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11. 发明授权

US06274132B1 Method for treating HIV with chlorine dioxide and a phosphate compound 有权
标题翻译：用二氧化氯和磷酸盐化合物治疗HIV的方法
公开(公告)号：US06274132B1
公开(公告)日：2001-08-14
申请号：US09706219
申请日：2000-11-03
申请人： Perry A. Ratcliff
发明人： Perry A. Ratcliff
IPC分类号： A61K900
CPC分类号： A61K9/0014 , A61K8/20 , A61K8/22 , A61K8/24 , A61K33/40 , A61K33/42 , A61K47/02 , A61Q11/00 , A61Q15/00 , Y10S424/15 , Y10S514/887 , Y10S514/931 , Y10S514/934 , Y10S514/937 , Y10S514/944 , Y10S514/966 , Y10S514/967 , Y10S514/968 , A61K2300/00
摘要： A method and solution or gel composition containing activated chlorine dioxide and phosphates, such as disodium hydrogen phosphate, sodium dihydrogen phosphate, trisodium phosphate, and sodium monofluorophosphate, is disclosed for lubricating the vagina and for treating HIV. The preferred concentration ranges are between about 0.005% to about 2.0% chlorine dioxide, and between about 0.02% to about 3.0% phosphate. The phosphate compound retards escape of chlorine dioxide in the pH range of about 6.0 to 7.4, at which pH the chlorine dioxide becomes activated and releases sufficient chlorine dioxide to reduce motility and become lethal to the involved micro-organisms.
摘要翻译：公开了含有活性二氧化氯和磷酸盐的方法和溶液或凝胶组合物，例如磷酸氢二钠，磷酸二氢钠，磷酸三钠和单氟磷酸钠，用于润滑阴道和治疗HIV。优选的浓度范围为约0.005％至约2.0％的二氧化氯和约0.02％至约3.0％的磷酸盐。磷酸盐化合物在约6.0至7.4的pH范围内阻止二氧化氯的逸出，其中二氧化氯在该pH被激活并释放足够的二氧化氯以降低运动性并对所涉及的微生物致死。

12. 发明授权

US6153635A Methods and kits for treating vulvovaginal candidiasis with miconazole nitrate 失效
标题翻译：用硝酸咪康唑治疗外阴阴道念珠菌病的方法和试剂盒
公开(公告)号：US6153635A
公开(公告)日：2000-11-28
申请号：US197019
申请日：1998-11-20
申请人： David H. Upmalis
发明人： David H. Upmalis
IPC分类号： A61K9/06 , A61K9/00 , A61K9/02 , A61K31/4164 , A61K31/4174 , A61K31/415
CPC分类号： A61K31/4174 , A61K9/0034 , A61K9/02 , Y10S514/931
摘要： A method for treating vulvovaginal candidiasis including the steps of: (a) administering a single dose of an effective amount of miconazole nitrate in a pharmaceutically acceptable carrier intra-vaginally; and (b) applying miconazole nitrate in a pharmaceutically acceptable carrier to the vulva. Also a kit for the treatment of vulvovaginal candidiasis including: (a) a single dose of an effective amount of miconazole nitrate in a pharmaceutically acceptable carrier and in a form adapted to be administered intra-vaginally; and (b) an amount of miconazole nitrate in a pharmaceutically acceptable carrier adapted to be applied topically to the vulva.
摘要翻译：一种治疗外阴阴道念珠菌病的方法，包括以下步骤：（a）在阴道内的药学上可接受的载体中施用单剂量的有效量的硝酸咪康唑; 和（b）将硝酸咪康唑在药学上可接受的载体中施用于外阴。还包括治疗外阴阴道念珠菌病的试剂盒，其包括：（a）单一剂量的有效量的硝酸咪康唑在药学上可接受的载体中并且适于经阴道内施用的形式; 和（b）适于局部施用于外阴的药学上可接受的载体中硝酸咪康唑的量。

