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11. 发明授权

US5945577A Cloning using donor nuclei from proliferating somatic cells 失效
标题翻译：使用供体核从增殖体细胞克隆
公开(公告)号：US5945577A
公开(公告)日：1999-08-31
申请号：US781752
申请日：1997-01-10
申请人： Steven L. Stice , Jose Cibelli , James Robl , Paul Golueke , F. Abel Ponce de Leon , D. Joseph Jerry
发明人： Steven L. Stice , Jose Cibelli , James Robl , Paul Golueke , F. Abel Ponce de Leon , D. Joseph Jerry
IPC分类号： A01K67/02 , A01K67/027 , A61K35/12 , A61P1/18 , A61P3/10 , A61P9/00 , A61P9/04 , A61P13/02 , A61P17/02 , A61P21/00 , A61P25/16 , A61P25/28 , A61P31/18 , A61P35/00 , C12N5/073 , C12N5/10 , C12N15/09 , C12N15/877 , C12N5/00 , C12N15/00 , A01K67/00
CPC分类号： A01K67/0275 , A01K67/027 , C12N15/8771 , C12N15/8778 , C12N5/0603 , A01K2217/05 , A01K2227/101 , A01K2227/106 , A61K35/12 , C12N2510/00 , C12N2517/02 , C12N2517/04
摘要： An improved method of nuclear transfer involving the transplantation of donor differentiated cell nuclei into enucleated oocytes of the same species as the donor cell is provided. The resultant nuclear transfer units are useful for multiplication of genotypes and transgenic genotypes by the production of fetuses and offspring, and for production of isogenic CICM cells, including human isogenic embryonic or stem cells. Production of genetically engineered or transgenic mammalian embryos, fetuses and offspring is facilitated by the present method since the differentiated cell source of the donor nuclei can be genetically modified and clonally propagated.
摘要翻译：提供了涉及将供体分化的细胞核移植到与供体细胞相同物种的去核卵母细胞中的改进的核转移方法。所产生的核转移单位可用于通过胎儿和后代的产生以及用于产生包括人同种异体胚胎或干细胞在内的等基因CICM细胞的基因型和转基因基因型的倍增。通过本方法促进遗传工程或转基因哺乳动物胚胎，胎儿和后代的生产，因为供体核的分化细胞源可以被遗传修饰和克隆繁殖。

12. 发明申请

US20120201788A1 METHODS AND COMPOSITIONS FOR CELL THERAPY 审中-公开
标题翻译：细胞治疗方法与组合物
公开(公告)号：US20120201788A1
公开(公告)日：2012-08-09
申请号：US13339614
申请日：2011-12-29
申请人： Jose Cibelli , Tanja Dominko
发明人： Jose Cibelli , Tanja Dominko
IPC分类号： A61K35/12 , A61P25/16 , A61P25/28 , A61P25/00
CPC分类号： A01K67/0271 , A01K2217/05 , A61K35/12 , A61K48/00 , C12N15/873 , C12N2517/02 , C12N2517/04
摘要： Improved methods of cell therapy are provided using cells and tissues that are histocompatible with a human or non-human transplant recipient. The cells and tissues for transplant produced by the present invention exhibit a youthful state and can be committed to specific cell lineages to better infiltrate and proliferate at a desired target, e.g., a tissue, or organ in need of cell replacement therapy. For providing cells and tissues for transplant to a non-human mammal, the cells and tissues can be isolated from a gastrulating embryo produced by same-species nuclear transfer.
摘要翻译：使用与人或非人类移植受体组织相容的细胞和组织提供改进的细胞治疗方法。本发明生产的用于移植的细胞和组织表现出年轻状态，并且可以致力于特定的细胞谱系，以在期望的靶，例如需要细胞替代疗法的组织或器官中更好地渗透和增殖。为了提供用于移植到非人哺乳动物的细胞和组织，细胞和组织可以从通过相同种类的核转移产生的诱导胚胎中分离出来。

