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11. 发明授权

US4137243A Polymeric anthraquinone derived colorants 失效
标题翻译：聚合蒽醌衍生着色剂
公开(公告)号：US4137243A
公开(公告)日：1979-01-30
申请号：US815486
申请日：1977-07-14
申请人： Larry B. Farmer
发明人： Larry B. Farmer
IPC分类号： C08G65/331 , C09B69/10 , C07C97/24
CPC分类号： C09B69/101 , C08G65/3315
摘要： Polymeric anthraquinone derived colorants having improved light and alkali fastness properties represented by the formula: ##STR1## wherein R.sub.1 is a member selected from the group consisting of H, OH, a halogen, NH.sub.2, NO.sub.2 and ##STR2## R.sub.2 and R.sub.3 are members selected from the group consisting of H and OH, R.sub.4 is an alkyl moiety containing at least 1 carbon atom, said polymeric constituent is a member of the group consisting of polyalkylene oxides and copolymers thereof in which the alkylene moiety contains from 2 to about 4 carbon atoms, polyalkylene polyamines in which the alkylene moiety contains from 2 to about 4 carbon atoms, polysaccarides, polyamides, and copolymers of vinyl amine and acrylamide, x is an integer of at least 1, and R.sub.5 is selected from the group consisting of OR.sub.6 or NHR.sub.7 and wherein R.sub.6 is H, an aryl moiety or an alkyl moiety containing from 1 to about 18 carbon atoms and wherein R.sub.7 is an aryl moiety or R.sub.4 - (polymeric constituent-(NH.sub.2).sub.x wherein R.sub.4, polymeric constituent and x are as previously defined.
摘要翻译：具有由下式表示的具有改善的耐光牢度特性的聚合蒽醌衍生着色剂：其中R 1是选自H，OH，卤素，NH 2，NO 2和R 2和R 3的成员，其选自由H和OH组成的组，R4是含有至少1个碳原子的烷基部分，所述聚合物成分是由聚环氧烷及其共聚物构成的组中的一部分，其中亚烷基部分含有2至约4个碳原子，其中亚烷基部分含有2至约4个碳原子的聚亚烷基多胺，多糖，聚酰胺和乙烯基胺和丙烯酰胺的共聚物，x为至少1的整数，R 5选自OR 6或NHR 7 并且其中R 6是H，芳基部分或含有1至约18个碳原子的烷基部分，并且其中R 7是芳基部分或R 4 - （聚合物成分 - （NH 2）x），其中R 4，聚合物成分a nd x如前所述。

12. 发明授权

US10617643B2 Expansile crosslinked polymersome for pH-sensitive delivery of anticancer drugs 有权
公开(公告)号：US10617643B2
公开(公告)日：2020-04-14
申请号：US16221144
申请日：2018-12-14
申请人： Mayo Foundation for Medical Education and Research
发明人： Xifeng Liu , Michael J. Yaszemski , Lichun Lu
IPC分类号： C07D319/06 , A61K31/704 , A61K9/127 , C08G65/332 , C08G65/337 , C08G65/331 , A61K9/00
CPC分类号： A61K9/1273 , A61K9/0019 , A61K31/704 , C07D319/06 , C08G65/332 , C08G65/337 , C08G65/3315 , C08G65/3318 , C08G65/3328
摘要： This disclosure relates to polymersomes comprising a crosslinked polymer and their use as drug delivery vehicles. Specifically, polymersomes comprising a polymer of Formula I:

wherein each R is independently C1-6 alkyl; and n is an integer between 1 and 50.

13. 发明申请

US20170258926A1 MICELLAR NANOCOMPLEX 审中-公开
公开(公告)号：US20170258926A1
公开(公告)日：2017-09-14
申请号：US15309675
申请日：2015-05-08
申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
发明人： Motoichi KURISAWA , Yongvongsoontorn NUNNARPAS , Jackie Y. YING , Joo Eun CHUNG , Ki Hyun BAE , Min-han TAN , Esther LEE
IPC分类号： A61K9/127 , A61K31/704 , A61K31/353 , C08G65/332 , A61K9/107 , A61K31/404 , C07D405/14
CPC分类号： A61K31/404 , A61K9/107 , A61K31/353 , A61K31/704 , A61K47/10 , A61K47/48215 , A61K47/60 , B82Y5/00 , C08G65/331 , C08G65/3315 , C08G65/3317 , C08G65/3318 , C08G65/332 , C08G65/3326 , C08G65/3328 , C08G65/33396 , C08L1/02 , C08L3/02 , C08L5/00 , C08L5/02 , C08L5/16 , C08L89/00 , C08L2203/02
摘要： The present invention relates to micellar nanocomplexes and a method of forming the same. The micellar nanocomplex comprises a micelle and an agent encapsulated within said micelle, where the micelle comprises a polymer-flavonoid conjugate, wherein said polymer is bonded to the B ring of said flavonoid. The micellar nanocomplex may have useful applications as a drug-delivery system.

