专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

11. 发明授权

US09194875B2 Platelet aggregation test and device 有权
标题翻译：血小板聚集试验及装置
公开(公告)号：US09194875B2
公开(公告)日：2015-11-24
申请号：US14730770
申请日：2015-06-04
申请人： Chrono-Log Corporation
发明人： Andrew Roth , Nicholas J. Veriabo
IPC分类号： G01N33/00 , G01N27/00 , B01J19/00 , G01N37/00 , A61B5/00 , G01N33/86 , G01N27/02 , G01N33/49
CPC分类号： G01N33/4905 , G01N27/02 , G01N27/07 , G01N27/12 , G01N33/49 , G01N33/5005 , G01N33/86 , Y10T436/10 , Y10T436/101666
摘要： An assembly for testing platelet aggregation including an electrode subassembly that is mounted in a cuvette subassembly for use with relatively small samples containing platelets.
摘要翻译：一种用于测试血小板聚集的组件，包括安装在比色皿子组件中用于与含有血小板的较小样品一起使用的电极子组件。

12. 发明授权

US09157113B2 Self-encoding sensor with microspheres 有权
标题翻译：具有微球的自编码传感器
公开(公告)号：US09157113B2
公开(公告)日：2015-10-13
申请号：US14179135
申请日：2014-02-12
申请人： Trustees of Tufts College, Tufts University
发明人： David R. Walt , Todd A. Dickinson
IPC分类号： C12Q1/68 , G01N21/64 , G01N21/77 , G01N33/543 , C40B60/14 , G01N33/00
CPC分类号： C12Q1/682 , B01J2219/00317 , B01J2219/0045 , B01J2219/00466 , B01J2219/005 , B01J2219/00524 , B01J2219/00585 , B01J2219/00648 , B01J2219/00659 , C12Q1/6834 , C40B60/14 , G01N21/6428 , G01N21/6452 , G01N21/7703 , G01N33/0031 , G01N33/54313 , G01N2201/0846 , Y10T436/101666 , Y10T436/109163
摘要： Disclosed herein are compositions and methods for combining the output obtained from redundant sensor elements in a sensor array.
摘要翻译：这里公开了用于组合从传感器阵列中的冗余传感器元件获得的输出的组合物和方法。

13. 发明授权

US09115384B2 Methods and compositions for detecting receptor-ligand interactions in single cells 有权
标题翻译：用于检测单细胞中受体 - 配体相互作用的方法和组合物
公开(公告)号：US09115384B2
公开(公告)日：2015-08-25
申请号：US13098932
申请日：2011-05-02
申请人： Omar D. Perez , Garry P. Nolan
发明人： Omar D. Perez , Garry P. Nolan
IPC分类号： G01N33/68 , C12Q1/48 , G01N33/50 , G01N33/569 , G01N33/573
CPC分类号： G01N33/6845 , C12Q1/485 , G01N33/5008 , G01N33/5041 , G01N33/5091 , G01N33/5094 , G01N33/56966 , G01N33/573 , Y10S435/973 , Y10T436/101666 , Y10T436/13 , Y10T436/25
摘要： The invention provides methods and compositions for simultaneously detecting the activation state of a plurality of proteins in single cells using flow cytometry. The invention further provides methods and compositions of screening for bioactive agents capable of coordinately modulating the activity of a plurality of proteins in single cells. The methods and compositions can be used to determine the protein activation profile of a cell for predicting or diagnosing a disease state, and for monitoring treatment of a disease state.
摘要翻译：本发明提供了使用流式细胞术同时检测单细胞中多种蛋白质的活化状态的方法和组合物。本发明还提供了筛选能够协调调节单细胞中多种蛋白质的活性的生物活性剂的方法和组合物。方法和组合物可用于确定用于预测或诊断疾病状态的细胞的蛋白质活化谱，并用于监测疾病状态的治疗。