13. 发明授权

US07858308B2 Identification of genes or polypeptides the expression of which correlates to fertility, ovarian function and/or fetal/newborn viability 有权
标题翻译：识别基因或多肽，其表达与生育力，卵巢功能和/或胎儿/新生儿存活力相关
公开(公告)号：US07858308B2
公开(公告)日：2010-12-28
申请号：US11584580
申请日：2006-10-23
申请人： Jose Cibelli , Javier Crosby , Emilio Fernandez , Arif Kocabas , Guilherme Jordao De Magalhaes Rosa
发明人： Jose Cibelli , Javier Crosby , Emilio Fernandez , Arif Kocabas , Guilherme Jordao De Magalhaes Rosa
IPC分类号： C12Q1/68 , C12P19/34 , A01N43/04
CPC分类号： C12Q1/6883 , C12Q2600/158
摘要： A genetic means of determining whether a female subject produces “pregnancy competent” oocytes is provided. The means comprises detecting the level of expression of one or more genes that are expressed at characteristic levels (upregulated or downregulated) in cumulus cells derived from pregnancy competent oocytes. This characteristic gene expression level, or pattern referred to herein as the “pregnancy signature”, also can be used to identify subjects with underlying conditions that impair or prevent the development of a viable pregnancy, e.g., pre-menopausal condition, other hormonal dysfunction, ovarian dysfunction, ovarian cyst, cancer or other cell proliferation disorder, autoimmune disease and the like. Microarrays containing “pregnancy signature” genes or corresponding polypeptides provide another preferred aspect of the invention. Still further, the subject invention can be used to derive animal models, e.g., non-human primate animal models, for the evaluation of the efficacy of putative female fertility treatments.
摘要翻译：提供确定女性受试者是否产生“怀孕受精”卵母细胞的遗传手段。该方法包括检测在源于妊娠合格卵母细胞的卵丘细胞中以特征水平（上调或下调）表达的一种或多种基因的表达水平。这种特征性基因表达水平或本文称为“怀孕签名”的模式也可以用于鉴定有潜在病症的受试者，其损害或预防可行妊娠的发展，例如绝经前期，其他激素功能障碍，卵巢功能障碍，卵巢囊肿，癌症或其他细胞增殖障碍，自身免疫性疾病等。包含“怀孕特征”基因或相应多肽的微阵列提供本发明的另一优选方面。此外，本发明可以用于衍生动物模型，例如非人灵长类动物模型，以评估推定的女性生育力治疗的功效。

14. 发明申请

US20070238111A1 Identification of genes or polypeptides the expression of which correlates to fertility, ovarian function and/or fetal/newborn viability 有权
标题翻译：识别基因或多肽，其表达与生育力，卵巢功能和/或胎儿/新生儿存活力相关
公开(公告)号：US20070238111A1
公开(公告)日：2007-10-11
申请号：US11584580
申请日：2006-10-23
申请人： Jose Cibelli , Javier Crosby , Emilio Fernandez , Arif Kocabas , Guilherme Jordao Rosa
发明人： Jose Cibelli , Javier Crosby , Emilio Fernandez , Arif Kocabas , Guilherme Jordao Rosa
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/158
摘要： A genetic means of determining whether a female subject produces “pregnancy competent” oocytes is provided. The means comprises detecting the level of expression of one or more genes that are expressed at characteristic levels (upregulated or downregulated) in cumulus cells derived from pregnancy competent oocytes. This characteristic gene expression level, or pattern referred to herein as the “pregnancy signature”, also can be used to identify subjects with underlying conditions that impair or prevent the development of a viable pregnancy, e.g., pre-menopausal condition, other hormonal dysfunction, ovarian dysfunction, ovarian cyst, cancer or other cell proliferation disorder, autoimmune disease and the like. Microarrays containing “pregnancy signature” genes or corresponding polypeptides provide another preferred aspect of the invention. Still further, the subject invention can be used to derive animal models, e.g., non-human primate animal models, for the evaluation of the efficacy of putative female fertility treatments.
摘要翻译：提供确定女性受试者是否产生“怀孕受精”卵母细胞的遗传手段。该方法包括检测在源于妊娠合格卵母细胞的卵丘细胞中以特征水平（上调或下调）表达的一种或多种基因的表达水平。这种特征性基因表达水平或本文称为“怀孕签名”的模式也可以用于鉴定有潜在病症的受试者，其损害或预防可行妊娠的发展，例如绝经前期，其他激素功能障碍，卵巢功能障碍，卵巢囊肿，癌症或其他细胞增殖障碍，自身免疫性疾病等。包含“怀孕特征”基因或相应多肽的微阵列提供本发明的另一优选方面。此外，本发明可以用于衍生动物模型，例如非人灵长类动物模型，以评估推定的女性生育力治疗的功效。

