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11. 发明授权

US06680071B1 Opioid agonist in a fast dispersing dosage form 有权
标题翻译：阿片样物质激动剂为快速分散剂型
公开(公告)号：US06680071B1
公开(公告)日：2004-01-20
申请号：US09936060
申请日：2002-01-14
申请人： Edward Stewart Johnson , Jon Lacy
发明人： Edward Stewart Johnson , Jon Lacy
IPC分类号： A61K914
CPC分类号： A61K31/4468 , A61K9/0056 , A61K9/2095 , Y10S514/816 , Y10S514/817 , Y10S514/818
摘要： This invention relates to a pharmaceutical composition for oral administration comprising a carrier and, as active ingredient, an opioid (&mgr;receptor) agonist, such as fentanyl, or a salt thereof, characterized in that the composition is in the form of a fast-dispersing dosage form designed to release the active ingredient rapidly in the oral cavity. A process for preparing such a composition and the use of such a composition as an analgesic, for the treatment of chronic pain and/or breakthrough pain, as an anesthetic premedication, for the induction of anesthesia, as a sedative and/or for the treatment of anxiety are also provided.
摘要翻译：本发明涉及用于口服给药的药物组合物，其包含载体和作为活性成分的阿片样物质（mureceptor）激动剂如芬太尼或其盐，其特征在于所述组合物为快速分散剂量形式旨在在口腔内快速释放活性成分。用于制备这种组合物的方法以及使用这样的组合物作为止痛剂，用于治疗慢性疼痛和/或突破性疼痛作为麻醉剂预处理，用于诱导麻醉，作为镇静剂和/或用于治疗也提供了焦虑。

12. 发明授权

US06667371B2 Block copolymers based on poly(ortho esters) containing amine groups 失效
标题翻译：基于含有胺基的聚（原酸酯）的嵌段共聚物
公开(公告)号：US06667371B2
公开(公告)日：2003-12-23
申请号：US10295766
申请日：2002-11-14
申请人： Steven Y. Ng , Jorge Heller
发明人： Steven Y. Ng , Jorge Heller
IPC分类号： C08F28302
CPC分类号： C08G63/668 , C08G65/002 , C08G65/34 , C08G2650/42 , Y10S514/816 , Y10S514/817 , Y10S514/887
摘要： Block copolymers based on poly(ortho esters) containing amine groups. These block copolymers have both hydrophilic and hydrophobic blocks. They form micelles in aqueous solution, making them suitable for encapsulation or solubilization of hydrophobic or water-insoluble materials; and they also form bioerodible matrices for the sustained release of active agents.
摘要翻译：基于含有胺基的聚（原酸酯）的嵌段共聚物。这些嵌段共聚物具有亲水性和疏水性嵌段。它们在水溶液中形成胶束，使其适合于疏水或水不溶性材料的包封或溶解; 并且它们还形成用于持续释放活性剂的生物可蚀解基质。

13. 发明授权

US06534547B1 Propofol-based anesthetic and method of making same 失效
标题翻译：基于异丙酚的麻醉药及其制备方法
公开(公告)号：US06534547B1
公开(公告)日：2003-03-18
申请号：US09659899
申请日：2000-09-12
申请人： John R. Carpenter
发明人： John R. Carpenter
IPC分类号： A61K3105
CPC分类号： A61K31/05 , Y10S514/816
摘要： An anesthetic is provided that includes a mixture of propofol, a tonicity agent, a substantially phospholipid-free emulsifying agent, a preservative such as benzyl alcohol, and water. This anesthetic is made by combining these components and then filtering the mixture of these components through a sterilizing filter. This anesthetic may be parenterally administered to both induce and maintain anesthesia in animals.
摘要翻译：提供麻醉剂，其包括丙泊酚，张力剂，基本上不含磷脂的乳化剂，防腐剂如苄醇和水的混合物。通过组合这些组分然后通过消毒过滤器过滤这些组分的混合物来制备麻醉剂。该麻醉剂可以肠胃外给药以诱导和维持动物麻醉。

