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11. 发明申请

US20170204380A1 GLYCOSYL TRANSFERASES AND THEIR USES 审中-公开
公开(公告)号：US20170204380A1
公开(公告)日：2017-07-20
申请号：US15322376
申请日：2015-06-26
申请人： TECHNISCHE UNIVERSITAT MUNCHEN
发明人： Wilfried SCHWAB
IPC分类号： C12N9/10 , C12N15/82 , C07H15/10 , C12P19/44
CPC分类号： C12N9/1048 , C07H15/10 , C12N15/8242 , C12N15/8245 , C12P19/44 , C12Y204/00
摘要： The present invention relates to novel glycosyl transferases from Vitis vinifera that are capable of catalyzing the formation of certain glycosides with high efficiency, to nucleic acid molecules encoding such glycosyl transferases, to vectors, host cells and transgenic plants comprising nucleic acid sequences coding for such glycosyl transferases, and to methods for preparing and uses of such glycosyl transferases.

12. 发明授权

US09695208B2 Sialic acid (A-(2-6))-D-aminopyranose derivatives, synthesis methods and uses thereof 有权
公开(公告)号：US09695208B2
公开(公告)日：2017-07-04
申请号：US13703007
申请日：2011-04-08
申请人： Xinshan Ye , Fan Yang , Xiujing Zheng
发明人： Xinshan Ye , Fan Yang , Xiujing Zheng
IPC分类号： C07H15/10 , C07H15/04 , C07H13/00 , A61K47/48 , C07K1/107 , C07K2/00 , A61K39/00
CPC分类号： C07H13/00 , A61K39/0011 , A61K47/48092 , A61K47/48284 , A61K47/549 , A61K47/643 , A61K2039/585 , A61K2039/6081 , C07H15/04 , C07H15/10 , C07K1/1077
摘要： N-acyl modified sialic acid (α-(2→6))-D-aminopyranose derivatives, their synthesis methods and uses are disclosed. Sialic acid (α-(2→6))-D-aminopyranose derivatives represented by formula 1 are synthesized by using D-aminogalactose (glucose) and sialic acid as raw materials, which are coupled with carrier proteins or polypeptides to obtain glycoprotein (glycopeptide) conjugates. Acetyl is replaced by derivative acyl in the structures of said compounds, therefore the compounds show good activity in antitumor vaccines.

13. 发明授权

US09629863B2 CDK5 inhibitors and therapeutic uses thereof 有权
公开(公告)号：US09629863B2
公开(公告)日：2017-04-25
申请号：US14586443
申请日：2014-12-30
申请人： The Hong Kong University of Science and Technology
发明人： Nancy Yuk-Yu Ip , Fanny Chui-Fun Ip , Wing Yu Fu , Guangmiao Fu
IPC分类号： A61K31/7048 , A61K31/353 , A61K31/352 , A61K36/41 , A61K31/19 , A61K31/7004 , A61K31/7016 , C07H15/10 , C07D311/62
CPC分类号： A61K31/7048 , A61K31/19 , A61K31/352 , A61K31/353 , A61K31/7004 , A61K31/7016 , A61K36/41 , C07D311/62 , C07H15/10
摘要： Natural occurring inhibitors of cyclin-dependent protein kinase 5 (Cdk5), isolated from the root of Rhodiola rosea are structurally different from the known Cdk inhibitors. They show selectivity among different Cdks and efficacy to inhibit Cdk via a mixed-type of inhibition, which should lead to less toxicity and side-effects. They are useful in preventing and treating diseases and disorders associated with aberrant Cdk5 activities, such as acute and/or chronic pain, neuropathic pain, diabetes mellitus, cancer, neurodegenerative diseases and neuropathological disorders.

14. 发明授权

US09522928B2 Mannosylated compounds useful for the prevention and the treatment of infectious diseases 有权
标题翻译：用于预防和治疗感染性疾病的甘露糖基化化合物
公开(公告)号：US09522928B2
公开(公告)日：2016-12-20
申请号：US14358157
申请日：2012-11-14
申请人： UNIVERSITE DE STRASBOURG , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
发明人： Rachid Baati , Laure Dehuyser , Christopher Mueller , Evelyne Schaeffer , Alain Wagner
IPC分类号： C07H15/08 , A61F6/04 , A61K47/48 , C07H15/06 , C07H15/10
CPC分类号： C07H15/08 , A61F6/04 , A61K47/60 , C07H15/06 , C07H15/10
摘要： The present invention relates to new anti-infectious compounds consisting of (i) a polar head having from one to three mannose, dimannose or trimannose moieties, which is coupled through an appropriate linker to (ii) a single lipid chain of at least 17 carbon atoms in length. Pharmaceutical compositions and therapeutic uses thereof are also provided.
摘要翻译：本发明涉及新的抗感染化合物，其由（i）具有一至三个甘露糖，二甘露糖或三甘氨糖部分的极性头部组成，其通过合适的接头与（ii）至少17个碳的单个脂链连接原子长度。还提供了药物组合物及其治疗用途。