15. 发明申请

US20070067861A1 Cloning pigs using donor nuclei from differentiated cells 审中-公开
标题翻译：使用来自分化细胞的供体核克隆猪
公开(公告)号：US20070067861A1
公开(公告)日：2007-03-22
申请号：US11603036
申请日：2006-11-22
申请人： Steven Stice , James Robl , Jose Cibelli , Paul Golueke
发明人： Steven Stice , James Robl , Jose Cibelli , Paul Golueke
IPC分类号： A01K67/027
CPC分类号： C12N15/8778 , A01K67/027 , A01K67/0273 , A01K67/0275 , A01K2217/05 , A01K2227/101 , A61K35/12 , A61K38/00 , C12N5/0603 , C12N15/8771 , C12N2510/00 , C12N2517/02 , C12N2517/04
摘要： An improved method of nuclear transfer involving the transplantation of donor differentiated pig cell nuclei into enucleated pig oocytes is provided. The resultant nuclear transfer units are useful for multiplication of genotypes and transgenic genotypes by the production of fetuses and offspring. Production of genetically engineered or transgenic pig embryos, fetuses and offspring is facilitated by the present method since the differentiated cell source of the donor nuclei can be genetically modified and clonally propagated.
摘要翻译：提供了涉及将供体分化的猪细胞核移植到去核猪卵母细胞中的改进的核转移方法。所产生的核转移单位可用于通过胎儿和后代的产生来增殖基因型和转基因基因型。通过本发明的方法促进转基因植物或转基因猪胚胎，胎儿和后代的生产，因为供体核的分化细胞源可被遗传修饰和克隆繁殖。

16. 发明申请

US20060021070A1 Production of chimeric bovine or porcine animals using cultured inner cell mass 审中-公开
标题翻译：使用培养的内细胞块生产嵌合牛或猪动物
公开(公告)号：US20060021070A1
公开(公告)日：2006-01-26
申请号：US11024010
申请日：2004-12-28
申请人： Steven Stice , Jose Cibelli , James Robl , Paul Golueke , F. Leon , D. Jerry
发明人： Steven Stice , Jose Cibelli , James Robl , Paul Golueke , F. Leon , D. Jerry
IPC分类号： A01K67/027
CPC分类号： C12N15/8771 , A01K2217/05 , C12N15/8778
摘要： Novel cultured inner cell mass (CICM) cells, and cell lines, derived from ungulates, in particular, pigs and cows, and methods for their preparation are provided. The subject CICMs possess similar morphology and express cell markers identically or substantially similarly to ICMs of undifferentiated developing embryos for prolonged culturing periods. Heterologous DNA is inserted into the subject CICM cells and cell lines so as produce transgenic CICM cell which are introduced into non-human fertilized embryos to produce transgenic chimeric embryos. The transgenic chimeric embryos are transferred into recipient females where they are permitted to develop into transgenic chimeric fetuses. Recipient females give birth to transgenic chimeric animals which are capable of transmitting the heterologous DNA to their progeny. Transgenic CICM cells are also used to produce cloned transgenic embryos, fetuses and offspring.
摘要翻译：提供了新颖的培养的内细胞团（CICM）细胞和源自有蹄类动物，特别是猪和牛的细胞系及其制备方法。受试者CICM具有与未分化发育的胚胎的ICM相似或基本上类似于延长培养期的相似形态和表达细胞标记。将异源DNA插入受试者CICM细胞和细胞系中，以产生转入非人受精胚胎以产生转基因嵌合胚胎的转基因CICM细胞。将转基因嵌合胚胎转移到受体雌性中，在其中允许其转化为转基因嵌合胎儿。受体女性产生能够将异源DNA转移到其后代的转基因嵌合动物。转基因CICM细胞也用于产生克隆的转基因胚胎，胎儿和后代。