13. 发明授权

US6011051A Use of isoxazole and crotonamide derivatives for the modulation of apoptosis 失效
标题翻译：异恶唑和巴豆酰胺衍生物用于凋亡调节的应用
公开(公告)号：US6011051A
公开(公告)日：2000-01-04
申请号：US898756
申请日：1997-07-23
申请人： Stefan Mullner , Claudia Dax
发明人： Stefan Mullner , Claudia Dax
IPC分类号： C07D213/40 , A61K31/275 , A61K31/41 , A61K31/42 , A61K31/421 , A61K31/435 , A61K31/4418 , A61K31/445 , A61K38/13 , A61K45/00 , A61K45/06 , A61P1/00 , A61P9/08 , A61P9/10 , A61P11/00 , A61P13/02 , A61P15/00 , A61P17/00 , A61P29/00 , A61P31/04 , A61P31/12 , A61P37/00 , A61P43/00 , C07D213/75 , C07D263/34 , C07D413/12 , A61K31/36
CPC分类号： A61K31/445 , A61K31/275 , A61K31/42 , A61K38/13 , A61K45/06 , Y10S514/931
摘要： Compounds of the formula I or II ##STR1## are suitable for the production of pharmaceuticals for the modulation of apoptosis. These compounds can be employed for the treatment of infarct, stroke, neurodegeneration or hypertrophic disorders.
摘要翻译：式I或II的化合物适用于制备调节细胞凋亡的药物。这些化合物可用于治疗梗塞，中风，神经变性或肥大性疾病。

14. 发明授权

US5880101A Clinical uses of polyene macrolides 失效
标题翻译：多烯大环内酯的临床应用
公开(公告)号：US5880101A
公开(公告)日：1999-03-09
申请号：US765616
申请日：1997-02-27
申请人： Georgi Stankov
发明人： Georgi Stankov
IPC分类号： A61K9/00 , A61K31/70
CPC分类号： A61K31/7048 , A61K9/006 , Y10S514/824 , Y10S514/825 , Y10S514/838 , Y10S514/851 , Y10S514/859 , Y10S514/861 , Y10S514/863 , Y10S514/866 , Y10S514/877 , Y10S514/894 , Y10S514/899 , Y10S514/903 , Y10S514/93 , Y10S514/931
摘要： The present invention relates to the use of at least one polyene macrolide for the preparation of pharmaceutical compositions for the treatment of diseases that are associated with an impaired energy turnover. Particularly, the present inventions allows to specifically stimulate the energy conversion in human cell, i.e. to stimulate the cell metabolism, and thus to treat or prevent a series of diseases.
摘要翻译： PCT No.PCT / EP95 / 02518 Sec。 371日期1997年2月27日 102（e）日期1997年2月27日PCT提交1995年6月28日PCT公布。公开号WO96 / 00576 日期1996年1月11日本发明涉及至少一种多烯大环内酯在制备用于治疗与能量转换受损的疾病相关的药物组合物中的用途。特别地，本发明允许特异性地刺激人细胞中的能量转换，即刺激细胞新陈代谢，从而治疗或预防一系列疾病。

15. 发明授权

US5747070A Methods for the treatment of herpes virus infections 失效
标题翻译：治疗疱疹病毒感染的方法
公开(公告)号：US5747070A
公开(公告)日：1998-05-05
申请号：US779827
申请日：1997-01-07
申请人： Satyanarayana Majeti
发明人： Satyanarayana Majeti
IPC分类号： A61K31/32 , A61K33/24 , A61K45/06 , A61K31/19
CPC分类号： A61K45/06 , A61K31/32 , A61K33/24 , Y10S514/931 , Y10S514/934
摘要： Disclosed are methods for treatment of herpes virus infections in a human or lower animal subject comprising administering to the subject stannous salt and one or more pharmaceutically acceptable carriers suitable for topical administration. The stannous salt may be one or more stannous carboxylates, a stannous halide selected from the groups consisting of stannous bromide, stannous iodide, and stannous chloride dihydrate, two or more stannous halides, or one or more stannous halides and one or more stannous carboxylates. Another therapeutic agent, such as an anesthetic, analgesic, or antibiotic, may also be administered. Also disclosed are compositions effective in treating herpes virus infections in a human or lower animal subject comprising stannous fluoride, one or more therapeutic agents, and one or more pharmaceutically acceptable carriers suitable for topical administration.
摘要翻译：公开了用于治疗人类或低等动物受试者的疱疹病毒感染的方法，包括给予受试者亚锡盐和适合于局部给药的一种或多种药用载体。亚锡盐可以是一种或多种亚锡酸盐，选自溴化亚锡，碘化亚锡和二氯化锡二水合物，两种或更多种卤化亚锡，或一种或多种亚锡卤化物和一种或多种亚硫酸钠的亚锡卤化物。还可以施用另一种治疗剂，例如麻醉剂，止痛剂或抗生素。还公开了有效治疗包含氟化亚锡，一种或多种治疗剂和一种或多种适用于局部给药的药学上可接受的载体的人类或低级动物受试者的疱疹病毒感染的组合物。