14. 发明授权

US06524606B1 Bioerodible polyorthoesters containing amine groups 失效
标题翻译：含有胺基的生物可降解的聚原酸酯
公开(公告)号：US06524606B1
公开(公告)日：2003-02-25
申请号：US09991537
申请日：2001-11-16
申请人： Steven Y. Ng , Jorge Heller
发明人： Steven Y. Ng , Jorge Heller
IPC分类号： A61F200
CPC分类号： C08G63/668 , C08G65/002 , C08G65/34 , C08G2650/42 , Y10S514/816 , Y10S514/817 , Y10S514/887
摘要： Bioerodible polyorthoesters useful as orthopedic implants or vehicles for the sustained delivery of pharmaceutical, cosmetic and agricultural agents contain amine functionalities and &agr;-hydroxy acid-containing groups.
摘要翻译：可用作矫形植入物或用于药物，化妆品和农药的持续递送的载体的生物可降解的聚原酸酯包含胺官能团和含有α-羟基酸的基团。

15. 发明授权

US06511453B2 Device for controlled anaesthesia, analgesia and/or sedation 失效
公开(公告)号：US06511453B2
公开(公告)日：2003-01-28
申请号：US09953185
申请日：2001-09-17
申请人： Michael Georgieff
发明人： Michael Georgieff
IPC分类号： A61M3700
CPC分类号： A61K33/00 , A61K9/0026 , A61K9/0029 , A61M16/085 , A61M2230/43 , A61M2230/437 , Y10S514/816 , Y10S514/937 , A61M2230/005 , A61K31/445 , A61K2300/00
摘要： A device for inducing anaesthesia, analgesia and/or sedation is described which comprises a container holding an inert gas-containing liquid preparation, and means for the controlled administration of the preparation to a patient.

16. 发明申请

US20020120002A1 Use of melatonin analogues for induction of general anesthesia 失效
标题翻译：使用褪黑素类似物诱导全身麻醉
公开(公告)号：US20020120002A1
公开(公告)日：2002-08-29
申请号：US10078643
申请日：2002-02-19
申请人： University of Iowa Research Foundation
发明人： Max T. Baker , Mohamed Naguib Attala
IPC分类号： A61K031/405
CPC分类号： A61K31/40 , A61K31/4045 , Y10S514/816 , Y10S514/817 , Y10S514/818
摘要： Melatonin (N-acetyl-5-methoxytryptamine), or its biologically active analogues, are used to induce anesthesia.
摘要翻译：褪黑激素（N-乙酰基-5-甲氧基色胺）或其生物活性类似物用于诱导麻醉。

17. 发明申请

US20020052573A1 Device for controlled anaesthesia, analgesia and/or sedation 失效
标题翻译：用于控制麻醉，止痛和/或镇静的装置
公开(公告)号：US20020052573A1
公开(公告)日：2002-05-02
申请号：US09953185
申请日：2001-09-17
发明人： Michael Georgieff
IPC分类号： A61M037/00
CPC分类号： A61K33/00 , A61K9/0026 , A61K9/0029 , A61M16/085 , A61M2230/43 , A61M2230/437 , Y10S514/816 , Y10S514/937 , A61M2230/005 , A61K31/445 , A61K2300/00
摘要： A device for inducing anaesthesia, analgesia and/or sedation is described which comprises a container holding an inert gas-containing liquid preparation, and means for the controlled administration of the preparation to a patient.
摘要翻译：描述了用于诱导麻醉，镇痛和/或镇静的装置，其包括容纳含惰性气体的液体制剂的容器和用于将制剂受控制给患者的装置。

18. 发明授权

US06277838B1 Methods for allosteric modulation of the GABA receptor by members of the androstane and pregnane series 有权
标题翻译：通过雄甾烷和孕烷系列成员对GABA受体进行变构调节的方法
公开(公告)号：US06277838B1
公开(公告)日：2001-08-21
申请号：US09547041
申请日：2000-04-11
申请人： Ravindra B. Upasani , Haiji Xia , Derk Hogenkamp
发明人： Ravindra B. Upasani , Haiji Xia , Derk Hogenkamp
IPC分类号： A61K3158
CPC分类号： A61K31/58 , A61K31/56 , A61K31/565 , A61K31/57 , A61K31/575 , C07J5/0015 , C07J7/002 , C07J7/0085 , C07J17/00 , C07J31/006 , C07J33/002 , C07J41/005 , C07J41/0094 , C07J43/003 , C07J51/00 , Y10S514/816 , Y10S514/817 , Y10S514/818 , Y10S514/899
摘要： Methods, compositions, and compounds for modulating the GABAA receptor-chloride ionophore complex to alleviate stress, anxiety, seizures, mood disorders, PMS and PND and to induce anesthesia.
摘要翻译：用于调节GABA A受体 - 氯离子载体复合物以缓解压力，焦虑，癫痫发作，情绪障碍，PMS和PND并诱导麻醉的方法，组合物和化合物。

