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11. 发明授权

US5747070A Methods for the treatment of herpes virus infections 失效
标题翻译：治疗疱疹病毒感染的方法
公开(公告)号：US5747070A
公开(公告)日：1998-05-05
申请号：US779827
申请日：1997-01-07
申请人： Satyanarayana Majeti
发明人： Satyanarayana Majeti
IPC分类号： A61K31/32 , A61K33/24 , A61K45/06 , A61K31/19
CPC分类号： A61K45/06 , A61K31/32 , A61K33/24 , Y10S514/931 , Y10S514/934
摘要： Disclosed are methods for treatment of herpes virus infections in a human or lower animal subject comprising administering to the subject stannous salt and one or more pharmaceutically acceptable carriers suitable for topical administration. The stannous salt may be one or more stannous carboxylates, a stannous halide selected from the groups consisting of stannous bromide, stannous iodide, and stannous chloride dihydrate, two or more stannous halides, or one or more stannous halides and one or more stannous carboxylates. Another therapeutic agent, such as an anesthetic, analgesic, or antibiotic, may also be administered. Also disclosed are compositions effective in treating herpes virus infections in a human or lower animal subject comprising stannous fluoride, one or more therapeutic agents, and one or more pharmaceutically acceptable carriers suitable for topical administration.
摘要翻译：公开了用于治疗人类或低等动物受试者的疱疹病毒感染的方法，包括给予受试者亚锡盐和适合于局部给药的一种或多种药用载体。亚锡盐可以是一种或多种亚锡酸盐，选自溴化亚锡，碘化亚锡和二氯化锡二水合物，两种或更多种卤化亚锡，或一种或多种亚锡卤化物和一种或多种亚硫酸钠的亚锡卤化物。还可以施用另一种治疗剂，例如麻醉剂，止痛剂或抗生素。还公开了有效治疗包含氟化亚锡，一种或多种治疗剂和一种或多种适用于局部给药的药学上可接受的载体的人类或低级动物受试者的疱疹病毒感染的组合物。

12. 发明授权

US5710177A Synergistic combinations of active substance for the cosmetic or dermatological care of the skin, hair & nails 失效
标题翻译：用于皮肤，头发和指甲的化妆品或皮肤病学护理的活性物质的协同组合
公开(公告)号：US5710177A
公开(公告)日：1998-01-20
申请号：US448620
申请日：1995-08-11
申请人： Gerhard Sauermann , Uwe Schonrock , Volker Schreiner , Franz Stab
发明人： Gerhard Sauermann , Uwe Schonrock , Volker Schreiner , Franz Stab
IPC分类号： A61K47/44 , A61K8/00 , A61K8/30 , A61K8/36 , A61K8/362 , A61K8/365 , A61K8/368 , A61K8/37 , A61K8/44 , A61K8/49 , A61K8/60 , A61K8/64 , A61K8/67 , A61K8/98 , A61K31/19 , A61K31/195 , A61K31/20 , A61K31/32 , A61K31/415 , A61P17/00 , A61P29/00 , A61P43/00 , A61Q3/00 , A61Q5/00 , A61Q5/12 , A61Q19/00 , A61Q19/08
CPC分类号： A61K8/67 , A61K8/365 , A61Q19/00 , A61Q19/08 , A61Q3/00 , A61Q5/00 , A61K2800/59 , A61Q19/007 , Y10S514/861 , Y10S514/864 , Y10S514/88 , Y10S514/881
摘要： Cosmetic and/or dermatological active compound combinations comprising a) an active amount of biotin and/or biotin esters, b) an active amount of one or more .alpha.-hydroxycarboxylic acids of the formula R'(R")(OH)C COOH and/or an active amount of one or more .alpha.-ketocarboxylic acids of the formula R'C(O) COOH or their physiologically acceptable salts or esters wherein R' and R" represent H-; branched or unbranched C.sub.1-25 -alkyl- or C.sub.1-25 -alkyl-substituted by one or more carboxyl groups and/or hydroxyl groups and/or a aldehyde groups and/or oxo groups (keto groups); phenyl- or phenyl substituted by one or more carboxyl groups and/or hydroxyl groups and/or branched and/or unbranched C.sub.1-25 -alkyl groups; or wherein the .alpha.-carbon atom of the .alpha.-hydroxycarboxylic acid, together with R' and R", forms a cycloalkyl group having 3 to 7 ring atoms or the cycloalkyl substituted by one or more carboxyl groups and/or hydroxyl groups and/or oxo groups (keto groups) and/or branched and/or unbranched C.sub.1-25 -alkyl groups; and c) an active amount of one or more antioxidants.
摘要翻译： PCT No.PCT / DE93 / 01166 Sec。 371日期：1995年8月11日 102（e）日期1995年8月11日PCT提交1993年12月7日PCT公布。出版物WO94 / 14412 PCT 日期1994年7月7日化妆品和/或皮肤病学活性化合物组合包含a）活性量的生物素和/或生物素酯，b）活性量的一种或多种式R'（R“）的α-羟基羧酸，（OH）C COOH和/或活性量的一种或多种式R'C（O）COOH的α-酮羧酸及其生理上可接受的盐或酯，其中R'和R“表示H; 由一个或多个羧基和/或羟基和/或醛基和/或氧代基（酮基）取代的支化或非支链C 1-5 - 烷基 - 或C 1-5 - 烷基 - 。被一个或多个羧基和/或羟基和/或支链和/或非支链的C 1-5 - 烷基取代的苯基或苯基; 或其中α-羟基羧酸的α-碳原子与R'和R“一起形成具有3-7个环原子的环烷基或被一个或多个羧基和/或羟基取代的环烷基和/ 或氧基（酮基）和/或支链和/或无支链的C1-4-烷基; 和c）活性量的一种或多种抗氧化剂。

