开(公告)号：US11186553B2
公开(公告)日：2021-11-30
申请号：US15531429
申请日：2015-11-27
申请人： GE HEALTHCARE AS
发明人： Mikkel Jacob Thaning , Andreas Richard Meijer
IPC分类号： A61K49/10 , C07D257/02 , A61K49/18 , A61K47/54 , A61K49/00 , A61K31/28
摘要： The present invention relates to a method of preparation of formulations of lanthanide metal complexes of macrocyclic chelators which further comprise a small excess of free chelator. The method uses a solid phase-bound scavenger chelator to remove excess lanthanide metal ions, prior to the addition of a defined excess chelator. Also provided is a method of preparation of MRI contrast agents, together with solid-phase bound chelator meglumine salts useful in the methods.

14. 发明授权

US10953099B2 Compositions comprising a metal source, dithiocarbamate and cyclodextrin 有权
公开(公告)号：US10953099B2
公开(公告)日：2021-03-23
申请号：US16335520
申请日：2017-10-13
申请人： DEUTSCHES KREBSFORSCHUNGSZENTRUM STIFTUNG DES ÖFFENTLICHEN RECHTS
发明人： Eberhard Amtmann , Nikolas Gunkel , Aubry Miller , Michael Morgen
IPC分类号： A61K47/40 , A61P35/00 , A61K31/28 , A61P35/02 , A61K33/243 , A61K31/27 , A61K31/555 , A61K31/7048 , C07F1/00
摘要： The present invention provides a novel class of dithiocarbamate-metal complexes and their uses in medicine. Also provided by the invention are combinations and pharmaceutical compositions, comprising a dithiocarbamate (or thiuram disulphide) such as disulfiram and cyclodextrin, with a source of a heavy metal. Surprisingly, the inventors found a synergistic potentiation of the anti-tumor effect, when a dithiocarbamate/heavy metal mixture was combined with a cyclodextrin. The compounds and combination of the invention are particularly useful in the treatment of tumor diseases, and other disorders. Provided are the compounds, combination, pharmaceutical compositions and kits, as well as methods for the preparation of the combinations of the invention.

15. 发明申请

US20210052632A1 SELECTIVE PARP1 INHIBITORS TO TREAT CANCER 有权
公开(公告)号：US20210052632A1
公开(公告)日：2021-02-25
申请号：US16959519
申请日：2019-01-16
申请人： Cambridge Enterprise Limited
发明人： Melinda DUER , David REID , Uliana BASHTANOVA
IPC分类号： A61K31/7135 , A61K31/28
摘要： The disclosure provides a selective inhibitor of DNA-binding to poly (ADP-ribose) polymerase 1 (PARP1), or a pharmaceutically acceptable salt or solvate thereof, for use in treating, ameliorating or preventing cancer. The treatment may be given to a subject suffering from or at risk of osteoporosis or a subject requiring a long-term therapy.

16. 发明授权

US10828326B2 Compositions and methods for treating and preventing venom related poisoning 有权
公开(公告)号：US10828326B2
公开(公告)日：2020-11-10
申请号：US16399454
申请日：2019-04-30
申请人： Arizona Board of Regents on Behalf of the University of Arizona
发明人： Vance G. Nielsen , Leslie V. Boyer
IPC分类号： A61P39/02 , A61K33/26 , A61K31/295 , A61K45/06 , A61K31/28 , A61K31/69 , A61K33/24
摘要： This invention relates to compositions and methods for treating, ameliorating and preventing the toxic effects of venom poisoning. In particular, the invention provides compositions comprising carbon monoxide releasing molecules (CORM) or compositions comprising CORM and iron releasing molecules (IRM) for one or more of enhancing coagulation, reducing fibrinolysis, and/or inactivating venom related metalloproteinase activity in a subject suffering from or at risk of suffering from venom poisoning.

17. 发明授权

US10786531B2 Mineral salt-sulfonic acid compositions and methods of use 有权
公开(公告)号：US10786531B2
公开(公告)日：2020-09-29
申请号：US16449632
申请日：2019-06-24
申请人： BMG PHARMA SPA
发明人： William A. Goolsbee , Jeffrey L. Lillard
IPC分类号： A61K33/30 , A61P17/02 , A01N41/08 , A61K31/185 , A01N25/24 , A01N37/36 , A01N55/02 , A61K9/00 , A61K31/28 , A61K38/40 , A61K31/145 , A61K31/191 , A61K38/48 , A61K9/08
摘要： The present disclosure generally relates to the medical use of compositions comprising a mineral salt and a sulfonic acid for prevention and/or treatment of one or more mucosal diseases, disorders, or conditions or one or more dermal diseases, disorders, or conditions.