14. 发明申请

US20170121459A1 POLYMERIC ALPHA-HYDROXY ALDEHYDE AND KETONE REAGENTS AND CONJUGATION METHOD 有权
公开(公告)号：US20170121459A1
公开(公告)日：2017-05-04
申请号：US15408037
申请日：2017-01-17
申请人： Nektar Therapeutics
发明人： Sean M. Culbertson , Xiaoming Shen , Antoni Kozlowski , Samuel P. McManus
IPC分类号： C08G65/332 , C08G65/333
CPC分类号： C08G65/2606 , A61K38/00 , A61K47/60 , C07K1/003 , C07K17/08 , C08G65/26 , C08G65/2609 , C08G65/331 , C08G65/3315 , C08G65/3318 , C08G65/3326 , C08G65/33306 , C08G65/33313 , C08G65/33317 , C08G65/33327 , C08L71/02
摘要： Provided herein are polymeric α-hydroxy aldehyde or α-hydroxy ketone reagents which can be conjugated to amine-containing compounds to form stable conjugates in a single-step reaction. In selected embodiments, the polymeric reagent itself incorporates an internal proton-abstracting (basic) functional group, to promote more efficient reaction. The substituent is appropriately situated, via a linker if necessary, to position the group for proton abstraction, preferably providing a 4- or 5-bond spacing between the abstracting atom and the hydrogen atom on the α-carbon. Also provided are methods of using the reagents and stable, solubilized conjugates of the reagents with biologically active compounds. In preferred embodiments, the polymeric component of the reagent or conjugate is a polyethylene glycol.

15. 发明授权

US09579392B2 Polymeric alpha-hydroxy aldehyde and ketone reagents and conjugation method 有权
标题翻译：聚合α-羟基醛和酮试剂及共轭法
公开(公告)号：US09579392B2
公开(公告)日：2017-02-28
申请号：US14951035
申请日：2015-11-24
申请人： Nektar Therapeutics
发明人： Sean M. Culbertson , Xiaoming Shen , Antoni Kozlowski , Samuel P. McManus
IPC分类号： A61K47/48 , C08L71/02 , C08G65/26 , C07K1/00 , C07K17/08 , C08G65/331 , C08G65/333 , A61K38/16 , A61K38/28 , A61K38/47
CPC分类号： C08G65/2606 , A61K38/00 , A61K47/60 , C07K1/003 , C07K17/08 , C08G65/26 , C08G65/2609 , C08G65/331 , C08G65/3315 , C08G65/3318 , C08G65/3326 , C08G65/33306 , C08G65/33313 , C08G65/33317 , C08G65/33327 , C08L71/02
摘要： Provided herein are polymeric α-hydroxy aldehyde or α-hydroxy ketone reagents which can be conjugated to amine-containing compounds to form stable conjugates in a single-step reaction. In selected embodiments, the polymeric reagent itself incorporates an internal proton-abstracting (basic) functional group, to promote more efficient reaction. The substituent is appropriately situated, via a linker if necessary, to position the group for proton abstraction, preferably providing a 4- or 5-bond spacing between the abstracting atom and the hydrogen atom on the α-carbon. Also provided are methods of using the reagents and stable, solubilized conjugates of the reagents with biologically active compounds. In preferred embodiments, the polymeric component of the reagent or conjugate is a polyethylene glycol.
摘要翻译：本文提供的是聚合α-羟基醛或α-羟基酮试剂，其可以与含胺化合物结合以在单步反应中形成稳定的共轭物。在选择的实施方案中，聚合物试剂本身包含内部质子抽提（碱性）官能团，以促进更有效的反应。如果需要，取代基通过接头适当地定位，以使基团定位以进行质子抽提，优选在提取的原子和α-碳上的氢原子之间提供4-或5-键的间隔。还提供了使用试剂和试剂的稳定的，溶解的缀合物与生物活性化合物的方法。在优选的实施方案中，试剂或缀合物的聚合物组分是聚乙二醇。