13. 发明授权

US5559147A Aromatic fluorine-containing organotin compounds and anti-tumour composition 失效
标题翻译：芳香族含氟有机锡化合物和抗肿瘤组成
公开(公告)号：US5559147A
公开(公告)日：1996-09-24
申请号：US519026
申请日：1995-08-24
申请人： Marcel Gielen , Rudolph Willem , Abdeslam Bouhdid , Dick de Vos
发明人： Marcel Gielen , Rudolph Willem , Abdeslam Bouhdid , Dick de Vos
IPC分类号： C07F7/22 , A61K31/32
CPC分类号： C07F7/2256 , C07F7/2292
摘要： The invention relates to novel aromatic fluorine-containing organotin compounds of the formula {(F.sub.5 C.sub.6 RCO.sub.2 SnBu.sub.2).sub.2 O}.sub.2 and {(F.sub.5 C.sub.6 RCO.sub.2).sub.2 SnBu.sub.2 } wherein R is CH.sub.2, CH.dbd.CH or a single bond between the phenyl ring and the CO.sub.2 group, and Bu is a butyl group; as well as to anti-tumour compositions containing as an active ingredient one or more of these compounds.
摘要翻译：本发明涉及式{（F5C6RCO2SnBu2）2O} 2和{（F5C6RCO2）2SnBu2}的新型芳族含氟有机锡化合物，其中R是CH 2，CH = CH或苯环和CO 2基团之间的单键，以及 Bu是丁基; 以及含有这些化合物中的一种或多种作为活性成分的抗肿瘤组合物。

14. 发明授权

US4675336A Platinum complexes of amines with dibasic acids 失效
标题翻译：胺与二元酸的铂络合物
公开(公告)号：US4675336A
公开(公告)日：1987-06-23
申请号：US748788
申请日：1985-06-26
申请人： Panayota Bitha , Ralph G. Child , Joseph J. Hlavka , Yang-I Lin
发明人： Panayota Bitha , Ralph G. Child , Joseph J. Hlavka , Yang-I Lin
IPC分类号： C07F15/00 , A01N55/04 , A61K31/32
CPC分类号： C07F15/0093
摘要： Novel organic compounds of the formula ##STR1## Where R.sub.1 and R.sub.2 are individually selected from the group consisting of hydrogen and alkyl(C.sub.1 -C.sub.6); or R.sub.1 and R.sub.2 taken together are selected from the group consisting of ##STR2## where n is an integer 3-6, ##STR3## where m is an integer 3-6, and ##STR4## and L is selected from the group consisting of --O--, --CH.sub.2 --, ##STR5## where R.sub.3 is alkyl(C.sub.1 -C.sub.6) or --CH.sub.2 CH.sub.2 OH, which have antineoplastic activity, compositions containing the compounds and method of using the compounds to treat tumors in mammals.
摘要翻译：新的有机化合物，其中R 1和R 2分别选自氢和烷基（C 1 -C 6）; 或者R 1和R 2一起选自由下列组成的组：其中n是3-6的整数，其中m是3-6的整数，并且L选自 -O-，-CH 2 - ，其中R 3是具有抗肿瘤活性的烷基（C 1 -C 6）或-CH 2 CH 2 OH，含有这些化合物的组合物和使用该化合物治疗哺乳动物肿瘤的方法。

