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11. 发明申请

US20130172264A1 INHIBITORS OF IAP 有权
标题翻译： IAP的抑制剂
公开(公告)号：US20130172264A1
公开(公告)日：2013-07-04
申请号：US13733244
申请日：2013-01-03
申请人： GENENTECH, INC.
发明人： Frederick COHEN , Michael KOEHLER , Lewis J. GAZZARD , Vickie Hsiao-Wei TSUI
IPC分类号： C07K5/09
CPC分类号： A61K38/06 , A61K38/00 , A61K45/06 , C07K5/08 , C07K5/0804 , C07K5/0806 , C07K5/0812 , C07K5/0815
摘要： Novel inhibitors of IAP that are useful as therapeutic agents for treating malignancies and have the general formula I: wherein R1,R2,R3,R4,R5 and R6 are as described herein.
摘要翻译：可用作治疗恶性肿瘤的治疗剂并具有通式I的IAP的新型抑制剂：其中R1，R2，R3，R4，R5和R6如本文所述。

12. 发明授权

US08461107B2 HCV NS3 protease inhibitors 有权
公开(公告)号：US08461107B2
公开(公告)日：2013-06-11
申请号：US12989672
申请日：2009-04-16
申请人： Nigel J. Liverton , John A. McCauley , John W. Butcher , Kevin F. Gilbert , Charles J. McIntyre , Michael T. Rudd
发明人： Nigel J. Liverton , John A. McCauley , John W. Butcher , Kevin F. Gilbert , Charles J. McIntyre , Michael T. Rudd
IPC分类号： A61K38/00
CPC分类号： C07K5/123 , A61K38/00 , C07D498/18 , C07K5/08 , C07K5/0804 , C07K5/0812
摘要： The present invention relates to macrocyclic compounds of formula (I) that are useful as inhibitors of the hepatitis C virus (HCV) NS3 protease, their synthesis, and their use for treating or preventing HCV infections.

13. 发明申请

US20130142754A1 Hepatitis C Virus Inhibitors 有权
公开(公告)号：US20130142754A1
公开(公告)日：2013-06-06
申请号：US13492982
申请日：2012-06-11
申请人： Ramkumar Rajamani , Kishore V. Renduchintala , Kandhasamy Sarkunam , Pulicharla Nagalakshmi , Nicholas A. Meanwell , Paul Michael Scola
发明人： Ramkumar Rajamani , Kishore V. Renduchintala , Kandhasamy Sarkunam , Pulicharla Nagalakshmi , Nicholas A. Meanwell , Paul Michael Scola
IPC分类号： A61K38/06 , A61K38/21 , C07K5/02 , A61K38/20
CPC分类号： A61K38/06 , A61K38/2013 , A61K38/204 , A61K38/208 , A61K38/21 , A61K38/212 , C07D401/12 , C07D487/04 , C07K5/02 , C07K5/0804
摘要： Hepatitis C virus inhibitors having the general formula (I) are disclosed. Compositions comprising the compounds and methods for using the compounds to inhibit HCV are also disclosed.

14. 发明申请

US20130131105A1 HCV PROTEASE INHIBITORS AND USES THEREOF 审中-公开
公开(公告)号：US20130131105A1
公开(公告)日：2013-05-23
申请号：US13646018
申请日：2012-10-05
申请人： Celgene Avilomics Research, Inc.
发明人： Russell C. Petter , Juswinder Singh , Arthur F. Kluge , Deqiang Niu , Lixin Qiao , Shomir Ghosh
IPC分类号： C07D401/12
CPC分类号： A61K38/06 , A61K38/00 , A61K38/005 , A61K38/12 , A61K47/64 , C07D401/12 , C07K5/0202 , C07K5/06165 , C07K5/0804 , C07K5/0806 , C07K5/0808 , C07K5/081 , C07K5/0812 , C07K5/0815 , C07K5/0821 , C12N9/506 , C12N9/96 , C12Y304/00
摘要： The present invention provides compounds, pharmaceutically acceptable compositions thereof, and methods of using the same.

15. 发明授权

US08420597B2 Antiviral compounds 有权
公开(公告)号：US08420597B2
公开(公告)日：2013-04-16
申请号：US13598430
申请日：2012-08-29
申请人： Aesop Cho , Michael O'Neil Hanrahan Clarke , Choung U. Kim , John O. Link , Hyung-jung Pyun , Xiaoning C. Sheng , Qiaoyin Wu
发明人： Aesop Cho , Michael O'Neil Hanrahan Clarke , Choung U. Kim , John O. Link , Hyung-jung Pyun , Xiaoning C. Sheng , Qiaoyin Wu
IPC分类号： A61K38/00
CPC分类号： C07D417/14 , C07D207/16 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D413/14 , C07D487/04 , C07K5/0804 , C07K5/0808 , C07K5/0819 , C07K5/0821
摘要： The invention is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.