16. 发明申请

US20160144046A1 POLYMERIC ALPHA-HYDROXY ALDEHYDE AND KETONE REAGENTS AND CONJUGATION METHOD 有权
标题翻译：聚合型ALPHA-羟基醛和酮试剂及其结合方法
公开(公告)号：US20160144046A1
公开(公告)日：2016-05-26
申请号：US14951035
申请日：2015-11-24
申请人： Nektar Therapeutics
发明人： Sean M. Culbertson , Xiaoming Shen , Antoni Kozlowski , Samuel P. McManus
IPC分类号： A61K47/48 , A61K38/28 , A61K38/47 , A61K38/16
CPC分类号： C08G65/2606 , A61K38/00 , A61K47/60 , C07K1/003 , C07K17/08 , C08G65/26 , C08G65/2609 , C08G65/331 , C08G65/3315 , C08G65/3318 , C08G65/3326 , C08G65/33306 , C08G65/33313 , C08G65/33317 , C08G65/33327 , C08L71/02
摘要： Provided herein are polymeric α-hydroxy aldehyde or α-hydroxy ketone reagents which can be conjugated to amine-containing compounds to form stable conjugates in a single-step reaction. In selected embodiments, the polymeric reagent itself incorporates an internal proton-abstracting (basic) functional group, to promote more efficient reaction. The substituent is appropriately situated, via a linker if necessary, to position the group for proton abstraction, preferably providing a 4- or 5-bond spacing between the abstracting atom and the hydrogen atom on the α-carbon. Also provided are methods of using the reagents and stable, solubilized conjugates of the reagents with biologically active compounds. In preferred embodiments, the polymeric component of the reagent or conjugate is a polyethylene glycol.
摘要翻译：本文提供的是聚合α-羟基醛或α-羟基酮试剂，其可以与含胺化合物结合以在单步反应中形成稳定的共轭物。在选择的实施方案中，聚合物试剂本身包含内部质子抽提（碱性）官能团，以促进更有效的反应。如果需要，取代基通过接头适当地定位，以使基团定位以进行质子抽提，优选在提取的原子和α-碳上的氢原子之间提供4-或5-键的间隔。还提供了使用试剂和试剂的稳定的，溶解的缀合物与生物活性化合物的方法。在优选的实施方案中，试剂或缀合物的聚合物组分是聚乙二醇。

17. 发明申请

US20110230618A1 Polymeric Alpha-Hydroxy Aldehyde and Ketone Reagents and Conjugation Method 有权
标题翻译：聚合α-羟基醛和酮试剂和共轭法
公开(公告)号：US20110230618A1
公开(公告)日：2011-09-22
申请号：US13063720
申请日：2009-09-11
申请人： Sean M. Culbertson , Xiaoming Shen , Antoni Kozlowski , Samuel P. McManus
发明人： Sean M. Culbertson , Xiaoming Shen , Antoni Kozlowski , Samuel P. McManus
IPC分类号： C08G65/48
CPC分类号： C08G65/2606 , A61K38/00 , A61K47/60 , C07K1/003 , C07K17/08 , C08G65/26 , C08G65/2609 , C08G65/331 , C08G65/3315 , C08G65/3318 , C08G65/3326 , C08G65/33306 , C08G65/33313 , C08G65/33317 , C08G65/33327 , C08L71/02
摘要： Provided herein are polymeric α-hydroxy aldehyde or α-hydroxy ketone reagents which can be conjugated to amine-containing compounds to form stable conjugates in a single-step reaction. In selected embodiments, the polymeric reagent itself incorporates an internal proton-abstracting (basic) functional group, to promote more efficient reaction. The substituent is appropriately situated, via a linker if necessary, to position the group for proton abstraction, preferably providing a 4- or 5-bond spacing between the abstracting atom and the hydrogen atom on the α-carbon. Also provided are methods of using the reagents and stable, solubilized conjugates of the reagents with biologically active compounds. In preferred embodiments, the polymeric component of the reagent or conjugate is a polyethylene glycol.
摘要翻译：本文提供的是聚合α-羟基醛或α-羟基酮试剂，其可以与含胺化合物结合以在单步反应中形成稳定的共轭物。在选择的实施方案中，聚合物试剂本身包含内部质子抽提（碱性）官能团，以促进更有效的反应。如果需要，取代基通过接头适当地定位，以使基团定位以进行质子抽提，优选在提取的原子和α-碳上的氢原子之间提供4-或5-键的间隔。还提供了使用试剂和试剂的稳定的，溶解的缀合物与生物活性化合物的方法。在优选的实施方案中，试剂或缀合物的聚合物组分是聚乙二醇。