15. 发明授权

US4598091A (1,2-diphenyl)-ethylenediamine)-platinum (II) complex compounds 失效
标题翻译：（1,2-二苯基） - 乙二胺） - 铂（II）络合物
公开(公告)号：US4598091A
公开(公告)日：1986-07-01
申请号：US580238
申请日：1984-02-15
申请人： Helmut Schonenberger , Beate Wappes , Margaretha Jennerwein , Erwin von Angerer , Jurgen Engel
发明人： Helmut Schonenberger , Beate Wappes , Margaretha Jennerwein , Erwin von Angerer , Jurgen Engel
IPC分类号： A61K31/28 , A61K31/555 , A61P35/00 , C07F15/00 , A01N55/02 , A61K31/32
CPC分类号： C07F15/0093
摘要： There are prepared antitumor active (1,2-diphenyl-ethylenediamine)-platinum (II) complex compounds of the formula ##STR1## where the groups R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are the same or different and are hydrogen, hydroxy groups, C.sub.1 -C.sub.6 -alkoxy groups, C.sub.2 -C.sub.6 -alkanoyloxy groups which optionally are substituted by halogen atoms or C.sub.1 -C.sub.4 -alkanesulfonyloxy groups or C.sub.3 -C.sub.6 -alkenoyloxy groups and at least one of R.sub.1, R.sub.2, R.sub.3 and R.sub.4 is not hydrogen and X is the equivalent of a physiologically compatible or pharmaceutically acceptable anion.
摘要翻译：制备式Ⅰ的抗肿瘤活性（1,2-二苯基 - 乙二胺） - 铂（II）配合物，其中基团R 1，R 2，R 3和R 4相同或不同，为氢，羟基， C 1 -C 6烷氧基，任选被卤素原子或C 1 -C 4烷基磺酰氧基或C 3 -C 6 - 烯酰氧基取代的C 2 -C 6 - 烷酰氧基，R 1，R 2，R 3和R 4中的至少一个不是氢， X相当于生理上相容或药学上可接受的阴离子。

16. 发明授权

US4444791A Pharmaceutical composition and method for treating cachexia in humans due to cancer 失效
标题翻译：用于治疗由于癌症引起的人类恶病质的药物组合物和方法
公开(公告)号：US4444791A
公开(公告)日：1984-04-24
申请号：US380883
申请日：1982-05-21
申请人： Hector C. Simon
发明人： Hector C. Simon
IPC分类号： A61K31/12 , A61K31/32
CPC分类号： A61K31/12
摘要： A pharmaceutical composition and method of treatment is provided for retarding and/or reducing cachexia in humans due carcinoma, sarcoma, and leukemia which comprises the administration of a therapeutically effective amount of a composition comprising friedelan-3-one contained in a physiologically acceptable solution sufficient to retard and/or reduce said cachexia.
摘要翻译：提供药物组合物和治疗方法用于延缓和/或减轻人类恶性肿瘤，肉瘤和白血病的恶病质，其包括给予治疗有效量的组合物，所述组合物包含在生理上可接受的溶液中的足量的包含Friedelan-3的组合物以延缓和/或减少所述恶病质。

17. 发明授权

US2702777A Veterinary tetravalent tin compositions 失效
标题翻译：兽药四价锡组合物
公开(公告)号：US2702777A
公开(公告)日：1955-02-22
申请号：US46167154
申请日：1954-10-11
申请人： SALSBURY S LAB DR
发明人： KERR KATHEL B , WALDE ARTHUR W
IPC分类号： A61K31/32 , C07F7/22
CPC分类号： A61K31/32 , C07F7/22