17. 发明申请

US20050265976A1 Method of differentiation of morula or inner cell mass cells and method of making lineage-defective embryonic stem cells 审中-公开
标题翻译：桑ula或内细胞群细胞的分化方法及其谱系缺陷胚胎干细胞的制备方法
公开(公告)号：US20050265976A1
公开(公告)日：2005-12-01
申请号：US11025893
申请日：2004-12-29
申请人： Jose Cibelli , Michael West , Robert Lanza
发明人： Jose Cibelli , Michael West , Robert Lanza
IPC分类号： C12N15/09 , A61K35/12 , A61K35/28 , A61K35/30 , A61K35/48 , A61P1/16 , A61P3/10 , A61P9/00 , A61P9/02 , A61P11/00 , A61P13/02 , A61P17/02 , A61P19/04 , A61P21/04 , A61P25/00 , A61P25/14 , A61P25/16 , A61P25/28 , A61P31/18 , A61P35/00 , A61P37/06 , C12N5/0735 , C12N5/10 , A61K48/00 , C12N5/08
CPC分类号： C12N5/16 , A61K35/12 , C12N5/0606 , C12N2510/00
摘要： An improved method of producing differentiated progenitor cells comprising obtaining inner cell mass cells from a blastocyst and inducing differentiation of the inner cell mass cells to produce differentiated progenitor cells. The differentiated progenitor cells may be transfected such that there is an addition, deletion or alteration of a desired gene. The differentiated progenitor cells are useful in cell therapy and as a I source of cells for the production of tissues and organs for transplantation. Also provided is a method of producing a lineage-defective human embryonic stem cell.
摘要翻译：一种改进的产生分化祖细胞的方法，包括从囊胚获得内细胞质量细胞并诱导内细胞大量细胞的分化以产生分化祖细胞。可以转染分化的祖细胞，使得存在所需基因的添加，缺失或改变。分化的祖细胞可用于细胞治疗和作为用于产生移植组织和器官的细胞的I来源。还提供了产生谱系缺陷型人胚胎干细胞的方法。

18. 发明申请

US20050255596A1 Methods of repairing tandemly repeated DNA sequences and extending cell life-span nuclear transfer 审中-公开
标题翻译：修复串联重复DNA序列和延长细胞寿命核转移的方法
公开(公告)号：US20050255596A1
公开(公告)日：2005-11-17
申请号：US11079930
申请日：2005-03-09
申请人： Michael West , Robert Lanza , Jose Cibelli
发明人： Michael West , Robert Lanza , Jose Cibelli
IPC分类号： C12N5/08 , C12N15/63 , C12N15/85 , C12Q1/68
CPC分类号： C12N15/85 , C12N2517/04
摘要： This invention relates to methods for rejuvenating normal somatic cells and for making normal somatic cells of a different type having the same genotype as a normal somatic cell of interest. These cells have particular application in cell and tissue transplantation. Also encompassed are methods of re-cloning cloned animals, particularly methods where the offspring of cloned mammals are designed to be genetically altered in comparison to their cloned parent, e.g., that are “hyper-young.” These animals should be healthier and possess desirable properties relative to their cloned parent. Also included are methods for activating endogenous telomerase, EPC-1 activity, and or the ALT pathway and/or extending the life-span of a normal somatic cell, and other genes associated with cell aging and proliferation capacity.
摘要翻译：本发明涉及用于恢复正常体细胞和用于制备具有与感兴趣的正常体细胞相同基因型的不同类型的正常体细胞的方法。这些细胞在细胞和组织移植中具有特殊应用。还包括重新克隆克隆动物的方法，特别是其克隆的哺乳动物的后代被设计为与其克隆的亲本（例如“超年龄”）相比被遗传改变的方法。这些动物应该更健康，并且相对于其克隆的亲本具有所需的性质。还包括用于激活内源性端粒酶，EPC-1活性和/或ALT途径和/或延长正常体细胞的寿命和与细胞衰老和增殖能力相关的其它基因的方法。