14. 发明申请

US20150111276A1 BLOOD CELL SORTING METHODS AND SYSTEMS 审中-公开
标题翻译：血细胞分选方法和系统
公开(公告)号：US20150111276A1
公开(公告)日：2015-04-23
申请号：US14291313
申请日：2014-05-30
申请人： The General Hospital Corporation
发明人： Denise L. Faustman , Douglas E. Burger
IPC分类号： C12N13/00 , C12N5/078
CPC分类号： C12N13/00 , C12N5/0087 , C12N5/0634 , G01N33/491 , Y10T436/10 , Y10T436/101666 , Y10T436/108331 , Y10T436/25 , Y10T436/25125 , Y10T436/25375 , Y10T436/255
摘要： The invention relates to methods of isolating white blood cells (WBCs) from a sample, e.g., whole blood, using magnetic particles that specifically bind to WBCs and a series of specific steps and conditions. The methods can include one or more of decreasing the viscosity of the sample prior to WBC isolation, agitating the sample at specified frequencies, and/or using a sample container arranged such that all of the sample is placed in close proximity (e.g., within 5, 2, 1, or 0.5 mm) to the source of the magnetic field. The new methods provide for isolation of WBC preparations with high yield, purity, and viability. The methods are designed for compatibility with automation protocols for rapid processing of multiple samples.
摘要翻译：本发明涉及使用特异性结合WBC的磁性颗粒和一系列特定步骤和条件从样品例如全血分离白细胞（WBC）的方法。所述方法可以包括以下一种或多种：在WBC分离之前降低样品的粘度，以特定频率搅拌样品，和/或使用样品容器来排列，使得所有样品都放置在非常接近的位置，2,1或0.5mm）到磁场源。新方法提供了高产率，纯度和生存能力的WBC制剂的分离。这些方法旨在与自动化协议的兼容性快速处理多个样品。

15. 发明申请

US20140377741A1 USE OF FOCUSED LIGHT SCATTERING TECHNIQUES IN BIOLOGICAL APPLICATIONS 有权
标题翻译：聚焦光散射技术在生物应用中的应用
公开(公告)号：US20140377741A1
公开(公告)日：2014-12-25
申请号：US14481618
申请日：2014-09-09
申请人： Don Gabriel
发明人： Don Gabriel
IPC分类号： G01N33/569
CPC分类号： G01N15/0211 , G01N15/147 , G01N33/569 , G01N33/56905 , G01N33/56911 , G01N33/56961 , G01N33/56966 , G01N33/56983 , G01N33/574 , G01N2015/0073 , G01N2015/008 , G01N2015/0084 , G01N2015/0088 , G01N2015/0092 , G01N2015/1486 , G01N2015/1493 , G01N2500/04 , G01N2500/10 , Y10T436/101666
摘要： Methods for using focused light scattering techniques for the optical sensing of biological particles suspended in a liquid medium are disclosed. The optical sensing enables one to characterize particles size and/or distribution in a given sample. This, in turn, allows one to identify the biological particles, determine their relative particle density, detect particle shedding, and identify particle aggregation. The methods are also useful in screening and optimizing drug candidates, evaluating the efficacy and dosage levels of such drugs, and in personalized medicine applications.
摘要翻译：公开了将聚焦光散射技术用于光学传感悬浮在液体介质中的生物颗粒的方法。光学传感使得能够表征给定样品中的颗粒尺寸和/或分布。这反过来又允许人们识别生物颗粒，确定其相对颗粒密度，检测颗粒脱落和识别颗粒聚集。该方法在筛选和优化候选药物，评估这些药物的功效和剂量水平以及个性化药物应用中也是有用的。