15. 发明申请

US20160298169A1 COMPOUNDS AND METHODS RELATING TO LYSOSOMAL STORAGE DISORDERS 审中-公开
标题翻译：化合物和与物理储存障碍相关的方法
公开(公告)号：US20160298169A1
公开(公告)日：2016-10-13
申请号：US15188239
申请日：2016-06-21
申请人： University of Washington through its Center of Commercialization , PerkinElmer Health Sciences, Inc.
发明人： Alexander Cherkassky , Jason Coumoyer , Michael Gelb
IPC分类号： C12Q1/34 , C07C233/18 , C07H15/10
摘要： Methods are provided for detecting enzymatic activity of various lysosomal storage enzymes using substrates that include: a sugar moiety; a linker moiety allowing the conjugation of sugar moiety with the remaining structure of the substrate; and two or more fatty acid chains or derivatives thereof at least one of which is sufficiently structured to provide improved solubility in aqueous or organic solvent systems. Also provided are internal standards, and inhibitors for use in detecting or reducing enzymatic activity using the inventive substrates.
摘要翻译：提供了用于使用底物检测各种溶酶体储存酶的酶活性的方法，其包括：糖部分; 连接部分，允许糖部分与底物的剩余结构共轭; 和两种或更多种脂肪酸链或其衍生物，其至少一种具有足够的结构以在水溶液或有机溶剂体系中提供改善的溶解度。还提供了内标物，以及用于使用本发明的底物检测或降低酶活性的抑制剂。

16. 发明授权

US09266918B2 Alkenyl glycosides and their preparation 有权
标题翻译：烯基糖苷及其制备方法
公开(公告)号：US09266918B2
公开(公告)日：2016-02-23
申请号：US14202863
申请日：2014-03-10
申请人： Elevance Renewable Sciences, Inc.
发明人： Ryan A. Littich , Jonathan Brekan , Timothy Montavon
IPC分类号： C07H15/10 , C07H1/00
CPC分类号： C07H15/10 , C07H1/00
摘要： An alkenyl glycoside is prepared by reacting a metathesis-derived unsaturated fatty alcohol containing 10 to 30 carbon atoms with either (1) a reducible monosaccharide or composition hydrolyzable to a reducible monosaccharide, or (2) a hydrocarbyl glycoside produced by reacting an alcohol containing up to 6 carbon atoms with a reducible monosaccharide or composition hydrolyzable to a reducible monosaccharide. Each of these reactions is performed in the presence of an acid catalyst and under conditions sufficient to form the alkenyl glycoside or hydrocarbyl glycoside. The preferred alkenyl glycosides are 9-decen-1-yl glycoside; 9-dodecen-1-yl glycoside; 9-tridecen-1-yl glycoside; 9-pentadecen-1-yl glycoside; 9-octadecen-yl glycoside; or 9-octadecen-1,18-diyl glycoside.
摘要翻译：通过使含有10〜30个碳原子的复分解衍生的不饱和脂肪醇与（1）可还原的单糖或可还原的单糖可水解的组合物反应来制备烯基糖苷，或（2）通过使含有酒精的醇反应生成的烃基糖苷至6个碳原子，可还原的单糖或组合物可水解成可还原的单糖。这些反应各自在酸催化剂的存在下和在足以形成烯基糖苷或烃基糖苷的条件下进行。优选的烯基糖苷是9-癸烯-1-基苷; 9-十二碳烯-1-基苷; 9-十三碳烯-1-基苷; 9-十五碳烯-1-基苷; 9-十八烯酸苷; 或9-十八碳烯-1,18-二基糖苷。

17. 发明申请

US20150368284A1 Surfactant 审中-公开
标题翻译：表面活性剂
公开(公告)号：US20150368284A1
公开(公告)日：2015-12-24
申请号：US14746280
申请日：2015-06-22
申请人： BASF SE
发明人： Laurence Pottie , Eva Max , Frank Clasen , Christian Schade
IPC分类号： C07H15/04 , C07H15/10 , A61Q19/10 , A61K8/60 , A61Q5/02
CPC分类号： C07H15/04 , A61K8/604 , A61Q5/02 , A61Q19/10 , C07H15/10
摘要： Described is an di(alkyl-glycoside) sulfomethylsuccinate having the formula R1—O—Sn—R2—Sn—O—R1 wherein R1 is an alkyl radical having 6 to 30 carbon atoms, S is a monosaccharide moiety, and R2 is a sulfomethylsuccinate moiety. Furthermore, described is a process for making this di(alkyl-glycoside) sulfomethylsuccinate and to an di(alkyl-glycoside) itaconate which is a useful intermediate for use in this process. Also described is a cosmetic composition comprising the alkyl glycoside sulfomethylsuccinate.
摘要翻译：描述了具有式R1-O-Sn-R2-Sn-O-R1的二（烷基 - 糖苷）磺基甲基琥珀酸酯，其中R1是具有6-30个碳原子的烷基，S是单糖部分，R2是磺基甲基琥珀酸酯部分。此外，描述了制备该二（烷基 - 糖苷）磺基甲基琥珀酸盐和衣康酸二（烷基 - 糖苷）的方法，该二（烷基 - 糖苷）衣康酸盐是用于该方法的有用中间体。还描述了包含烷基糖苷磺基甲基琥珀酸盐的化妆品组合物。