19. 发明申请

US20120076761A1 Cloned ungulate embryos and animals, use of cells, tissues and organs thereof for transplantation therapies including Parkinson's disease 审中-公开
标题翻译：克隆有蹄类动物的胚胎和动物，使用细胞，组织和器官进行移植治疗，包括帕金森病
公开(公告)号：US20120076761A1
公开(公告)日：2012-03-29
申请号：US12896396
申请日：2010-10-01
申请人： Steven Stice , Jose Cibelli , James Robl , Paul Golueke , F. Abel Ponce De Leon , D. Joseph Jerry
发明人： Steven Stice , Jose Cibelli , James Robl , Paul Golueke , F. Abel Ponce De Leon , D. Joseph Jerry
IPC分类号： A61K35/30 , C12N5/0793 , A61P25/16 , A61P37/06 , C12N5/079 , C12N5/10
CPC分类号： A01K67/02 , A01K67/027 , A01K67/0271 , A01K67/0275 , A01K2217/05 , A01K2227/101 , A61K35/12 , A61K35/30 , A61K38/00 , C12N5/0603 , C12N15/8771 , C12N2510/00 , C12N2517/02 , C12N2517/04
摘要： Methods and cell lines for cloning ungulate embryos and offspring, in particular bovines and porcines, are provided. The resultant fetuses, embryos or offspring are especially useful for the expression of desired heterologous DNAs, and may be used as a source of cells or tissue for transplantation therapy for the treatment of diseases such as Parkinson's disease.
摘要翻译：提供用于克隆有蹄类胚胎和后代的方法和细胞系，特别是牛和猪。所产生的胎儿，胚胎或后代对于所需的异源DNA的表达特别有用，并且可以用作用于治疗诸如帕金森病之类疾病的移植治疗的细胞或组织来源。

20. 发明申请

US20110293580A1 GYNOGENETIC OR ANDROGENETIC PRODUCTION OF PLURIPOTENT CELLS AND CELL LINES, AND USE THEREOF TO PRODUCE DIFFERENTIATED CELLS AND TISSUES 有权
标题翻译：胞内细胞和细胞系的促生或生殖作用，以及用于生产不同细胞和组织的用途
公开(公告)号：US20110293580A1
公开(公告)日：2011-12-01
申请号：US13117184
申请日：2011-05-27
申请人： James M. ROBL , Jose Cibelli , Amy Burnside
发明人： James M. ROBL , Jose Cibelli , Amy Burnside
IPC分类号： A61K35/12 , C12Q1/02 , C12N5/02 , C12N5/00
CPC分类号： C12N5/0606 , A61K35/12 , A61K35/545 , C12N5/0696 , C12N15/873 , C12N2500/14 , C12N2501/999 , C12N2502/13 , C12N2506/04 , C12N2510/00 , C12N2517/10 , G01N33/5008 , G01N33/502 , G01N33/5044 , G01N33/5073 , G01N33/5088 , G01N2333/475
摘要： Methods for obtaining pluripotent (embryonic stem) cells from parthenogenetic embryos, especially primates, are provided. These cells are useful for producing differentiated cells, tissues and organs, especially human and non-human primate cells, tissues and organs.
摘要翻译：提供了从孤雌胚胎，特别是灵长类动物获得多能（胚胎干）细胞的方法。这些细胞可用于产生分化的细胞，组织和器官，特别是人和非人灵长类细胞，组织和器官。

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