16. 发明授权

US08828671B2 Simultaneous assay of target and target-drug binding 有权
标题翻译：同时测定靶和靶药物结合
公开(公告)号：US08828671B2
公开(公告)日：2014-09-09
申请号：US13759158
申请日：2013-02-05
申请人： Laboratory Corporation of America Holdings
发明人： Norman B. Purvis , Gregory T. Stelzer
IPC分类号： G01N33/53 , G01N33/574 , G01N33/557 , A61K49/00 , G01N33/50 , G01N33/68
CPC分类号： G01N33/94 , G01N33/5008 , G01N33/5091 , G01N33/6854 , G01N33/6863 , G01N33/6872 , G01N2333/70514 , G01N2333/70553 , G01N2333/70596 , G01N2333/7158 , Y10T436/101666
摘要： Whole cell, simultaneous target and drug-target assay using differentially labeled antibodies and flow cytometry. First antibody binds to total target and second antibody binds to the drug binding site of the target, thus drug binding will competitively inhibit the second antibody allowing for a competitive inhibition assay of drug-target binding. The assay allows for whole cell analysis and even analysis of mixed populations of cells, yet provides detailed kinetic assessment of drug activity.
摘要翻译：使用差异标记的抗体和流式细胞术的全细胞，同时靶标和药物靶标测定。第一抗体与总靶标结合，第二抗体结合靶标的药物结合位点，因此药物结合将竞争性地抑制第二抗体，允许药物靶标结合的竞争性抑制测定。该测定允许对细胞的混合群体进行全细胞分析和均匀分析，但提供药物活性的详细的动力学评估。

17. 发明授权

US08765392B2 Methods for diagnosis of myelodysplastic syndromes (MDS) 有权
标题翻译：骨髓增生异常综合征（MDS）诊断方法
公开(公告)号：US08765392B2
公开(公告)日：2014-07-01
申请号：US13739250
申请日：2013-01-11
申请人： The Trustees of the University of Pennsylvania
发明人： Jonni Moore , Sundhu Cherian , Adam Bagg
IPC分类号： G01N33/00 , G01N33/48 , G01N21/64
CPC分类号： G01N33/5091 , B82Y5/00 , B82Y10/00 , G01N33/5094 , G01N2333/70553 , G01N2333/70589 , G01N2800/22 , Y10S435/973 , Y10S436/811 , Y10S436/813 , Y10T436/101666 , Y10T436/13
摘要： The present invention relates to methods and kits for diagnosing, ascertaining the clinical course of myelodysplastic syndrome (MDS) and ascertaining response to a therapy regimen of myelodysplastic syndrome. Specifically the invention provides methods and kits useful in the diagnosis and determination of clinical parameters associated with MDS based on surface markers unique to MDS.
摘要翻译：本发明涉及用于诊断，确定骨髓增生异常综合征（MDS）的临床过程并确定对骨髓增生异常综合征治疗方案的反应的方法和试剂盒。具体地，本发明提供了可用于诊断和确定与MDS相关的临床参数的方法和试剂盒，其基于MDS特有的表面标记。

18. 发明授权

US08716026B2 Methods and systems for determining composition and completion of an experiment 有权
标题翻译：用于确定实验的组成和完成的方法和系统
公开(公告)号：US08716026B2
公开(公告)日：2014-05-06
申请号：US13655101
申请日：2012-10-18
申请人： Luminex Corporation
发明人： Allen G. Ward
IPC分类号： G01N33/50 , G01N15/14 , G01N15/12 , G01N33/49
CPC分类号： G01N33/4915 , G01N15/1425 , G01N15/1429 , G01N15/1456 , G01N21/6428 , Y10S436/805 , Y10T436/101666 , Y10T436/11 , Y10T436/115831 , Y10T436/117497 , Y10T436/12
摘要： Methods and systems for determining composition and completion of an experiment are provided. One-computer-implemented method for determining composition and completion of an experiment includes determining one or more characteristics of data acquired during the experiment and determining if the experiment is completed based on the one or more characteristics. One system configured to determine composition and completion of an experiment includes a processor configured to determine one or more characteristics of data acquired during the experiment and to determine if the experiment is completed based on the one or more characteristics. Another system configured to perform an experiment includes a measurement subsystem configured to acquire data during the experiment and a processor configured to determine one or more characteristics of the data during the experiment and to determine the composition of the experiment and if the experiment is completed based on the one or more characteristics.
摘要翻译：提供了用于确定实验的组成和完成的方法和系统。用于确定实验的组成和完成的单一计算机实现的方法包括确定在实验期间获取的数据的一个或多个特性，并基于一个或多个特性来确定实验是否完成。被配置为确定实验的组成和完成的一个系统包括被配置为确定在实验期间获取的数据的一个或多个特征并且基于一个或多个特性来确定实验是否完成的处理器。被配置为执行实验的另一系统包括被配置为在实验期间获取数据的测量子系统和配置成在实验期间确定数据的一个或多个特征并确定实验的组成以及如果基于一个或多个特征。