16. 发明申请

US20130053577A1 ANTIVIRAL COMPOUNDS 有权
公开(公告)号：US20130053577A1
公开(公告)日：2013-02-28
申请号：US13598430
申请日：2012-08-29
申请人： Aesop Cho , Michael O' Neil Hanrahan Clarke , Choung U. Kim , John O. Link , Hyung-jung Pyun , Xiaoning C. Sheng , Qiaoyin Wu
发明人： Aesop Cho , Michael O' Neil Hanrahan Clarke , Choung U. Kim , John O. Link , Hyung-jung Pyun , Xiaoning C. Sheng , Qiaoyin Wu
IPC分类号： C07D207/16
CPC分类号： C07D417/14 , C07D207/16 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D413/14 , C07D487/04 , C07K5/0804 , C07K5/0808 , C07K5/0819 , C07K5/0821
摘要： The invention is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.

17. 发明授权

US08268776B2 Macrocylic oximyl hepatitis C protease inhibitors 失效
标题翻译：大蓖麻丙型肝炎蛋白酶抑制剂
公开(公告)号：US08268776B2
公开(公告)日：2012-09-18
申请号：US12016643
申请日：2008-01-18
申请人： Ying Sun , Deqiang Niu , Guoyou Xu , Yat Sun Or , Zhe Wang
发明人： Ying Sun , Deqiang Niu , Guoyou Xu , Yat Sun Or , Zhe Wang
IPC分类号： A61K38/00
CPC分类号： C07K5/0804 , C07K5/0812 , C07K7/06
摘要： The present invention discloses compounds of formula I, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit serine protease activity, particularly the activity of hepatitis C virus (HCV) NS3-NS4A protease. Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.
摘要翻译：本发明公开了式I化合物或其药学上可接受的盐，酯或前药：其抑制丝氨酸蛋白酶活性，特别是丙型肝炎病毒（HCV）NS3-NS4A蛋白酶的活性。因此，本发明的化合物干扰丙型肝炎病毒的生命周期，也可用作抗病毒剂。本发明还涉及药物组合物，其包含用于给患有HCV感染的受试者施用的上述化合物。本发明还涉及通过施用包含本发明化合物的药物组合物来治疗受试者的HCV感染的方法。

18. 发明授权

US08193346B2 Process for making macrocyclic oximyl hepatitis C protease inhibitors 有权
标题翻译：制备大环脯氨酰丙型肝炎蛋白酶抑制剂的方法
公开(公告)号：US08193346B2
公开(公告)日：2012-06-05
申请号：US12328380
申请日：2008-12-04
申请人： Seble Wagaw , Matthew Ravn , Kenneth Engstrom , Guoyou Xu , Zhe Wang , Ying Sun , Deqiang Niu , Yat Sun Or
发明人： Seble Wagaw , Matthew Ravn , Kenneth Engstrom , Guoyou Xu , Zhe Wang , Ying Sun , Deqiang Niu , Yat Sun Or
IPC分类号： C07K5/08 , C07K5/12
CPC分类号： C07D487/04 , C07D519/00 , C07K5/0802 , C07K5/0804 , C07K5/081
摘要： The present invention relates to a process for the preparation of macrocyclic compounds that are useful as hepatitis C virus (HCV) protease inhibitor compounds.
摘要翻译：本发明涉及可用作丙型肝炎病毒（HCV）蛋白酶抑制剂化合物的大环化合物的制备方法。

19. 发明申请

US20120121624A1 HEPATITIS C VIRUS NS3 PROTEASE INHIBITORS 有权
标题翻译： HEPATITIS C VIRUS NS3 PROTEASE抑制剂
公开(公告)号：US20120121624A1
公开(公告)日：2012-05-17
申请号：US13387542
申请日：2010-07-27
申请人： Nigel J. Liverton , John A. McCauley , Michael T. Rudd
发明人： Nigel J. Liverton , John A. McCauley , Michael T. Rudd
IPC分类号： A61K38/06 , A61P31/00 , A61K39/00 , A61P37/00 , C07K5/087 , A61P31/14
CPC分类号： C07K5/0804 , A61K38/00
摘要： The present invention relates to macrocyclic compounds of Formula (I) that are useful as inhibitors of the hepatitis C virus (HCV) NS3 protease, their synthesis, and their use for treating or preventing HCV infections.
摘要翻译：本发明涉及可用作丙型肝炎病毒（HCV）NS3蛋白酶抑制剂，其合成及其用于治疗或预防HCV感染的式（I）的大环化合物。

20. 发明授权

US08178491B2 Antiviral compounds 有权
公开(公告)号：US08178491B2
公开(公告)日：2012-05-15
申请号：US12215605
申请日：2008-06-26
申请人： Aesop Cho , Michael O'Neil Hanrahan Clarke , Choung U. Kim , John O. Link , Hyung-jung Pyun , Xiaoning C. Sheng , Qiaoyin Wu
发明人： Aesop Cho , Michael O'Neil Hanrahan Clarke , Choung U. Kim , John O. Link , Hyung-jung Pyun , Xiaoning C. Sheng , Qiaoyin Wu
IPC分类号： A61K38/00
CPC分类号： C07D417/14 , C07D207/16 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D413/14 , C07D487/04 , C07K5/0804 , C07K5/0808 , C07K5/0819 , C07K5/0821
摘要： The invention is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.

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