18. 发明申请

US20150166594A1 MOENOMYCIN ANALOGS, METHODS OF SYNTHESIS, AND USES THEREOF 审中-公开
标题翻译：咪唑啉酮类似物，合成方法及其用途
公开(公告)号：US20150166594A1
公开(公告)日：2015-06-18
申请号：US14101251
申请日：2013-12-09
申请人： President and Fellows of Harvard College
发明人： Daniel Evan Kahne , Suzanne Walker Kahne , Masaatsu Adachi , Emma Doud , Shinichiro Fuse , Xiaonan Lin , Yi Zhang , Hirokazu Tsukamoto , Bohdan Omelyanovich Ostash
IPC分类号： C07H15/10
CPC分类号： C07H15/10 , C07H11/04
摘要： The present invention provides novel moenomycin analogs as well as pharmaceutical compositions thereof, methods of synthesis, and methods of use in treating an infection by administering an inventive compound to a subject in need thereof. The moenomycin analogs may be prepared synthetically, biosynthetically, or semi-synthetically. The analogs are particularly useful in treating or preventing infections caused by Gram-positive organisms. Certain inventive compounds may have a broader spectrum of coverage, which includes Gram-negative organisms.
摘要翻译：本发明通过向有需要的受试者施用本发明化合物来提供新颖的新霉素类似物及其药物组合物，合成方法和用于治疗感染的方法。门霉素类似物可以合成，生物合成或半合成制备。类似物在治疗或预防革兰氏阳性生物引起的感染中特别有用。某些本发明化合物可具有更广泛的覆盖范围，其包括革兰氏阴性生物体。

19. 发明授权

US09051347B2 Sophorolipid analog compositions 有权
标题翻译：索索糖脂类似物组合物
公开(公告)号：US09051347B2
公开(公告)日：2015-06-09
申请号：US14031696
申请日：2013-09-19
申请人： Synthezyme, LLC
发明人： Richard A. Gross , Mark H. Schofield
IPC分类号： A61K31/70 , C07H15/00 , C07H15/10 , A01N25/30 , A01N43/16 , A01N43/90 , A61K31/7028 , A61K8/60 , A61Q19/00 , C07H9/02 , C07H15/04 , A61Q17/00
CPC分类号： C07H15/10 , A01N25/30 , A01N43/16 , A01N43/90 , A61K8/602 , A61K31/7028 , A61K2800/10 , A61Q17/005 , A61Q19/00 , C07H9/02 , C07H15/04
摘要： A composition of matter comprising sophorolipids as antimicrobial agents, antifungal agents, biopesticides, for uses as drugs to treat HIV, septic shock, cancer, asthma, dermatological conditions, as spermicidal agents, as anti-inflammatory drugs, as ingredients in cosmetics and building blocks for monomers and polymers and self-assembled templates for further chemical elaboration.
摘要翻译：包含作为抗微生物剂的槐糖脂，抗真菌剂，生物杀虫剂，用作药物治疗HIV，败血性休克，癌症，哮喘，皮肤病学条件的杀螨剂作为抗炎药物的物质组合物，作为化妆品和构件中的成分用于单体和聚合物以及自组装模板，用于进一步的化学处理。

20. 发明申请

US20150018291A1 The Utility of Nematode Small Molecules 有权
标题翻译：线虫小分子的应用
公开(公告)号：US20150018291A1
公开(公告)日：2015-01-15
申请号：US14237795
申请日：2012-08-08
申请人： Andrea Choe , Paul W. Sternberg , Frank C. Schroeder
发明人： Andrea Choe , Paul W. Sternberg , Frank C. Schroeder
IPC分类号： C07H15/04 , C07H15/10
CPC分类号： C07H15/04 , A01N37/36 , A01N43/16 , A01N43/38 , A01N63/02 , A61K31/454 , A61K31/7028 , C07D309/10 , C07H15/08 , C07H15/10 , C07H15/18 , C07H15/26
摘要： The present invention relates to methods of treating immune disorders and/or inflammation using certain modulator compounds. In one embodiment, the present invention provides a method of treating an immune and inflammatory disorders disorder by administering a composition comprising a therapeutically effective dosage of an ascaroside compound, or a mixture of ascaroside compounds, or a mixture containing at least one ascaroside.
摘要翻译：本发明涉及使用某些调节剂化合物治疗免疫疾病和/或炎症的方法。在一个实施方案中，本发明提供了一种治疗免疫和炎性疾病病症的方法，该方法是通过施用包含治疗有效剂量的微生物胆固醇化合物或焦糖苷化合物的混合物或含有至少一种果糖苷的混合物的组合物。

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