18. 发明申请

US20230113424A1 NUTRITIONAL COMPOSITION 有权
公开(公告)号：US20230113424A1
公开(公告)日：2023-04-13
申请号：US18079155
申请日：2022-12-12
申请人： Houn Simon HSIA
发明人： Houn Simon HSIA
IPC分类号： A61K36/064 , A61K36/06 , A61K35/60 , A61K31/05 , A61K31/593 , A61K31/122 , A61K31/4415 , A61K33/30 , A61K33/24 , A61K31/198 , A61K31/202 , A61K31/18 , A61K31/24 , A61K31/30 , A61K31/32 , A61K31/34 , A61K31/519 , A61K33/18 , A61K33/32 , A61K33/34 , A23L33/105 , A23L33/115 , A23L33/14 , A23L33/15 , A23L33/155 , A23L33/16 , A23L33/175 , A61K31/015
摘要： The present invention provides nutritional compositions that are employed as oral supplementation to the human diet and methods for using such nutritional compositions. The compositions of the present invention provide for supplementation to the diet of the cancer patient, as well as preventative dietary supplementation aimed at supporting the human immune system for those not currently suffering from cancer. Methods are provided that utilize specific combinations of selected forms selenium. chromium, and molybdenum in combination with fish oil.

19. 发明授权

US10117902B2 Nutritional composition 有权
公开(公告)号：US10117902B2
公开(公告)日：2018-11-06
申请号：US15205786
申请日：2016-07-08
申请人： Houn Simon Hsia
发明人： Houn Simon Hsia
IPC分类号： A61K36/064 , A61K36/06 , A61K35/60 , A61K31/05 , A61K31/593 , A61K31/122 , A61K31/4415 , A61K33/30 , A61K33/24 , A61K31/198 , A61K31/202 , A61K31/18 , A61K31/24 , A61K31/30 , A61K31/32 , A61K31/34 , A61K31/519 , A61K33/18 , A61K33/32 , A61K33/34 , A23L33/105 , A23L33/115 , A23L33/14 , A23L33/15 , A23L33/155 , A23L33/16 , A23L33/175 , A61K31/015
摘要： The present invention provides nutritional compositions that are employed as oral supplementation to the human diet. The compositions of the present invention provide for supplementation to the diet of the cancer patient, as well as preventative dietary supplementation aimed at supporting the human immune system for those not currently suffering from cancer. The present invention is comprised of specific combinations of selected forms of unique sets of certain vitamins, minerals, protein, carbohydrates and phytochemicals.

20. 发明授权

US09827314B2 Edible compositions which are adapted for use by a companion animal 有权
公开(公告)号：US09827314B2
公开(公告)日：2017-11-28
申请号：US10730346
申请日：2003-12-08
申请人： Edward Russell Cox , Douglas Joseph Dobrozsi , Thomas Edward Huetter , Allan John Lepine , Susan Ruth Ward
发明人： Edward Russell Cox , Douglas Joseph Dobrozsi , Thomas Edward Huetter , Allan John Lepine , Susan Ruth Ward
IPC分类号： A61K45/06 , A23K1/00 , A23K1/175 , A23K1/18 , A61K33/42 , A61K33/34 , A61K33/32 , A61K33/30 , A61K31/28 , A61K31/30 , A61K31/315 , A61K31/32 , A61K33/24
CPC分类号： A61K45/06 , A23K20/30 , A23K40/30 , A23K50/42 , A23K50/45 , A61K31/28 , A61K31/30 , A61K31/315 , A61K31/32 , A61K33/24 , A61K33/30 , A61K33/32 , A61K33/34 , A61K33/42 , A61K2300/00
摘要： Disclosed herein are a variety of embodiments of compositions and methods which are each adapted for use by a companion animal. In one embodiment, an edible composition comprising an amount of a soluble mineral component is disclosed, wherein the soluble mineral component comprises one or more minerals selected from the group consisting of zinc, manganese, tin, copper, and mixtures thereof, wherein the amount is an effective amount for use as an oral medicament. In further embodiments, a phosphate component is included. The edible compositions are advantageously companion animal foods or supplements. Further disclosed are methods selected from treating oral cavity tartar, oral cavity plaque, periodontal disease, gingivitis, breath odor and combinations thereof comprising orally administering a described composition to a companion animal.

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