18. 发明申请

US20100184989A1 De Novo Synthesis of Conjugates 审中-公开
标题翻译： De Novo共轭体合成
公开(公告)号：US20100184989A1
公开(公告)日：2010-07-22
申请号：US12530438
申请日：2008-03-12
申请人： Jennifer Riggs-Sauthier , Bo-Liang Deng , Zhongxu Ren , Wen Zhang , Xuyuan Gu , Franco J. Duarte
发明人： Jennifer Riggs-Sauthier , Bo-Liang Deng , Zhongxu Ren , Wen Zhang , Xuyuan Gu , Franco J. Duarte
IPC分类号： A61K47/48
CPC分类号： C08G65/3315 , A61K47/60 , C08G65/33306 , C08G65/33337 , C08G65/33368 , C08G65/33389 , C08L2203/02
摘要： The invention provides methods for the preparation of small molecule drugs that are chemically modified by covalent attachment of a water-soluble oligomer obtained from a water-soluble oligomer composition. Such drugs are produced through modification of a synthetic pathway to attach the oligomer to an intermediate compound followed by completion of the synthetic path.
摘要翻译：本发明提供了通过共价连接由水溶性低聚物组合物获得的水溶性低聚物进行化学修饰的小分子药物的制备方法。通过修饰合成途径产生这样的药物，以将低聚物连接到中间体化合物，然后完成合成路径。

19. 发明申请

US20090093610A1 Catechol Functionalized Polymers and Method for Preparing Them 有权
标题翻译：儿茶酚官能化聚合物及其制备方法
公开(公告)号：US20090093610A1
公开(公告)日：2009-04-09
申请号：US12064564
申请日：2005-08-24
申请人： Marcus Textor , Stefan Zurcher , Karl Gademann , Samuele Tosatti
发明人： Marcus Textor , Stefan Zurcher , Karl Gademann , Samuele Tosatti
IPC分类号： C08G73/06
CPC分类号： C08G65/3315 , A61K47/60 , C08G65/329 , Y10T428/265 , Y10T428/31511 , Y10T428/31663 , Y10T428/31725 , Y10T428/31855
摘要： Described are compounds that are capable of forming adlayers, the compounds comprising at least one headgroup A, an optional linker B, a polymer C, a terminal group D and an optional crosslinking group R, wherein the headgroup A is a compound of the following formula wherein X is independently selected from an acidic group, Y is a group derived from a convenient coupling group, Z1, Z3, and Z4 are C or N+ Z2, Z5 and Z6 are C-L1 or N+-L, wherein L1 is H or an electron withdrawing group, L is C1-C6 alkyl, in particular C1-C4 alkyl L2 and L3 are independently selected from H or C1-C6 alkyl, or L2 may form together with L1 or L of Z6 a heterocycle, in particular a positively charged heterocycle, n is 0, or 1, or 2, or 3, m is 0 or 1.
摘要翻译：描述的是能够形成附着物的化合物，所述化合物包含至少一个头基A，任选的接头B，聚合物C，末端基团D和任选的交联基团R，其中头基A是下式的化合物其中X独立地选自酸性基团，Y是衍生自方便偶合基团的基团，Z 1，Z 3和Z 4是C或N + Z 2，Z 5和Z 6是C-L 1或N + -L，其中L 1是H或吸电子基团，L是C1-C6烷基，特别是C1-C4烷基L2和L3独立地选自H或C1-C6烷基，或L2可以与Z6的L1或L一起形成杂环，特别是正带电杂环，n为0或1，或2或3，m为0或1。

20. 发明授权

US11649397B1 Polyaromatic hydrocarbon-based host-guest complex for heavy crude oil viscosity reduction 有权
公开(公告)号：US11649397B1
公开(公告)日：2023-05-16
申请号：US17875203
申请日：2022-07-27
申请人： Saudi Arabian Oil Company
发明人： Shaohua Chen , Ming Han , Abdulkareem AlSofi
IPC分类号： C09K8/588 , C08G65/331 , C08L33/26 , C08L71/02 , C08F220/56
CPC分类号： C09K8/588 , C08F220/56 , C08G65/3315 , C08L33/26 , C08L71/02
摘要： This disclosure relates to water-soluble viscosity reducer complexes for use in reducing the viscosity of heavy oil in oil recovery operations. The viscosity reducer complexes contain a hydrophilic component of polyaromatic-hydrocarbon-based polymers and a hydrophilic component of cyclodextrin-based polymers.

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