16. 发明授权

US5580571A Nucleoside analogues 失效
标题翻译：核苷类似物
公开(公告)号：US5580571A
公开(公告)日：1996-12-03
申请号：US60258
申请日：1993-05-12
申请人： Karl Y. Hostetler
发明人： Karl Y. Hostetler
IPC分类号： A61K31/675 , C07H19/04 , C07H19/10 , C07H19/20 , A61K9/70 , A01N43/90 , A61K31/52 , A61K31/74
CPC分类号： A61K31/522 , A61K31/675 , A61K31/685 , A61K31/7072 , C07H19/04 , C07H19/10 , C07H19/20 , Y10S514/931 , Y10S514/934 , Y10S514/969
摘要： Compositions for topical use in herpes virus infections comprising anti-herpes nucleoside analogue phosphate esters, such as acyclovir monophosphate and acyclovir diphosphate, which show increased activity against native strains of herpes virus as well as against resistant strains, particularly thymidine kinase negative strains of virus. Also disclosed are methods for using the topical compositions in treatment of herpes disease.
摘要翻译：用于在疱疹病毒感染中局部使用的组合物，其包含抗疱疹核苷类似物磷酸酯，例如阿昔洛韦单磷酸酯和阿昔洛韦二磷酸酯，其显示出对天然疱疹病毒株的活性以及抗性菌株，特别是胸苷激酶阴性病毒株的活性。还公开了使用局部组合物治疗疱疹病的方法。

17. 发明授权

US5466680A Method and compositions for enhancing white blood cell functioning on a mucosal or cutaneous surface 失效
标题翻译：用于增强粘膜或皮肤表面上的白细胞功能的方法和组合物
公开(公告)号：US5466680A
公开(公告)日：1995-11-14
申请号：US858290
申请日：1992-03-26
申请人： Michael A. Rudy
发明人： Michael A. Rudy
IPC分类号： A61K9/00 , A61K33/14 , A61K45/08 , A61K31/70 , A61K31/195 , A61K38/00
CPC分类号： A61K33/14 , Y10S514/866 , Y10S514/885 , Y10S514/887 , Y10S514/917 , Y10S514/921 , Y10S514/925 , Y10S514/926 , Y10S514/927 , Y10S514/928 , Y10S514/931 , Y10S514/932 , Y10S514/933 , Y10S514/934
摘要： The present invention relates to a method for enhancing white blood cell functioning and metabolism on a mucosal surface of a mammal. The present invention also relates to a method for treating or preventing a condition in a mammal caused by the presence of a disease-causing agent on a mucosal surface or a cutaneous surface wherein the disease-causing agent can be diminished by the actions of the white blood cells. The present invention yet also relates to a method for healing a wound of a mucosal or cutaneous surface. The present invention also relates to compositions for use in such methods.
摘要翻译：本发明涉及一种增强哺乳动物粘膜表面白细胞功能和代谢的方法。本发明还涉及一种用于治疗或预防由于在粘膜表面或皮肤表面上存在致病剂而导致的哺乳动物状况的方法，其中致病剂可被白色的作用减弱血细胞。本发明还涉及一种治愈粘膜或皮肤表面伤口的方法。本发明还涉及用于这些方法的组合物。

18. 发明授权

US5232695A Method of ameliorating herpes simplex virus infections using purified nerve growth factor 失效
标题翻译：使用纯化的神经生长因子改善单纯疱疹病毒感染的方法
公开(公告)号：US5232695A
公开(公告)日：1993-08-03
申请号：US624488
申请日：1990-12-06
申请人： Christine L. Wilcox , Eugene M. Johnson, Jr.
发明人： Christine L. Wilcox , Eugene M. Johnson, Jr.
IPC分类号： A61K38/18
CPC分类号： A61K38/185 , Y10S514/931 , Y10S514/934
摘要： Methods of treatment are described for use of purified nerve growth factor to ameliorate viral infections in an animal caused by Herpes Simplex Virus Types 1 and 2. Compositions are described for use in the treatment comprising purified nerve growth factor alone or in conjunction with a Herpes Simplex Viral antiviral agent.
摘要翻译：描述了治疗方法用于纯化的神经生长因子以改善由单纯疱疹病毒1型和2型引起的动物中的病毒感染。组合物描述用于治疗，其包括纯化的神经生长因子单独或与单纯疱疹病毒抗病毒剂。