19. 发明授权

US5939545A Method, compositions, and compounds for allosteric modulation of the gaba receptor by members of the androstane and pregnane series 失效
标题翻译：通过雄甾烷和孕烷系列成员对gaba受体进行变构调节的方法，组合物和化合物
公开(公告)号：US5939545A
公开(公告)日：1999-08-17
申请号：US887229
申请日：1997-07-02
申请人： Ravindra B. Upasani , Haiji Xia , Derk Hogenkamp
发明人： Ravindra B. Upasani , Haiji Xia , Derk Hogenkamp
IPC分类号： A61K31/56 , A61K31/565 , A61K31/57 , A61K31/575 , A61K31/58 , C07J5/00 , C07J7/00 , C07J17/00 , C07J31/00 , C07J33/00 , C07J41/00 , C07J43/00 , C07J51/00
CPC分类号： A61K31/58 , A61K31/56 , A61K31/565 , A61K31/57 , A61K31/575 , C07J17/00 , C07J31/006 , C07J33/002 , C07J41/005 , C07J41/0094 , C07J43/003 , C07J5/0015 , C07J51/00 , C07J7/002 , C07J7/0085 , Y10S514/816 , Y10S514/817 , Y10S514/818 , Y10S514/899
摘要： Methods, compositions, and compounds for modulating the GABA.sub.A receptor-chloride ionophore complex to alleviate stress, anxiety, seizures, mood disorders, PMS and PND and to induce anesthesia.
摘要翻译：用于调节GABA A受体 - 氯离子载体复合物以缓解压力，焦虑，癫痫发作，情绪障碍，PMS和PND并诱导麻醉的方法，组合物和化合物。

20. 发明授权

US5326763A Methods for using (2-imidazolin-2-ylamino) quinoxaline derivatives 失效
标题翻译：使用（2-咪唑啉-2-基氨基）喹喔啉衍生物的方法
公开(公告)号：US5326763A
公开(公告)日：1994-07-05
申请号：US10954
申请日：1993-01-29
申请人： Charles Gluchowski , Michael E. Garst , James A. Burke , Larry A. Wheeler
发明人： Charles Gluchowski , Michael E. Garst , James A. Burke , Larry A. Wheeler
IPC分类号： A61K31/495 , C07D403/12 , A61K31/50
CPC分类号： C07D403/12 , A61K31/495 , Y10S514/816 , Y10S514/854 , Y10S514/93
摘要： A method of treating a mammal comprises administering to a mammal an effective amount to provide a reduction inflammation in the mammal of a compound selected from the group consisting of those having the formula: ##STR1## pharmaceutically acceptable acid addition salts thereof and mixtures thereof, wherein R.sub.1 and R.sub.4 are independently selected from the group consisting of H and alkyl radicals having 1 to 4 carbon atoms; the R.sub.2 s are independently selected from H or alkyl radicals having 1 to 4 carbon atoms or are, together, oxo; the R.sub.3 s are independently selected from H or alkyl radicals having 1 to 4 carbon atoms or are, together, oxo; the 2-imidazolin-2-ylamino group may be in any of the 5-, 6, 7- or 8- positions of the quinoxaline nucleus; and R.sub.5, R.sub.6 and R.sub.7 each is located in one of the remaining 5-, 6-, 7- or 8- positions of the quinoxaline nucleus and is independently selected from the group consisting of Cl, Br, H and alkyl radicals having 1 to 3 carbon atoms.
摘要翻译：治疗哺乳动物的方法包括向哺乳动物施用有效量以在哺乳动物中提供选自下列化合物的化合物的还原性炎症：具有下式的那些化合物：其药学上可接受的酸加成盐及其混合物，其中 R 1和R 4独立地选自H和具有1至4个碳原子的烷基; R 2独立地选自H或具有1至4个碳原子的烷基，或者一起是氧代; R 3独立地选自H或具有1至4个碳原子的烷基，或者一起是氧代; 2-咪唑啉-2-基氨基可以在喹喔啉核的5-,6,7或8-位中的任一个中; 并且R5，R6和R7各自位于喹喔啉核的剩余的5-，6-，7-或8-位中的一个中，并且独立地选自Cl，Br，H和具有1至 3个碳原子。

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