19. 发明申请

US20140065608A1 METHOD FOR THE ENUMERATION OF MAMMALIAN MICRONUCLEATED ERYTHROCYTE POPULATIONS, WHILE DISTINGUISHING PLATELETS AND/OR PLATELET-ASSOCIATED AGGREGATES 有权
标题翻译：用于产生马马利亚微球蛋白质人群的方法，在分解平板和/或平板相关聚集体
公开(公告)号：US20140065608A1
公开(公告)日：2014-03-06
申请号：US14075082
申请日：2013-11-08
申请人： Litron Laboratories, Ltd.
发明人： Stephen D. DERTINGER
IPC分类号： G01N33/50
CPC分类号： G01N33/56966 , G01N33/5094 , G01N33/80 , G01N2333/70582 , G01N2333/70596 , Y02A50/58 , Y10S435/968 , Y10S435/973 , Y10T436/101666
摘要： A method for the enumeration of micronucleated erythrocyte populations while distinguishing platelet and platelet-associated aggregates involves the use of a first fluorescent labeled antibody having binding specificity for a surface marker for reticulocytes, a second fluorescent labeled antibody having binding specificity for a surface marker for platelets, and a nucleic acid staining dye that stains DNA (micronuclei) in erythrocyte populations. Because the fluorescent emission spectra of the first and second fluorescent labeled antibodies do not substantially overlap with one another or with the emission spectra of the nucleic acid staining dye, upon excitation of the labels and dye it is possible to detect the fluorescent emission and light scatter produced by the erythrocyte populations and platelets, and count the number of cells from one or more erythrocyte populations in said sample. In particular, the use of the second antibody prevents interference by platelet-associated aggregates in the scoring procedures.
摘要翻译：用于计数微核红细胞群体同时区分血小板和血小板相关聚集体的方法涉及使用具有对网织红细胞表面标志物具有结合特异性的第一荧光标记抗体，对于血小板表面标志物具有结合特异性的第二荧光标记抗体，以及在红细胞群体中染色DNA（微核）的核酸染色染料。因为第一和第二荧光标记的抗体的荧光发射光谱基本上彼此不重叠或者与核酸染色染料的发射光谱基本重叠，所以在标记和染料激发时，可以检测荧光发射和光散射由红细胞群体和血小板产生，并计数所述样品中一种或多种红细胞群体的细胞数。特别地，使用第二抗体可防止血小板相关聚集体在评分程序中的干扰。

20. 发明授权

US08597952B2 Reagent, reagent kit and analyzing method 有权
标题翻译：试剂，试剂盒和分析方法
公开(公告)号：US08597952B2
公开(公告)日：2013-12-03
申请号：US13590843
申请日：2012-08-21
申请人： Yusuke Mori , Hiroki Takeshita
发明人： Yusuke Mori , Hiroki Takeshita
IPC分类号： G01N21/64 , G01N21/00
CPC分类号： G01N33/86 , Y10T436/10 , Y10T436/101666 , Y10T436/107497
摘要： A method for analyzing platelets is described. In the method, a measurement sample is prepared by mixing a sample and a dye for staining platelets. The dye is selected from the group consisting of Capri blue, Nile blue and brilliant cresyl blue. Upon irradiating cells in the measurement sample with light, scattered light and fluorescence emitted from the cells are measured. The platelets are detected on the basis of the scattered light and the fluorescence. A reagent kit and a reagent are also described.
摘要翻译：描述了分析血小板的方法。在该方法中，通过混合样品和用于染色血小板的染料来制备测量样品。染料选自卡普兰蓝，尼罗河蓝和亮丽甲酚蓝。当用光照射测量样品中的细胞时，测量从细胞发射的散射光和荧光。基于散射光和荧光检测血小板。还描述了试剂盒和试剂。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式