19. 发明授权

US5208031A Sexual lubricants containing zinc as an anti-viral agent 失效
标题翻译：含有锌作为抗病毒剂的性润滑剂
公开(公告)号：US5208031A
公开(公告)日：1993-05-04
申请号：US737169
申请日：1991-07-29
申请人： Patrick D. Kelly
发明人： Patrick D. Kelly
IPC分类号： A61K9/00 , A61K31/315 , A61K33/30
CPC分类号： A61K33/30 , A61K31/315 , A61K9/0034 , Y10S514/886 , Y10S514/931 , Y10S514/934 , Y10S514/944 , Y10S514/966 , Y10S514/967 , Y10S514/968 , Y10S514/969
摘要： This invention relates to the use of zinc salts as anti-viral agents in sexual lubricants. A zinc salt which releases divalent zinc ions in an aqueous carrier fluid is provided in a sexual lubricant formulation which is spread on the genitals before sexual intercourse. The mixture is non-irritating, and the zinc ions serve as an anti-viral agent to reduce the risk of contracting genital herpes if a sexual partner is infected. These lubricants may also reduce the risk of infection by other sexually transmitted viral diseases, such as hepatitis, papilloma viruses, and AIDS. A preferred lubricant formulation comprises water, a thickening or suspending agent, a lubricating agent, and a suitable zinc salt. Salts which have been tested and shown to be non-irritating during sexual intercourse include zinc acetate, zinc propionate, and zinc gluconate. Other zinc salts have also been identified which are soluble in water and have low pK values, which indicates a high rate of zinc ion release.
摘要翻译：本发明涉及在性润滑剂中锌盐作为抗病毒剂的用途。在水性载体流体中释放二价锌离子的锌盐被提供在性润滑剂制剂中，其在性交前在生殖器上传播。该混合物是无刺激性的，并且锌离子作为抗病毒剂，以降低性伴侣感染生殖器疱疹的风险。这些润滑剂也可能降低其他性传播病毒性疾病如肝炎，乳头瘤病毒和艾滋病感染的风险。优选的润滑剂制剂包含水，增稠剂或悬浮剂，润滑剂和合适的锌盐。已经测试并显示在性交时不刺激的盐包括醋酸锌，丙酸锌和葡萄糖酸锌。还已经鉴定出其它可溶于水并且具有低pK值的锌盐，这表明锌离子释放率高。

20. 发明授权

US4405610A Drug for curing inflammatory and/or degenerative and/or atrophic mucous-membrane diseases 失效
标题翻译：用于治疗炎症和/或退行性和/或萎缩性粘膜疾病的药物
公开(公告)号：US4405610A
公开(公告)日：1983-09-20
申请号：US247375
申请日：1981-03-25
申请人： Hrvoje Krnjevic
发明人： Hrvoje Krnjevic
IPC分类号： A61K8/49 , A61K8/60 , A61K31/195 , A61K31/505 , A61Q11/00 , A61Q19/00 , A61K31/70
CPC分类号： A61K31/70 , A61K31/195 , A61K31/505 , A61K8/4953 , A61K8/606 , A61Q11/00 , A61Q19/00 , Y10S514/90 , Y10S514/902 , Y10S514/914 , Y10S514/926 , Y10S514/928 , Y10S514/931
摘要： The invention relates to a pharmacuetical agent for curing inflammatory and/or degenerative and/or atrophic mucous-membrane diseases, more particularly for local application, which are characterized by the proportion of the nucleoside inoside (=hypoxanthineriboside) and of lysine orotate.
摘要翻译：本发明涉及一种用于治疗炎症和/或退行性和/或萎缩性粘膜疾病（特别是局部应用）的药物试剂，其特征在于核苷（=次黄苷）和赖氨酸酯的比例。

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