18. 发明授权

US10603381B2 Synthesis of nanocompounds comprising anatase-phase titanium oxide and compositions containing same for the treatment of cancer 有权
公开(公告)号：US10603381B2
公开(公告)日：2020-03-31
申请号：US15511222
申请日：2015-02-17
申请人： UNIVERSIDAD DEL VALLE
发明人： Rubén Jesús Camargo Amado , José Oscar Gutiérrez Montes , Mónica Jimena Basante Romo , William David Criollo Gómez
IPC分类号： A61K31/28 , A61N5/06 , C07F7/28 , B82Y5/00 , A61K41/00 , A61K9/51 , A61K9/00 , A61K47/69 , A61K47/55
摘要： This invention relates to novel nanocompounds that are cytotoxic to tumor cells when combined with ultraviolet light, the nanocompounds comprising multilayered carbon nanotubes with anatase-phase titanium dioxide or anatase-phase titanium dioxide and folate. The invention also relates to a composition containing said nanocompounds and to a method for the treatment of cancer; comprising the administration of said composition in co-treatment with UV radiation. The invention further relates to a method for the synthesis of the nano-compounds.

19. 发明申请

US20200046685A1 COMBINATION THERAPY 审中-公开
公开(公告)号：US20200046685A1
公开(公告)日：2020-02-13
申请号：US16654912
申请日：2019-10-16
申请人： DIMERIX BIOSCIENCE PTY LTD
发明人： Kevin D. G. Pfleger , Elizabeth McCall , James Williams
IPC分类号： A61K31/4184 , A61K31/4178 , A61K31/80 , A61K45/06 , A61K9/00 , A61K9/20 , A61K31/537 , A61K31/28 , A61P13/12 , A61P9/06 , A61P9/12
摘要： The invention relates to pharmaceutical compositions comprising: (a) at least one angiotensin receptor blocker or a pharmaceutically acceptable salt thereof, and (b) at least one chemokine receptor pathway inhibitor or a pharmaceutically acceptable salt thereof. The invention also relates to pharmaceutical compositions comprising: (a) at least one angiotensin receptor blocker or a pharmaceutically acceptable salt thereof; and (b) at least one chemokine receptor pathway inhibitor or a pharmaceutically acceptable salt thereof which inhibits a component of the chemokine receptor pathway other than the chemokine receptor. Oral sustained release pharmaceutical compositions comprising the pharmaceutical composition, as well as injectable sustained release pharmaceutical compositions comprising the pharmaceutical composition are described. The invention further relates to tablets, capsules, injectable suspensions, and compositions for pulmonary or nasal delivery comprising the pharmaceutical composition. Also described are: methods for assessing the efficacy of the pharmaceutical composition; methods for assessing the inhibition or partial inhibition activity of the pharmaceutical composition; methods for the treatment, amelioration or prevention of a condition or disease comprising administering to a subject a therapeutically effective amount of the pharmaceutical composition; and the use of the pharmaceutical composition for the manufacture of a dosage form for the treatment of a disease.

20. 发明申请

US20190328886A1 COMPOSITIONS COMPRISING A METAL SOURCE, DITHIOCARBAMATE AND CYCLODEXTRIN 审中-公开
公开(公告)号：US20190328886A1
公开(公告)日：2019-10-31
申请号：US16335520
申请日：2017-10-13
申请人： DEUTSCHES KREBSFORSCHUNGSZENTRUM STIFTUNG DES ÖFFENTLICHEN RECHTS
发明人： Eberhard AMTMANN , Nikolas GUNKEL , Aubry MILLER , Michael MORGEN
IPC分类号： A61K47/40 , A61P35/02 , A61K31/27 , A61K33/243 , C07F1/00 , A61P35/00 , A61K31/555 , A61K31/28 , A61K31/7048
摘要： The present invention provides a novel class of dithiocarbamate-metal complexes and their uses in medicine. Also provided by the invention are combinations and pharmaceutical compositions, comprising a dithiocarbamate (or thiuram disulphide) such as disulfiram and cyclodextrin, with a source of a heavy metal. Surprisingly, the inventors found a synergistic potentiation of the anti-tumor effect, when a dithiocarbamate/heavy metal mixture was combined with a cyclodextrin. The compounds and combination of the invention are particularly useful in the treatment of tumor diseases, and other disorders. Provided are the compounds, combination, pharmaceutical compositions and kits, as well as methods for the preparation of the combinations of the invention.

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